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Determination of phenobarbital in real sample using carbon quantum dots modified with tungsten as a fluorescent nanoprobe

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Abstract

In this study, a sensitive and selective fluorescence nanoprobe has been designed based on carbon quantum dots modified by tungsten (WCQDs) for the detection of phenobarbital. Tungsten WCQDs were synthesized via a hydrothermal method using tungsten nitrate and glucose as a carbon source. The fluorescence signal of WCQDs was selectively increased by phenobarbital. The fluorescence increasing signal was applied for phenobarbital sensing at the pH = 8 without the interference of other materials. After optimizing the factors affecting the sensor’s response, a linear range between 25 and 500 µM with a detection limit of 5 µM was obtained. The sensor’s capability in the real-sample analysis was investigated by phenobarbital determination in human blood plasma samples.

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Acknowledgements

We are grateful to the Department of Medical Science, Faculty of Sciences, Islamic Azad University, Sanandaj Branch, Sanandaj, Iran for their support for this work.

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Author notes

  1. Hossein Javadzad, Nahid Haghnazari and Changiz Karami have contributed equally to this work.

Authors and Affiliations

  1. Department of Medical Science, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran

    Hossein Javadzad & Nahid Haghnazari

  2. Department of Chemistry, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran

    Changiz Karami

Authors
  1. Hossein Javadzad
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  2. Nahid Haghnazari
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  3. Changiz Karami
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All authors have contributed equally.

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Correspondence to Nahid Haghnazari.

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Javadzad, H., Haghnazari, N. & Karami, C. Determination of phenobarbital in real sample using carbon quantum dots modified with tungsten as a fluorescent nanoprobe. J Mater Sci: Mater Electron 33, 12075–12082 (2022). https://doi.org/10.1007/s10854-022-08167-z

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  • DOI: https://doi.org/10.1007/s10854-022-08167-z

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