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Investigation of the Binding Properties of the Cosmetic Peptide Argireline and Its Derivatives Towards Copper(II) Ions

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Abstract

Isothermal titration calorimetry, potentiometric titration and circular dichroism spectroscopy were used to study the interaction of copper(II) ions with Argireline (Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2) and three of its point mutation derivatives: Glu-Ala-Met-Gln-Arg-Arg-NH2 (AN1), Glu-Ala-His-Gln-Arg-Arg-NH2 (AN2) and Glu-Ala-Met-Gln-Ala-Arg-NH2 (AN3). Under the experimental conditions (20 mmol·L−1 Caco solution, pH 6, 298.15 K), copper(II) ions form 1:1 complexes with the peptides Argireline, AN1, and AN2. The complexation reactions are entropy-driven processes. The stability of the resulting complexes increases in the order log10KCu(AN1) < log10KCu(Argireline) < log10KCu(AN2). The relationship between the point mutations of Argireline and the binding properties of these peptides towards copper(II) ions is discussed.

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Authors and Affiliations

  1. Faculty of Chemistry, University of Gdańsk, ul. Wita Stwosza 63, 80-308, Gdańsk, Poland

    Joanna Makowska, Aleksandra Tesmar, Dariusz Wyrzykowski & Lech Chmurzyński

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  1. Joanna Makowska
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  2. Aleksandra Tesmar
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  3. Dariusz Wyrzykowski
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  4. Lech Chmurzyński
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Correspondence to Joanna Makowska.

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Makowska, J., Tesmar, A., Wyrzykowski, D. et al. Investigation of the Binding Properties of the Cosmetic Peptide Argireline and Its Derivatives Towards Copper(II) Ions. J Solution Chem 47, 80–91 (2018). https://doi.org/10.1007/s10953-017-0705-9

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  • DOI: https://doi.org/10.1007/s10953-017-0705-9

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