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Copper Spinel Ferrite Superparamagnetic Nanoparticles as a Novel Radiotherapy Enhancer Effect in Cancer Treatment

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Abstract

In this study, copper spinel ferrite superparamagnetic nanoparticles (CuFe2O4 SPMNPs) were synthesized by a hydrothermal reaction method properly. Here, combination effect of radiotherapy (RT) and CuFe2O4 SPMNPs as radiosensitizer of X-ray radiation, on the MCF-7 breast cancer cells were assessed. Magnetic, crystalline structure, optical and morphological properties of CuFe2O4 SPMNPs were studied by vibration sample magnetometer (VSM), X-ray diffraction (XRD), Fourier transform infrared (FTIR), UV–visible spectrophotometer (UV–vis), atomic force microscopy (AFM) and scanning electron microscopy (SEM). Cytotoxicity and viability of cancer cells exposed to superparamagnetic CuFe2O4 NPs at different concentrations was studied by MTT assay. Cell viability results showed that the CuFe2O4 SPMNPs not only had high increasing in the cell destruction under X-ray radiation (6-MV), but also no significant cytotoxicity at low concentrations was observed. Furthermore, superparamagnetic properties of CuFe2O4 NPs make it easy to localize and displace, by external magnetic field. Therefore, results suggested that CuFe2O4 SPMNPs, are a promising option as an application for treatment of breast cancer cells by RT due to their high cell destruction and low cytotoxicity effects.

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Authors and Affiliations

  1. Department of Physics, Payame Noor University (PNU), P.O. Box 19395-3697, Tehran, Iran

    Alireza Meidanchi & Hoorieh Ansari

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  1. Alireza Meidanchi
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  2. Hoorieh Ansari
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Correspondence to Alireza Meidanchi.

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Meidanchi, A., Ansari, H. Copper Spinel Ferrite Superparamagnetic Nanoparticles as a Novel Radiotherapy Enhancer Effect in Cancer Treatment. J Clust Sci 32, 657–663 (2021). https://doi.org/10.1007/s10876-020-01832-5

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  • DOI: https://doi.org/10.1007/s10876-020-01832-5

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