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A 2-Fold Interpenetrating Zn(II)-MOF: Sensitive Detection of Fe3+ Ion and Anti-Cancer Activity on Breast Cancer Through high Intensity Focused Ultrasound

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Abstract

In the current study, via using a mixed ligand approach, a new three-dimensional metal–organic framework, [Zn2(L)2(bpp)(H2O)2]n (bpp = 1,3-di(4-pyridyl)propane and H2L = 2,5-thiophenedicarboxylic acid) was synthesized with a high yield under the condition of solvothermal reaction, and its structure was characterized through the diffraction of single crystal X-ray along with EA. Luminescence studies revealed that complex 1 can be utilized as the highly sensitive fluorescent sensor for sensing Fe3+ in aqueous solution. The apoptosis assay was used to assess the death of breast cancer cells after the compound treatment, and the relative expression of the genes related to ROS was also detected. The results for the simulation of molecular docking provided the novel design strategy of the anti-cancer drug and provided deeper insights into the anti-cancer activities.

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Author notes

  1. Jing Huang and Xiao-Yan Pu have contributed equally to this work.

Authors and Affiliations

  1. Department of Ultrasound, Zhuhai People’s Hospital (Zhuhai Hospital Affiliated With Jinan University), Zhuhai, Guangdong, China

    Jing Huang

  2. Department of Ultrasound, Suzhou Ninth People’s Hospital, Suzhou, Jiangsu, China

    Xiao-Yan Pu

  3. The Second Department of General Surgery, Zhuhai People’s Hospital (Zhuhai Hospital Affiliated With Jinan University), Zhuhai, Guangdong, China

    Zheng Liu

  4. Medical Center, Wuhu First People’s Hospital, Wuhu, Anhui, China

    Xiang-Yun Cao

  5. Department of Ultrasound, Affiliated Hai’an Hospital of Nantong University, Nantong, Jiangsu, China

    Jian Fu

Authors
  1. Jing Huang
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  2. Xiao-Yan Pu
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  3. Zheng Liu
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  4. Xiang-Yun Cao
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  5. Jian Fu
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Correspondence to Jian Fu.

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Huang, J., Pu, XY., Liu, Z. et al. A 2-Fold Interpenetrating Zn(II)-MOF: Sensitive Detection of Fe3+ Ion and Anti-Cancer Activity on Breast Cancer Through high Intensity Focused Ultrasound. J Inorg Organomet Polym 31, 2209–2217 (2021). https://doi.org/10.1007/s10904-021-01921-6

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  • DOI: https://doi.org/10.1007/s10904-021-01921-6

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