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Nitrogen and Sulfur Co-doped Carbon Quantum Dots for Detecting Fe3+, Ascorbic Acid and Alkaline Phosphatase Activities

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Abstract

A method utilizing nitrogen-doped and sulfur-doped carbon quantum dots (N, S-CQDs) as fluorescent probes for the rapid detection of Fe3+, L-ascorbic acid (AA), and alkaline phosphatase (ALP) was presented. The fluorescence intensity of N, S-CQDs nanoprobes can be rapidly and efficiently quenched by Fe3+ and based on the fluorescence “turn off-on” characteristic of N, S-CQDs nanoprobes, the fluorescence signals of the N, S-CQDs/Fe3+can be recovered after the addition of AA. By coupling a fluorescent nanoprobe to an enzyme and L-ascorbic acid-2-phosphate (AA2P), a green, simple, rapid and effective fluorescent analytical method for the determination of ALP was developed. The prepared N, S-CQDs showed high sensitivity and selectivity to Fe3+, AA and ALP with the detection limit of 0.42 μM, 12.7 nM and 0.017 U·L−1 and their optimal concentration ranges were10—600 µM, 10—200 μM, 0.18—54 U·L−1, respectively. The fluorescence quantum yield of N, S-CQDs (0.2 mg·mL−1) at 393 nm excitation wavelength was 4.41%. Additionally, the fluorescent nanoprobes have been employed to successfully measure ALP in serum samples. It is expected that the established method may offer a new approach for biomolecular detection in clinical diagnosis and pharmaceutical analysis.

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Acknowledgements

Associate professor Yang Wang, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road Shenhe District, 110016, Shenyang, Liaoning Province, P. R. China; Shandong Lukang Pharmaceutical Co., Ltd., Jining, Shandong Province, P. R. China.

Funding

This work was supported by the Middle-aged Backbone Personnel Training Program of Shenyang Pharmaceutical University (ZQN2016011) and Science and Technology Department of Liaoning Province(2019-ZD-0450).

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Authors and Affiliations

  1. School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road Shenhe District Liaoning Province, Shenyang, 110016, People’s Republic of China

    Runuo Wang, Yang Wang, Na Zhao, Hanqing Zhao, Xucan Yuan & Longshan Zhao

  2. Shandong Lukang Pharmaceutical Co. Ltd., Jining, Shandong, 272021, People’s Republic of China

    Yang Wang

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  1. Runuo Wang
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Contributions

RNW: Conceptualization, Methodology, Data curation, Writing-original draft. YW and NZ: Formal analysis, Investigation, Software, Data curation. HQZ and XCY: Writing-review & Editing, Supervision. Longshan Zhao: Writing-review & Editing, Project administration.All authors reviewed the manuscript.

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Correspondence to Yang Wang or Longshan Zhao.

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The human serum samples used in this study were provided by the First Affiliated Hospital of Jilin University and were approved by the Ethics Committee.

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Wang, R., Wang, Y., Zhao, N. et al. Nitrogen and Sulfur Co-doped Carbon Quantum Dots for Detecting Fe3+, Ascorbic Acid and Alkaline Phosphatase Activities. J Fluoresc (2023). https://doi.org/10.1007/s10895-023-03539-y

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