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A Fluorescein-Based Colorimetric and Fluorescent Probe for Hydrazine and its Bioimaging in Live Cells

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Abstract

A turn-on fluorescent probe (FN) for detection of hydrazine has been developed. Probe FN exhibited high selectivity and excellent sensitivity towards hydrazine with a detection limit as low as 4.6 × 10−10 M. Probe FN selectively reacts with hydrazine (N2H4) in a physiological environment, leading to an off-on fluorescence response along with the color change from colorless to yellow, allowing colorimetric detection of hydrazine by the naked eye. Furthermore, probe FN was successfully applied for visualizing hydrazine in living cells.

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Acknowledgments

This work was supported by the National Science Foundation of China (Nos. 21572209) and Program for Innovative Research Team (in Science and Technology) in University of Henan Province (No. 17IRTSTHN002).

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Authors and Affiliations

  1. School of Chemistry and Chemical Engineering, Xuchang University, Xuchang, 461000, China

    Gongchun Li

  2. Phosphorus Chemical Engineering Research Center of Henan Province, the College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 450052, China

    Yongxiang Liu, Jianhua Song & Yong Ye

Authors
  1. Gongchun Li
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  2. Yongxiang Liu
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  3. Jianhua Song
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  4. Yong Ye
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Corresponding author

Correspondence to Yong Ye.

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Li, G., Liu, Y., Song, J. et al. A Fluorescein-Based Colorimetric and Fluorescent Probe for Hydrazine and its Bioimaging in Live Cells. J Fluoresc 27, 323–329 (2017). https://doi.org/10.1007/s10895-016-1961-6

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  • DOI: https://doi.org/10.1007/s10895-016-1961-6

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