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Synthesis of Organotin Polyamine Ethers Containing Thiamine (Vitamin B1) and Preliminary Ability to Inhibit Select Cancer Cell Lines

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Abstract

Organotin polyamine ethers containing thiamine (Vitamin B1) were synthesized employing the interfacial polymerization of thiamine and organotin dichlorides. Reaction is rapid occurring in less than 15 s in moderate to poor yield with chain length ranging from 86 to 860 units. Infrared spectroscopy shows new bands characteristic of the formation of the Sn–N and Sn–O linkages. Proton NMR shows the presence of both the organotin and thiamine moieties. MALDI MS results shows ion fragment clusters to three units with ion abundance results consistent with the presence of tin atoms within the ion fragment clusters. The polymers all exhibit inhibition of the cancer cell lines including two breast, two pancreatic, prostate, and colon cancer cell lines at levels better than those for the standard cisplatin, one of the most widely employed anticancer drugs.

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Authors and Affiliations

  1. Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL, 33431, USA

    Charles E. Carraher Jr., Raven E. Lambert & Luis Arroyo

  2. Department of Biology, University of Texas at Arlington, Arlington, TX, 76010, USA

    Michael R. Roner & Lindsey C. Miller

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  1. Charles E. Carraher Jr.
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  2. Michael R. Roner
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  3. Raven E. Lambert
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  4. Luis Arroyo
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  5. Lindsey C. Miller
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Correspondence to Michael R. Roner.

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Carraher, C.E., Roner, M.R., Lambert, R.E. et al. Synthesis of Organotin Polyamine Ethers Containing Thiamine (Vitamin B1) and Preliminary Ability to Inhibit Select Cancer Cell Lines. J Inorg Organomet Polym 25, 1414–1424 (2015). https://doi.org/10.1007/s10904-015-0254-x

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  • DOI: https://doi.org/10.1007/s10904-015-0254-x

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