Skip to main content
SpringerLink
Log in

Preparation of chitosan microspheres loading of 3,5-dihydroxy-4-i-propylstilbene and in vitro release

  • Original Paper
  • Published:
Journal of Polymer Research Aims and scope Submit manuscript

Abstract

3,5-Dihydroxy-4-i-propylstilbene (DHPS) is a compound expected to be developed into effective drugs for many inflammatory and autoimmune diseases. In order to improve the stablity of DHPS, the cross-linked chitosan (CS) microspheres loading of DHPS were prepared and characterized. The optimal conditions for preparing CS-microspheres loading of DHPS were investigated. The results showed that the CS-microspheres loading of DHPS had spherical shape with diameters between 8 and 12 microns. The entrapment of DHPS in the CS-microspheres was more than 36%. The released percentage of CS-microspheres loading of DHPS in pH 3.6 buffer solution was up to 30.9% within 96 h. In transdermal in vitro release, DHPS kept release within 60 h through rat skin and the released percentage could arrive 76.2%. The CS-microspheres loading of DHPS had excellent stability and ability of sustained release.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Scheme 1
Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

  1. Akbuga J, Durmaz G (1994) Inter J Pharm 111:217

    Article  CAS  Google Scholar 

  2. Chen GH, Webster JM (2008) US Patent Office 0255245

  3. Paul VJ, Frautschy S, Fenical W, Nealson KH (1981) J Chem Ecol 7:589

    Article  CAS  Google Scholar 

  4. Krow GR, Miles WH, Smiley PM (1992) J Org Chem 57:4040

    Article  CAS  Google Scholar 

  5. Richardson WH, Schmidt TM, Nealson KH (1988) Appl Environ Microb 54:1602

    CAS  Google Scholar 

  6. Hu K, Li J, Webster JM (1996) Can J Plant Pathol 18:104

    Article  Google Scholar 

  7. Hu K, Webster JM (2000) FEMS Microbiol Let 189:219

    CAS  Google Scholar 

  8. Tang LR, Chen GH, Li B (2007) Clin Immunol 123.

  9. Hu KJ, Li JX, Li B (2006) Bioorgan Med Chem 14:4677

    Article  CAS  Google Scholar 

  10. Babazadeh M, Edjlali L, Rashidian L (2007) J Polym Res 14:207

    CAS  Google Scholar 

  11. Wang TW, Jing M, Wu Y (2010) J Polym Res 17:335

    Article  CAS  Google Scholar 

  12. Liu CC, Chang KY, Wang YJ (2010) J Polym Res 17:459

    Article  CAS  Google Scholar 

  13. Wu Y, Li MG, Gao HG (2009) J Polym Res 16:11

    Article  CAS  Google Scholar 

  14. Zhang C, Cheng Y, Qu GW, Wu XL, Ding Y, Cheng ZH, Yu LL, Ping QN (2008) Carbohyd Polym 72:390

    Article  CAS  Google Scholar 

  15. Gupta KC, Jabrail FH (2006) Carbohyd Polym 66:43

    Article  CAS  Google Scholar 

  16. Zhang Y (2009) CN Patent Office, 101 648 851

  17. Chinese Pharmacopoeia, 2010: The guiding principles for stability test of drugs and drug preparations

  18. Wang ZX (1989) Infrared spectroscopy and characterization of polymer. Sichuan Univ Bub Co, Chengdu, pp 179–183

    Google Scholar 

Download references

Acknowledgment

The authors would like to thank Dr Yanyan Zhao and her collegues for the HPLC measurements.

Author information

Authors and Affiliations

  1. College of Chemistry and Enviromental Science, Hebei University, Baoding, 071002, China

    Jun-gang Gao & Yue Zhang

  2. School of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, 050018, China

    Yue Zhang, Yi-feng Yu, Yu-cui Han, Bing-zhu Zhang & Chun-hui Gao

Authors
  1. Jun-gang Gao
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yue Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yi-feng Yu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yu-cui Han
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Bing-zhu Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Chun-hui Gao
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jun-gang Gao.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gao, Jg., Zhang, Y., Yu, Yf. et al. Preparation of chitosan microspheres loading of 3,5-dihydroxy-4-i-propylstilbene and in vitro release. J Polym Res 18, 1501–1508 (2011). https://doi.org/10.1007/s10965-010-9555-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10965-010-9555-5

Keywords

Search

Navigation