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Development of a halloysite nanotube-based 19F NMR probe as a promising detection tool for H2O2

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Abstract

The 19F nuclear magnetic resonance (NMR) has been widely employed as a detection tool in biological studies due to its low biological background, noninvasiveness, high sensitivity, and real-time monitoring capability. Herein, we report a one-pot synthesis of halloysite nanotubes (HNTs) treated with benzeneboronic acids (6FBB) to afford the HNT-based 19F NMR probe which is capable to detect the H2O2 in low concentration. The product was well characterized by nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FTIR), transmission electron microscope (TEM), X-ray photoelectron spectroscopy (XPS), and X-ray diffraction (XRD). The intensity of signals of 19F was enhanced with the increasing concentration of fluorine, and the signals apparently shifted from − 62.68 to − 62.85 ppm upon the addition of H2O2. The obtained 19F NMR probes also displayed a long spin-spin (T2) relaxation time (91.27 ms), which can strengthen image intensity. Moreover, the 19F NMR probe exhibited non-toxic against HeLa cell. The 19F NMR probe may serve as a desirable candidate to predict the change of H2O2 in vivo.

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Acknowledgments

We are thankful to Qian Zhou, Cong Cheng, Dr. Li Huo, Dr. Dong Yang, and Dr. Gang Ma for their technical help and advice.

Funding

This work was supported by the Natural Science Foundation of Hebei Province (B2019201221 and B2019201337).

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Authors and Affiliations

  1. College of Chemistry and Environmental Science, Hebei University, Baoding, 071002, People’s Republic of China

    Wenshan Gao, Yuangong Zhang, Ying Zheng, Hailei Zhang, Xiaoke Wang, Libin Bai, Yonggang Wu & Xinwu Ba

  2. Affiliated Hospital of Hebei University, Baoding, 071000, Hebei Province, People’s Republic of China

    Wenshan Gao

  3. Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Hebei University, Baoding, 071002, People’s Republic of China

    Xiaoke Wang

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  1. Wenshan Gao
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Correspondence to Xiaoke Wang or Libin Bai.

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Gao, W., Zhang, Y., Zheng, Y. et al. Development of a halloysite nanotube-based 19F NMR probe as a promising detection tool for H2O2. J Nanopart Res 22, 342 (2020). https://doi.org/10.1007/s11051-020-05073-5

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