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Biosynthesis of TiO2 Nanoparticles Using Edible Mushroom (Pleurotus djamor) Extract: Mosquito Larvicidal, Histopathological, Antibacterial and Anticancer Effect

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Abstract

The titanium dioxide nanoparticles (TiO2NPs) were synthesized by the aqueous extract from P. djamor. The UV–Vis spectrum of TiO2NPs showed maximum absorption at 345 nm and the XRD pattern reflects peaks at 2θ value of 27.51°, 36.16°, 41.31°, 54.37°, 56.68°, 62.80° and 69.04° can be indexed to the (110), (101), (111), (211), (220), (204) and (301) were confirm the presence of TiO2NPs. The FT-IR spectrum of TiO2NPs showed a peak at 3432, 1631, 1400, 1109, and 619 cm−1. The SEM and HRTEM analysis revealed the spherical shape size and EDAX pattern confirmed the purity of TiO2NPs. The particle size of TiO2NPs found to be 31 nm and the zeta potential showed 16.4mV. Antibacterial activity TiO2NPs recorded the highest zone of inhibition 33 ± 0.2 mm, 32 ± 0.4 mm and 32 ± 0.1 mm against P. fluorescens, S. aureus and C. diphtheriae. Further, the anticancer activity of TiO2NPs showed 9.08–64.71% at 6.25–100 µg/ml concentration against A549 cancer cells. The larvicidal activities of TiO2 NPs on IVth instar larvae of Ae. aegypti and Cx quinquefasciatus results showed LC50 (5.88 and 4.84 mg/l) and LC90 (22.80 and 19.33 mg/l) in better effect. The multi biological activity of TiO2NPs was utilized in future pharmacological application.

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Acknowledgements

The author (K.M and S.M) are thankful to Science Engineering and Research Board (SERB), Department of Science and Technology, Government of India, New Delhi, for the financial assistance under EMEQ sponsored major research project (File No.SB/EMEQ-286/2014).

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Authors and Affiliations

  1. Edible and Medicinal Mushroom Laboratory, Department of Botany, School of Life Sciences, Periyar University, Periyar Palkalai Nagar, Salem, Tamil Nadu, 636 011, India

    Kumar Manimaran & Subban Murugesan

  2. Natural Drug Research Laboratory, Department of Biotechnology, School of Biosciences, Periyar University, Periyar Palkalai Nagar, Salem, Tamil Nadu, 636 011, India

    Chinnasamy Ragavendran & Devarajan Natarajan

  3. School of Pharmaceutical Science and Technology, Health Science Platform, Tianjin University, Tianjin, 300072, China

    Govindasamy Balasubramani

  4. Department of Food Science, School of Applied Sciences, College of Engineering, Science and Technology, Fiji National University, Suva, 7222, Fiji Islands

    Abirami Ganesan

  5. Department of Environmental Science, Periyar University, Salem, Tamil Nadu, 636011, India

    Palaniappan Seedevi

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  1. Kumar Manimaran
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Manimaran, K., Murugesan, S., Ragavendran, C. et al. Biosynthesis of TiO2 Nanoparticles Using Edible Mushroom (Pleurotus djamor) Extract: Mosquito Larvicidal, Histopathological, Antibacterial and Anticancer Effect. J Clust Sci 32, 1229–1240 (2021). https://doi.org/10.1007/s10876-020-01888-3

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