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Animal PET scanner with a large field of view is suitable for high-throughput scanning of rodents

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Annals of Nuclear Medicine Aims and scope Submit manuscript

Abstract

Objective

In preclinical studies, high-throughput positron emission tomography (PET) imaging, known as simultaneous multiple animal scanning, can reduce the time spent on animal experiments, the cost of PET tracers, and the risk of synthesis of PET tracers. It is well known that the image quality acquired by high-throughput imaging depends on the PET system. Herein, we investigated the influence of large field of view (FOV) PET scanner on high-throughput imaging.

Methods

We investigated the influence of scanning four objects using a small animal PET scanner with a large FOV. We compared the image quality acquired by four objects scanned with the one acquired by one object scanned using phantoms and animals. We assessed the image quality with uniformity, recovery coefficient (RC), and spillover ratio (SOR), which are indicators of image noise, spatial resolution, and quantitative precision, respectively. For the phantom study, we used the NEMA NU 4-2008 image quality phantom and evaluated uniformity, RC, and SOR, and for the animal study, we used Wistar rats and evaluated the spillover in the heart and kidney.

Results

In the phantom study, four phantoms had little effect on imaging quality, especially SOR compared with that for one phantom. In the animal study as well, four rats had little effect on spillover from the heart muscle and kidney cortex compared with that for one rat.

Conclusions

This study demonstrated that an animal PET scanner with a large FOV was suitable for high-throughput imaging. Thus, the large FOV PET scanner can support drug discovery and bridging research through rapid pharmacological and pathological evaluation.

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Data availability

The datasets used and/or analyzed during this study are available from the corresponding author on reasonable request.

Abbreviations

PET:

Positron emission tomography

FOV:

Field of view

RI:

Radioisotope

DOI:

Depth of interaction

PSF:

Point spread function

LGSO:

Lutetium gadolinium oxy orthosilicate

3D:

Three dimensional

DRAMA:

Dynamic row-action maximum likelihood algorithm

NEMA:

National Electrical Manufacturers Association

NU4IQ:

NU 4-2008 image quality

STD:

Standard deviation

ROI:

Region of interest

VOI:

Volume of interest

RC(s):

Recovery coefficient(s)

SOR(s):

Spillover ratio(s)

[18F] BCPP-BF:

2-tert-butyl-4-chloro-5-[6-(4-18F-fluorobutoxy)-pyridin-3-ylmethoxy]-2H-pyridazin-3-one

LW:

Left heart wall

AS:

Atrial septum

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Acknowledgements

We would like to thank Masakatsu Kanazawa for PET probe synthesis and Dai Fukumoto for the animal study. All members are employees of Hamamatsu Photonics K.K. We all have no control over this work by the company and declare no conflict of interest.

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Authors and Affiliations

  1. Central Research Laboratory, Hamamatsu Photonics K.K, Hamana, Hamamatsu, Shizuoka, 434-8601, Japan

    Yuki Tomonari, Yuya Onishi, Fumio Hashimoto, Kibo Ote & Hiroyuki Ohba

  2. Department 13, Electron Tube Division, Hamamatsu Photonics K.K, Iwata, Shizuoka, 438-0193, Japan

    Takashi Okamoto

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  1. Yuki Tomonari
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Contributions

YT designed this study, did the phantom and animal studies, analyzed the data, and wrote the manuscript draft. YO did the phantom study and wrote the manuscript draft. FH designed this study and advised on analysis. KO advised on study design. TO oversaw the system description. HO did the phantom study and advised on study design. All the authors read, revised, and approved the final manuscript.

Corresponding author

Correspondence to Yuki Tomonari.

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Ethics approval and consent to participate

This animal study was approved with permission No. HPK-2022-17 by the Institutional Animal Care and Use Committee at the Hamamatsu Photonics.

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Tomonari, Y., Onishi, Y., Hashimoto, F. et al. Animal PET scanner with a large field of view is suitable for high-throughput scanning of rodents. Ann Nucl Med (2024). https://doi.org/10.1007/s12149-024-01937-1

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