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Radiosynthesis, chromatographic evaluation and biodistribution of [125I]iododobutamine as a radiotracer for myocardial perfusion imaging

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Abstract

The objective of this work was to develop a potential selective radiotracer for the non-invasive assessment of heart imaging. [125I]iododobutamine was obtained via direct electrophilic substitution reaction with a high labeling yield of 96.79 ± 0.86%. The in vivo biodistribution of iodinated dobutamine showed high heart uptake of 31.49 ± 1.3%ID/g at 2 min after injection with low lungs and liver consumption which alleviate rapid myocardial imaging with significant minimum radiation hazards risk to the patients. Receptor blocking study showed reduction of heart uptake to 0.9 ± 0.01% which confirm the selectivity and specificity of [125I]iododobutamine for beta-adrenoceptors.

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Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Umm A-Qura University, Makkah, Saudi Arabia

    Faisal A. Almalki

  2. Labeled Compounds Department, Hot Laboratories Center, Egyptian Atomic Energy Authority (EAEA), P.O. Box 13759, Cairo, Egypt

    M. A. Motaleb, I. T. Ibrahim & R. S. Abo Rizq

  3. Analytical Department, Faculty of Pharmacy, Cairo University, Giza, Egypt

    E. S. Elzanfaly

  4. Faculty of Pharmacy, Albayan University, Baghdad, Iraq

    I. T. Ibrahim

Authors
  1. Faisal A. Almalki
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  2. M. A. Motaleb
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  3. I. T. Ibrahim
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  4. R. S. Abo Rizq
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  5. E. S. Elzanfaly
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Correspondence to M. A. Motaleb.

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Almalki, F.A., Motaleb, M.A., Ibrahim, I.T. et al. Radiosynthesis, chromatographic evaluation and biodistribution of [125I]iododobutamine as a radiotracer for myocardial perfusion imaging. J Radioanal Nucl Chem 324, 459–466 (2020). https://doi.org/10.1007/s10967-020-07120-w

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  • DOI: https://doi.org/10.1007/s10967-020-07120-w

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