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Cyclotron 99mTc Production and Quality Control for Medical Applications

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Radiochemistry Aims and scope

Abstract

A new production method of 99mTc using a high-current solid target was tested. The separation and purification setup was developed to produce high quantity and high specific activity of 99mTcO −4 suitable for labeling various ligands for nuclear medicine imaging. A semiautomated target dissolution and separation system has been developed for 99mTcO −4 production. The separation is based on a chromatographic column system. The chemical and radiochemical purity was found to be in accordance with the US and European Pharmacopoeia specifications. 99% of activity in the final product belonged to 99mTc. Less than 1% of the 99mTc activity was not incorporated in the target product with MDP kits. Biodistribution data for the labeled MDP kits show that the quality of the produced 99mTc-pertechnetate is identical to that of the pertechnetate from 99Mo/99mTc generators. The application of 99mTc-ethylenedicysteine in human proves the good quality of the produced Na99mTcO4.

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Authors and Affiliations

  1. Cyclotron Division, Radioisotopes Department, Atomic Energy Commission of Syria, P.O. Box 6091, Damascus, Syria

    A. H. Al Rayyes, T. Assaad & Y. Ailouti

Authors
  1. A. H. Al Rayyes
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  2. T. Assaad
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  3. Y. Ailouti
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Correspondence to A. H. Al Rayyes.

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Al Rayyes, A.H., Assaad, T. & Ailouti, Y. Cyclotron 99mTc Production and Quality Control for Medical Applications. Radiochemistry 61, 81–85 (2019). https://doi.org/10.1134/S1066362219010120

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  • DOI: https://doi.org/10.1134/S1066362219010120

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