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Development of monodispersed and functional magnetic polymeric liposomes via simple liposome method

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Abstract

We are reporting a simple and rapid method to prepare superparamagnetic, controlled size, and monodispersed magnetic cationic polymeric liposomes (MCPL) by octadecyl quaternized carboxymethyl chitosan (OQCMC) and cholesterol. The whole process is only about 25 min with simple thin-film dispersion and solvent evaporation method. Hydrophilic magnetic nanoparticles (LM) and hydrophobic magnetic nanoparticles (BM) can be encapsulated into these cationic polymeric liposomes, simultaneously or respectively. A model hydrophobic drug indomethacin can be successfully filled in MCPL with high drug loading capacity 22%. MCPL encapsulating BM also showed strong DNA (pEGFP) binding ability. Drug-loaded MCPL have a long and controlled sustained release profile by changing the number of polymeric lipid layer. These functional MCPL nanospheres can be allowed to serve as ideal candidates for many biomedical applications.

Graphical Abstract

A simple and rapid liposome method was reported to prepare superparamagnetic, controlled size, and monodispersed magnetic cationic polymeric liposomes (MCPL) by polymeric surfactant, octadecyl quaternized carboxymethyl chitosan (OQCMC), and cholesterol. Hydrophilic Fe3O4 ferrofluid and hydrophobic magnetic nanoparticles can be encapsulated into these cationic polymeric liposomes, simultaneously or respectively. Hydrophobic drug indomethacin can be encapsulated into this MCPL with high encapsulating efficiency and with controlled release profile by changing the number of polymeric lipid layer.

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Acknowledgments

This work was supported by National Basic Research Program of China (973 Program, No. 2007CB935800), and National Natural Science Foundation of China (No. 50873076, 30772245, 30876203). We thank the Instrumental Analysis Center of Tianjin University for Materials Characterization.

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Authors and Affiliations

  1. Institute of Nanobiotechnology, School of Materials Science and Engineering, Tianjin University and Tianjin Key Laboratory of Composites and Functional Materials, Tianjin, 300072, People’s Republic of China

    Xiaofei Liang, Hanjie Wang & Jin Chang

  2. School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, People’s Republic of China

    Xinguo Jiang

  3. Cancer Institute of Shanghai JiaoTong University, Shanghai, 200032, People’s Republic of China

    Xiaofei Liang

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  1. Xiaofei Liang
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  2. Hanjie Wang
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  3. Xinguo Jiang
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  4. Jin Chang
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Correspondence to Jin Chang.

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Liang, X., Wang, H., Jiang, X. et al. Development of monodispersed and functional magnetic polymeric liposomes via simple liposome method. J Nanopart Res 12, 1723–1732 (2010). https://doi.org/10.1007/s11051-010-9896-3

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  • DOI: https://doi.org/10.1007/s11051-010-9896-3

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