Abstract
The 90YCl3 radionuclide precursor (solution of 90Y3+ in diluted HCl) of high purity and high specific activity is already commercially produced and successfully used in nuclear medicine. At the Nuclear Physics Institute ASCR, the 90YCl3 radionuclide precursor is prepared using extraction 90Sr/90Y generator (technology of centrifuge extractors with di-2-ethylhexylphosphoric acid, D2EHPA).1 Its radionuclidic, radiochemical, and chemical purity were examined and specified. The procedure developed for labeling of DOTA-Tyr3-octreotide (DOTATOC) with carrier-free 86/90Y by Rösch 2 at the Institute of Nuclear Chemistry of the University Mainz was optimized and modified in our Department of Radiopharmaceuticals at NPI ASCR as standard labeling test (SLT) for analytical purposes. The SLT as a method for 90YCl3 radionuclide precursor quality control determining its labeling efficiency using ITLC SG chromatography is described and proposed thereinafter. The labeling-efficiency of the tested batches of our product reached more than 95%.
Similar content being viewed by others
References
G. E. Kodina, G. Korpusov, A. T. Filyanin, Radiochemistry, 44 (2002) 62.
F. Rösch, University Mainz, Institute of Nuclear Chemistry, Personal Communication, 2006.
B. Neumaier, F. Rösch, Radiochim. Acta, 81 (1998) 171.
B. Neumaier, F. Rösch, Radiochim. Acta, 84 (1999) 201.
R. E. Weiner, M. L. Thakur, BioDrugs, 19 (2005) 145.
I. Virgolini, T. Traub, C. Novotny, M. Leimer, B. Füger, S. R. Li, P. Patri, T. Pangerl, P. Angelberger, M. Raderer, G. Bourggasser, F. Andreae, A. Kurtaran, R. Dudczak, Curr. Pharm. Des., 8 (2002) 1781.
W. A. P. Breeman, M. T. M. de Jong, E. de Blois, B. F. Bernard, M. de Jong, E. P. Krenning, Nucl. Med. Biol., 31 (2004) 821.
A. Otte, R. Herrmann, A. Heppeler, M. Behe, E. Jermann, P. Powell, H. R. Maecke, J. Muller, Eur. J. Nucl. Med., 26 (1999) 1439.
D. Wild, J. S. Schmitt, M. Ginj, H. R. Maecke, B. F. Bernard, E. P. Krenning, M. de Jong, S. Wenger, J. C. Reubi, Eur. J. Nucl. Med. Mol. Imaging, 30 (2003) 1338.
J. R. Buscombe, K. Pigott, Eur. J. Nucl. Med., 29 (2002) 1697.
V. J. Lewington, Endocr. Relat. Cancer, 10 (2003) 497.
L. Bodei, M. Cremonesi, H. Grana, P. Rocca, M. Bartolomei, M. Chinol, G. Paganelli, Eur. J. Nucl. Med. Mol. Imaging, 31 (2004) 1038.
D. Kwekkeboom, E. P. Krenning, M. de Jong, J. Nucl. Med., 41 (2000) 1704.
S. Froidevaux, A. Heppeler, A. N. Eberle, A. M. Meier, M. Häusler, C. Beglinger, M. Behe, P. Powell, H. R. Mäcke, Endocrinology, 141 (2000) 3304.
V. L. Gates, B. Atassi, R. J. Lewandowski, R. K. Ryu, K. T. Sato, A. A. Nemcek, R. Omary, R. Salem, Future Oncol., 3 (2007) 73.
R. Salem, K. G. Thurston, J. Vasc. Interv. Radiol., 17 (2006) 1571.
R. Salem, R. D. Hunter, Intern. J. Radiat. Oncol. Biol. Phys., 66(2 Suppl) (2006) 83.
J. S. Welsh, A. S. Kennedy, B. Thomadsen, Intern. J. Radiat. Oncol. Biol. Phys., 66(2 Suppl) (2006) S62.
R. W. Kozak, A. Raubitschek, S. Mirzadeh, M. W. Brechbiel, R. Junghaus, O. A. Gansow, T. A. Waldmann, Cancer Res., 49 (1989) 2639.
J. A. Carrasquillo, J. D. White, C. H. Paik, A. Raubitschek, N. Le, M. Rotman, M. W. Brechbiel, O. A. Gansow, L. E. Top, P. Perentesis, J. C. Reynolds, D. L. Nelson, T. A. Waldmann, J. Nucl. Med., 40 (1999) 268.
M. Roselli, M. Schlom, O. A. Gansow, A. Raubitschek, S. Mirzadeh, M. W. Brechbiel D. Corchel, J. Nucl. Med., 30 (1989) 672.
T. E. Witzig, L. I. Gordon, F. Cabanillas, M. S. Czuczman, C. Emmanouilides, R. Joyce, B. L. Pohlman, N. L. Bartlett, G. A. Wiseman, N. Padre, A. J. Grillo-López, P. Multani, C. A. White, J. Clin. Oncol., 20 (2002) 2453.
W. A. P. Breeman, M. de Jong, T. J. Visser, J. L. Erjon, E. P. Krenning, Eur. J. Nucl. Med. Mol. Imaging, 30 (2003) 917.
S. Walrand, F. Jamar, I. Mathieu, J. de Camps, M. Loneux, S. Pauwels, M. Sibomana, D. Labar, C. Michel, Eur. J. Nucl. Med. Mol. Imaging, 30 (2003) 354.
F. Rösch, H. Herzog, B. Stolz, J. Brockmann, M. Köhle, M. Mühlensupen, P. Marbach, W.-H. Müller-Gärtner, Eur. J. Nucl. Chem., 26 (1999) 358.
S. Malja, K. Schomacher, G. Damani, T. Cuci, A. Sallaku, E. Malja, IAEA-SR-209/1, p. 16.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Eigner Henke, K., Beran, M., Srank, J. et al. Quality control of no-carrier-added 90YCl3 by estimating the labeling efficiency using its reaction with DOTATOC. J Radioanal Nucl Chem 278, 25–29 (2008). https://doi.org/10.1007/s10967-007-7186-z
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10967-007-7186-z