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Labelling of peptides with 99mTc complexes through the modified C-terminal group

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Abstract

Easy and efficient way to modify of the C-terminus of the peptide using amino acid lysine has been proposed and experimentally verified. The synthesis yield was high (≥85%) and it was found that reactions can be carried out even with microgram amounts of the peptide. Using Fmoc-alanine (as the peptide model) with modified C-terminus the procedure of peptide labelling with monovalent and trivalent 99mTc complexes has been elaborated.

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Acknowledgments

The study has been supported by a grant from the Polish Ministry of Science and Higher Education No NN204 186039.

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Authors and Affiliations

  1. Institute of Nuclear Chemistry and Technology, Warsaw, Poland

    Przemysław Koźmiński, Ewa Gniazdowska, Leon Fuks & Agata Oszczak

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  1. Przemysław Koźmiński
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  2. Ewa Gniazdowska
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  3. Leon Fuks
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  4. Agata Oszczak
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Correspondence to Przemysław Koźmiński.

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Koźmiński, P., Gniazdowska, E., Fuks, L. et al. Labelling of peptides with 99mTc complexes through the modified C-terminal group. J Radioanal Nucl Chem 292, 67–74 (2012). https://doi.org/10.1007/s10967-011-1384-4

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  • DOI: https://doi.org/10.1007/s10967-011-1384-4

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