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Synthesis and Initial Cell Line Results of Organotin Polyethers Containing Diethylstilbestrol

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Abstract

Organotin polyethers containing the synthetic estrogen diethylstilbestrol have been made in moderate yield with chain lengths ranging from 20 to 200 repeat units employing the interfacial polycondensation procedure. Infrared spectroscopy shows the absence of the O–H group and formation of the Sn–O linkage consistent with the formation of the polyether. F-MALDI MS results are consistent with the presence of organotin-containing fragmentation clusters containing one and two tin atoms and ion fragments up to about 30 units long. The polymers all show moderate to good inhibition of a group of cancer cell lines including colon, breast and prostrate cell lines. Many of them show significant CI50 values showing a preference to inhibit the cancer cell lines in preference to the normal cell lines.

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Authors and Affiliations

  1. Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL, 33431, USA

    Charles E. Carraher Jr., Yuki Ashida & Girish Barot

  2. Florida Center for Environmental Studies, Palm Beach Gardens, FL, 33410, USA

    Charles E. Carraher Jr., Yuki Ashida & Girish Barot

  3. Department of Biology, University of Texas, Arlington, Arlington, TX, 76010, USA

    Michael R. Roner & Kimberly Shahi

  4. Department of Engineering, Tokushima University, Tokushima, 770-8506, Japan

    Yuki Ashida

Authors
  1. Charles E. Carraher Jr.
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  2. Michael R. Roner
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  3. Kimberly Shahi
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  4. Yuki Ashida
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  5. Girish Barot
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Correspondence to Charles E. Carraher Jr..

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This article is dedicated to Professor Astruc.

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Carraher, C.E., Roner, M.R., Shahi, K. et al. Synthesis and Initial Cell Line Results of Organotin Polyethers Containing Diethylstilbestrol. J Inorg Organomet Polym 18, 180–188 (2008). https://doi.org/10.1007/s10904-007-9184-6

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  • DOI: https://doi.org/10.1007/s10904-007-9184-6

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