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Silica xerogel-chitosan nano-hybrids for use as drug eluting bone replacement

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Abstract

Silica xerogel-chitosan hybrids containing vancomycin were fabricated by the sol–gel process at room temperature and their potential as a drug eluting bone replacement was evaluated in terms of their mechanical properties and drug release behaviors. Regardless of the content of chitosan, all of the prepared hybrids had a uniform mesoporous structure, which would allow the effectual loading of vancomycin. As the content of chitosan was increased, the strength, strain to failure, and work of fracture of the hybrids were significantly enhanced, while the elastic modulus was decreased. These changes in the mechanical properties were mainly attributed to the mitigation of the brittleness of the silica xerogel through its hybridization with the flexible chitosan phase. In addition, the initial burst-effect was remarkably reduced by increasing the content of chitosan. The hybrids with more than 30% chitosan could release the vancomycin for an extended period of time in a controlled manner.

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Acknowledgments

This research was supported by a grant from the Fundamental R&D Program for Core Technology of Materials funded by Ministry of Knowledge Economy, Republic of Korea.

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Authors and Affiliations

  1. Department of Materials Science and Engineering, Seoul National University, Seoul, 151-744, Republic of Korea

    Eun-Jung Lee, Shin-Hee Jun & Hyoun-Ee Kim

  2. Department of Biomaterials Science of School of Dentistry and Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, 330-714, Korea

    Hae-Won Kim

  3. Department of Dental Laboratory Science and Engineering, Korea University, Seoul, 136-703, Korea

    Young-Hag Koh

  4. Department of Biochemistry, School of Medicine, Inha University, Incheon, 400-712, Korea

    Jun-Hyeog Jang

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  1. Eun-Jung Lee
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  2. Shin-Hee Jun
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Correspondence to Hyoun-Ee Kim.

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Lee, EJ., Jun, SH., Kim, HE. et al. Silica xerogel-chitosan nano-hybrids for use as drug eluting bone replacement. J Mater Sci: Mater Med 21, 207–214 (2010). https://doi.org/10.1007/s10856-009-3835-9

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  • DOI: https://doi.org/10.1007/s10856-009-3835-9

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