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Preparation and evaluation of 188Re-labeled octreotide analog in C6 glioma tumor

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Abstract

In the present study, preparation of [188Re]Re-Tricine-HYNIC-Tyr3-octreotide, stability in human serum, internalization, cell viability analysis, and in vivo tissue biodistribution in rats bearing C6 glioma tumor were investigated. Radiolabeled peptide exhibited a molar activity of 8.60 ± 0.76 GBq/µmol, with over 90% (n = 3) of radiochemical yield. The findings indicated significant internalization of radiolabeled peptide into glioma cells and the ability to reduce cancerous cell viability in MTT analysis. High tumor-to-muscle ratios were observed at various time points following injection. The results suggest that the radiolabeled peptide could be considered for treating tumors expressing somatostatin receptors.

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Acknowledgements

We greatly appreciate the support of this work by research councils of Nuclear Science and Technology Research Institute (NSTRI).

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  1. Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), Tehran, 1439951113, Iran

    Mostafa Erfani, Zhila Fallah, Mostafa Goudarzi & Azadeh Mikaeili

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  1. Mostafa Erfani
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  2. Zhila Fallah
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  3. Mostafa Goudarzi
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  4. Azadeh Mikaeili
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Correspondence to Azadeh Mikaeili.

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Erfani, M., Fallah, Z., Goudarzi, M. et al. Preparation and evaluation of 188Re-labeled octreotide analog in C6 glioma tumor. J Radioanal Nucl Chem (2024). https://doi.org/10.1007/s10967-024-09479-6

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