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A Near-Infrared Colorimetric Fluorescent Probe for Ferrous Ion Detection and Imaging

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Abstract

Based on the N-redox mechanism, a turn-on near-infrared fluorescence probe (SWJT-15) with cyano isophorone as skeleton was designed and synthesized for the detection of ferrous ions (Fe2+). The probe has a lower detection limit (83 nM) and fast response (200 s) to Fe2+ ions. And the probe has unique selectivity and good anti-interference performance against Fe2+ ions compared to other metal ions. Moreover, the probe has been successfully applied to imaging Fe2+ ions in HeLa cells.

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Acknowledgements

We would like to thank Analytical and Testing Center of Southwest Jiaotong University for the laser confocal microscope test.

Funding

This work was supported by the National Natural Science Foundation of China (No. 21572091). We also thank Student Research Training Program of Southwest Jiaotong University (202210613080).

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Authors and Affiliations

  1. School of Life Science and Engineering, School of Chemistry, Southwest Jiaotong University, Chengdu, 610031, People’s Republic of China

    Sheng-Nan Suo, Yang Tian, Wei-Lun Tan, Xiao-Yang Lou, Hai Xu, Ya-Wen Wang & Yu Peng

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  1. Sheng-Nan Suo
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  2. Yang Tian
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  3. Wei-Lun Tan
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  4. Xiao-Yang Lou
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  5. Hai Xu
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  7. Yu Peng
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Contributions

Sheng-Nan Suo conceived the work and performed most of the experiments. Yang Tian carried out the bioimaging. Sheng-Nan Suo, Yang Tian, Wei-Lun Tan, Xiao-Yang Lou, Hai Xu, Ya-WenWang and Yu Peng analyzed the data and wrote the manuscript.Hai Xu and Ya-Wen Wang supervised the project and conceived the style of the manuscript.

Corresponding authors

Correspondence to Hai Xu or Ya-Wen Wang.

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Suo, SN., Tian, Y., Tan, WL. et al. A Near-Infrared Colorimetric Fluorescent Probe for Ferrous Ion Detection and Imaging. J Fluoresc (2023). https://doi.org/10.1007/s10895-023-03354-5

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