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Folate-modified–chitosan-coated liposomes for tumor-targeted drug delivery

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Abstract

In this study, a folate-modified–chitosan-coated liposome (FCCL) was prepared for tumor-targeted drug delivery. The folate–chitosan conjugates were characterized using 1H NMR and infrared spectrum analysis. The properties of folate–chitosan-coated liposomes (FCCLs) were studied and compared with those of traditional liposomes and chitosan-coated liposomes (CCLs). FCCLs were spherical in shape with a classic core–shell structure. Compared with conventional liposomes, FCCLs had larger size (average diameter: 182.0 nm), higher zeta potential (10.1 mV), prolonged drug release behaviors (55.76 % after 24 h), and better physical stability when stored at 25 °C, all similar to the properties of CCLs. With fluorescein as a model drug, fluorescein-loaded liposomes, CCLs, and FCCLs were prepared and their tumor targeting ability was evaluated according to the in vitro cellular uptake of fluorescein loaded nanoparticles by MCF-7 and HUVEC cells. Results demonstrated that FCCLs had a significant higher uptake by folate receptor positive cells (MCF-7) as compared to traditional liposomes and CCLs, which indicated that the FCCLs were promising nano-carriers for tumor-targeted drug delivery.

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Acknowledgements

This research was granted by Science and Technology Breakthrough Project (2011GSF12124), National Natural Science Foundation of China (81071274) and International Science and Technology Cooperation Project (2011DFA31270).

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Authors and Affiliations

  1. College of Marine Life Science, Ocean University of China, 5# Yushan Road, Qingdao, 266003, People’s Republic of China

    Kui Kun Yang, Ming Kong, Ya Nan Wei, Ya Liu, Xiao Jie Cheng, Jing Li & Xi Guang Chen

  2. College of Life Sciences and Biotechnology, Korea University, 1, 5-Ka, Anam-Dong, Sungbuk-gu, Seoul, 136-701, South Korea

    Hyun Jin Park

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  1. Kui Kun Yang
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  2. Ming Kong
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  3. Ya Nan Wei
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  4. Ya Liu
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  6. Jing Li
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  7. Hyun Jin Park
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  8. Xi Guang Chen
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Correspondence to Hyun Jin Park or Xi Guang Chen.

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Yang, K.K., Kong, M., Wei, Y.N. et al. Folate-modified–chitosan-coated liposomes for tumor-targeted drug delivery. J Mater Sci 48, 1717–1728 (2013). https://doi.org/10.1007/s10853-012-6930-0

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