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Study on the preparation of genipin crosslinked chitosan microspheres of resveratrol and in vitro release

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Abstract

Resveratrol has attracted considerable public and scientific attention because of its beneficial effects on human health. In this study, resveratrol was encapsulated into chitosan microspheres for improving the stability and evaluating the ability of controlled release. Chitosan microspheres were prepared by using an emulsification-crosslinking method, and specifically, a natural extraction genipin was used as crosslinking agent for pursuit better physiological compatibility. Factors which influence on the shape and dispersity of microspheres were investigated to optimize the preparing process of resveratrol loaded genipin-chitosanmicrospheres. The optimum condition was obtained and the prepared resveratrol loaded genipin-chitosanmicrospheres were characterized by many technical instruments. Entrapment efficiency of resveratrol in genipin-chitosanmicrospheres is up to 87.6 %, and loading capacity is 7.9 %. The in vitro release rate in pH 3.6 buffer solution reached to 33.8 % within 72 h, but was lower in pH 7.4 buffer solution.

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Acknowledgments

The authors would like to thank the mutual funds of Hebei Natural Science Foundation and CSPC Pharmaceutical Co., Ltd. (C2011208114). Supports for Hebei Research Center of Pharmaceutical and Chemical Engineering, Hebei Province Key Laboratory of Molecular Chemistry for Drug, and Innovation Team Funding of Hebei University of Science and Technology are also appreciated.

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Authors and Affiliations

  1. School of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, 050018, China

    Yue Zhang, Yi-feng Yu, Xian-xian Shi, Shu-chun Zhao, Ai-bing Chen, Dao-wei Huang, Dong-jie Niu & Zhen Qin

  2. Hebei Research Center of Pharmaceutical and Chemical Engineering, Shijiazhuang, 050018, China

    Yue Zhang, Yi-feng Yu, Shu-chun Zhao & Ai-bing Chen

  3. State Key Laboratory Breeding Base-Hebei Province Key Laboratory of Molecular Chemistry for Drug, Shijiazhuang, 050018, China

    Yue Zhang, Yi-feng Yu & Shu-chun Zhao

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  1. Yue Zhang
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  2. Yi-feng Yu
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  3. Xian-xian Shi
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  4. Shu-chun Zhao
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  5. Ai-bing Chen
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Correspondence to Yi-feng Yu.

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Zhang, Y., Yu, Yf., Shi, Xx. et al. Study on the preparation of genipin crosslinked chitosan microspheres of resveratrol and in vitro release. J Polym Res 20, 175 (2013). https://doi.org/10.1007/s10965-013-0175-8

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  • DOI: https://doi.org/10.1007/s10965-013-0175-8

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