Skip to main content
SpringerLink
Log in

Synthesis and Crystal Structure Analysis of Methyl 2-Hydroxyimino-3-phenyl-propionate

  • Original Paper
  • Published:
Journal of Chemical Crystallography Aims and scope Submit manuscript

Abstract

As precursors of α-amino acids, methyl 2-hydroxyimino-3-phenyl-propionate (F.W. 193.20) was synthesized, characterized by 1H NMR, IR, element analysis and confirmed by X-ray crystal structure analysis. This compound crystallizes in monoclinic class under the space group P21/c with cell parameters, a = 8.6435(17) Å, b = 5.4957(11) Å, c = 21.146(4) Å; β = 97.12(3)°, and Z = 4. The structure exhibits inter-molecular hydrogen bonds of the type O–H···N, O–H···O, C–H···O.

Graphical Abstract

The title compound, methyl 2-hydroxyimino-3-phenyl-propionate was synthesized by nitrosation oximation of substituted malonic esters and its crystal structure was determined.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Scheme 1
Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Hoffman C, Tanke RS, Miller MJ (1989) J Org Chem 54:3750

    Article  CAS  Google Scholar 

  2. Ottenheijm HCJ, Herscheid JD (1986) J Chem Rev 86:697

    Article  CAS  Google Scholar 

  3. Ungnade HE, Kissinger LW (1959) J Org Chem 24:666

    Article  CAS  Google Scholar 

  4. Kissinger LW, Ungnade HE (1958) J Org Chem 23:1517

    Article  CAS  Google Scholar 

  5. Barry RH, Hartung WH (1947) J Org Chem 12:460

    Article  CAS  Google Scholar 

  6. Granacher C (1922) Helv Chim Acta 6:610

    Article  Google Scholar 

  7. Lepereq GM (1894) Bull Soc Chim 11:295

    Google Scholar 

  8. Hantzsch A, Wild W (1896) Ann 289:295

    Google Scholar 

  9. Hamlin KE, Hartung WH (1942) J Bid Chem 146:349

    Google Scholar 

  10. Redemann CE, Dunn MS (1939) J Bid Chem 130:341

    CAS  Google Scholar 

  11. Onischenxo AD (1941) J Gen Chem USSR 11:197

    Google Scholar 

  12. Sheldrick GM (1997) SHELXS97. Program package for crystal structure solution and refinement. University of Gottingen, Germany

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. College of Chemistry and Environmental Science, Hebei University, 071002, Baoding, People’s Republic of China

    Xiao-liu Li & Xiao-li Zhen

  2. College of Sciences, Hebei University of Science and Technology, 050018, Shijiazhuang, People’s Republic of China

    Xiao-li Zhen & Jian-rong Han

  3. College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, 050018, Shijiazhuang, People’s Republic of China

    Shouxin Liu

Authors
  1. Xiao-liu Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Xiao-li Zhen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jian-rong Han
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Shouxin Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Xiao-liu Li or Shouxin Liu.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Li, Xl., Zhen, Xl., Han, Jr. et al. Synthesis and Crystal Structure Analysis of Methyl 2-Hydroxyimino-3-phenyl-propionate. J Chem Crystallogr 39, 870–873 (2009). https://doi.org/10.1007/s10870-009-9581-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10870-009-9581-5

Keywords

Search

Navigation