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Synthesis and biodistribution of 99mTc(CO)3-DMSA-MIBI in mice

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Abstract

Mixed ligand fac-tricarbonyl complex of [99mTc(CO)3-DMSA-MIBI] has been prepared starting from the precursor [99mTc(OH2)3(CO)3]+. The complex can be obtained in good yield and purity in a two-step procedure by first attaching meso-2,3-dimercaptosuccinic acid (DMSA, HOOCCH(SH)CH(SH)COOH) with [99mTc(OH2)3(CO)3]+, followed by addition of MIBI [tetrakis-2-methoxyisobutylisonitrile (CH3OC(CH3)2CH2-N≡C) copper(I) tetrafluoroborate] solution. The complex was characterized by TLC and HPLC and was studied by means of octanol-water partition coefficient, electrophoresis, stability in vitro, and normal mice experiment. Biodistribution in mice demonstrated that the complex showed higher myocardial uptake after 0.5-hour p.i. The ratios of heart/liver (%ID/g) in the case of 99mTc(CO)3-DMSA-MIBI was higher (1.88) than that observed in case of 99mTc-MIBI1 (0.93) after 0.5-hour p.i. (P<0.05). Results showed that the complex may be developed to a novel myocardial perfusion-imaging agent.

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References

  1. X. Z. Zhang, X. B. Wang, J. B. Zhang, J. Isot., 10(3) (1996) 158.

    Google Scholar 

  2. R. Alberto, R. Schibli, A. Egli, A. P. Schubiger, U. Abram, T. A. Kaden, J. Am. Chem. Soc., 120 (1998) 7987.

    Article  CAS  Google Scholar 

  3. S. Mundwiler, M. Kundig, K. Orner, R. Alberto, J. Chem. Soc., Dalton Trans., 4 (2004) 1320.

    Google Scholar 

  4. R. Schibli, R. Alberto, U. Abram, A. Egli, T. A. Kaden, P. A. Schubiger, Inorg. Chem., 37 (1998) 3509.

    Article  CAS  Google Scholar 

  5. G. Z. Liu, S. P. Dou, J. He, J. L. Vanderheyden, M. Rusckowski, D. J. Hnatowich, Bioconjugate Chem., 15 (2004) 1441.

    Article  CAS  Google Scholar 

  6. C. L. Ferreira, S. R. Bayly, D. E. Green, T. Storr, C. A. Barta, J. Steele, M. J. Adam, C. Orvig, Bioconjugate Chem., 17 (2006) 1321.

    Article  CAS  Google Scholar 

  7. J. Shelly, P. M. Kevin, G. A. Damian, F. V. John, E. William, W. B. John, Z. Jon, Bioconjugate Chem., 17 (2006) 579.

    Article  CAS  Google Scholar 

  8. H. W. Li, W. B. John, O. Wayne, Z. Jon, Inorg. Chem., 45 (2006) 3057.

    Article  CAS  Google Scholar 

  9. A. S. Karin, R. B. Sangeeta, B. Travis, O. S. Oyebola, K. L. Murali, M. Nicole, A. L. Jennifer, R. B. Douglas, P. M. Kevin, D. B. John, W. B. John, Z. Jon, F. V. John, J. Am. Chem. Soc., 126 (2004) 8598.

    Article  CAS  Google Scholar 

  10. L. Neva, B. John, V. John, S. Paul, J. Shelly, Z. Jon, Inorg. Chem., 44 (2005) 6763.

    Article  CAS  Google Scholar 

  11. V. Papantoniou, J. Christodoulidou, E. Papadaki, V. Valotassiou, M. Souvatzoglou, A. Louvrou, H. Feida, M. Sotiropoulou, G. Pampouras, S. Michalas, C. Zerva, Nucl. Me. Commun., 23 (2002) 461.

    Article  CAS  Google Scholar 

  12. A. Mushtaq, Sh. Pervez, I. Haider, M. S. Mansur, M. Jehangir, J. Radioanal. Nucl. Chem., 243 (2000) 827.

    Article  CAS  Google Scholar 

  13. O. Jeghers, N. Puttemans, D. Urbain, J. Lefebvre, H. R. Ham, Appl. Radiation Isotopes, 38 (1987) 13.

    Article  CAS  Google Scholar 

  14. P. J. Blower, J. Singh, S. E. M. Clarke, J. Nucl. Med., 32 (1991) 845.

    CAS  Google Scholar 

  15. G. Y. Hao, J. Y. Zang, L. Zhu, Y. Z. Guo, B. L. Liu, J. Label. Comp. Radiopharm., 47 (2004) 513.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Key Laboratory of Radiopharmaceutics, (Beijing Normal University), Ministry of Education, College of Chemistry, Beijing Normal University, Beijing, 100875, P.R. China

    Shuye Yang, Xuebin Wang, Haixun Guo, Jian Liu, Fenglong Wang & Xianzhong Zhang

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  1. Shuye Yang
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  2. Xuebin Wang
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  3. Haixun Guo
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  4. Jian Liu
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  5. Fenglong Wang
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  6. Xianzhong Zhang
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Correspondence to Xuebin Wang.

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Yang, S., Wang, X., Guo, H. et al. Synthesis and biodistribution of 99mTc(CO)3-DMSA-MIBI in mice. J Radioanal Nucl Chem 278, 165–171 (2008). https://doi.org/10.1007/s10967-007-7213-0

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  • DOI: https://doi.org/10.1007/s10967-007-7213-0

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