Abstract
In this study, metabolic stability and biological evaluation of 99mTc labelled 6-hydrazinopyridine-3-carboxylic-acid (HYNIC)-Tyr3-Octreotide was reported as a candidate for imaging somatostatin-receptor (SSTR)-positive tumors. The metabolic stability analysis did not show any evidence of breaking of the labeled compound and formation of free 99mTc. In biodistribution and scintigraphy imaging study, radiopeptide have showed high and receptor-specific uptake in the SSTR2 positive organs, tumor with rapid renal excretion from non-target tissues, illustrating the excellent properties of this agent for SSTR tumor imaging.
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Acknowledgments
The authors gratefully acknowledge Prof. Siddhartha Roy, Ex-Director, CSIR-Indian Institute of Chemical Biology (CSIR-IICB), Kolkata, India and Dr. N. Sivaprasad, Ex-Sr. General Manager, Board of Radiation and Isotope Technology (BRIT), Navi Mumbai, India for their support. And special thanks to Mr. Indranil Banerjee, CSIR-Indian Institute of Chemical Biology (CSIR-IICB), Kolkata, India for kind support, during animal handling. Authors sincerely acknowledge Dr. Santanu Ganguly (Head of the Department of Nuclear Medicine), Bharat Ratna Sarkar and Samarendu Sinha of Regional Radiation Medicine Centre, Thakurpukur Cancer Research Institute, Kolkata, for their kind help in taking gamma camera images of rat. We also thank the Board of Research in Nuclear Sciences, Department of Atomic Energy (BRNS-DAE) and Council of scientific and industrial research (CSIR) for financial support.
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Behera, A., De, K., Chattopadhayay, S. et al. Metabolic stability and biological evaluation of 99mTc-HYNIC-Tyr3-Octreotide as somatostatin receptor positive tumor imaging agent. J Radioanal Nucl Chem 304, 595–602 (2015). https://doi.org/10.1007/s10967-014-3867-6
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DOI: https://doi.org/10.1007/s10967-014-3867-6