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Zinc-based metal-organic frameworks: synthesis and recent progress in biomedical application

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Abstract

This review based on Zn-based MOF is summarized on new insights for targeted drug delivery of medicinal compounds and developed for medicinal applications. The stability of the MOF may be controlled by functionalization and the proper structure and composition choices. Thus, one of the most crucial factors to consider when it comes to bio-applications of MOF is the management of their particle size distribution and the alteration of their surface. Recent research was shown that Zn-based MOF can be used as a viable delivery system for non-toxic/biocompatible medicines and therapeutic agents in biological and medical applications. The toxicity, biocompatibility, stability, and recently reported production techniques for MOF’s zinc-based building block as a possible platform with biological applications were explored and presented in this review study to offer ideal venues for further research. The factors including The surface area and pore volumes, functional groups, and synthetic methods for adsorption and desorption of drugs were studied. Antibacterial and anticancer activities of Zn-based MOF and their mechanisms were investigated. At last, the adsorption and release mechanism of drugs was investigated.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, University of Qom, Qom, Iran

    Mojtaba Moharramnejad & Ali Ehsani

  2. Department of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran

    Saba salmani

  3. Department of Chemistry, Semnan University, Semnan, Semnan Province, Iran

    Mehrnaz shahi

  4. Department of Chemistry, Iran University of Science and Technology, Tehran, Tehran Province, Iran

    Rahime Eshaghi Malekshah & Zahra Sadat Robatjazi

  5. Department of Chemistry, University of New Brunswick, E3B 5A3, Fredericton, NB, Canada

    Hamidreza Parsimehr

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  1. Mojtaba Moharramnejad
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  2. Ali Ehsani
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  3. Saba salmani
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Correspondence to Ali Ehsani.

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Moharramnejad, M., Ehsani, A., salmani, S. et al. Zinc-based metal-organic frameworks: synthesis and recent progress in biomedical application. J Inorg Organomet Polym 32, 3339–3354 (2022). https://doi.org/10.1007/s10904-022-02385-y

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  • DOI: https://doi.org/10.1007/s10904-022-02385-y

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