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Preparation of radioiodinated ritodrine as a potential agent for lung imaging

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Abstract

Ritodrine (a beta-2 adrenergic receptor agonist) was successfully labeled with 125I via direct electrophilic substitution reaction at ambient temperature. 125I-ritodrine was obtained with a maximum labeling yield of 97 ± 0.163 % and in vitro stability up to 24 h. Biodistribution studies showed that maximum in vivo uptake of 125I-ritodrine in lungs was 20.4 ± 0.22 % injected activity/g tissue at 1 h post-injection, whereas the clearance from mice appeared to proceed mainly via the renal pathway. 125I-ritodrine is not a blood product and so it is more safe than the currently available 99mTc-MAA, and its lung uptake is higher than that of the recently discovered 99mTc(CO)5I and 99mTc-DHPM. As a conclusion, radioiodinated ritodrine could be used as a novel radiopharmaceutical for lung perfusion scan safer than the currently available 99mTc-MAA and more potential than the recently discovered 99mTc(CO)5I and 99mTc-DHPM.

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Authors and Affiliations

  1. Labeled Compound Department, Hot Laboratory Center, Atomic Energy Authority, P.O. 13759, Cairo, Egypt

    H. M. Rashed, I. T. Ibrahim & M. A. Motaleb

  2. Pharmaceutics Department, Faculty of Pharmacy, Cairo University, Giza, Egypt

    A. Abd El-Bary

Authors
  1. H. M. Rashed
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  2. I. T. Ibrahim
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  3. M. A. Motaleb
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  4. A. Abd El-Bary
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Correspondence to H. M. Rashed.

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Rashed, H.M., Ibrahim, I.T., Motaleb, M.A. et al. Preparation of radioiodinated ritodrine as a potential agent for lung imaging. J Radioanal Nucl Chem 300, 1227–1233 (2014). https://doi.org/10.1007/s10967-014-3077-2

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  • DOI: https://doi.org/10.1007/s10967-014-3077-2

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