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Difunctional Fluorescent Probes for Iron and Hydrogen Sulfide Detection Based on Diphenyl Derivative

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Abstract

In order to better monitor the content of Fe3+ and H2S in the biological environment, two new fluorescent probes were designed and synthesized. With the addition of Fe3+, the strong fluorescence emission of two probes was significantly quenched due to the paramagnetic effect of Fe3+. With the further addition of S2−, the fluorescence intensity was quickly restored. Two probes showed high selectivity and strong sensitivity for the detection of Fe3+ and S2−, and the fluorescence intensity “ON-OFF-ON” was accompanied with the interaction process. At the same time, two probes displayed good anti-interference ability which was not interfered by the existence of other ions. In addition, two probes illustrated fast response time to Fe3+, S2− and small cytotoxicity to cells. Therefore, two probes can provide a potential ideal tool for detecting Fe3+ and H2S in organisms and the environment.

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Data Availability

The datasets generated during and/or analysed during the current study are available from the corresponding author.

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Funding

This work was supported by Henan Provincial Science and Technology Research Project, China (222102230027). Author Lixia Liu has received research support from Henan Province, China.

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Authors and Affiliations

  1. Department of Medical Chemistry, Xinxiang Medical University, Xinxiang, 453003, Henan, China

    Xuefang Shang, Bingqing Liu, Lixia Liu, Jia Wang & Yingling Wang

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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Bingqing Liu, Lixia Liu, Jia Wang and Yingling Wang. The first draft of the manuscript was written by Xuefang Shang and all authors commented on previous versions of the manuscript.

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Correspondence to Xuefang Shang.

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Shang, X., Liu, B., Liu, L. et al. Difunctional Fluorescent Probes for Iron and Hydrogen Sulfide Detection Based on Diphenyl Derivative. J Fluoresc 34, 1269–1278 (2024). https://doi.org/10.1007/s10895-023-03374-1

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