Abstract
Bismuth sulphide nanoparticles are prepared by sol–gel method using gelatine as capping agent. Synthesized nanoparticles are well dispersed in water and the medium is nearly neutral, both essential for biological application. Triethanolamine is used as a complexing agent for solubilization of Bi3+ in water and sodium sulphide as a sulphur source. Nanoparticles are well characterized by standard methods and show marked cytotoxicity and alter membrane potentials of both mitochondria and HeLa cells.
Graphical Abstract
Schematic route to synthesize water-soluble Bi2S3 nanoparticles
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Acknowledgments
The authors wish to acknowledge the help received from Prof. K. Ghosh, Department of Chemistry and from Prof. T. Basu, Department of Biochemistry and Biophysics, University of Kalyani, and their research students. Without assistance from Prof. A. K. Dasgupta, Department of Biochemistry, CU, size analysis of TEM image could not be carried out. Help from DST-FIST and UGC-SAP (DRS) projects to the Department of Chemistry, KU, and DST-PURSE to the Faculty of Science, KU, are gratefully acknowledged. The authors wish to thank the anonymous reviewers as their comments have substantially improved the quality of the manuscript. A.R.K.B. wishes to thank UGC, New Delhi, for the award of Emeritus Fellowship.
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Roy, B., Chattopadhyay, A.P., Samadder, A. et al. Target synthesis of biocompatible spherical bismuth sulphide nanoparticles for biological application. J Sol-Gel Sci Technol 77, 446–452 (2016). https://doi.org/10.1007/s10971-015-3873-3
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DOI: https://doi.org/10.1007/s10971-015-3873-3