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Mesoporous silica nanoparticle-functionalized poly(methyl methacrylate)-based bone cement for effective antibiotics delivery

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Abstract

Poly(methyl methacrylate)-based bone cements are functionalized with mesoporous silica nanoparticles (MSN) to enable a highly efficient and sustained release of antibiotics to reduce the risk of post-operative joint infection. To overcome the limited drug release of 5% for only 1 day with the current commercial-grade bone cements, a 8 wt% MSN-formulated bone cement is able to increase the drug release efficiency by 14-fold and sustain the release for up to 80 days. The loaded MSN is suggested to build up an effective network of rod-shaped silica particles with uniformly arranged nanoporous channels, which is responsible for the effective drug diffusion and extend time-release to the external surfaces. MSN has no detrimental effect on the critical weight-bearing bending modulus and compression strength of bone cement. In vitro assay test results show a much sustained antibacterial effect and low cytotoxicity of MSN demonstrating the potential applicability of MSN-formulated bone cement.

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Acknowledgment

This work was generously supported by Institute of Chemical Engineering and Science, Agency of Science Technology and Research, Singapore.

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Authors and Affiliations

  1. Institute of Chemical and Engineering Sciences, A*STAR (Agency for Science, Technology and Research), 1 Pesek Road, Jurong Island, Singapore, 627833, Singapore

    Shou-Cang Shen, Wai Kiong Ng, Leonard Chia & Reginald Beng Hee Tan

  2. Department of Chemical and Biomolecular Engineering, The National University of Singapore, 4 Engineering Drive 4, Singapore, 117576, Singapore

    Zhilong Shi, Koon Gee Neoh & Reginald Beng Hee Tan

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  1. Shou-Cang Shen
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  2. Wai Kiong Ng
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  3. Zhilong Shi
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  4. Leonard Chia
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Correspondence to Shou-Cang Shen or Reginald Beng Hee Tan.

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Shen, SC., Ng, W.K., Shi, Z. et al. Mesoporous silica nanoparticle-functionalized poly(methyl methacrylate)-based bone cement for effective antibiotics delivery. J Mater Sci: Mater Med 22, 2283 (2011). https://doi.org/10.1007/s10856-011-4397-1

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