Abstract
Graft copolymers of 2-(dimethylamino)ethylmethacrylate (DMAEMA) and acrylic acid (AAc) onto polypropylene films were investigated for obtaining a pH- and thermo-sensitive material. DMAEMA and AAc were grafted by direct irradiation and pre-irradiation methods, respectively, using a 60Co γ-source. Due to the acidic and basic nature of the monomers, this novel copolymer corresponds to the class of polyzwitterions. Their behavior was studied in presence of different buffer solutions from pH 2 to 12 for different grafting percentages (from 9 to 362%) of AAc and keeping the DMAEMA grafting percentage constant. These modified films showed the same critical pH point at 7.6 in a range of temperatures from 23 to 37 °C. The swelling percentage showed a dependence on AAc content and pH. The lower critical solution temperature was observed at 36 °C when AAc content was less than 30% of grafting. The grafted films were characterized by swelling behavior, FTIR-ATR and UV–Vis spectrometry for study of loading and release of vancomycin as a model drug at room temperature.
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References
Uyama Y, Kato K, Ikada Y (2008) Advances in polymer science. Springer, Berlin
Palacios O, Roustam R, Burillo G (2003) Polym Bull 51:191–197
Qiu Y, Park K (2001) Adv Drug Deliver Rev 53:321–339
Bhattacharya A, Misra BN (2004) Prog Polym Sci 29:767–814
Estrada GM, Macosay J, Bucio E (2010) J Radioanal Nucl Chem 284:131–135
Meléndez-Ortiz HI, Bucio E, Burillo G (2009) Radiat Phys Chem 78:1–7
Bucio E, Burillo G, Adem E, Coqueret X (2005) Macromol Mater Eng 290:745–752
Chan CM (1994) Polymer surface modification and characterization. Hanser Publishers, New York, pp 193–222
Stannett VT (1990) Radiat Phys Chem 35:82–87
Roy I, Gupta MN (2003) Chem Biol 10:1161–1171
Schmaljohann D (2006) Adv Drug Deliver Rev 58:1655–1670
El-Hag Ali Said A (2005) Biomaterials 26:2733–2739
Melendez-Ortiz HI, Bucio E (2008) Polym Bull 61:619–629
Feil H, Bae YH, Feijen J, Kim SW (1992) Macromol 25:5528–5530
Bucio E, Aliev R, Burillo G (1998) Radiat Phys Chem 52:193–196
Bucio E, Aliev R, Burillo G (2002) Polymer Bull 47:571–577
Staikos G (1996) Polym Int 41:345–350
Bokias G, Staikos G, Iliopoulos I (2000) Polymer 41:7399–7405
Titaux GA, Contreras-García A, Bucio E (2009) Radiat Phys Chem 78:485–488
Lowe AB, McCormick CL (2002) Polym Chem Rev 102:4177–4190
Chen J (2007) Radiat Phys Chem 76:1367–1370
Qiu J, Zhang J, Chen J et al (2009) J Membr Sci 334:9–15
Acknowledgments
The authors are grateful to S. Castillo and G. González from ICN-UNAM, for technical assistance. This work was financially support by DGAPA-UNAM (Grant No. IN202311).
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Estrada-Villegas, G.M., Bucio, E. Temperature- and pH-responsive behavior of a novel copolymer of (PP-g-DMAEMA)-g-AAc. J Radioanal Nucl Chem 292, 1–6 (2012). https://doi.org/10.1007/s10967-011-1603-z
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DOI: https://doi.org/10.1007/s10967-011-1603-z