Skip to main content
SpringerLink
Log in

Synthesis, characterization and sustaining controlled release effect of mesoporous SBA-15/ramipril composite drug

  • Original Article
  • Published:
Journal of Inclusion Phenomena and Macrocyclic Chemistry Aims and scope Submit manuscript

Abstract

A loading of ramipril in SBA-15 (Santa Barbara Amorphous) mesoporous material was studied. (SBA-15)-ramipril composite material was characterized by chemical analysis, infrared spectroscopy, powder X-ray diffraction, low temperature N2 adsorption–desorption at 77 K characterization techniques. Ramipril drug release processes from SBA-15 host to simulated body fluid (SBF), simulated gastric juice (SGJ), simulated intestinal fluid (SIF) were monitored in a simulated way and actions of the sustained release of (SBA-15)-ramipril was studied. The results showed that the loading amount of ramipril drug in SBA-15 was 90.30 mg/g. The cumulative sustained release rate of ramipril composite drug in SBF achieved 99.7 % after 27 h. When the sustained release of composite drug in SGJ was 8 h, the maximum cumulative sustained release ratio achieved 54.9 %. When the sustained release of composite drug was 9 h in SIF, the maximum cumulative sustained release ratio achieved 34.9 %. The method described in this study is suitable for carrying ramipril drug on SBA-15, and a new carrier to load ramipril drug was found. Meanwhile, the efficacy of ramipril drug and time efficacy could be improved.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

Similar content being viewed by others

References

  1. Kresge, C.T., Leonowicz, M.E., Roth, W.J., Vartuli, J.C., Beck, J.S.: Ordered mesoporous molecular sieve synthesized by a liquid-crystal template mechanism. Nature 359, 710–712 (1992)

    Article  CAS  Google Scholar 

  2. Suh, M., Lee, H.J., Park, J.Y., Lee, H., Kwon, Y.U., Kim, D.J.: A mesoporous silica thin film as uptake host for guest molecules with retarded release kinetics. Chem. Phys. Chem. 9, 1402–1408 (2008)

    Article  CAS  Google Scholar 

  3. Kortesuo, P., Ahola, M., Karlsson, S., Kangasniemi, I., Kiesvaara, J., Yli-Urpo, A.: Sol-gel-processed sintered silica xerogel as a carrier in controlled drug delivery. J. Biomed. Mater. Res. 44B, 162–167 (1999)

    Article  Google Scholar 

  4. Barbe, C., Bartlett, J., Kong, L., Finnie, K., Lin, H.Q., Larkin, M., Calleja, S., Bush, A.: Silica particles: a novel drug-delivery system. Adv. Mater. 16, 1959–1966 (2004)

    Article  CAS  Google Scholar 

  5. Corma, A.: From microporous to mesoporous molecular sieve materials and their use in catalysis. Chem. Rev. 97, 2373–2420 (1997)

    Article  CAS  Google Scholar 

  6. Zhao, D.Y., Feng, J.L., Huo, Q.S., Melosh, N., Fredrickson, G.H., Chmelka, B.F., Stucky, G.D.: Triblock copolymer synthesis of mesoporous silica with periodic 50 to 300 angstrom pores. Science 279, 548–552 (1998)

    Article  CAS  Google Scholar 

  7. Zhao, D.Y., Huo, Q.S., Feng, J.L., Chmelka, B.F., Stucky, G.D.: Nonionic triblock and star diblock copolymer and oligomeric surfactant syntheses of highly ordered, hydrothermally stable, mesoporous silica structures. J. Am. Chem. Soc. 120, 6024–6036 (1998)

    Article  CAS  Google Scholar 

  8. Ajitha, S., Sugunan, S.: Tuning mesoporous molecular sieve SBA-15 for the immobilization of α-amylase. J. Porous Mater. 17, 341–349 (2010)

    Article  CAS  Google Scholar 

  9. Li, Y., Zhou, G., Li, C., Qin, D., Qiao, W., Chu, B.: Adsorption and catalytic activity of porcine pancreatic liase on rod-like SBA-15 mesoporous material. Colloid Surf. A Physicochem. Eng. Aspects 341, 79–85 (2009)

    Article  CAS  Google Scholar 

  10. Ma, J., Chu, J., Qiang, L.S., Xue, J.Q.: Research on the advances in modification of SBA-15 and its application. Bull. Chin. Ceram. Soc. 31, 301–305 (2012)

    CAS  Google Scholar 

  11. Zhao, F., Li, G., Wang, X., Sun, D., Jin, C.: Loading and release of ibuprofen on mesoporous molecular sieve Ti-HMS. J. Porous Mater. 17, 629–634 (2010)

    Article  CAS  Google Scholar 

  12. Luan, Z.H., Hartmann, M., Zhao, D.Y., Kevan, L.: Alumination and ion exchange of mesoporous SBA-15 molecular sieves. Chem. Mater. 11, 1621–1627 (1999)

    Article  CAS  Google Scholar 

  13. Kokubo, T., Kushitani, H., Sakka, S., Kitsugi, T., Yamamuro, T.: Solutions able to reproduce in vivo surface-structure changes in bioactive glass-ceramic A-W. J. Biomed. Mater. Res. 24, 721–734 (1990)

    Article  CAS  Google Scholar 

  14. Horcajada, P., Ramila, A., Perez-Pariente, J., Vallet-Regi, M.: Influence of pore size of MCM-41 matrices on drug delivery rate. Micropor. Mesopor. Mater. 68, 105–109 (2004)

    Article  CAS  Google Scholar 

  15. Hisham, E.A.: Spectrophotometric and spectrofluorimetric methods for the determination of ramipril in its pure and dosage form. Spectrochim Acta 66A, 701–706 (2006)

    Google Scholar 

  16. Brunauer, S., Emmett, P.H., Teller, E.: Adsorption of gases in multimolecular layers. J. Am. Chem. Soc. 60, 309–319 (1938)

    Article  CAS  Google Scholar 

  17. Barrett, E., Joyner, L.G., Halenda, P.P.: The determination of pore volume and area distributions in porous substances: computations from nitrogen isotherms. J. Am. Chem. Soc. 73, 350–373 (1951)

    Article  Google Scholar 

  18. Vradman, L., Landau, M.V., Kantorovieh, D., Koltypin, Y., Gedanken, A.: Evaluation of metal oxide phase assembling mode inside the nanotubular pores of mesostructured silica. Micropor. Mesopor. Mater. 79, 307–318 (2005)

    Article  CAS  Google Scholar 

  19. Doadrio, J.C., Sousa, E.M.B., Izquierdo-Barba, I., Doadrio, A.L., Perez-Pariente, J., Vallet-Regi, M.: Functionalization of mesoporous materials with long alkyl chains as a strategy for controlling drug delivery pattern. J. Mater. Chem. 16, 462–466 (2006)

    Article  CAS  Google Scholar 

  20. Vallet-Regi, M., Doadrio, J.C., Doadrio, A.L., Izquierdo-Barba, I., Perez-Pariente, J.: Hexagonal ordered mesoporous material as a matrix for the controlled release of amoxicillin. Solid State Ionics 172, 435–439 (2004)

    Article  CAS  Google Scholar 

  21. Doadrio, A.L., Sousa, E.M.B., Doadrio, J.C., Perez-Pariente, J., Izquierdo-Barba, I., Vallet-Regi, M.: Mesoporous SBA-15 HPLC evaluation for controlled gentamicin drug delivery. J. Control. Release 97, 125–132 (2004)

    Article  CAS  Google Scholar 

  22. Higuchi, T.: Mechanism of sustained-action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J. Pharm. Sci. 52, 1145–1147 (1963)

    Article  CAS  Google Scholar 

  23. Yang, L.B., Fassihix, A.R.: Zero-order release kinetics from a self-correcting floatable asymmetric configuration drug delivery system. J. Pharm. Sci. 85, 170–173 (1996)

    Article  CAS  Google Scholar 

  24. Kim, H.J., Ahn, J.E., Haam, S.J., Shul, Y.G., Song, S.Y., Tatsumi, T.S.: Synthesis and characterization of mesoporous Fe/SiO2 for magnetic drug targeting. J. Mater. Chem. 16, 1617–1621 (2006)

    Article  CAS  Google Scholar 

  25. Fassihi, A.R., Ritschel, W.A.: Multiple-layer, direct-compression, controlled-release system: in vitro and in vivo evaluation. J. Pharm. Sci. 82, 750–754 (1993)

    Article  CAS  Google Scholar 

  26. Song, S.M., Wang, Z.L., Li, W.B.: Physical Chemistry, pp. 219–231. Higher Education Publishing House, Beijing (1993)

    Google Scholar 

Download references

Acknowledgments

The authors acknowledge financial support by Education Department of Jilin Province, P. R. China. The number of the project was 2010JYT10, KYC -JC-XM-2010-014.

Author information

Authors and Affiliations

  1. Research Center for Nanotechnology, Changchun University of Science and Technology, South Campus, 7186 Weixing Road, Changchun, 130022, Jilin, People’s Republic of China

    Qing-Zhou Zhai, Yan-Ying Wu & Xiao-Han Wang

Authors
  1. Qing-Zhou Zhai
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yan-Ying Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Xiao-Han Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Qing-Zhou Zhai.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zhai, QZ., Wu, YY. & Wang, XH. Synthesis, characterization and sustaining controlled release effect of mesoporous SBA-15/ramipril composite drug. J Incl Phenom Macrocycl Chem 77, 113–120 (2013). https://doi.org/10.1007/s10847-012-0222-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10847-012-0222-9

Keywords

Search

Navigation