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Periodic 3D nanoporous silica modified by amine or SPION nanoparticles as NSAID delivery system

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Abstract

Nonsteroidal anti-inflammatory drug (NSAID) indomethacin (indo) was loaded into cubic nanoporous silica SBA-16 modified by amine groups (A-SBA-16) or hematite SPIONs (Fe-SBA-16). The kinetic of the indomethacin release into physiological solution with pH = 7.4 was studied. After 72 h the released amount represented 91 % of the loaded amount for the unmodified SBA-16 and 63 % for the amine modified one. To study vectored drug delivery to the affected body organs with the assistance of magnetic field, SBA-16 was modified by Fe2O3 SPION nanoparticles and the magnetic properties of the sample were investigated by SQIUD magnetometry. The results show on superparamagnetic behaviour of the composite sample Fe-SBA-16 at room temperature with the value of effective magnetic moment m p  ~ 384 μ B . It was shown that the superparamagnetic behaviour of Fe-SBA-16 did not change after the indomethacin incorporation. The kinetic of the drug release from the Fe-SBA-16/indo sample was similar to the SBA-16/indo sample in the first 50 h. However, the total released amount after the 72 h was for the Fe-SBA-16/indo sample lower (68 % of the loaded amount), indicating the stronger interaction of the drug with the porous carrier.

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Acknowledgments

This work was supported by the Slovak Research and Development Agency under the contract No. APVV-15-0520. V.Z. thanks Desy, Hasylab, Hamburg Germany for the support during synchrotron related measurements.

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Authors and Affiliations

  1. Institute of Chemistry, P. J. Šafárik University, Moyzesova 11, 041 54, Košice, Slovakia

    Vladimír Zeleňák & Dáša Halamová

  2. Institute of Physics, P. J. Šafárik University, Park Angelinum 9, 04001, Košice, Slovakia

    Adriána Zeleňáková & Vladimír Girman

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  1. Vladimír Zeleňák
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Zeleňák, V., Halamová, D., Zeleňáková, A. et al. Periodic 3D nanoporous silica modified by amine or SPION nanoparticles as NSAID delivery system. J Porous Mater 23, 1633–1645 (2016). https://doi.org/10.1007/s10934-016-0224-x

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