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Pleurotus sajor caju Mediated TiO2 Nanoparticles: A Novel Source for Control of Mosquito Larvae, Human Pathogenic Bacteria and Bone Cancer Cells

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Abstract

The present work was aimed to screen the antibacterial, anticancer and mosquito-larvicidal potentials of the titanium dioxide mediated nanoparticles (TiO2NPs) from the Pleurotus sajor caju fruiting bodies. The synthesized TiO2NPs were characterized using UV–Vis spectrum, FTIR, XRD, FESEM, EDX, HRTEM, Zeta potential and Particle size analyses. The XRD pattern show pure crystalline nature of the TiO2NPs and spherical shape morphology was noted. The average size of nanoparticles was 85 nm and Zeta potential analysis, resulted the surface charge of the nanomaterial was − 8.05 mV. The larvicidal activity of TiO2NPs treated IVth instar larvae of Aedes aegypti and Culex quinquefasciatus showed better LC50 and LC90 values (14.56, 26.56 and 12.76, 24.38 mg/l). The broad spectrum of antibacterial activity was observed both gram-positive and gram-negative bacteria and maximum growth inhibition zone was recorded in Klebsiella pneumoniae (8.0 ± 0.3 mm) followed by other tested organisms. The anticancer activity [bone cancer (MG-63) cell line] of TiO2NPs expressed best IC50 value as 61.34 µg/ml, which conferred the cytotoxic effects of TiO2NPs on the proliferation of MG-63 cell line. Based on the findings of present study the biosynthesized TiO2NPs from P. sajor caju served as an alternative and eco-friendly nano medicine in the near future.

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Acknowledgements

This study was supported by Science Engineering and Research Board (SERB), Department of Science and Technology, Government of India, New Delhi under EMEQ sponsored major research project (Sanction Number: SB/EMEQ-286/2014). All authors thank to the Department of Botany, School of Life Sciences, Periyar University, Salem, Tamil Nadu India, for providing necessary laboratory and infrastructure facilities for the success of this research contribution.

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Authors and Affiliations

  1. Edible and Medicinal Mushroom Laboratory, Department of Botany, School of Life Sciences, Periyar University, Periyar Palkalai Nagar, Salem, Tamil Nadu, 636 011, India

    Kumar Manimaran & Subban Murugesan

  2. Natural Drug Research Laboratory, Department of Biotechnology, School of Biosciences, Periyar University, Periyar Palkalai Nagar, Salem, Tamil Nadu, 636 011, India

    Devarajan Natarajan

  3. School of Pharmaceutical Science and Technology, Health Science Platform, Tianjin University, Tianjin, 300072, China

    Govindasamy Balasubramani

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  1. Kumar Manimaran
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Manimaran, K., Natarajan, D., Balasubramani, G. et al. Pleurotus sajor caju Mediated TiO2 Nanoparticles: A Novel Source for Control of Mosquito Larvae, Human Pathogenic Bacteria and Bone Cancer Cells. J Clust Sci 33, 1489–1499 (2022). https://doi.org/10.1007/s10876-021-02073-w

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