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Functionalized Metallic Nanoparticles: Theranostic Applications

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Multifunctional And Targeted Theranostic Nanomedicines

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Abstract

Metallic nanoparticles such as magnetic (iron, manganese, cobalt, chromium, and nickel), gold, silver, and transition element-based nanoparticles have been extensively studied for the development of new generation cancer therapeutic and diagnostic tools. These metallic nanoparticles are easy to synthesize, surface functionalize, and also possess unique physical and chemical properties which are suitable for theranostic applications. The role of metallic nanoparticles as nanoimaging (fluorescence imaging, magnetic resonance imaging) has been potentially used in detection and diagnosis of cancer at early stage. A multifunctional targeted drug delivery using intrinsic stimuli-responsive (pH, thermal) or extrinsic such as light, heat, and ultrasound has endowed a huge nanoplatform for their therapeutic potential for simultaneous detection (diagnostic) and treatment (therapeutic) of cancer. Moreover, the new development of theranostic hybrid multifunctional nanocarriers has greatly expanded their application in nanomedicines through combining the suitable imaging modalities agents with chemotherapeutic drugs to treat cancer with better, more precise, and minimally invasive approaches. This chapter provides the basic characteristics of multifunctional metallic nanoparticles and their nanotechnological application in theranostics. Finally, we will highlight the future perspective of multifunctional metallic nanoparticles in clinical and nanotechnological cancer research.

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Acknowledgments

The authors would like to acknowledge the Engineering and Physical Science Research Council (EPSRC), the UK, for emPOWER program at the University of Bristol under Grant No. EP/T020792/1.

Conflicts of Interest

The authors declare no competing financial interest.

Author information

Authors and Affiliations

  1. School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK

    Kapil D. Patel & Adam W. Perriman

  2. Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel

    Anup Kumar Patel

  3. Division of Surgery and Interventional Science, University College London, London, UK

    Prasad Sawadkar

  4. Department of Immunology, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

    Bineta Singh

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  1. Kapil D. Patel
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  2. Anup Kumar Patel
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  3. Prasad Sawadkar
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  4. Bineta Singh
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  5. Adam W. Perriman
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Editors and Affiliations

  1. Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER) – Raebareli, Lucknow, India

    Keerti Jain

  2. Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar, Madhya Pradesh, India

    N. K. Jain

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Patel, K.D., Patel, A.K., Sawadkar, P., Singh, B., Perriman, A.W. (2023). Functionalized Metallic Nanoparticles: Theranostic Applications. In: Jain, K., Jain, N.K. (eds) Multifunctional And Targeted Theranostic Nanomedicines. Springer, Singapore. https://doi.org/10.1007/978-981-99-0538-6_5

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  • DOI: https://doi.org/10.1007/978-981-99-0538-6_5

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