In the last three decades, ablation of atrial fibrillation (AF) has become an evidence-based safe and efficacious treatment for managing the most common cardiac arrhythmia. In 2007, the first joint expert consensus document was issued, guiding healthcare professionals involved in catheter or surgical AF ablation. Mounting research evidence and technological advances have resulted in a rapidly changing landscape in the field of catheter and surgical AF ablation, thus stressing the need for regularly updated versions of this partnership which were issued in 2012 and 2017. Seven years after the last consensus, an updated document was considered necessary to define a contemporary framework for selection and management of patients considered for or undergoing catheter or surgical AF ablation. This consensus is a joint effort from collaborating cardiac electrophysiology societies, namely the European Heart Rhythm Association, the Heart Rhythm Society (HRS), the Asia Pacific HRS, and the Latin American HRS.
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Calkins H, Brugada J, Packer DL, Cappato R, Chen SA, Crijns HJ, et al. HRS/EHRA/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: recommendations for personnel, policy, procedures and follow-up. A report of the Heart Rhythm Society (HRS) task force on catheter and surgical ablation of atrial fibrillation developed in partnership with the European Heart Rhythm Association (EHRA) and the European Cardiac Arrhythmia Society (ECAS); in collaboration with the American College of Cardiology (ACC), American Heart Association (AHA), and the Society of Thoracic Surgeons (STS). Endorsed and approved by the governing bodies of the American College of Cardiology, the American Heart Association, the European Cardiac Arrhythmia Society, the European Heart Rhythm Association, the Society of Thoracic Surgeons, and the Heart Rhythm Society. Europace. 2007;9:335–79.
Calkins H, Kuck KH, Cappato R, Brugada J, Camm AJ, Chen SA, et al. 2012 HRS/EHRA/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design: a report of the Heart Rhythm Society (HRS) task force on catheter and surgical ablation of atrial fibrillation. Developed in partnership with the European Heart Rhythm Association (EHRA), a registered branch of the European Society of Cardiology (ESC) and the European Cardiac Arrhythmia Society (ECAS); and in collaboration with the American College of Cardiology (ACC), American Heart Association (AHA), the Asia Pacific Heart Rhythm Society (APHRS), and the Society of Thoracic Surgeons (STS). Endorsed by the governing bodies of the American College of Cardiology Foundation, the American Heart Association, the European Cardiac Arrhythmia Society, the European Heart Rhythm Association, the Society of Thoracic Surgeons, the Asia Pacific Heart Rhythm Society, and the Heart Rhythm Society. Heart Rhythm. 2012;9:632-96.e21.
Calkins H, Hindricks G, Cappato R, Kim Y-H, Saad EB, Aguinaga L, et al. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: executive summary. J Arrhythm. 2017;33:369–409.
January CT, Wann LS, Calkins H, Chen LY, Cigarroa JE, Cleveland JC Jr, et al. 2019 AHA/ACC/HRS focused update of the 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association task force on clinical practice guidelines and the Heart Rhythm Society in collaboration with the Society of Thoracic Surgeons. Circulation. 2019;140:e125-51.
Hindricks G, Potpara T, Dagres N, Arbelo E, Bax JJ, Blomstrom-Lundqvist C, et al. 2020 ESC guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): the task force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. Eur Heart J. 2021;42:373–498.
Diederichsen SZ, Haugan KJ, Brandes A, Lanng MB, Graff C, Krieger D, et al. Natural history of subclinical atrial fibrillation detected by implanted loop recorders. J Am Coll Cardiol. 2019;74:2771–81.
Aguilar M, Macle L, Deyell MW, Yao R, Hawkins NM, Khairy P, et al. Influence of monitoring strategy on assessment of ablation success and postablation atrial fibrillation burden assessment: implications for practice and clinical trial design. Circulation. 2022;145:21–30.
January CT, Wann LS, Calkins H, Chen LY, Cigarroa JE, Cleveland JC Jr, et al. 2019 AHA/ACC/HRS focused update of the 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association task force on clinical practice guidelines and the Heart Rhythm Society. J Am Coll Cardiol. 2019;74:104–32.
Andrade JG, Aguilar M, Atzema C, Bell A, Cairns JA, Cheung CC, et al. The 2020 Canadian Cardiovascular Society/Canadian Heart Rhythm Society comprehensive guidelines for the management of atrial fibrillation. Can J Cardiol. 2020;36:1847–948.
NHFA CSANZ Atrial Fibrillation Guideline Working Group, Brieger D, Amerena J, Attia J, Bajorek B, Chan KH, et al. National Heart Foundation of Australia and the Cardiac Society of Australia and New Zealand: Australian clinical guidelines for the diagnosis and management of atrial fibrillation 2018. Heart Lung Circ. 2018;27:1209–66.
Cheung CC, Nattel S, Macle L, Andrade JG. Management of atrial fibrillation in 2021: an updated comparison of the current CCS/CHRS, ESC, and AHA/ACC/HRS guidelines. Can J Cardiol. 2021;37:1607–18.
Wijffels MC, Kirchhof CJ, Dorland R, Allessie MA. Atrial fibrillation begets atrial fibrillation. A study in awake chronically instrumented goats. Circulation. 1995;92:1954–68.
Fareh S, Villemaire C, Nattel S. Importance of refractoriness heterogeneity in the enhanced vulnerability to atrial fibrillation induction caused by tachycardia-induced atrial electrical remodeling. Circulation. 1998;98:2202–9.
Crijns HJ, van Wijk LM, van Gilst WH, Kingma JH, van Gelder IC, Lie KI. Acute conversion of atrial fibrillation to sinus rhythm: clinical efficacy of flecainide acetate. Comparison of two regimens. Eur Heart J. 1988;9:634–8.
Suttorp MJ, Kingma JH, Jessurun ER, Lie AHL, van Hemel NM, Lie KI. The value of class IC antiarrhythmic drugs for acute conversion of paroxysmal atrial fibrillation or flutter to sinus rhythm. J Am Coll Cardiol. 1990;16:1722–7.
Andrade JG, Deyell MW, Verma A, Macle L, Champagne J, Leong-Sit P, et al. Association of atrial fibrillation episode duration with arrhythmia recurrence following ablation: a secondary analysis of a randomized clinical trial. JAMA Netw Open. 2020;3: e208748.
Boriani G, Botto GL, Padeletti L, Santini M, Capucci A, Gulizia M, et al. Improving stroke risk stratification using the CHADS2 and CHA2DS2-VASc risk scores in patients with paroxysmal atrial fibrillation by continuous arrhythmia burden monitoring. Stroke. 2011;42:1768–70.
Van Gelder IC, Healey JS, Crijns H, Wang J, Hohnloser SH, Gold MR, et al. Duration of device-detected subclinical atrial fibrillation and occurrence of stroke in ASSERT. Eur Heart J. 2017;38:1339–44.
Chew DS, Li Z, Steinberg BA, O’Brien EC, Pritchard J, Bunch TJ, et al. Arrhythmic burden and the risk of cardiovascular outcomes in patients with paroxysmal atrial fibrillation and cardiac implanted electronic devices. Circ Arrhythm Electrophysiol. 2022;15: e010304.
Charitos EI, Purerfellner H, Glotzer TV, Ziegler PD. Clinical classifications of atrial fibrillation poorly reflect its temporal persistence: insights from 1,195 patients continuously monitored with implantable devices. J Am Coll Cardiol. 2014;63:2840–8.
Andrade JG, Yao RRJ, Deyell MW, Hawkins NM, Rizkallah J, Jolly U, et al. Clinical assessment of AF pattern is poorly correlated with AF burden and post ablation outcomes: a CIRCA-DOSE sub-study. J Electrocardiol. 2020;60:159–64.
De With RR, Erkuner O, Rienstra M, Nguyen BO, Korver FWJ, Linz D, et al. Temporal patterns and short-term progression of paroxysmal atrial fibrillation: data from RACE V. Europace. 2020;22:1162–72.
Blum S, Meyre P, Aeschbacher S, Berger S, Auberson C, Briel M, et al. Incidence and predictors of atrial fibrillation progression: a systematic review and metaanalysis. Heart Rhythm. 2019;16:502–10.
Kopecky SL, Gersh BJ, McGoon MD, Whisnant JP, Holmes DR, Ilstrup DM, et al. The natural history of lone atrial fibrillation. A population-based study over three decades. N Engl J Med. 1987;317:669–74.
Pappone C, Radinovic A, Manguso F, Vicedomini G, Ciconte G, Sacchi S, et al. Atrial fibrillation progression and management: a 5-year prospective follow-up study. Heart Rhythm. 2008;5:1501–7.
Simantirakis EN, Papakonstantinou PE, Kanoupakis E, Chlouverakis GI, Tzeis S, Vardas PE. Recurrence rate of atrial fibrillation after the first clinical episode: a prospective evaluation using continuous cardiac rhythm monitoring. Clin Cardiol. 2018;41:594–600.
Andrade JG, Deyell MW, Macle L, Wells GA, Bennett M, Essebag V, et al. Progression of atrial fibrillation after cryoablation or drug therapy. N Engl J Med. 2022;388:105–16.
Nguyen BO, Weberndorfer V, Crijns HJ, Geelhoed B, Ten Cate H, Spronk H, et al. Prevalence and determinants of atrial fibrillation progression in paroxysmal atrial fibrillation. Heart. 2022;109:186–94.
Potpara TS, Stankovic GR, Beleslin BD, Polovina MM, Marinkovic JM, Ostojic MC, et al. A 12-year follow-up study of patients with newly diagnosed lone atrial fibrillation: implications of arrhythmia progression on prognosis: the Belgrade atrial fibrillation study. Chest. 2012;141:339–47.
Padfield GJ, Steinberg C, Swampillai J, Qian H, Connolly SJ, Dorian P, et al. Progression of paroxysmal to persistent atrial fibrillation: 10-year follow-up in the Canadian Registry of Atrial Fibrillation. Heart Rhythm. 2017;14:801–7.
Piccini JP, Passman R, Turakhia M, Connolly AT, Nabutovsky Y, Varma N. Atrial fibrillation burden, progression, and the risk of death: a case-crossover analysis in patients with cardiac implantable electronic devices. Europace. 2019;21:404–13.
de Vos CB, Pisters R, Nieuwlaat R, Prins MH, Tieleman RG, Coelen RJ, et al. Progression from paroxysmal to persistent atrial fibrillation clinical correlates and prognosis. J Am Coll Cardiol. 2010;55:725–31.
Kerr CR, Humphries KH, Talajic M, Klein GJ, Connolly SJ, Green M, et al. Progression to chronic atrial fibrillation after the initial diagnosis of paroxysmal atrial fibrillation: results from the Canadian Registry of Atrial Fibrillation. Am Heart J. 2005;149:489–96.
Parkash R, Green MS, Kerr CR, Connolly SJ, Klein GJ, Sheldon R, et al. The association of left atrial size and occurrence of atrial fibrillation: a prospective cohort study from the Canadian Registry of Atrial Fibrillation. Am Heart J. 2004;148:649–54.
Tsang TS, Barnes ME, Miyasaka Y, Cha SS, Bailey KR, Verzosa GC, et al. Obesity as a risk factor for the progression of paroxysmal to permanent atrial fibrillation: a longitudinal cohort study of 21 years. Eur Heart J. 2008;29:2227–33.
Vitolo M, Proietti M, Imberti JF, Bonini N, Romiti GF, Mei DA, et al. Factors associated with progression of atrial fibrillation and impact on all-cause mortality in a cohort of European patients. J Clin Med. 2023;12:768.
De With RR, Marcos EG, Dudink E, Spronk HM, Crijns H, Rienstra M, et al. Atrial fibrillation progression risk factors and associated cardiovascular outcome in well-phenotyped patients: data from the AF-RISK study. Europace. 2020;22:352–60.
Ellinor PT, Yoerger DM, Ruskin JN, MacRae CA. Familial aggregation in lone atrial fibrillation. Hum Genet. 2005;118:179–84.
Arnar DO, Thorvaldsson S, Manolio TA, Thorgeirsson G, Kristjansson K, Hakonarson H, et al. Familial aggregation of atrial fibrillation in Iceland. Eur Heart J. 2006;27:708–12.
Lubitz SA, Yin X, Fontes JD, Magnani JW, Rienstra M, Pai M, et al. Association between familial atrial fibrillation and risk of new-onset atrial fibrillation. JAMA. 2010;304:2263–9.
Chen YH, Xu SJ, Bendahhou S, Wang XL, Wang Y, Xu WY, et al. KCNQ1 gain-of-function mutation in familial atrial fibrillation. Science. 2003;299:251–4.
Olesen MS, Bentzen BH, Nielsen JB, Steffensen AB, David JP, Jabbari J, et al. Mutations in the potassium channel subunit KCNE1 are associated with early-onset familial atrial fibrillation. BMC Med Genet. 2012;13:24.
Yang Y, Xia M, Jin Q, Bendahhou S, Shi J, Chen Y, et al. Identification of a KCNE2 gain-of-function mutation in patients with familial atrial fibrillation. Am J Hum Genet. 2004;75:899–905.
Mann SA, Otway R, Guo G, Soka M, Karlsdotter L, Trivedi G, et al. Epistatic effects of potassium channel variation on cardiac repolarization and atrial fibrillation risk. J Am Coll Cardiol. 2012;59:1017–25.
Sinner MF, Pfeufer A, Akyol M, Beckmann BM, Hinterseer M, Wacker A, et al. The non-synonymous coding IKr-channel variant KCNH2-K897T is associated with atrial fibrillation: results from a systematic candidate gene-based analysis of KCNH2 (HERG). Eur Heart J. 2008;29:907–14.
Olesen MS, Refsgaard L, Holst AG, Larsen AP, Grubb S, Haunso S, et al. A novel KCND3 gain-of-function mutation associated with early-onset of persistent lone atrial fibrillation. Cardiovasc Res. 2013;98:488–95.
Christophersen IE, Olesen MS, Liang B, Andersen MN, Larsen AP, Nielsen JB, et al. Genetic variation in KCNA5: impact on the atrial-specific potassium current IKur in patients with lone atrial fibrillation. Eur Heart J. 2013;34:1517–25.
Tsai CT, Hsieh CS, Chang SN, Chuang EY, Juang JM, Lin LY, et al. Next-generation sequencing of nine atrial fibrillation candidate genes identified novel de novo mutations in patients with extreme trait of atrial fibrillation. J Med Genet. 2015;52:28–36.
Olesen MS, Yuan L, Liang B, Holst AG, Nielsen N, Nielsen JB, et al. High prevalence of long QT syndrome-associated SCN5A variants in patients with early-onset lone atrial fibrillation. Circ Cardiovasc Genet. 2012;5:450–9.
Watanabe H, Darbar D, Kaiser DW, Jiramongkolchai K, Chopra S, Donahue BS, et al. Mutations in sodium channel beta1- and beta2-subunits associated with atrial fibrillation. Circ Arrhythm Electrophysiol. 2009;2:268–75.
Li RG, Wang Q, Xu YJ, Zhang M, Qu XK, Liu X, et al. Mutations of the SCN4B-encoded sodium channel beta4 subunit in familial atrial fibrillation. Int J Mol Med. 2013;32:144–50.
Feghaly J, Zakka P, London B, MacRae CA, Refaat MM. Genetics of atrial fibrillation. J Am Heart Assoc. 2018;7: e009884.
Pessente GD, Sacilotto L, Calil ZO, Olivetti NQS, Wulkan F, de Oliveira TGM, et al. Effect of occurrence of Lamin A/C (LMNA) genetic variants in a cohort of 101 consecutive apparent “Lone AF” patients: results and insights. Front Cardiovasc Med. 2022;9: 823717.
Gudbjartsson DF, Arnar DO, Helgadottir A, Gretarsdottir S, Holm H, Sigurdsson A, et al. Variants conferring risk of atrial fibrillation on chromosome 4q25. Nature. 2007;448:353–7.
Roselli C, Chaffin MD, Weng LC, Aeschbacher S, Ahlberg G, Albert CM, et al. Multi-ethnic genome-wide association study for atrial fibrillation. Nat Genet. 2018;50:1225–33.
Roselli C, Rienstra M, Ellinor PT. Genetics of atrial fibrillation in 2020: GWAS, genome sequencing, polygenic risk, and beyond. Circ Res. 2020;127:21–33.
Lee JY, Kim TH, Yang PS, Lim HE, Choi EK, Shim J, et al. Korean atrial fibrillation network genome-wide association study for early-onset atrial fibrillation identifies novel susceptibility loci. Eur Heart J. 2017;38:2586–94.
Low SK, Takahashi A, Ebana Y, Ozaki K, Christophersen IE, Ellinor PT, et al. Identification of six new genetic loci associated with atrial fibrillation in the Japanese population. Nat Genet. 2017;49:953–8.
Weng LC, Choi SH, Klarin D, Smith JG, Loh PR, Chaffin M, et al. Heritability of atrial fibrillation. Circ Cardiovasc Genet. 2017;10: e001838.
Shoemaker MB, Shah RL, Roden DM, Perez MV. How will genetics inform the clinical care of atrial fibrillation? Circ Res. 2020;127:111–27.
Wilde AAM, Semsarian C, Márquez MF, Shamloo AS, Ackerman MJ, Ashley EA, et al. European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) expert consensus statement on the state of genetic testing for cardiac diseases. Europace. 2022;24:1307–67.
Weiss JN, Garfinkel A, Karagueuzian HS, Chen PS, Qu Z. Early afterdepolarizations and cardiac arrhythmias. Heart Rhythm. 2010;7:1891–9.
Nattel S, Heijman J, Zhou L, Dobrev D. Molecular basis of atrial fibrillation pathophysiology and therapy: a translational perspective. Circ Res. 2020;127:51–72.
Andrade J, Khairy P, Dobrev D, Nattel S. The clinical profile and pathophysiology of atrial fibrillation: relationships among clinical features, epidemiology, and mechanisms. Circ Res. 2014;114:1453–68.
Haïssaguerre M, Jaïs P, Shah DC, Takahashi A, Hocini M, Quiniou G, et al. Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins. N Engl J Med. 1998;339:659–66.
Ehrlich JR, Cha TJ, Zhang L, Chartier D, Melnyk P, Hohnloser SH, et al. Cellular electrophysiology of canine pulmonary vein cardiomyocytes: action potential and ionic current properties. J Physiol. 2003;551:801–13.
Teh AW, Kistler PM, Lee G, Medi C, Heck PM, Spence S, et al. Electroanatomic properties of the pulmonary veins: slowed conduction, low voltage and altered refractoriness in AF patients. J Cardiovasc Electrophysiol. 2011;22:1083–91.
Elbatran AI, Anderson RH, Mori S, Saba MM. The rationale for isolation of the left atrial pulmonary venous component to control atrial fibrillation: a review article. Heart Rhythm. 2019;16:1392–8.
Santangeli P, Marchlinski FE. Techniques for the provocation, localization, and ablation of non-pulmonary vein triggers for atrial fibrillation. Heart Rhythm. 2017;14:1087–96.
Mansour M, Mandapati R, Berenfeld O, Chen J, Samie FH, Jalife J. Left-to-right gradient of atrial frequencies during acute atrial fibrillation in the isolated sheep heart. Circulation. 2001;103:2631–6.
Lazar S, Dixit S, Marchlinski FE, Callans DJ, Gerstenfeld EP. Presence of left-to-right atrial frequency gradient in paroxysmal but not persistent atrial fibrillation in humans. Circulation. 2004;110:3181–6.
Mandapati R, Skanes A, Chen J, Berenfeld O, Jalife J. Stable microreentrant sources as a mechanism of atrial fibrillation in the isolated sheep heart. Circulation. 2000;101:194–9.
Davidenko JM, Pertsov AV, Salomonsz R, Baxter W, Jalife J. Stationary and drifting spiral waves of excitation in isolated cardiac muscle. Nature. 1992;355:349–51.
Hansen BJ, Zhao J, Csepe TA, Moore BT, Li N, Jayne LA, et al. Atrial fibrillation driven by micro-anatomic intramural reentry revealed by simultaneous sub-epicardial and sub-endocardial optical mapping in explanted human hearts. Eur Heart J. 2015;36:2390–401.
Narayan SM, Wright M, Derval N, Jadidi A, Forclaz A, Nault I, et al. Classifying fractionated electrograms in human atrial fibrillation using monophasic action potentials and activation mapping: evidence for localized drivers, rate acceleration, and nonlocal signal etiologies. Heart Rhythm. 2011;8:244–53.
Zaman JAB, Sauer WH, Alhusseini MI, Baykaner T, Borne RT, Kowalewski CAB, et al. Identification and characterization of sites where persistent atrial fibrillation is terminated by localized ablation. Circ Arrhythm Electrophysiol. 2018;11: e005258.
Baykaner T, Rogers AJ, Meckler GL, Zaman J, Navara R, Rodrigo M, et al. Clinical implications of ablation of drivers for atrial fibrillation: a systematic review and metaanalysis. Circ Arrhythm Electrophysiol. 2018;11: e006119.
Garrey WE. Auricular fibrillation. Physiol Rev. 1924;4:215–50.
Moe GK, Rheinboldt WC, Abildskov JA. A computer model of atrial fibrillation. Am Heart J. 1964;67:200–20.
Kirchhof C, Chorro F, Scheffer GJ, Brugada J, Konings K, Zetelaki Z, et al. Regional entrainment of atrial fibrillation studied by high-resolution mapping in open-chest dogs. Circulation. 1993;88:736–49.
Lee S, Sahadevan J, Khrestian CM, Cakulev I, Markowitz A, Waldo AL. Simultaneous biatrial high-density (510–512 electrodes) epicardial mapping of persistent and long-standing persistent atrial fibrillation in patients: new insights into the mechanism of its maintenance. Circulation. 2015;132:2108–17.
Kamali R, Kump J, Ghafoori E, Lange M, Hu N, Bunch TJ, et al. Area available for atrial fibrillation to propagate is an important determinant of recurrence after ablation. JACC Clin Electrophysiol. 2021;7:896–908.
Eckstein J, Maesen B, Linz D, Zeemering S, van Hunnik A, Verheule S, et al. Time course and mechanisms of endo-epicardial electrical dissociation during atrial fibrillation in the goat. Cardiovasc Res. 2011;89:816–24.
Zhang L, van Schie MS, Knops P, Taverne Y, de Groot NMS. A novel diagnostic tool to identify atrial endo-epicardial asynchrony using signal fingerprinting. Hellenic J Cardiol. 2024;75:9–20.
Lee G, Kumar S, Teh A, Madry A, Spence S, Larobina M, et al. Epicardial wave mapping in human long-lasting persistent atrial fibrillation: transient rotational circuits, complex wavefronts, and disorganized activity. Eur Heart J. 2014;35:86–97.
Allessie MA, de Groot NM, Houben RP, Schotten U, Boersma E, Smeets JL, et al. Electropathological substrate of long-standing persistent atrial fibrillation in patients with structural heart disease: longitudinal dissociation. Circ Arrhythm Electrophysiol. 2010;3:606–15.
Parameswaran R, Teuwen CP, Watts T, Nalliah CJ, Royse A, Goldblatt J, et al. Functional atrial endocardial-epicardial dissociation in patients with structural heart disease undergoing cardiac surgery. JACC Clin Electrophysiol. 2020;6:34–44.
Parameswaran R, Kalman JM, Royse A, Goldblatt J, Larobina M, Watts T, et al. Endocardial-epicardial phase mapping of prolonged persistent atrial fibrillation recordings: high prevalence of dissociated activation patterns. Circ Arrhythm Electrophysiol. 2020;13: e008512.
Hong KL, Baley J, Baranchuk A, Bisleri G, Glover BM. Epicardial electrical activation during atrial fibrillation: looking at the other side of the coin. JACC Case Rep. 2019;1:401–2.
Jiang R, Buch E, Gima J, Upadhyay GA, Nayak HM, Beaser AD, et al. Feasibility of percutaneous epicardial mapping and ablation for refractory atrial fibrillation: insights into substrate and lesion transmurality. Heart Rhythm. 2019;16:1151–9.
Hoit BD. Left atrial size and function: role in prognosis. J Am Coll Cardiol. 2014;63:493–505.
Mahnkopf C, Badger TJ, Burgon NS, Daccarett M, Haslam TS, Badger CT, et al. Evaluation of the left atrial substrate in patients with lone atrial fibrillation using delayed-enhanced MRI: implications for disease progression and response to catheter ablation. Heart Rhythm. 2010;7:1475–81.
Platonov PG, Mitrofanova LB, Orshanskaya V, Ho SY. Structural abnormalities in atrial walls are associated with presence and persistency of atrial fibrillation but not with age. J Am Coll Cardiol. 2011;58:2225–32.
Kottkamp H. Fibrotic atrial cardiomyopathy: a specific disease/syndrome supplying substrates for atrial fibrillation, atrial tachycardia, sinus node disease, AV node disease, and thromboembolic complications. J Cardiovasc Electrophysiol. 2012;23:797–9.
Cochet H, Mouries A, Nivet H, Sacher F, Derval N, Denis A, et al. Age, atrial fibrillation, and structural heart disease are the main determinants of left atrial fibrosis detected by delayed-enhanced magnetic resonance imaging in a general cardiology population. J Cardiovasc Electrophysiol. 2015;26:484–92.
Chrispin J, Ipek EG, Habibi M, Yang E, Spragg D, Marine JE, et al. Clinical predictors of cardiac magnetic resonance late gadolinium enhancement in patients with atrial fibrillation. Europace. 2017;19:371–7.
Ben Amar B, Bianca C. Towards a unified approach in the modeling of fibrosis: a review with research perspectives. Phys Life Rev. 2016;17:61–85.
Jalife J. Mechanisms of persistent atrial fibrillation. Curr Opin Cardiol. 2014;29:20–7.
Xintarakou A, Tzeis S, Psarras S, Asvestas D, Vardas P. Atrial fibrosis as a dominant factor for the development of atrial fibrillation: facts and gaps. Europace. 2020;22:342–51.
Allessie M, Ausma J, Schotten U. Electrical, contractile and structural remodeling during atrial fibrillation. Cardiovasc Res. 2002;54:230–46.
Yue L, Xie J, Nattel S. Molecular determinants of cardiac fibroblast electrical function and therapeutic implications for atrial fibrillation. Cardiovasc Res. 2011;89:744–53.
Fedorov VV, Hansen BJ. A secret marriage between fibrosis and atrial fibrillation drivers. JACC Clin Electrophysiol. 2018;4:30–2.
Marrouche NF, Wilber D, Hindricks G, Jais P, Akoum N, Marchlinski F, et al. Association of atrial tissue fibrosis identified by delayed enhancement MRI and atrial fibrillation catheter ablation: the DECAAF study. JAMA. 2014;311:498–506.
Spragg DD, Khurram I, Zimmerman SL, Yarmohammadi H, Barcelon B, Needleman M, et al. Initial experience with magnetic resonance imaging of atrial scar and co-registration with electroanatomic voltage mapping during atrial fibrillation: success and limitations. Heart Rhythm. 2012;9:2003–9.
Oakes RS, Badger TJ, Kholmovski EG, Akoum N, Burgon NS, Fish EN, et al. Detection and quantification of left atrial structural remodeling with delayed-enhancement magnetic resonance imaging in patients with atrial fibrillation. Circulation. 2009;119:1758–67.
Chen J, Arentz T, Cochet H, Müller-Edenborn B, Kim S, Moreno-Weidmann Z, et al. Extent and spatial distribution of left atrial arrhythmogenic sites, late gadolinium enhancement at magnetic resonance imaging, and low-voltage areas in patients with persistent atrial fibrillation: comparison of imaging vs. electrical parameters of fibrosis and arrhythmogenesis. Europace. 2019;21:1484–93.
Haemers P, Hamdi H, Guedj K, Suffee N, Farahmand P, Popovic N, et al. Atrial fibrillation is associated with the fibrotic remodelling of adipose tissue in the subepicardium of human and sheep atria. Eur Heart J. 2017;38:53–61.
Nalliah CJ, Bell JR, Raaijmakers AJA, Waddell HM, Wells SP, Bernasochi GB, et al. Epicardial adipose tissue accumulation confers atrial conduction abnormality. J Am Coll Cardiol. 2020;76:1197–211.
Mahajan R, Lau DH, Brooks AG, Shipp NJ, Manavis J, Wood JP, et al. Electrophysiological, electroanatomical, and structural remodeling of the atria as consequences of sustained obesity. J Am Coll Cardiol. 2015;66:1–11.
Wong CX, Ganesan AN, Selvanayagam JB. Epicardial fat and atrial fibrillation: current evidence, potential mechanisms, clinical implications, and future directions. Eur Heart J. 2017;38:1294–302.
Rocken C, Peters B, Juenemann G, Saeger W, Klein HU, Huth C, et al. Atrial amyloidosis: an arrhythmogenic substrate for persistent atrial fibrillation. Circulation. 2002;106:2091–7.
Leone O, Boriani G, Chiappini B, Pacini D, Cenacchi G, Martin Suarez S, et al. Amyloid deposition as a cause of atrial remodelling in persistent valvular atrial fibrillation. Eur Heart J. 2004;25:1237–41.
Steiner I, Hajkova P. Patterns of isolated atrial amyloid: a study of 100 hearts on autopsy. Cardiovasc Pathol. 2006;15:287–90.
Heijman J, Voigt N, Nattel S, Dobrev D. Cellular and molecular electrophysiology of atrial fibrillation initiation, maintenance, and progression. Circ Res. 2014;114:1483–99.
Nattel S, Burstein B, Dobrev D. Atrial remodeling and atrial fibrillation: mechanisms and implications. Circ Arrhythm Electrophysiol. 2008;1:62–73.
Caballero R, de la Fuente MG, Gomez R, Barana A, Amoros I, Dolz-Gaiton P, et al. In humans, chronic atrial fibrillation decreases the transient outward current and ultrarapid component of the delayed rectifier current differentially on each atria and increases the slow component of the delayed rectifier current in both. J Am Coll Cardiol. 2010;55:2346–54.
Voigt N, Trausch A, Knaut M, Matschke K, Varro A, Van Wagoner DR, et al. Left-to-right atrial inward rectifier potassium current gradients in patients with paroxysmal versus chronic atrial fibrillation. Circ Arrhythm Electrophysiol. 2010;3:472–80.
Van Wagoner DR, Pond AL, Lamorgese M, Rossie SS, McCarthy PM, Nerbonne JM. Atrial L-type Ca2+ currents and human atrial fibrillation. Circ Res. 1999;85:428–36.
Martins RP, Kaur K, Hwang E, Ramirez RJ, Willis BC, Filgueiras-Rama D, et al. Dominant frequency increase rate predicts transition from paroxysmal to long-term persistent atrial fibrillation. Circulation. 2014;129:1472–82.
Deshmukh A, Barnard J, Sun H, Newton D, Castel L, Pettersson G, et al. Left atrial transcriptional changes associated with atrial fibrillation susceptibility and persistence. Circ Arrhythm Electrophysiol. 2015;8:32–41.
Burstein B, Qi XY, Yeh YH, Calderone A, Nattel S. Atrial cardiomyocyte tachycardia alters cardiac fibroblast function: a novel consideration in atrial remodeling. Cardiovasc Res. 2007;76:442–52.
Amar D, Zhang H, Miodownik S, Kadish AH. Competing autonomic mechanisms precedethe onset of postoperative atrial fibrillation. J Am Coll Cardiol. 2003;42:1262–8.
Bettoni M, Zimmermann M. Autonomic tone variations before the onset of paroxysmal atrial fibrillation. Circulation. 2002;105:2753–9.
Tomita T, Takei M, Saikawa Y, Hanaoka T, Uchikawa S, Tsutsui H, et al. Role of autonomic tone in the initiation and termination of paroxysmal atrial fibrillation in patients without structural heart disease. J Cardiovasc Electrophysiol. 2003;14:559–64.
Scherlag BJ, Yamanashi W, Patel U, Lazzara R, Jackman WM. Autonomically induced conversion of pulmonary vein focal firing into atrial fibrillation. J Am Coll Cardiol. 2005;45:1878–86.
Patterson E, Po SS, Scherlag BJ, Lazzara R. Triggered firing in pulmonary veins initiated by in vitro autonomic nerve stimulation. Heart Rhythm. 2005;2:624–31.
Zhou J, Scherlag BJ, Edwards J, Jackman WM, Lazzara R, Po SS. Gradients of atrial refractoriness and inducibility of atrial fibrillation due to stimulation of ganglionated plexi. J Cardiovasc Electrophysiol. 2007;18:83–90.
Patterson E, Jackman WM, Beckman KJ, Lazzara R, Lockwood D, Scherlag BJ, et al. Spontaneous pulmonary vein firing in man: relationship to tachycardia-pause early afterdepolarizations and triggered arrhythmia in canine pulmonary veins in vitro. J Cardiovasc Electrophysiol. 2007;18:1067–75.
Jayachandran JV, Sih HJ, Winkle W, Zipes DP, Hutchins GD, Olgin JE. Atrial fibrillation produced by prolonged rapid atrial pacing is associated with heterogeneous changes in atrial sympathetic innervation. Circulation. 2000;101:1185–91.
Lu Z, Scherlag BJ, Lin J, Niu G, Fung KM, Zhao L, et al. Atrial fibrillation begets atrial fibrillation: autonomic mechanism for atrial electrical remodeling induced by short-term rapid atrial pacing. Circ Arrhythm Electrophysiol. 2008;1:184–92.
Stavrakis S, Stoner JA, Humphrey MB, Morris L, Filiberti A, Reynolds JC, et al. TREAT AF (transcutaneous electrical vagus nerve stimulation to suppress atrial fibrillation): a randomized clinical trial. JACC Clin Electrophysiol. 2020;6:282–91.
Shen MJ, Hao-Che C, Park HW, George Akingba A, Chang PC, Zheng Z, et al. Low-level vagus nerve stimulation upregulates small conductance calcium-activated potassium channels in the stellate ganglion. Heart Rhythm. 2013;10:910–5.
Bernstein SA, Wong B, Vasquez C, Rosenberg SP, Rooke R, Kuznekoff LM, et al. Spinal cord stimulation protects against atrial fibrillation induced by tachypacing. Heart Rhythm. 2012;9:1426-33.e3.
Pokushalov E, Romanov A, Shugayev P, Artyomenko S, Shirokova N, Turov A, et al. Selective ganglionated plexi ablation for paroxysmal atrial fibrillation. Heart Rhythm. 2009;6:1257–64.
Katritsis D, Giazitzoglou E, Sougiannis D, Goumas N, Paxinos G, Camm AJ. Anatomic approach for ganglionic plexi ablation in patients with paroxysmal atrial fibrillation. Am J Cardiol. 2008;102:330–4.
Katritsis DG, Giazitzoglou E, Zografos T, Pokushalov E, Po SS, Camm AJ. Rapid pulmonary vein isolation combined with autonomic ganglia modification: a randomized study. Heart Rhythm. 2011;8:672–8.
Nakagawa H, Scherlag BJ, Wu R, Po S, Lockwood D, Yokoyama K, et al. Addition of selective ablation of autonomic ganglia to pulmonary vein antrum isolation for treatment of paroxysmal and persistent atrial fibrillation. Circulation. 2004;110:543.
Chen SA, Hsieh MH, Tai CT, Tsai CF, Prakash VS, Yu WC, et al. Initiation of atrial fibrillation by ectopic beats originating from the pulmonary veins: electrophysiological characteristics, pharmacological responses, and effects of radiofrequency ablation. Circulation. 1999;100:1879–86.
Jaïs P, Hocini M, Macle L, Choi KJ, Deisenhofer I, Weerasooriya R, et al. Distinctive electrophysiological properties of pulmonary veins in patients with atrial fibrillation. Circulation. 2002;106:2479–85.
Cherry EM, Ehrlich JR, Nattel S, Fenton FH. Pulmonary vein reentry–properties and size matter: insights from a computational analysis. Heart Rhythm. 2007;4:1553–62.
Bonczar M, Piątek-Koziej K, Wolska J, Tomala O, Stitou EA, Pękala J, et al. Variations in human pulmonary vein ostia morphology: a systematic review with metaanalysis. Clin Anat. 2022;35:906–26.
Anselmino M, Blandino A, Beninati S, Rovera C, Boffano C, Belletti M, et al. Morphologic analysis of left atrial anatomy by magnetic resonance angiography in patients with atrial fibrillation: a large single center experience. J Cardiovasc Electrophysiol. 2011;22:1–7.
Cheruiyot I, Munguti J, Olabu B, Gichangi P. A metaanalysis of the relationship between anatomical variations of pulmonary veins and atrial fibrillation. Acta Cardiol. 2020;75:1–9.
Nathan H, Eliakim M. The junction between the left atrium and the pulmonary veins. An anatomic study of human hearts. Circulation. 1966;34:412–22.
Rivaud MR, Blok M, Jongbloed MRM, Boukens BJ. How Cardiac Embryology Translates into Clinical Arrhythmias. J Cardiovasc Dev Dis. 2021;8:70.
Teres C, Soto-Iglesias D, Penela D, Jáuregui B, Ordoñez A, Chauca A, et al. Left atrial wall thickness of the pulmonary vein reconnection sites during atrial fibrillation redo procedures. Pacing Clin Electrophysiol. 2021;44:824–34.
Barrio-Lopez MT, Sanchez-Quintana D, Garcia-Martinez J, Betancur A, Castellanos E, Arceluz M, et al. Epicardial connections involving pulmonary veins: the prevalence, predictors, and implications for ablation outcome. Circ Arrhythm Electrophysiol. 2020;13: e007544.
Perez-Castellano N, Villacastin J, Salinas J, Vega M, Moreno J, Doblado M, et al. Epicardial connections between the pulmonary veins and left atrium: relevance for atrial fibrillation ablation. J Cardiovasc Electrophysiol. 2011;22:149–59.
Barrio-Lopez MT, Castellanos E, Ortiz M, Arceluz M, Lazaro C, Salas J, et al. Atrial mapping during pulmonary vein pacing to detect conduction gaps in a second pulmonary vein isolation procedure. J Interv Card Electrophysiol. 2018;53:195–205.
Yoshida K, Baba M, Shinoda Y, Harunari T, Tsumagari Y, Koda N, et al. Epicardial connection between the right-sided pulmonary venous carina and the right atrium in patients with atrial fibrillation: a possible mechanism for preclusion of pulmonary vein isolation without carina ablation. Heart Rhythm. 2019;16:671–8.
Cabrera JA, Ho SY, Climent V, Fuertes B, Murillo M, Sanchez-Quintana D. Morphological evidence of muscular connections between contiguous pulmonary venous orifices: relevance of the interpulmonary isthmus for catheter ablation in atrial fibrillation. Heart Rhythm. 2009;6:1192–8.
Cabrera JA, Ho SY, Climent V, Sanchez-Quintana D. The architecture of the left lateral atrial wall: a particular anatomic region with implications for ablation of atrial fibrillation. Eur Heart J. 2008;29:356–62.
Ho SY, Cabrera JA, Sanchez-Quintana D. Left atrial anatomy revisited. Circ Arrhythm Electrophysiol. 2012;5:220–8.
Ho SY, Anderson RH, Sanchez-Quintana D. Atrial structure and fibres: morphologic bases of atrial conduction. Cardiovasc Res. 2002;54:325–36.
Ho SY, Sanchez-Quintana D. The importance of atrial structure and fibers. Clin Anat. 2009;22:52–63.
Patel PJ, D’Souza B, Saha P, Chik WW, Riley MP, Garcia FC. Electroanatomic mapping of the intercaval bundle in atrial fibrillation. Circ Arrhythm Electrophysiol. 2014;7:1262–7.
Anderson RH, Spicer DE, Brown NA, Mohun TJ. The development of septation in the four-chambered heart. Anat Rec. 2014;297:1414–29.
Klimek-Piotrowska W, Hołda MK, Koziej M, Piątek K, Hołda J. Anatomy of the true interatrial septum for transseptal access to the left atrium. Ann Anat. 2016;205:60–4.
Tzeis S, Andrikopoulos G, Deisenhofer I, Ho SY, Theodorakis G. Transseptal catheterization: considerations and caveats. Pacing Clin Electrophysiol. 2010;33:231–42.
Meier D, Antiochos P, Herrera-Siklody C, Eeckhout E, Delabays A, Tzimas G, et al. Interatrial septum dissection and atrial wall hematoma following transseptal puncture: a systematic review of the literature. Catheter Cardiovasc Interv. 2020;96:424–31.
Kerut EK, Norfleet WT, Plotnick GD, Giles TD. Patent foramen ovale: a review of associated conditions and the impact of physiological size. J Am Coll Cardiol. 2001;38:613–23.
Hagen PT, Scholz DG, Edwards WD. Incidence and size of patent foramen ovale during the first 10 decades of life: an autopsy study of 965 normal hearts. Mayo Clin Proc. 1984;59:17–20.
Benvenuti F, Meucci F, Vuolo L, Nistri R, Pracucci G, Picchioni A, et al. Relation between the size of patent foramen ovale and the volume of acute cerebral ischemic lesion in young patients with cryptogenic ischemic stroke. Neurol Sci. 2022;43:453–8.
Knecht S, Wright M, Lellouche N, Nault I, Matsuo S, O’Neill MD, et al. Impact of a patent foramen ovale on paroxysmal atrial fibrillation ablation. J Cardiovasc Electrophysiol. 2008;19:1236–41.
Miyazaki S, Shah AJ, Nault I, Wright M, Jadidi AS, Forclaz A, et al. Impact of patent foramen ovale on left atrial linear lesions in the context of atrial fibrillation ablation. J Cardiovasc Electrophysiol. 2011;22:846–50.
Barrio-Lopez MT, Castellanos E, Betancur A, Zorita B, Medina J, Losada N, et al. The presence of a large patent foramen ovale reduces acute and chronic success in atrial fibrillation ablation. J Interv Card Electrophysiol. 2022;64:705–13.
Almendarez M, Alvarez-Velasco R, Pascual I, Alperi A, Moris C, Avanzas P. Transseptal puncture: review of anatomy, techniques, complications and challenges, a critical view. Int J Cardiol. 2022;351:32–8.
De Ponti R, Cappato R, Curnis A, Della Bella P, Padeletti L, Raviele A, et al. Trans-septal catheterization in the electrophysiology laboratory: data from a multicenter survey spanning 12 years. J Am Coll Cardiol. 2006;47:1037–42.
Li X, Wissner E, Kamioka M, Makimoto H, Rausch P, Metzner A, et al. Safety and feasibility of transseptal puncture for atrial fibrillation ablation in patients with atrial septal defect closure devices. Heart Rhythm. 2014;11:330–5.
Santangeli P, Di Biase L, Burkhardt JD, Horton R, Sanchez J, Bailey S, et al. Transseptal access and atrial fibrillation ablation guided by intracardiac echocardiography in patients with atrial septal closure devices. Heart Rhythm. 2011;8:1669–75.
Wang K, Ho SY, Gibson DG, Anderson RH. Architecture of atrial musculature in humans. Br Heart J. 1995;73:559–65.
Jais P, Hocini M, Hsu LF, Sanders P, Scavee C, Weerasooriya R, et al. Technique and results of linear ablation at the mitral isthmus. Circulation. 2004;110:2996–3002.
Derval N, Takigawa M, Frontera A, Mahida S, Konstantinos V, Denis A, et al. Characterization of complex atrial tachycardia in patients with previous atrial interventions using high-resolution mapping. JACC Clin Electrophysiol. 2020;6:815–26.
Hocini M, Jais P, Sanders P, Takahashi Y, Rotter M, Rostock T, et al. Techniques, evaluation, and consequences of linear block at the left atrial roof in paroxysmal atrial fibrillation: a prospective randomized study. Circulation. 2005;112:3688–96.
Ho SY. Normal and abnormal atrial anatomy relevant to atrial flutters: areas of physiological and acquired conduction blocks and delays predisposing to reentry. Card Electrophysiol Clin. 2022;14:375–84.
van Campenhout MJ, Yaksh A, Kik C, de Jaegere PP, Ho SY, Allessie MA, et al. Bachmann’s bundle: a key player in the development of atrial fibrillation? Circ Arrhythm Electrophysiol. 2013;6:1041–6.
Papez J. Heart musculature of the atria. Am J Anat. 1920;27:255–85.
Ho SY, Sanchez-Quintana D, Cabrera JA, Anderson RH. Anatomy of the left atrium: implications for radiofrequency ablation of atrial fibrillation. J Cardiovasc Electrophysiol. 1999;10:1525–33.
Pambrun T, Duchateau J, Delgove A, Denis A, Constantin M, Ramirez FD, et al. Epicardial course of the septopulmonary bundle: anatomical considerations and clinical implications for roof line completion. Heart Rhythm. 2021;18:349–57.
Chauvin M, Shah DC, Haissaguerre M, Marcellin L, Brechenmacher C. The anatomic basis of connections between the coronary sinus musculature and the left atrium in humans. Circulation. 2000;101:647–52.
von Ludinghausen M, Ohmachi N, Besch S, Mettenleiter A. Atrial veins of the human heart. Clin Anat. 1995;8:169–89.
Kim DT, Lai AC, Hwang C, Fan LT, Karagueuzian HS, Chen PS, et al. The ligament of Marshall: a structural analysis in human hearts with implications for atrial arrhythmias. J Am Coll Cardiol. 2000;36:1324–7.
Makino M, Inoue S, Matsuyama TA, Ogawa G, Sakai T, Kobayashi Y, et al. Diverse myocardial extension and autonomic innervation on ligament of Marshall in humans. J Cardiovasc Electrophysiol. 2006;17:594–9.
Von Lüdinghausen M, Ohmachi N, Boot C. Myocardial coverage of the coronary sinus and related veins. Clin Anat. 1992;5:1–15.
Marshall J. On the development of the great anterior veins in man and mammalia; including an account of certain remnants of foetal structure found in the adult, a comparative view of these great veins in the different mammalia, and an analysis of their occasional peculiarities in the human subject. Philos Trans Roy Soc Lond. 1850;140:133–70.
DeSimone CV, Noheria A, Lachman N, Edwards WD, Gami AS, Maleszewski JJ, et al. Myocardium of the superior vena cava, coronary sinus, vein of Marshall, and the pulmonary vein ostia: gross anatomic studies in 620 hearts. J Cardiovasc Electrophysiol. 2012;23:1304–9.
Baez-Escudero JL, Keida T, Dave AS, Okishige K, Valderrabano M. Ethanol infusion in the vein of Marshall leads to parasympathetic denervation of the human left atrium: implications for atrial fibrillation. J Am Coll Cardiol. 2014;63:1892–901.
Hwang C, Chen PS. Ligament of Marshall: why it is important for atrial fibrillation ablation. Heart Rhythm. 2009;6:S35-40.
Hwang C, Wu TJ, Doshi RN, Peter CT, Chen PS. Vein of Marshall cannulation for the analysis of electrical activity in patients with focal atrial fibrillation. Circulation. 2000;101:1503–5.
Ulphani JS, Arora R, Cain JH, Villuendas R, Shen S, Gordon D, et al. The ligament of Marshall as a parasympathetic conduit. Am J Physiol Heart Circ Physiol. 2007;293:H1629-35.
Hwang C, Karagueuzian HS, Chen PS. Idiopathic paroxysmal atrial fibrillation induced by a focal discharge mechanism in the left superior pulmonary vein: possible roles of the ligament of Marshall. J Cardiovasc Electrophysiol. 1999;10:636–48.
Wittkampf FH, van Oosterhout MF, Loh P, Derksen R, Vonken EJ, Slootweg PJ, et al. Where to draw the mitral isthmus line in catheter ablation of atrial fibrillation: histological analysis. Eur Heart J. 2005;26:689–95.
Pambrun T, Denis A, Duchateau J, Sacher F, Hocini M, Jaïs P, et al. Marshall bundles elimination, pulmonary veins isolation and Lines completion for anatomical ablation of persistent atrial fibrillation: Marshall-PLAN case series. J Cardiovasc Electrophysiol. 2019;30:7–15.
Becker AE. Left atrial isthmus: anatomic aspects relevant for linear catheter ablation procedures in humans. J Cardiovasc Electrophysiol. 2004;15:809–12.
Baez-Escudero JL, Morales PF, Dave AS, Sasaridis CM, Kim YH, Okishige K, et al. Ethanol infusion in the vein of Marshall facilitates mitral isthmus ablation. Heart Rhythm. 2012;9:1207–15.
Takigawa M, Vlachos K, Martin CA, Bourier F, Denis A, Kitamura T, et al. Acute and mid-term outcome of ethanol infusion of vein of Marshall for the treatment of perimitral flutter. Europace. 2020;22:1252–60.
Pambrun T, Derval N, Duchateau J, Denis A, Chauvel R, Tixier R, et al. Epicardial course of the musculature related to the great cardiac vein: anatomical considerations and clinical implications for mitral isthmus block after vein of Marshall ethanol infusion. Heart Rhythm. 2021;18:1951–8.
Tsai CF, Tai CT, Hsieh MH, Lin WS, Yu WC, Ueng KC, et al. Initiation of atrial fibrillation by ectopic beats originating from the superior vena cava: electrophysiological characteristics and results of radiofrequency ablation. Circulation. 2000;102:67–74.
Nyuta E, Takemoto M, Sakai T, Mito T, Masumoto A, Todoroki W, et al. Importance of the length of the myocardial sleeve in the superior vena cava in patients with atrial fibrillation. J Arrhythm. 2021;37:43–51.
Depes D, Mennander A, Paavonen T, Kholová I. Autonomic nerves in myocardial sleeves around caval veins: potential role in cardiovascular mortality? Cardiovasc Pathol. 2022;59: 107426.
Miyazaki S, Taniguchi H, Kusa S, Ichihara N, Nakamura H, Hachiya H, et al. Factors predicting an arrhythmogenic superior vena cava in atrial fibrillation ablation: insight into the mechanism. Heart Rhythm. 2014;11:1560–6.
Corradi D, Callegari S, Gelsomino S, Lorusso R, Macchi E. Morphology and pathophysiology of target anatomical sites for ablation procedures in patients with atrial fibrillation: part II: pulmonary veins, caval veins, ganglionated plexi, and ligament of Marshall. Int J Cardiol. 2013;168:1769–78.
Wickramasinghe SR, Patel VV. Local innervation and atrial fibrillation. Circulation. 2013;128:1566–75.
Kusayama T, Wan J, Yuan Y, Chen PS. Neural mechanisms and therapeutic opportunities for atrial fibrillation. Methodist Debakey Cardiovasc J. 2021;17:43–7.
Kawashima T. The autonomic nervous system of the human heart with special reference to its origin, course, and peripheral distribution. Anat Embryol. 2005;209:425–38.
Shen MJ, Zipes DP. Role of the autonomic nervous system in modulating cardiac arrhythmias. Circ Res. 2014;114:1004–21.
Hou Y, Zhou Q, Po SS. Neuromodulation for cardiac arrhythmia. Heart Rhythm. 2016;13:584–92.
Armour JA, Murphy DA, Yuan BX, Macdonald S, Hopkins DA. Gross and microscopic anatomy of the human intrinsic cardiac nervous system. Anat Rec. 1997;247:289–98.
Kim MY, Sandler BC, Sikkel MB, Cantwell CD, Leong KM, Luther V, et al. Anatomical distribution of ectopy-triggering plexuses in patients with atrial fibrillation. Circ Arrhythm Electrophysiol. 2020;13: e008715.
Po SS, Nakagawa H, Jackman WM. Localization of left atrial ganglionated plexi in patients with atrial fibrillation. J Cardiovasc Electrophysiol. 2009;20:1186–9.
Scherlag BJ, Nakagawa H, Jackman WM, Yamanashi WS, Patterson E, Po S, et al. Electrical stimulation to identify neural elements on the heart: their role in atrial fibrillation. J Interv Card Electrophysiol. 2005;13:37–42.
Lemery R, Birnie D, Tang AS, Green M, Gollob M. Feasibility study of endocardial mapping of ganglionated plexuses during catheter ablation of atrial fibrillation. Heart Rhythm. 2006;3:387–96.
Stirrup J, Gregg S, Baavour R, Roth N, Breault C, Agostini D, et al. Hybrid solid-state SPECT/CT left atrial innervation imaging for identification of left atrial ganglionated plexi: technique and validation in patients with atrial fibrillation. J Nucl Cardiol. 2020;27:1939–50.
Lemoine MD, Mencke C, Nies M, Obergassel J, Scherschel K, Wieboldt H, et al. Pulmonary vein isolation by pulsed-field ablation induces less neurocardiac damage than cryoballoon ablation. Circ Arrhythm Electrophysiol. 2023;16: e011598.
Musikantow DR, Neuzil P, Petru J, Koruth JS, Kralovec S, Miller MA, et al. Pulsed field ablation to treat atrial fibrillation: autonomic nervous system effects. JACC Clin Electrophysiol. 2023;9:481–93.
von Olshausen G, Saluveer O, Schwieler J, Drca N, Bastani H, Tapanainen J, et al. Sinus heart rate post pulmonary vein ablation and long-term risk of recurrences. Clin Res Cardiol. 2021;110:851–60.
Yu HT, Kim TH, Uhm JS, Kim JY, Joung B, Lee MH, et al. Prognosis of high sinus heart rate after catheter ablation for atrial fibrillation. Europace. 2017;19:1132–9.
Goff ZD, Laczay B, Yenokyan G, Sivasambu B, Sinha SK, Marine JE, et al. Heart rate increase after pulmonary vein isolation predicts freedom from atrial fibrillation at 1 year. J Cardiovasc Electrophysiol. 2019;30:2818–22.
DeLurgio DB, Crossen KJ, Gill J, Blauth C, Oza SR, Magnano AR, et al. Hybrid convergent procedure for the treatment of persistent and long-standing persistent atrial fibrillation: results of CONVERGE clinical trial. Circ Arrhythm Electrophysiol. 2020;13: e009288.
Makati KJ, Sood N, Lee LS, Yang F, Shults CC, DeLurgio DB, et al. Combined epicardial and endocardial ablation for atrial fibrillation: best practices and guide to hybrid convergent procedures. Heart Rhythm. 2021;18:303–12.
Kress DC, Erickson L, Choudhuri I, Zilinski J, Mengesha T, Krum D, et al. Comparative effectiveness of hybrid ablation versus endocardial catheter ablation alone in patients with persistent atrial fibrillation. JACC Clin Electrophysiol. 2017;3:341–9.
Reddy VY, Neuzil P, D’Avila A, Ruskin JN. Isolating the posterior left atrium and pulmonary veins with a “box” lesion set: use of epicardial ablation to complete electrical isolation. J Cardiovasc Electrophysiol. 2008;19:326–9.
Piorkowski C, Kronborg M, Hourdain J, Piorkowski J, Kirstein B, Neudeck S, et al. Endo-/epicardial catheter ablation of atrial fibrillation: feasibility, outcome, and insights into arrhythmia mechanisms. Circ Arrhythm Electrophysiol. 2018;11: e005748.
Tung R. Percutaneous epicardial ablation of atrial fibrillation. Card Electrophysiol Clin. 2020;12:371–81.
D’Avila A, Scanavacca M, Sosa E, Ruskin JN, Reddy VY. Pericardial anatomy for the interventional electrophysiologist. J Cardiovasc Electrophysiol. 2003;14:422–30.
Smith NM, Segars L, Kauffman T, Olinger AB. Using anatomical landmark to avoid phrenic nerve injury during balloon-based procedures in atrial fibrillation patients. Surg Radiol Anat. 2017;39:1369–75.
Okumura Y, Henz BD, Bunch TJ, Dalegrave C, Johnson SB, Packer DL. Distortion of right superior pulmonary vein anatomy by balloon catheters as a contributor to phrenic nerve injury. J Cardiovasc Electrophysiol. 2009;20:1151–7.
Ströker E, de Asmundis C, Saitoh Y, Velagić V, Mugnai G, Irfan G, et al. Anatomic predictors of phrenic nerve injury in the setting of pulmonary vein isolation using the 28-mm second-generation cryoballoon. Heart Rhythm. 2016;13:342–51.
Romero J, Natale A, Lakkireddy D, Cerna L, Diaz JC, Alviz I, et al. Mapping and localization of the left phrenic nerve during left atrial appendage electrical isolation to avoid inadvertent injury in patients undergoing catheter ablation of atrial fibrillation. Heart Rhythm. 2020;17:527–34.
Gupta T, Cheema N, Randhawa A, Sahni D. Translational anatomy of the left atrium and esophagus as relevant to the pulmonary vein antral isolation for atrial fibrillation. Surg Radiol Anat. 2020;42:367–76.
Bunch TJ, May HT, Crandall BG, Weiss JP, Bair TL, Osborn JS, et al. Intracardiac ultrasound for esophageal anatomic assessment and localization during left atrial ablation for atrial fibrillation. J Cardiovasc Electrophysiol. 2013;24:33–9.
Jang SW, Kwon BJ, Choi MS, Kim DB, Shin WS, Cho EJ, et al. Computed tomographic analysis of the esophagus, left atrium, and pulmonary veins: implications for catheter ablation of atrial fibrillation. J Interv Card Electrophysiol. 2011;32:1–6.
Sarairah SY, Woodbury B, Methachittiphan N, Tregoning DM, Sridhar AR, Akoum N. Esophageal thermal injury following cryoballoon ablation for atrial fibrillation. JACC Clin Electrophysiol. 2020;6:262–8.
Lemola K, Sneider M, Desjardins B, Case I, Han J, Good E, et al. Computed tomographic analysis of the anatomy of the left atrium and the esophagus: implications for left atrial catheter ablation. Circulation. 2004;110:3655–60.
Good E, Oral H, Lemola K, Han J, Tamirisa K, Igic P, et al. Movement of the esophagus during left atrial catheter ablation for atrial fibrillation. J Am Coll Cardiol. 2005;46:2107–10.
Wilber DJ, Pappone C, Neuzil P, De Paola A, Marchlinski F, Natale A, et al. Comparison of antiarrhythmic drug therapy and radiofrequency catheter ablation in patients with paroxysmal atrial fibrillation: a randomized controlled trial. JAMA. 2010;303:333–40.
Calkins H, Reynolds MR, Spector P, Sondhi M, Xu Y, Martin A, et al. Treatment of atrial fibrillation with antiarrhythmic drugs or radiofrequency ablation: two systematic literature reviews and metaanalyses. Circ Arrhythm Electrophysiol. 2009;2:349–61.
Jaïs P, Cauchemez B, Macle L, Daoud E, Khairy P, Subbiah R, et al. Catheter ablation versus antiarrhythmic drugs for atrial fibrillation: the A4 study. Circulation. 2008;118:2498–505.
Packer DL, Kowal RC, Wheelan KR, Irwin JM, Champagne J, Guerra PG, et al. Cryoballoon ablation of pulmonary veins for paroxysmal atrial fibrillation: first results of the North American Arctic Front (STOP AF) pivotal trial. J Am Coll Cardiol. 2013;61:1713–23.
Poole JE, Bahnson TD, Monahan KH, Johnson G, Rostami H, Silverstein AP, et al. Recurrence of atrial fibrillation after catheter ablation or antiarrhythmic drug therapy in the CABANA trial. J Am Coll Cardiol. 2020;75:3105–18.
Mont L, Bisbal F, Hernández-Madrid A, Pérez-Castellano N, Viñolas X, Arenal A, et al. Catheter ablation vs. antiarrhythmic drug treatment of persistent atrial fibrillation: a multicentre, randomized, controlled trial (SARA study). Eur Heart J. 2014;35:501–7.
Scherr D, Khairy P, Miyazaki S, Aurillac-Lavignolle V, Pascale P, Wilton SB, et al. Five-year outcome of catheter ablation of persistent atrial fibrillation using termination of atrial fibrillation as a procedural endpoint. Circ Arrhythm Electrophysiol. 2015;8:18–24.
Wazni OM, Dandamudi G, Sood N, Hoyt R, Tyler J, Durrani S, et al. Cryoballoon ablation as initial therapy for atrial fibrillation. N Engl J Med. 2021;384:316–24.
Andrade JG, Wells GA, Deyell MW, Bennett M, Essebag V, Champagne J, et al. Cryoablation or drug therapy for initial treatment of atrial fibrillation. N Engl J Med. 2021;384:305–15.
Kuniss M, Pavlovic N, Velagic V, Hermida JS, Healey S, Arena G, et al. Cryoballoon ablation vs. antiarrhythmic drugs: first-line therapy for patients with paroxysmal atrial fibrillation. Europace. 2021;23:1033–41.
Cosedis Nielsen C, Johannessen A, Raatikainen P, Hindricks G, Walfridsson H, Kongstad O, et al. Radiofrequency ablation as initial therapy in paroxysmal atrial fibrillation. N Engl J Med. 2012;367:1587–95.
Morillo CA, Verma A, Connolly SJ, Kuck KH, Nair GM, Champagne J, et al. Radiofrequency ablation vs antiarrhythmic drugs as first-line treatment of paroxysmal atrial fibrillation (RAAFT-2): a randomized trial. JAMA. 2014;311:692–700.
Wazni OM, Marrouche NF, Martin DO, Verma A, Bhargava M, Saliba W, et al. Radiofrequency ablation vs antiarrhythmic drugs as first-line treatment of symptomatic atrial fibrillation: a randomized trial. JAMA. 2005;293:2634–40.
Hakalahti A, Biancari F, Nielsen JC, Raatikainen MJ. Radiofrequency ablation vs. antiarrhythmic drug therapy as first line treatment of symptomatic atrial fibrillation: systematic review and metaanalysis. Europace. 2015;17:370–8.
Prabhu S, Taylor AJ, Costello BT, Kaye DM, McLellan AJA, Voskoboinik A, et al. Catheter ablation versus medical rate control in atrial fibrillation and systolic dysfunction: the CAMERA-MRI study. J Am Coll Cardiol. 2017;70:1949–61.
Sugumar H, Prabhu S, Costello B, Chieng D, Azzopardi S, Voskoboinik A, et al. Catheter ablation versus medication in atrial fibrillation and systolic dysfunction: late outcomes of CAMERA-MRI study. JACC Clin Electrophysiol. 2020;6:1721–31.
Hunter RJ, Berriman TJ, Diab I, Kamdar R, Richmond L, Baker V, et al. A randomized controlled trial of catheter ablation versus medical treatment of atrial fibrillation in heart failure (the CAMTAF trial). Circ Arrhythm Electrophysiol. 2014;7:31–8.
Parkash R, Wells GA, Rouleau J, Talajic M, Essebag V, Skanes A, et al. Randomized ablation-based rhythm-control versus rate-control trial in patients with heart failure and atrial fibrillation: results from the RAFT-AF trial. Circulation. 2022;145:1693–704.
Romero J, Gabr M, Alviz I, Briceno D, Diaz JC, Rodriguez D, et al. Improved survival in patients with atrial fibrillation and heart failure undergoing catheter ablation compared to medical treatment: a systematic review and metaanalysis of randomized controlled trials. J Cardiovasc Electrophysiol. 2022;33:2356–66.
Di Biase L, Mohanty P, Mohanty S, Santangeli P, Trivedi C, Lakkireddy D, et al. Ablation versus amiodarone for treatment of persistent atrial fibrillation in patients with congestive heart failure and an implanted device: results from the AATAC multicenter randomized trial. Circulation. 2016;133:1637–44.
Sohns C, Zintl K, Zhao Y, Dagher L, Andresen D, Siebels J, et al. Impact of left ventricular function and heart failure symptoms on outcomes post ablation of atrial fibrillation in heart failure: CASTLE-AF trial. Circ Arrhythm Electrophysiol. 2020;13: e008461.
Packer DL, Piccini JP, Monahan KH, Al-Khalidi HR, Silverstein AP, Noseworthy PA, et al. Ablation versus drug therapy for atrial fibrillation in heart failure: results from the CABANA trial. Circulation. 2021;143:1377–90.
Asad ZUA, Yousif A, Khan MS, Al-Khatib SM, Stavrakis S. Catheter ablation versus medical therapy for atrial fibrillation: a systematic review and metaanalysis of randomized controlled trials. Circ Arrhythm Electrophysiol. 2019;12: e007414.
Briceño DF, Markman TM, Lupercio F, Romero J, Liang JJ, Villablanca PA, et al. Catheter ablation versus conventional treatment of atrial fibrillation in patients with heart failure with reduced ejection fraction: a systematic review and metaanalysis of randomized controlled trials. J Interv Card Electrophysiol. 2018;53:19–29.
Sohns C, Fox H, Marrouche NF, Crijns H, Costard-Jaeckle A, Bergau L, et al. Catheter ablation in end-stage heart failure with atrial fibrillation. N Engl J Med. 2023;389:1380–9.
Sciarra L, Rebecchi M, De Ruvo E, De Luca L, Zuccaro LM, Fagagnini A, et al. How many atrial fibrillation ablation candidates have an underlying supraventricular tachycardia previously unknown? Efficacy of isolated triggering arrhythmia ablation. Europace. 2010;12:1707–12.
Katritsis DG, Giazitzoglou E, Wood MA, Shepard RK, Parvez B, Ellenbogen KA. Inducible supraventricular tachycardias in patients referred for catheter ablation of atrial fibrillation. Europace. 2007;9:785–9.
Delise P, Gianfranchi L, Paparella N, Brignole M, Menozzi C, Themistoclakis S, et al. Clinical usefulness of slow pathway ablation in patients with both paroxysmal atrioventricular nodal reentrant tachycardia and atrial fibrillation. Am J Cardiol. 1997;79:1421–3.
Torbey E, Karam B, Sleiman E, Tabet R, Kirk M, Donaldson D, et al. Incidence and risk factors for atrial fibrillation recurrence after ablation of nodal and atrioventricular reentrant tachycardia: a metaanalysis. Cureus. 2020;12: e7824.
Inada K, Yamane T, Tokutake K, Yokoyama K, Mishima T, Hioki M, et al. The role of successful catheter ablation in patients with paroxysmal atrial fibrillation and prolonged sinus pauses: outcome during a 5-year follow-up. Europace. 2014;16:208–13.
Chen YW, Bai R, Lin T, Salim M, Sang CH, Long DY, et al. Pacing or ablation: which is better for paroxysmal atrial fibrillation-related tachycardia-bradycardia syndrome? Pacing Clin Electrophysiol. 2014;37:403–11.
Scharf C, Veerareddy S, Ozaydin M, Chugh A, Hall B, Cheung P, et al. Clinical significance of inducible atrial flutter during pulmonary vein isolation in patients with atrial fibrillation. J Am Coll Cardiol. 2004;43:2057–62.
Wazni O, Marrouche NF, Martin DO, Gillinov AM, Saliba W, Saad E, et al. Randomized study comparing combined pulmonary vein-left atrial junction disconnection and cavotricuspid isthmus ablation versus pulmonary vein-left atrial junction disconnection alone in patients presenting with typical atrial flutter and atrial fibrillation. Circulation. 2003;108:2479–83.
Pérez FJ, Schubert CM, Parvez B, Pathak V, Ellenbogen KA, Wood MA. Long-term outcomes after catheter ablation of cavo-tricuspid isthmus dependent atrial flutter: a metaanalysis. Circ Arrhythm Electrophysiol. 2009;2:393–401.
Prasitlumkum N, Tokavanich N, Trongtorsak A, Cheungpasitporn W, Kewcharoen J, Chokesuwattanaskul R, et al. Catheter ablation for atrial fibrillation in the elderly >75 years old: systematic review and metaanalysis. J Cardiovasc Electrophysiol. 2022;33:1435–49.
Kawamura I, Aikawa T, Yokoyama Y, Takagi H, Kuno T. Catheter ablation for atrial fibrillation in elderly patients: systematic review and a metaanalysis. Pacing Clin Electrophysiol. 2022;45:59–71.
Nielsen J, Kragholm KH, Christensen SB, Johannessen A, Torp-Pedersen C, Kristiansen SB, et al. Periprocedural complications and one-year outcomes after catheter ablation for treatment of atrial fibrillation in elderly patients: a nationwide Danish cohort study. J Geriatr Cardiol. 2021;18:897–907.
Providencia R, Elliott P, Patel K, McCready J, Babu G, Srinivasan N, et al. Catheter ablation for atrial fibrillation in hypertrophic cardiomyopathy: a systematic review and metaanalysis. Heart. 2016;102:1533–43.
Zhao DS, Shen Y, Zhang Q, Lin G, Lu YH, Chen BT, et al. Outcomes of catheter ablation of atrial fibrillation in patients with hypertrophic cardiomyopathy: a systematic review and metaanalysis. Europace. 2016;18:508–20.
Dinshaw L, Münkler P, Schäffer B, Klatt N, Jungen C, Dickow J, et al. Ablation of atrial fibrillation in patients with hypertrophic cardiomyopathy: treatment strategy, characteristics of consecutive atrial tachycardia and long-term outcome. J Am Heart Assoc. 2021;10: e017451.
Creta A, Elliott P, Earley MJ, Dhinoja M, Finlay M, Sporton S, et al. Catheter ablation of atrial fibrillation in patients with hypertrophic cardiomyopathy: a European observational multicentre study. Europace. 2021;23:1409–17.
Santangeli P, Di Biase L, Themistoclakis S, Raviele A, Schweikert RA, Lakkireddy D, et al. Catheter ablation of atrial fibrillation in hypertrophic cardiomyopathy: long-term outcomes and mechanisms of arrhythmia recurrence. Circ Arrhythm Electrophysiol. 2013;6:1089–94.
Rozen G, Elbaz-Greener G, Marai I, Andria N, Hosseini SM, Biton Y, et al. Utilization and complications of catheter ablation for atrial fibrillation in patients with hypertrophic cardiomyopathy. J Am Heart Assoc. 2020;9: e015721.
Ezzeddine FM, Agboola KM, Hassett LC, Killu AM, Del-Carpio Munoz F, DeSimone CV, et al. Catheter ablation of atrial fibrillation in patients with and without hypertrophic cardiomyopathy: systematic review and metaanalysis. Europace. 2023;25.
Dorian P, Guerra PG, Kerr CR, O’Donnell SS, Crystal E, Gillis AM, et al. Validation of a new simple scale to measure symptoms in atrial fibrillation: the Canadian Cardiovascular Society Severity in Atrial Fibrillation scale. Circ Arrhythm Electrophysiol. 2009;2:218–24.
Kirchhof P, Auricchio A, Bax J, Crijns H, Camm J, Diener HC, et al. Outcome parameters for trials in atrial fibrillation: recommendations from a consensus conference organized by the German Atrial Fibrillation Competence NETwork and the European Heart Rhythm Association. Europace. 2007;9:1006–23.
Rienstra M, Lubitz SA, Mahida S, Magnani JW, Fontes JD, Sinner MF, et al. Symptoms and functional status of patients with atrial fibrillation: state of the art and future research opportunities. Circulation. 2012;125:2933–43.
Sugishita K, Shiono E, Sugiyama T, Ashida T. Diabetes influences the cardiac symptoms related to atrial fibrillation. Circ J. 2003;67:835–8.
Hermans ANL, Gawalko M, Slegers DPJ, Andelfinger N, Pluymaekers N, Verhaert DVM, et al. Mobile app-based symptom-rhythm correlation assessment in patients with persistent atrial fibrillation. Int J Cardiol. 2022;367:29–37.
Kirchhof P, Camm AJ, Goette A, Brandes A, Eckardt L, Elvan A, et al. Early rhythm-control therapy in patients with atrial fibrillation. N Engl J Med. 2020;383:1305–16.
Freemantle N, Lafuente-Lafuente C, Mitchell S, Eckert L, Reynolds M. Mixed treatment comparison of dronedarone, amiodarone, sotalol, flecainide, and propafenone, for the management of atrial fibrillation. Europace. 2011;13:329–45.
Valembois L, Audureau E, Takeda A, Jarzebowski W, Belmin J, Lafuente-Lafuente C. Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation. Cochrane Database Syst Rev. 2019;9:Cd005049.
Chew DS, Black-Maier E, Loring Z, Noseworthy PA, Packer DL, Exner DV, et al. Diagnosis-to-ablation time and recurrence of atrial fibrillation following catheter ablation: a systematic review and metaanalysis of observational studies. Circ Arrhythm Electrophysiol. 2020;13: e008128.
Kawaji T, Shizuta S, Yamagami S, Aizawa T, Komasa A, Yoshizawa T, et al. Early choice for catheter ablation reduced readmission in management of atrial fibrillation: impact of diagnosis-to-ablation time. Int J Cardiol. 2019;291:69–76.
Bisbal F, Alarcón F, Ferrero-De-Loma-Osorio A, González-Ferrer JJ, Alonso-Martín C, Pachón M, et al. Diagnosis-to-ablation time in atrial fibrillation: a modifiable factor relevant to clinical outcome. J Cardiovasc Electrophysiol. 2019;30:1483–90.
Kalman JM, Al-Kaisey AM, Parameswaran R, Hawson J, Anderson RD, Lim M, et al. Impact of early vs. delayed atrial fibrillation catheter ablation on atrial arrhythmia recurrences. Eur Heart J. 2023;44:2447–54.
Andrade JG, Wazni OM, Kuniss M, Hawkins NM, Deyell MW, Chierchia GB, et al. Cryoballoon ablation as initial treatment for atrial fibrillation: JACC state-of-the-art review. J Am Coll Cardiol. 2021;78:914–30.
Andrade JG, Champagne J, Dubuc M, Deyell MW, Verma A, Macle L, et al. Cryoballoon or radiofrequency ablation for atrial fibrillation assessed by continuous monitoring: a randomized clinical trial. Circulation. 2019;140:1779–88.
Kuck KH, Brugada J, Fürnkranz A, Metzner A, Ouyang F, Chun KR, et al. Cryoballoon or radiofrequency ablation for paroxysmal atrial fibrillation. N Engl J Med. 2016;374:2235–45.
Walters TE, Wick K, Tan G, Mearns M, Joseph SA, Morton JB, et al. Psychological distress and suicidal ideation in patients with atrial fibrillation: prevalence and response to management strategy. J Am Heart Assoc. 2018;7: e005502.
Al-Kaisey AM, Parameswaran R, Bryant C, Anderson RD, Hawson J, Chieng D, et al. Atrial fibrillation catheter ablation vs medical therapy and psychological distress: a randomized clinical trial. JAMA. 2023;330:925–33.
Providencia R, Defaye P, Lambiase PD, Pavin D, Cebron JP, Halimi F, et al. Results from a multicentre comparison of cryoballoon vs. radiofrequency ablation for paroxysmal atrial fibrillation: is cryoablation more reproducible? Europace. 2017;19:48–57.
Deshmukh A, Patel NJ, Pant S, Shah N, Chothani A, Mehta K, et al. In-hospital complications associated with catheter ablation of atrial fibrillation in the United States between 2000 and 2010: analysis of 93 801 procedures. Circulation. 2013;128:2104–12.
Calkins H, Hindricks G, Cappato R, Kim YH, Saad EB, Aguinaga L, et al. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation. Heart Rhythm. 2017;14:e275-444.
Monahan KH, Bunch TJ, Mark DB, Poole JE, Bahnson TD, Al-Khalidi HR, et al. Influence of atrial fibrillation type on outcomes of ablation vs. drug therapy: results from CABANA. Europace. 2022;24:1430–40.
Khan MN, Jaïs P, Cummings J, Di Biase L, Sanders P, Martin DO, et al. Pulmonary-vein isolation for atrial fibrillation in patients with heart failure. N Engl J Med. 2008;359:1778–85.
MacDonald MR, Connelly DT, Hawkins NM, Steedman T, Payne J, Shaw M, et al. Radiofrequency ablation for persistent atrial fibrillation in patients with advanced heart failure and severe left ventricular systolic dysfunction: a randomised controlled trial. Heart. 2011;97:740–7.
Jones DG, Haldar SK, Hussain W, Sharma R, Francis DP, Rahman-Haley SL, et al. A randomized trial to assess catheter ablation versus rate control in the management of persistent atrial fibrillation in heart failure. J Am Coll Cardiol. 2013;61:1894–903.
Kuck KH, Merkely B, Zahn R, Arentz T, Seidl K, Schlüter M, et al. Catheter ablation versus best medical therapy in patients with persistent atrial fibrillation and congestive heart failure: the randomized AMICA trial. Circ Arrhythm Electrophysiol. 2019;12: e007731.
Chen S, Pürerfellner H, Meyer C, Acou WJ, Schratter A, Ling Z, et al. Rhythm control for patients with atrial fibrillation complicated with heart failure in the contemporary era of catheter ablation: a stratified pooled analysis of randomized data. Eur Heart J. 2020;41:2863–73.
Marrouche NF, Brachmann J, Andresen D, Siebels J, Boersma L, Jordaens L, et al. Catheter ablation for atrial fibrillation with heart failure. N Engl J Med. 2018;378:417–27.
Bergonti M, Spera F, Tijskens M, Bonomi A, Saenen J, Huybrechts W, et al. A new prediction model for left ventricular systolic function recovery after catheter ablation of atrial fibrillation in patients with heart failure: the ANTWOORD Study. Int J Cardiol. 2022;358:45–50.
Bergonti M, Ascione C, Marcon L, Pambrun T, Della Rocca DG, Ferrero TG, et al. Left ventricular functional recovery after atrial fibrillation catheter ablation in heart failure: a prediction model. Eur Heart J. 2023;44:3327–5.
Kawaji T, Shizuta S, Aizawa T, Yamagami S, Kato M, Yokomatsu T, et al. Impact of catheter ablation for atrial fibrillation on cardiac disorders in patients with coexisting heart failure. ESC Heart Fail. 2021;8:670–9.
Okada M, Tanaka N, Oka T, Tanaka K, Ninomiya Y, Hirao Y, et al. Clinical significance of left ventricular reverse remodeling after catheter ablation of atrial fibrillation in patients with left ventricular systolic dysfunction. J Cardiol. 2021;77:500–8.
Kirstein B, Neudeck S, Gaspar T, Piorkowski J, Wechselberger S, Kronborg MB, et al. Left atrial fibrosis predicts left ventricular ejection fraction response after atrial fibrillation ablation in heart failure patients: the Fibrosis-HF study. Europace. 2020;22:1812–21.
Tsuji A, Masuda M, Asai M, Iida O, Okamoto S, Ishihara T, et al. Impact of the temporal relationship between atrial fibrillation and heart failure on prognosis after ablation. Circ J. 2020;84:1467–74.
Ishiguchi H, Yoshiga Y, Shimizu A, Ueyama T, Fukuda M, Kato T, et al. Long-term events following catheter-ablation for atrial fibrillation in heart failure with preserved ejection fraction. ESC Heart Fail. 2022;9:3505–18.
Smit MD, Moes ML, Maass AH, Achekar ID, Van Geel PP, Hillege HL, et al. The importance of whether atrial fibrillation or heart failure develops first. Eur J Heart Fail. 2012;14:1030–40.
von Olshausen G, Benson L, Dahlström U, Lund LH, Savarese G, Braunschweig F. Catheter ablation for patients with atrial fibrillation and heart failure: insights from the Swedish Heart Failure Registry. Eur J Heart Fail. 2022;24:1636–46.
Shiraishi Y, Kohsaka S, Ikemura N, Kimura T, Katsumata Y, Tanimoto K, et al. Catheter ablation for patients with atrial fibrillation and heart failure with reduced and preserved ejection fraction: insights from the KiCS-AF multicentre cohort study. Europace. 2023;25:83–91.
Gu G, Wu J, Gao X, Liu M, Jin C, Xu Y. Catheter ablation of atrial fibrillation in patients with heart failure and preserved ejection fraction: a metaanalysis. Clin Cardiol. 2022;45:786–93.
Yamauchi R, Morishima I, Okumura K, Kanzaki Y, Morita Y, Takagi K, et al. Catheter ablation for non-paroxysmal atrial fibrillation accompanied by heart failure with preserved ejection fraction: feasibility and benefits in functions and B-type natriuretic peptide. Europace. 2021;23:1252–61.
Rordorf R, Scazzuso F, Chun KRJ, Khelae SK, Kueffer FJ, Braegelmann KM, et al. Cryoballoon ablation for the treatment of atrial fibrillation in patients with concomitant heart failure and either reduced or preserved left ventricular ejection fraction: results from the Cryo AF Global Registry. J Am Heart Assoc. 2021;10: e021323.
Aldaas OM, Lupercio F, Darden D, Mylavarapu PS, Malladi CL, Han FT, et al. Metaanalysis of the usefulness of catheter ablation of atrial fibrillation in patients with heart failure with preserved ejection fraction. Am J Cardiol. 2021;142:66–73.
Black-Maier E, Ren X, Steinberg BA, Green CL, Barnett AS, Rosa NS, et al. Catheter ablation of atrial fibrillation in patients with heart failure and preserved ejection fraction. Heart Rhythm. 2018;15:651–7.
Chieng D, Sugumar H, Segan L, Tan C, Vizi D, Nanayakkara S, et al. Atrial fibrillation ablation for heart failure with preserved ejection fraction. JACC Heart Fail. 2023;11:646–58.
Ganapathy AV, Monjazeb S, Ganapathy KS, Shanoon F, Razavi M. “Asymptomatic” persistent or permanent atrial fibrillation: a misnomer in selected patients. Int J Cardiol. 2015;185:112–3.
Shin DI, Jaekel K, Schley P, Sause A, Müller M, Fueth R, et al. Plasma levels of NT-pro-BNP in patients with atrial fibrillation before and after electrical cardioversion. Z Kardiol. 2005;94:795–800.
Stojadinović P, Deshraju A, Wichterle D, Fukunaga M, Peichl P, Kautzner J, et al. The hemodynamic effect of simulated atrial fibrillation on left ventricular function. J Cardiovasc Electrophysiol. 2022;33:2569–77.
Clark DM, Plumb VJ, Epstein AE, Kay GN. Hemodynamic effects of an irregular sequence of ventricular cycle lengths during atrial fibrillation. J Am Coll Cardiol. 1997;30:1039–45.
Ganesan AN, Chew DP, Hartshorne T, Selvanayagam JB, Aylward PE, Sanders P, et al. The impact of atrial fibrillation type on the risk of thromboembolism, mortality, and bleeding: a systematic review and metaanalysis. Eur Heart J. 2016;37:1591–602.
Link MS, Giugliano RP, Ruff CT, Scirica BM, Huikuri H, Oto A, et al. Stroke and mortality risk in patients with various patterns of atrial fibrillation: results from the ENGAGE AF-TIMI 48 trial (effective anticoagulation with factor Xa next generation in atrial fibrillation-thrombolysis in myocardial infarction 48). Circ Arrhythm Electrophysiol. 2017;10: e004267.
Kuck KH, Lebedev DS, Mikhaylov EN, Romanov A, Gellér L, Kalējs O, et al. Catheter ablation or medical therapy to delay progression of atrial fibrillation: the randomized controlled atrial fibrillation progression trial (ATTEST). Europace. 2021;23:362–9.
Mark DB, Anstrom KJ, Sheng S, Piccini JP, Baloch KN, Monahan KH, et al. Effect of catheter ablation vs medical therapy on quality of life among patients with atrial fibrillation: the CABANA randomized clinical trial. JAMA. 2019;321:1275–85.
Bahnson TD, Giczewska A, Mark DB, Russo AM, Monahan KH, Al-Khalidi HR, et al. Association between age and outcomes of catheter ablation versus medical therapy for atrial fibrillation: results from the CABANA trial. Circulation. 2022;145:796–804.
Willems S, Borof K, Brandes A, Breithardt G, Camm AJ, Crijns H, et al. Systematic, early rhythm control strategy for atrial fibrillation in patients with or without symptoms: the EAST-AFNET 4 trial. Eur Heart J. 2022;43:1219–30.
Sauer WH, Alonso C, Zado E, Cooper JM, Lin D, Dixit S, et al. Atrioventricular nodal reentrant tachycardia in patients referred for atrial fibrillation ablation: response to ablation that incorporates slow-pathway modification. Circulation. 2006;114:191–5.
Hamer ME, Wilkinson WE, Clair WK, Page RL, McCarthy EA, Pritchett EL. Incidence of symptomatic atrial fibrillation in patients with paroxysmal supraventricular tachycardia. J Am Coll Cardiol. 1995;25:984–8.
Dagres N, Clague JR, Lottkamp H, Hindricks G, Breithardt G, Borggrefe M. Impact of radiofrequency catheter ablation of accessory pathways on the frequency of atrial fibrillation during long-term follow-up; high recurrence rate of atrial fibrillation in patients older than 50 years of age. Eur Heart J. 2001;22:423–7.
Hocini M, Sanders P, Deisenhofer I, Jaïs P, Hsu LF, Scavée C, et al. Reverse remodeling of sinus node function after catheter ablation of atrial fibrillation in patients with prolonged sinus pauses. Circulation. 2003;108:1172–5.
Akoum N, McGann C, Vergara G, Badger T, Ranjan R, Mahnkopf C, et al. Atrial fibrosis quantified using late gadolinium enhancement MRI is associated with sinus node dysfunction requiring pacemaker implant. J Cardiovasc Electrophysiol. 2012;23:44–50.
Calkins H. Should catheter ablation be the preferred approach for treatment of atrial fibrillation related symptomatic sinus node dysfunction? Pacing Clin Electrophysiol. 2014;37:401–2.
Merino JL. Slow conduction and flutter following atrial fibrillation ablation: proarrhythmia or unmasking effect of radiofrequency application? J Cardiovasc Electrophysiol. 2006;17:516–9.
Hwang TH, Yu HT, Kim TH, Uhm JS, Kim JY, Joung B, et al. Permanent pacemaker implantations after catheter ablation in patients with atrial fibrillation associated with underlying sinus node dysfunction. Korean Circ J. 2020;50:346–57.
Waldo AL, Feld GK. Inter-relationships of atrial fibrillation and atrial flutter mechanisms and clinical implications. J Am Coll Cardiol. 2008;51:779–86.
Gupta D, Ding WY, Calvert P, Williams E, Das M, Tovmassian L, et al. Cryoballoon pulmonary vein isolation as first-line treatment for typical atrial flutter. Heart. 2023;109:364–71.
Chugh A, Oral H, Lemola K, Hall B, Cheung P, Good E, et al. Prevalence, mechanisms, and clinical significance of macroreentrant atrial tachycardia during and following left atrial ablation for atrial fibrillation. Heart Rhythm. 2005;2:464–71.
Chen J, Hocini M, Larsen TB, Proclemer A, Sciaraffia E, Blomström-Lundqvist C. Clinical management of arrhythmias in elderly patients: results of the European Heart Rhythm Association survey. Europace. 2015;17:314–7.
Ikenouchi T, Nitta J, Nitta G, Kato S, Iwasaki T, Murata K, et al. Propensity-matched comparison of cryoballoon and radiofrequency ablation for atrial fibrillation in elderly patients. Heart Rhythm. 2019;16:838–45.
Guttmann OP, Rahman MS, O’Mahony C, Anastasakis A, Elliott PM. Atrial fibrillation and thromboembolism in patients with hypertrophic cardiomyopathy: systematic review. Heart. 2014;100:465–72.
Rowin EJ, Orfanos A, Estes NAM, Wang W, Link MS, Maron MS, et al. Occurrence and natural history of clinically silent episodes of atrial fibrillation in hypertrophic cardiomyopathy. Am J Cardiol. 2017;119:1862–5.
Rowin EJ, Hausvater A, Link MS, Abt P, Gionfriddo W, Wang W, et al. Clinical profile and consequences of atrial fibrillation in hypertrophic cardiomyopathy. Circulation. 2017;136:2420–36.
Asad Z, Abbas M, Javed I, Korantzopoulos P, Stavrakis S. Obesity is associated with incident atrial fibrillation independent of gender: a metaanalysis. J Cardiovasc Electrophysiol. 2018;29:725–32.
Sivasambu B, Balouch MA, Zghaib T, Bajwa RJ, Chrispin J, Berger RD, et al. Increased rates of atrial fibrillation recurrence following pulmonary vein isolation in overweight and obese patients. J Cardiovasc Electrophysiol. 2018;29:239–45.
Glover BM, Hong KL, Dagres N, Arbelo E, Laroche C, Riahi S, et al. Impact of body mass index on the outcome of catheter ablation of atrial fibrillation. Heart. 2019;105:244–50.
Shoemaker MB, Muhammad R, Farrell M, Parvez B, White BW, Streur M, et al. Relation of morbid obesity and female gender to risk of procedural complications in patients undergoing atrial fibrillation ablation. Am J Cardiol. 2013;111:368–73.
Pathak RK, Middeldorp ME, Lau DH, Mehta AB, Mahajan R, Twomey D, et al. Aggressive risk factor reduction study for atrial fibrillation and implications for the outcome of ablation: the ARREST-AF cohort study. J Am Coll Cardiol. 2014;64:2222–31.
Pathak RK, Middeldorp ME, Meredith M, Mehta AB, Mahajan R, Wong CX, et al. Long-term effect of goal-directed weight management in an atrial fibrillation cohort: a long-term follow-up study (LEGACY). J Am Coll Cardiol. 2015;65:2159–69.
Zhang D, Ma Y, Xu J, Yi F. Association between obstructive sleep apnea (OSA) and atrial fibrillation (AF): a dose-response metaanalysis. Medicine. 2022;101: e29443.
Szymanski FM, Filipiak KJ, Platek AE, Hrynkiewicz-Szymanska A, Kotkowski M, Kozluk E, et al. Presence and severity of obstructive sleep apnea and remote outcomes of atrial fibrillation ablations—a long-term prospective, cross-sectional cohort study. Sleep Breath. 2015;19:849–56.
Li L, Wang ZW, Li J, Ge X, Guo LZ, Wang Y, et al. Efficacy of catheter ablation of atrial fibrillation in patients with obstructive sleep apnoea with and without continuous positive airway pressure treatment: a metaanalysis of observational studies. Europace. 2014;16:1309–14.
Kawakami H, Nagai T, Fujii A, Uetani T, Nishimura K, Inoue K, et al. Apnea-hypopnea index as a predictor of atrial fibrillation recurrence following initial pulmonary vein isolation: usefulness of type-3 portable monitor for sleep-disordered breathing. J Interv Card Electrophysiol. 2016;47:237–44.
Ng CY, Liu T, Shehata M, Stevens S, Chugh SS, Wang X. Metaanalysis of obstructive sleep apnea as predictor of atrial fibrillation recurrence after catheter ablation. Am J Cardiol. 2011;108:47–51.
Naruse Y, Tada H, Satoh M, Yanagihara M, Tsuneoka H, Hirata Y, et al. Concomitant obstructive sleep apnea increases the recurrence of atrial fibrillation following radiofrequency catheter ablation of atrial fibrillation: clinical impact of continuous positive airway pressure therapy. Heart Rhythm. 2013;10:331–7.
Li X, Zhou X, Xu X, Dai J, Chen C, Ma L, et al. Effects of continuous positive airway pressure treatment in obstructive sleep apnea patients with atrial fibrillation: a metaanalysis. Medicine. 2021;100: e25438.
Nalliah CJ, Wong GR, Lee G, Voskoboinik A, Kee K, Goldin J, et al. Impact of CPAP on the atrial fibrillation substrate in obstructive sleep apnea: the SLEEP-AF study. JACC Clin Electrophysiol. 2022;8:869–77.
Hunt TE, Traaen GM, Aakerøy L, Bendz C, Øverland B, Akre H, et al. Effect of continuous positive airway pressure therapy on recurrence of atrial fibrillation after pulmonary vein isolation in patients with obstructive sleep apnea: a randomized controlled trial. Heart Rhythm. 2022;19:1433–41.
Donnellan E, Aagaard P, Kanj M, Jaber W, Elshazly M, Hoosien M, et al. Association between preablation glycemic control and outcomes among patients with diabetes undergoing atrial fibrillation ablation. JACC Clin Electrophysiol. 2019;5:897–903.
Takahashi Y, Nitta J, Kobori A, Sakamoto Y, Nagata Y, Tanimoto K, et al. Alcohol consumption reduction and clinical outcomes of catheter ablation for atrial fibrillation. Circ Arrhythm Electrophysiol. 2021;14: e009770.
Cheng WH, Lo LW, Lin YJ, Chang SL, Hu YF, Hung Y, et al. Cigarette smoking causes a worse long-term outcome in persistent atrial fibrillation following catheter ablation. J Cardiovasc Electrophysiol. 2018;29:699–706.
Bertaglia E, Anselmino M, Zorzi A, Russo V, Toso E, Peruzza F, et al. NOACs and atrial fibrillation: incidence and predictors of left atrial thrombus in the real world. Int J Cardiol. 2017;249:179–83.
Lurie A, Wang J, Hinnegan KJ, McIntyre WF, Belley-Côté EP, Amit G, et al. Prevalence of left atrial thrombus in anticoagulated patients with atrial fibrillation. J Am Coll Cardiol. 2021;77:2875–86.
Lip GY, Frison L, Grind M. Stroke event rates in anticoagulated patients with paroxysmal atrial fibrillation. J Intern Med. 2008;264:50–61.
Al-Khatib SM, Thomas L, Wallentin L, Lopes RD, Gersh B, Garcia D, et al. Outcomes of apixaban vs. warfarin by type and duration of atrial fibrillation: results from the ARISTOTLE trial. Eur Heart J. 2013;34:2464–71.
Steinberg BA, Hellkamp AS, Lokhnygina Y, Patel MR, Breithardt G, Hankey GJ, et al. Higher risk of death and stroke in patients with persistent vs. paroxysmal atrial fibrillation: results from the ROCKET-AF Trial. Eur Heart J. 2015;36:288–96.
Jung H, Sung JH, Yang PS, Jang E, Yu HT, Kim TH, et al. Stroke risk stratification for atrial fibrillation patients with hypertrophic cardiomyopathy. J Am Coll Cardiol. 2018;72:2409–11.
Manjunath CN, Srinivasa KH, Panneerselvam A, Prabhavathi B, Ravindranath KS, Rangan K, et al. Incidence and predictors of left atrial thrombus in patients with rheumatic mitral stenosis and sinus rhythm: a transesophageal echocardiographic study. Echocardiography. 2011;28:457–60.
Saidi SJ, Motamedi MH. Incidence and factors influencing left atrial clot in patients with mitral stenosis and normal sinus rhythm. Heart. 2004;90:1342–3.
Ahmed K, Rehman Memon A, Liaquat H Sr, Mujtaba M, Parkash C, Sultan FAT, et al. The frequency of left atrial thrombus on transthoracic echocardiogram in patients with mitral stenosis. Cureus. 2020;12: e7453.
Feng D, Edwards WD, Oh JK, Chandrasekaran K, Grogan M, Martinez MW, et al. Intracardiac thrombosis and embolism in patients with cardiac amyloidosis. Circulation. 2007;116:2420–6.
Feng D, Syed IS, Martinez M, Oh JK, Jaffe AS, Grogan M, et al. Intracardiac thrombosis and anticoagulation therapy in cardiac amyloidosis. Circulation. 2009;119:2490–7.
El-Am EA, Dispenzieri A, Melduni RM, Ammash NM, White RD, Hodge DO, et al. Direct current cardioversion of atrial arrhythmias in adults with cardiac amyloidosis. J Am Coll Cardiol. 2019;73:589–97.
Touboul O, Algalarrondo V, Oghina S, Elbaz N, Rouffiac S, Hamon D, et al. Electrical cardioversion of atrial arrhythmias with cardiac amyloidosis in the era of direct oral anticogulants. ESC Heart Fail. 2022;9:3556–64.
Burczak DR, Julakanti RR, Kara Balla A, Scott CG, Geske JB, Ommen SR, et al. Risk of left atrial thrombus in patients with hypertrophic cardiomyopathy and atrial fibrillation. J Am Coll Cardiol. 2023;82:278–9.
Di Biase L, Burkhardt JD, Mohanty P, Sanchez J, Horton R, Gallinghouse GJ, et al. Periprocedural stroke and management of major bleeding complications in patients undergoing catheter ablation of atrial fibrillation: the impact of periprocedural therapeutic international normalized ratio. Circulation. 2010;121:2550–6.
Santangeli P, Di Biase L, Horton R, Burkhardt JD, Sanchez J, Al-Ahmad A, et al. Ablation of atrial fibrillation under therapeutic warfarin reduces periprocedural complications: evidence from a metaanalysis. Circ Arrhythm Electrophysiol. 2012;5:302–11.
Wazni OM, Beheiry S, Fahmy T, Barrett C, Hao S, Patel D, et al. Atrial fibrillation ablation in patients with therapeutic international normalized ratio: comparison of strategies of anticoagulation management in the periprocedural period. Circulation. 2007;116:2531–4.
Di Biase L, Burkhardt JD, Santangeli P, Mohanty P, Sanchez JE, Horton R, et al. Periprocedural stroke and bleeding complications in patients undergoing catheter ablation of atrial fibrillation with different anticoagulation management: results from the role of coumadin in preventing thromboembolism in atrial fibrillation (AF) patients undergoing catheter ablation (COMPARE) randomized trial. Circulation. 2014;129:2638–44.
Cappato R, Marchlinski FE, Hohnloser SH, Naccarelli GV, Xiang J, Wilber DJ, et al. Uninterrupted rivaroxaban vs. uninterrupted vitamin K antagonists for catheter ablation in non-valvular atrial fibrillation. Eur Heart J. 2015;36:1805–11.
Calkins H, Willems S, Gerstenfeld EP, Verma A, Schilling R, Hohnloser SH, et al. Uninterrupted dabigatran versus warfarin for ablation in atrial fibrillation. N Engl J Med. 2017;376:1627–36.
Kirchhof P, Haeusler KG, Blank B, De Bono J, Callans D, Elvan A, et al. Apixaban in patients at risk of stroke undergoing atrial fibrillation ablation. Eur Heart J. 2018;39:2942–55.
Hohnloser SH, Camm J, Cappato R, Diener HC, Heidbüchel H, Mont L, et al. Uninterrupted edoxaban vs. vitamin K antagonists for ablation of atrial fibrillation: the ELIMINATE-AF trial. Eur Heart J. 2019;40:3013–21.
Cardoso R, Knijnik L, Bhonsale A, Miller J, Nasi G, Rivera M, et al. An updated metaanalysis of novel oral anticoagulants versus vitamin K antagonists for uninterrupted anticoagulation in atrial fibrillation catheter ablation. Heart Rhythm. 2018;15:107–15.
Romero J, Cerrud-Rodriguez RC, Alviz I, Diaz JC, Rodriguez D, Arshad S, et al. Significant benefit of uninterrupted DOACs versus VKA during catheter ablation of atrial fibrillation. JACC Clin Electrophysiol. 2019;5:1396–405.
Di Biase L, Callans D, Haeusler KG, Hindricks G, Al-Khalidi H, Mont L, et al. Rationale and design of AXAFA-AFNET 5: an investigator-initiated, randomized, open, blinded outcome assessment, multi-centre trial to comparing continuous apixaban to vitamin K antagonists in patients undergoing atrial fibrillation catheter ablation. Europace. 2017;19:132–8.
Romero J, Cerrud-Rodriguez RC, Diaz JC, Michaud GF, Taveras J, Alviz I, et al. Uninterrupted direct oral anticoagulants vs. uninterrupted vitamin K antagonists during catheter ablation of non-valvular atrial fibrillation: a systematic review and metaanalysis of randomized controlled trials. Europace. 2018;20:1612–20.
Di Biase L, Lakkireddy D, Trivedi C, Deneke T, Martinek M, Mohanty S, et al. Feasibility and safety of uninterrupted periprocedural apixaban administration in patients undergoing radiofrequency catheter ablation for atrial fibrillation: results from a multicenter study. Heart Rhythm. 2015;12:1162–8.
Yu HT, Shim J, Park J, Kim TH, Uhm JS, Kim JY, et al. When is it appropriate to stop non-vitamin K antagonist oral anticoagulants before catheter ablation of atrial fibrillation? A multicentre prospective randomized study. Eur Heart J. 2019;40:1531–7.
Reynolds MR, Allison JS, Natale A, Weisberg IL, Ellenbogen KA, Richards M, et al. A Prospective randomized trial of apixaban dosing during atrial fibrillation ablation: the AEIOU trial. JACC Clin Electrophysiol. 2018;4:580–8.
Nakamura K, Naito S, Sasaki T, Take Y, Minami K, Kitagawa Y, et al. Uninterrupted vs. interrupted periprocedural direct oral anticoagulants for catheter ablation of atrial fibrillation: a prospective randomized single-centre study on postablation thromboembolic and haemorrhagic events. Europace. 2019;21:259–67.
Ando M, Inden Y, Yoshida Y, Sairaku A, Yanagisawa S, Suzuki H, et al. Differences in prothrombotic response between the uninterrupted and interrupted apixaban therapies in patients undergoing cryoballoon ablation for paroxysmal atrial fibrillation: a randomized controlled study. Heart Vessels. 2019;34:1533–41.
Nagao T, Suzuki H, Matsunaga S, Nishikawa Y, Harada K, Mamiya K, et al. Impact of periprocedural anticoagulation therapy on the incidence of silent stroke after atrial fibrillation ablation in patients receiving direct oral anticoagulants: uninterrupted vs. interrupted by one dose strategy. Europace. 2019;21:590–7.
Patel K, Natale A, Yang R, Trivedi C, Romero J, Briceno D, et al. Is transesophageal echocardiography necessary in patients undergoing ablation of atrial fibrillation on an uninterrupted direct oral anticoagulant regimen? Results from a prospective multicenter registry. Heart Rhythm. 2020;17:2093–9.
Wang Y, Zhao Y, Zhou K, Zei PC, Wang Y, Cheng H, et al. Intracardiac echocardiography is a safe and effective alternative to transesophageal echocardiography for left atrial appendage thrombus evaluation at the time of atrial fibrillation ablation: the ICE-TEE study. Pacing Clin Electrophysiol. 2023;46:3–10.
Morton JB, Sanders P, Sparks PB, Morgan J, Kalman JM. Usefulness of phased-array intracardiac echocardiography for the assessment of left atrial mechanical “stunning” in atrial flutter and comparison with multiplane transesophageal echocardiography(*). Am J Cardiol. 2002;90:741–6.
Baran J, Stec S, Pilichowska-Paszkiet E, Zaborska B, Sikora-Frąc M, Kryński T, et al. Intracardiac echocardiography for detection of thrombus in the left atrial appendage: comparison with transesophageal echocardiography in patients undergoing ablation for atrial fibrillation: the Action-Ice I study. Circ Arrhythm Electrophysiol. 2013;6:1074–81.
Tsyganov A, Shapieva A, Sandrikov V, Fedulova S, Mironovich S, Dzeranova A, et al. Transesophageal vs. intracardiac echocardiographic screening in patients undergoing atrial fibrillation ablation with uninterrupted rivaroxaban. BMC Cardiovasc Disord. 2017;17:171.
Saksena S, Sra J, Jordaens L, Kusumoto F, Knight B, Natale A, et al. A prospective comparison of cardiac imaging using intracardiac echocardiography with transesophageal echocardiography in patients with atrial fibrillation: the intracardiac echocardiography guided cardioversion helps interventional procedures study. Circ Arrhythm Electrophysiol. 2010;3:571–7.
Sriram CS, Banchs JE, Moukabary T, Moradkhan R, Gonzalez MD. Detection of left atrial thrombus by intracardiac echocardiography in patients undergoing ablation of atrial fibrillation. J Interv Card Electrophysiol. 2015;43:227–36.
Yu S, Zhang H, Li H. Cardiac computed tomography versus transesophageal echocardiography for the detection of left atrial appendage thrombus: a systemic review and metaanalysis. J Am Heart Assoc. 2021;10: e022505.
Vira T, Pechlivanoglou P, Connelly K, Wijeysundera HC, Roifman I. Cardiac computed tomography and magnetic resonance imaging vs. transoesophageal echocardiography for diagnosing left atrial appendage thrombi. Europace. 2019;21:e1-10.
Spagnolo P, Giglio M, Di Marco D, Cannaò PM, Agricola E, Della Bella PE, et al. Diagnosis of left atrial appendage thrombus in patients with atrial fibrillation: delayed contrast-enhanced cardiac CT. Eur Radiol. 2021;31:1236–44.
Berruezo A, Tamborero D, Mont L, Benito B, Tolosana JM, Sitges M, et al. Preprocedural predictors of atrial fibrillation recurrence after circumferential pulmonary vein ablation. Eur Heart J. 2007;28:836–41.
Wokhlu A, Hodge DO, Monahan KH, Asirvatham SJ, Friedman PA, Munger TM, et al. Long-term outcome of atrial fibrillation ablation: impact and predictors of very late recurrence. J Cardiovasc Electrophysiol. 2010;21:1071–8.
Arya A, Hindricks G, Sommer P, Huo Y, Bollmann A, Gaspar T, et al. Long-term results and the predictors of outcome of catheter ablation of atrial fibrillation using steerable sheath catheter navigation after single procedure in 674 patients. Europace. 2010;12:173–80.
Santoro F, Di Biase L, Trivedi C, Burkhardt JD, Paoletti Perini A, Sanchez J, et al. Impact of uncontrolled hypertension on atrial fibrillation ablation outcome. JACC Clin Electrophysiol. 2015;1:164–73.
Anselmino M, Matta M, D’Ascenzo F, Pappone C, Santinelli V, Bunch TJ, et al. Catheter ablation of atrial fibrillation in patients with diabetes mellitus: a systematic review and metaanalysis. Europace. 2015;17:1518–25.
Bogossian H, Frommeyer G, Brachmann J, Lewalter T, Hoffmann E, Kuck KH, et al. Catheter ablation of atrial fibrillation and atrial flutter in patients with diabetes mellitus: who benefits and who does not? Data from the German ablation registry. Int J Cardiol. 2016;214:25–30.
Creta A, Providencia R, Adragao P, de Asmundis C, Chun J, Chierchia G, et al. Impact of type-2 diabetes mellitus on the outcomes of catheter ablation of atrial fibrillation (European observational multicentre study). Am J Cardiol. 2020;125:901–6.
Wang A, Truong T, Black-Maier E, Green C, Campbell KB, Barnett AS, et al. Catheter ablation of atrial fibrillation in patients with diabetes mellitus. Heart Rhythm. 2020;O2(1):180–8.
Deshmukh A, Ghannam M, Liang J, Saeed M, Cunnane R, Ghanbari H, et al. Effect of metformin on outcomes of catheter ablation for atrial fibrillation. J Cardiovasc Electrophysiol. 2021;32:1232–9.
De Maat GE, Mulder BA, Berretty WL, Al-Jazairi MIH, Tan ES, Wiesfeld ACP, et al. Obesity is associated with impaired long-term success of pulmonary vein isolation: a plea for risk factor management before ablation. Open Heart. 2018;5: e000771.
Winkle RA, Mead RH, Engel G, Kong MH, Fleming W, Salcedo J, et al. Impact of obesity on atrial fibrillation ablation: patient characteristics, long-term outcomes, and complications. Heart Rhythm. 2017;14:819–27.
Chang SL, Tuan TC, Tai CT, Lin YJ, Lo LW, Hu YF, et al. Comparison of outcome in catheter ablation of atrial fibrillation in patients with versus without the metabolic syndrome. Am J Cardiol. 2009;103:67–72.
Tang RB, Dong JZ, Liu XP, Long DY, Yu RH, Kalifa J, et al. Metabolic syndrome and risk of recurrence of atrial fibrillation after catheter ablation. Circ J. 2009;73:438–43.
Mohanty S, Mohanty P, Di Biase L, Bai R, Pump A, Santangeli P, et al. Impact of metabolic syndrome on procedural outcomes in patients with atrial fibrillation undergoing catheter ablation. J Am Coll Cardiol. 2012;59:1295–301.
Donnellan E, Wazni OM, Harb S, Kanj M, Saliba WI, Jaber WA. Higher baseline cardiorespiratory fitness is associated with lower arrhythmia recurrence and death after atrial fibrillation ablation. Heart Rhythm. 2020;17:1687–93.
Mandsager KT, Phelan DM, Diab M, Baranowski B, Saliba WI, Tarakji KG, et al. Outcomes of pulmonary vein isolation in athletes. JACC Clin Electrophysiol. 2020;6:1265–74.
Liu MB, Lee JZ, Klooster L, Petty SA, Scott LR. Influence of endurance sports on atrial fibrillation ablation outcomes. J Arrhythm. 2022;38:1–16.
Koopman P, Nuyens D, Garweg C, La Gerche A, De Buck S, Van Casteren L, et al. Efficacy of radiofrequency catheter ablation in athletes with atrial fibrillation. Europace. 2011;13:1386–93.
Kato M, Ogano M, Mori Y, Kochi K, Morimoto D, Kito K, et al. Exercise-based cardiac rehabilitation for patients with catheter ablation for persistent atrial fibrillation: a randomized controlled clinical trial. Eur J Prev Cardiol. 2019;26:1931–40.
Congrete S, Bintvihok M, Thongprayoon C, Bathini T, Boonpheng B, Sharma K, et al. Effect of obstructive sleep apnea and its treatment of atrial fibrillation recurrence after radiofrequency catheter ablation: a metaanalysis. J Evid Based Med. 2018;11:145–51.
Matiello M, Nadal M, Tamborero D, Berruezo A, Montserrat J, Embid C, et al. Low efficacy of atrial fibrillation ablation in severe obstructive sleep apnoea patients. Europace. 2010;12:1084–9.
Takigawa M, Takahashi A, Kuwahara T, Takahashi Y, Okubo K, Nakashima E, et al. Impact of alcohol consumption on the outcome of catheter ablation in patients with paroxysmal atrial fibrillation. J Am Heart Assoc. 2016;5: e004149.
Qiao Y, Shi R, Hou B, Wu L, Zheng L, Ding L, et al. Impact of alcohol consumption on substrate remodeling and ablation outcome of paroxysmal atrial fibrillation. J Am Heart Assoc. 2015;4: e002349.
Fukamizu S, Sakurada H, Takano M, Hojo R, Nakai M, Yuba T, et al. Effect of cigarette smoking on the risk of atrial fibrillation recurrence after pulmonary vein isolation. J Arrhythm. 2010;26:21–9.
Elliott AD, Middeldorp ME, Van Gelder IC, Albert CM, Sanders P. Author correction: epidemiology and modifiable risk factors for atrial fibrillation. Nat Rev Cardiol. 2023;20:429.
Benjamin EJ, Levy D, Vaziri SM, D’Agostino RB, Belanger AJ, Wolf PA. Independent risk factors for atrial fibrillation in a population-based cohort. The Framingham Heart Study JAMA. 1994;271:840–4.
Kim D, Yang PS, Kim TH, Jang E, Shin H, Kim HY, et al. Ideal blood pressure in patients with atrial fibrillation. J Am Coll Cardiol. 2018;72:1233–45.
Okin PM, Hille DA, Larstorp AC, Wachtell K, Kjeldsen SE, Dahlof B, et al. Effect of lower on-treatment systolic blood pressure on the risk of atrial fibrillation in hypertensive patients. Hypertension. 2015;66:368–73.
Verdecchia P, Angeli F, Reboldi G. Hypertension and atrial fibrillation: doubts and certainties from basic and clinical studies. Circ Res. 2018;122:352–68.
Zylla MM, Hochadel M, Andresen D, Brachmann J, Eckardt L, Hoffmann E, et al. Ablation of atrial fibrillation in patients with hypertension-an analysis from the German Ablation Registry. J Clin Med. 2020;9:2402.
Parkash R, Wells GA, Sapp JL, Healey JS, Tardif JC, Greiss I, et al. Effect of aggressive blood pressure control on the recurrence of atrial fibrillation after catheter ablation: a randomized, open-label clinical trial (SMAC-AF [substrate modification with aggressive blood pressure control]). Circulation. 2017;135:1788–98.
Pokushalov E, Romanov A, Corbucci G, Artyomenko S, Baranova V, Turov A, et al. A randomized comparison of pulmonary vein isolation with versus without concomitant renal artery denervation in patients with refractory symptomatic atrial fibrillation and resistant hypertension. J Am Coll Cardiol. 2012;60:1163–70.
Steinberg JS, Shabanov V, Ponomarev D, Losik D, Ivanickiy E, Kropotkin E, et al. Effect of renal denervation and catheter ablation vs catheter ablation alone on atrial fibrillation recurrence among patients with paroxysmal atrial fibrillation and hypertension: the ERADICATE-AF randomized clinical trial. JAMA. 2020;323:248–55.
Hohl M, Selejan SR, Wintrich J, Lehnert U, Speer T, Schneider C, et al. Renal denervation prevents atrial arrhythmogenic substrate development in CKD. Circ Res. 2022;130:814–28.
Al-Kaisey AM, Kalman JM. Obesity and atrial fibrillation: epidemiology, pathogenesis and effect of weight loss. Arrhythm Electrophysiol Rev. 2021;10:159–64.
Wong CX, Sullivan T, Sun MT, Mahajan R, Pathak RK, Middeldorp M, et al. Obesity and the risk of incident, postoperative, and postablation atrial fibrillation: a metaanalysis of 626,603 individuals in 51 studies. JACC Clin Electrophysiol. 2015;1:139–52.
Abed HS, Samuel CS, Lau DH, Kelly DJ, Royce SG, Alasady M, et al. Obesity results in progressive atrial structural and electrical remodeling: implications for atrial fibrillation. Heart Rhythm. 2013;10:90–100.
Munger TM, Dong YX, Masaki M, Oh JK, Mankad SV, Borlaug BA, et al. Electrophysiological and hemodynamic characteristics associated with obesity in patients with atrial fibrillation. J Am Coll Cardiol. 2012;60:851–60.
Wong CX, Abed HS, Molaee P, Nelson AJ, Brooks AG, Sharma G, et al. Pericardial fat is associated with atrial fibrillation severity and ablation outcome. J Am Coll Cardiol. 2011;57:1745–51.
Hatem SN, Sanders P. Epicardial adipose tissue and atrial fibrillation. Cardiovasc Res. 2014;102:205–13.
Mohanty S, Mohanty P, Natale V, Trivedi C, Gianni C, Burkhardt JD, et al. Impact of weight loss on ablation outcome in obese patients with longstanding persistent atrial fibrillation. J Cardiovasc Electrophysiol. 2018;29:246–53.
Gessler N, Willems S, Steven D, Aberle J, Akbulak RO, Gosau N, et al. Supervised obesity reduction trial for AF ablation patients: results from the SORT-AF trial. Europace. 2021;23:1548–58.
Donnellan E, Wazni OM, Kanj M, Baranowski B, Cremer P, Harb S, et al. Association between preablation bariatric surgery and atrial fibrillation recurrence in morbidly obese patients undergoing atrial fibrillation ablation. Europace. 2019;21:1476–83.
Youssef I, Kamran H, Yacoub M, Patel N, Goulbourne C, Kumar S, et al. Obstructive sleep apnea as a risk factor for atrial fibrillation: a metaanalysis. J Sleep Disord Ther. 2018;7:282.
Linz D, Schotten U, Neuberger HR, Bohm M, Wirth K. Negative tracheal pressure during obstructive respiratory events promotes atrial fibrillation by vagal activation. Heart Rhythm. 2011;8:1436–43.
Holtstrand Hjalm H, Fu M, Hansson PO, Zhong Y, Caidahl K, Mandalenakis Z, et al. Association between left atrial enlargement and obstructive sleep apnea in a general population of 71-year-old men. J Sleep Res. 2018;27:252–8.
Iwasaki YK, Kato T, Xiong F, Shi YF, Naud P, Maguy A, et al. Atrial fibrillation promotion with long-term repetitive obstructive sleep apnea in a rat model. J Am Coll Cardiol. 2014;64:2013–23.
Qureshi WT, Nasir UB, Alqalyoobi S, O’Neal WT, Mawri S, Sabbagh S, et al. Metaanalysis of continuous positive airway pressure as a therapy of atrial fibrillation in obstructive sleep apnea. Am J Cardiol. 2015;116:1767–73.
Linz D, McEvoy RD, Cowie MR, Somers VK, Nattel S, Lévy P, et al. Associations of obstructive sleep apnea with atrial fibrillation and continuous positive airway pressure treatment: a review. JAMA Cardiol. 2018;3:532–40.
Gallagher C, Hendriks JML, Elliott AD, Wong CX, Rangnekar G, Middeldorp ME, et al. Alcohol and incident atrial fibrillation—a systematic review and metaanalysis. Int J Cardiol. 2017;246:46–52.
Voskoboinik A, Wong G, Lee G, Nalliah C, Hawson J, Prabhu S, et al. Moderate alcohol consumption is associated with atrial electrical and structural changes: insights from high-density left atrial electroanatomic mapping. Heart Rhythm. 2019;16:251–9.
Mandyam MC, Vedantham V, Scheinman MM, Tseng ZH, Badhwar N, Lee BK, et al. Alcohol and vagal tone as triggers for paroxysmal atrial fibrillation. Am J Cardiol. 2012;110:364–8.
Khawaja O, Bartz TM, Ix JH, Heckbert SR, Kizer JR, Zieman SJ, et al. Plasma free fatty acids and risk of atrial fibrillation (from the cardiovascular health study). Am J Cardiol. 2012;110:212–6.
McManus DD, Yin X, Gladstone R, Vittinghoff E, Vasan RS, Larson MG, et al. Alcohol consumption, left atrial diameter, and atrial fibrillation. J Am Heart Assoc. 2016;5: e004060.
Sagawa Y, Nagata Y, Miwa N, Yamaguchi T, Watanabe K, Kaneko M, et al. Alcohol consumption is associated with postablation recurrence but not changes in atrial substrate in patients with atrial fibrillation: insight from a high-density mapping study. J Am Heart Assoc. 2022;11: e025697.
Barmano N, Charitakis E, Kronstrand R, Walfridsson U, Karlsson JE, Walfridsson H, et al. The association between alcohol consumption, cardiac biomarkers, left atrial size and reablation in patients with atrial fibrillation referred for catheter ablation. PLoS One. 2019;14: e0215121.
Mohanty S, Mohanty P, Tamaki M, Natale V, Gianni C, Trivedi C, et al. Differential association of exercise intensity with risk of atrial fibrillation in men and women: evidence from a metaanalysis. J Cardiovasc Electrophysiol. 2016;27:1021–9.
Mozaffarian D, Furberg CD, Psaty BM, Siscovick D. Physical activity and incidence of atrial fibrillation in older adults: the cardiovascular health study. Circulation. 2008;118:800–7.
Jin MN, Yang PS, Song C, Yu HT, Kim TH, Uhm JS, et al. Physical activity and risk of atrial fibrillation: a nationwide cohort study in general population. Sci Rep. 2019;9:13270.
Morseth B, Graff-Iversen S, Jacobsen BK, Jørgensen L, Nyrnes A, Thelle DS, et al. Physical activity, resting heart rate, and atrial fibrillation: the Tromsø study. Eur Heart J. 2016;37:2307–13.
Pathak RK, Elliott A, Middeldorp ME, Meredith M, Mehta AB, Mahajan R, et al. Impact of CARDIOrespiratory FITness on arrhythmia recurrence in obese individuals with atrial fibrillation: the CARDIO-FIT study. J Am Coll Cardiol. 2015;66:985–96.
Elliott AD, Verdicchio CV, Mahajan R, Middeldorp ME, Gallagher C, Mishima RS, et al. An exercise and physical activity program in patients with atrial fibrillation: the ACTIVE-AF randomized controlled trial. JACC Clin Electrophysiol. 2023;9:455–65.
Calvo N, Mont L, Tamborero D, Berruezo A, Viola G, Guasch E, et al. Efficacy of circumferential pulmonary vein ablation of atrial fibrillation in endurance athletes. Europace. 2010;12:30–6.
Decroocq M, Ninni S, Klein C, Machuron F, Verbrugge E, Klug D, et al. No impact of sports practice before or after atrial fibrillation ablation on procedure efficacy in athletes: a case-control study. Europace. 2019;21:1833–42.
Aune D, Feng T, Schlesinger S, Janszky I, Norat T, Riboli E. Diabetes mellitus, blood glucose and the risk of atrial fibrillation: a systematic review and metaanalysis of cohort studies. J Diabetes Complicat. 2018;32:501–11.
Liu C, Fu H, Li J, Yang W, Cheng L, Liu T, et al. Hyperglycemia aggravates atrial interstitial fibrosis, ionic remodeling and vulnerability to atrial fibrillation in diabetic rabbits. Anadolu Kardiyol Derg. 2012;12:543–50.
Chamberlain AM, Agarwal SK, Folsom AR, Duval S, Soliman EZ, Ambrose M, et al. Smoking and incidence of atrial fibrillation: results from the atherosclerosis risk in communities (ARIC) study. Heart Rhythm. 2011;8:1160–6.
Smith JG, Platonov PG, Hedblad B, Engstrom G, Melander O. Atrial fibrillation in the Malmo diet and cancer study: a study of occurrence, risk factors and diagnostic validity. Eur J Epidemiol. 2010;25:95–102.
Zhu W, Yuan P, Shen Y, Wan R, Hong K. Association of smoking with the risk of incident atrial fibrillation: a metaanalysis of prospective studies. Int J Cardiol. 2016;218:259–66.
Albertsen IE, Rasmussen LH, Lane DA, Overvad TF, Skjoth F, Overvad K, et al. The impact of smoking on thromboembolism and mortality in patients with incident atrial fibrillation: insights from the Danish diet, cancer, and health study. Chest. 2014;145:559–66.
Kwon S, Kim TJ, Choi EK, Ahn HJ, Lee E, Lee SR, et al. Predictors of ischemic stroke for low-risk patients with atrial fibrillation: a matched case-control study. Heart Rhythm. 2021;18:702–8.
Pathak RK, Middeldorp ME, Stolcman S, Willoughby S, Mahajan R, Lau D, et al. Aggressive risk factor REduction STudy: implications for the substrate for atrial fibrillation (ARREST-AF substrate study). Circ J. 2015;132:S115–6.
John B, Stiles MK, Kuklik P, Brooks AG, Chandy ST, Kalman JM, et al. Reverse remodeling of the atria after treatment of chronic stretch in humans: implications for the atrial fibrillation substrate. J Am Coll Cardiol. 2010;55:1217–26.
Rienstra M, Hobbelt AH, Alings M, Tijssen JGP, Smit MD, Brügemann J, et al. Targeted therapy of underlying conditions improves sinus rhythm maintenance in patients with persistent atrial fibrillation: results of the RACE 3 trial. Eur Heart J. 2018;39:2987–96.
Pandey AK, Okaj I, Kaur H, Belley-Cote EP, Wang J, Oraii A, et al. Sodium-glucose co-transporter inhibitors and atrial fibrillation: a systematic review and metaanalysis of randomized controlled trials. J Am Heart Assoc. 2021;10: e022222.
Olsson LG, Swedberg K, Ducharme A, Granger CB, Michelson EL, McMurray JJ, et al. Atrial fibrillation and risk of clinical events in chronic heart failure with and without left ventricular systolic dysfunction: results from the Candesartan in heart failure-assessment of reduction in mortality and morbidity (CHARM) program. J Am Coll Cardiol. 2006;47:1997–2004.
Cheng WH, Lo LW, Lin YJ, Chang SL, Hu YF, Hung Y, et al. Ten-year ablation outcomes of patients with paroxysmal atrial fibrillation undergoing pulmonary vein isolation. Heart Rhythm. 2019;16:1327–33.
Sawhney N, Anousheh R, Chen WC, Narayan S, Feld GK. Five-year outcomes after segmental pulmonary vein isolation for paroxysmal atrial fibrillation. Am J Cardiol. 2009;104:366–72.
Uchiyama T, Miyazaki S, Taniguchi H, Komatsu Y, Kusa S, Nakamura H, et al. Six-year follow-up of catheter ablation in paroxysmal atrial fibrillation. Circ J. 2013;77:2722–7.
Gokoglan Y, Mohanty S, Gunes MF, Trivedi C, Santangeli P, Gianni C, et al. Pulmonary vein antrum isolation in patients with paroxysmal atrial fibrillation: more than a decade of follow-up. Circ Arrhythm Electrophysiol. 2016;9: e003660.
Hung Y, Lo LW, Lin YJ, Chang SL, Hu YF, Chung FP, et al. Characteristics and long-term catheter ablation outcome in long-standing persistent atrial fibrillation patients with non-pulmonary vein triggers. Int J Cardiol. 2017;241:205–11.
Wynn GJ, El-Kadri M, Haq I, Das M, Modi S, Snowdon R, et al. Long-term outcomes after ablation of persistent atrial fibrillation: an observational study over 6 years. Open Heart. 2016;3: e000394.
Chew DS, Jones KA, Loring Z, Black-Maier E, Noseworthy PA, Exner DV, et al. Diagnosis-to-ablation time predicts recurrent atrial fibrillation and rehospitalization following catheter ablation. Heart Rhythm. 2022;O2(3):23–31.
De Greef Y, Schwagten B, Chierchia GB, de Asmundis C, Stockman D, Buysschaert I. Diagnosis-to-ablation time as a predictor of success: early choice for pulmonary vein isolation and long-term outcome in atrial fibrillation: results from the Middelheim-PVI Registry. Europace. 2018;20:589–95.
Baysal E, Okşul M, Burak C, Yalin K, Soysal AU, Yalman H, et al. Decreasing time between first diagnosis of paroxysmal atrial fibrillation and cryoballoon ablation positively affects long-term consequences. J Interv Card Electrophysiol. 2022;65:365–72.
Takamiya T, Nitta J, Inaba O, Sato A, Inamura Y, Murata K, et al. Impact of diagnosis-to-ablation time on non-pulmonary vein triggers and ablation outcomes in persistent atrial fibrillation. J Cardiovasc Electrophysiol. 2021;32:1251–8.
D’Ascenzo F, Corleto A, Biondi-Zoccai G, Anselmino M, Ferraris F, di Biase L, et al. Which are the most reliable predictors of recurrence of atrial fibrillation after transcatheter ablation?: a metaanalysis. Int J Cardiol. 2013;167:1984–9.
Njoku A, Kannabhiran M, Arora R, Reddy P, Gopinathannair R, Lakkireddy D, et al. Left atrial volume predicts atrial fibrillation recurrence after radiofrequency ablation: a metaanalysis. Europace. 2018;20:33–42.
Costa FM, Ferreira AM, Oliveira S, Santos PG, Durazzo A, Carmo P, et al. Left atrial volume is more important than the type of atrial fibrillation in predicting the long-term success of catheter ablation. Int J Cardiol. 2015;184:56–61.
Zhuang J, Wang Y, Tang K, Li X, Peng W, Liang C, et al. Association between left atrial size and atrial fibrillation recurrence after single circumferential pulmonary vein isolation: a systematic review and metaanalysis of observational studies. Europace. 2012;14:638–45.
Blanche C, Tran N, Rigamonti F, Burri H, Zimmermann M. Value of P-wave signal averaging to predict atrial fibrillation recurrences after pulmonary vein isolation. Europace. 2013;15:198–204.
Yugo D, Kuo MJ, Hu YF, Liu CM, Lin YJ, Chang SL, et al. Dynamic changes in signal-averaged P wave after catheter ablation of atrial fibrillation. J Chin Med Assoc. 2022;85:549–53.
Salah A, Zhou S, Liu Q, Yan H. P wave indices to predict atrial fibrillation recurrences post pulmonary vein isolation. Arq Bras Cardiol. 2013;101:519–27.
Pranata R, Yonas E, Vania R. Prolonged P-wave duration in sinus rhythm preablation is associated with atrial fibrillation recurrence after pulmonary vein isolation-a systematic review and metaanalysis. Ann Noninvasive Electrocardiol. 2019;24: e12653.
Nakatani Y, Sakamoto T, Yamaguchi Y, Tsujino Y, Kataoka N, Kinugawa K. P-wave vector magnitude predicts recurrence of atrial fibrillation after catheter ablation in patients with persistent atrial fibrillation. Ann Noninvasive Electrocardiol. 2019;24: e12646.
Müller-Edenborn B, Chen J, Allgeier J, Didenko M, Moreno-Weidmann Z, Neumann FJ, et al. Amplified sinus-P-wave reveals localization and extent of left atrial low-voltage substrate: implications for arrhythmia freedom following pulmonary vein isolation. Europace. 2020;22:240–9.
Moreno-Weidmann Z, Müller-Edenborn B, Jadidi AS, Bazan-Gelizo V, Chen J, Park CI, et al. Easily available ECG and echocardiographic parameters for prediction of left atrial remodeling and atrial fibrillation recurrence after pulmonary vein isolation: a multicenter study. J Cardiovasc Electrophysiol. 2021;32:1584–93.
Liu P, Lv T, Yang Y, Gao Q, Zhang P. Use of P wave indices to evaluate efficacy of catheter ablation and atrial fibrillation recurrence: a systematic review and metaanalysis. J Interv Card Electrophysiol. 2022;65:827–40.
Jadidi A, Müller-Edenborn B, Chen J, Keyl C, Weber R, Allgeier J, et al. The duration of the amplified sinus-P-wave identifies presence of left atrial low voltage substrate and predicts outcome after pulmonary vein isolation in patients with persistent atrial fibrillation. JACC Clin Electrophysiol. 2018;4:531–43.
Koutalas E, Kallergis E, Nedios S, Kochiadakis G, Kanoupakis E. P-wave duration as a marker of atrial remodeling in patients referred to ablation for atrial fibrillation: a new stratification tool emerging? Hellenic J Cardiol. 2023.
Okumura Y, Watanabe I, Ohkubo K, Ashino S, Kofune M, Hashimoto K, et al. Prediction of the efficacy of pulmonary vein isolation for the treatment of atrial fibrillation by the signal-averaged P-wave duration. Pacing Clin Electrophysiol. 2007;30:304–13.
Kuppahally SS, Akoum N, Badger TJ, Burgon NS, Haslam T, Kholmovski E, et al. Echocardiographic left atrial reverse remodeling after catheter ablation of atrial fibrillation is predicted by preablation delayed enhancement of left atrium by magnetic resonance imaging. Am Heart J. 2010;160:877–84.
Akkaya M, Higuchi K, Koopmann M, Burgon N, Erdogan E, Damal K, et al. Relationship between left atrial tissue structural remodelling detected using late gadolinium enhancement MRI and left ventricular hypertrophy in patients with atrial fibrillation. Europace. 2013;15:1725–32.
McGann C, Akoum N, Patel A, Kholmovski E, Revelo P, Damal K, et al. Atrial fibrillation ablation outcome is predicted by left atrial remodeling on MRI. Circ Arrhythm Electrophysiol. 2014;7:23–30.
Ambale-Venkatesh B, Lima JA. Cardiac MRI: a central prognostic tool in myocardial fibrosis. Nat Rev Cardiol. 2015;12:18–29.
Nairn D, Eichenlaub M, Müller-Edenborn B, Huang T, Lehrmann H, Nagel C, et al. Differences in atrial substrate localization using late gadolinium enhancement-magnetic resonance imaging, electrogram voltage, and conduction velocity: a cohort study using a consistent anatomical reference frame in patients with persistent atrial fibrillation. Europace. 2023;25:euad278.
Nakahara S, Hori Y, Kobayashi S, Sakai Y, Taguchi I, Takayanagi K, et al. Epicardial adipose tissue-based defragmentation approach to persistent atrial fibrillation: its impact on complex fractionated electrograms and ablation outcome. Heart Rhythm. 2014;11:1343–51.
Chao TF, Hung CL, Tsao HM, Lin YJ, Yun CH, Lai YH, et al. Epicardial adipose tissue thickness and ablation outcome of atrial fibrillation. PLoS One. 2013;8: e74926.
Masuda M, Mizuno H, Enchi Y, Minamiguchi H, Konishi S, Ohtani T, et al. Abundant epicardial adipose tissue surrounding the left atrium predicts early rather than late recurrence of atrial fibrillation after catheter ablation. J Interv Card Electrophysiol. 2015;44:31–7.
Sepehri Shamloo A, Dagres N, Dinov B, Sommer P, Husser-Bollmann D, Bollmann A, et al. Is epicardial fat tissue associated with atrial fibrillation recurrence after ablation? A systematic review and metaanalysis. Int J Cardiol Heart Vasc. 2019;22:132–8.
Nagashima K, Okumura Y, Watanabe I, Nakai T, Ohkubo K, Kofune T, et al. Association between epicardial adipose tissue volumes on 3-dimensional reconstructed CT images and recurrence of atrial fibrillation after catheter ablation. Circ J. 2011;75:2559–65.
Vroomen M, Olsthoorn JR, Maesen B, L’Espoir V, La Meir M, Das M, et al. Quantification of epicardial adipose tissue in patients undergoing hybrid ablation for atrial fibrillation. Eur J Cardiothorac Surg. 2019;56:79–86.
El Mahdiui M, Simon J, Smit JM, Kuneman JH, van Rosendael AR, Steyerberg EW, et al. Posterior left atrial adipose tissue attenuation assessed by computed tomography and recurrence of atrial fibrillation after catheter ablation. Circ Arrhythm Electrophysiol. 2021;14: e009135.
Hindricks G, Potpara T, Dagres N, Arbelo E, Bax JJ, Blomström-Lundqvist C, et al. 2020 ESC guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): the task force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. Eur Heart J. 2021;42:373–498.
van Vugt SPG, Westra SW, Volleberg R, Hannink G, Nakamura R, de Asmundis C, et al. Metaanalysis of controlled studies on minimally interrupted vs. continuous use of non-vitamin K antagonist oral anticoagulants in catheter ablation for atrial fibrillation. Europace. 2021;23:1961–9.
Yadav R, Brilliant J, Akhtar T, Milstein J, Sampognaro JR, Marine J, et al. Relationship between amiodarone response prior to ablation and 1-year outcomes of catheter ablation for atrial fibrillation. J Cardiovasc Electrophysiol. 2023;34:860–8.
Dukes JW, Chilukuri K, Scherr D, Marine JE, Berger RD, Nazarian S, et al. The effect of antiarrhythmic medication management on atrial fibrillation ablation outcomes. J Cardiovasc Electrophysiol. 2013;24:882–7.
Miwa Y, Minamiguchi H, Bhandari AK, Cannom DS, Ho IC. Amiodarone reduces the amount of ablation during catheter ablation for persistent atrial fibrillation. Europace. 2014;16:1007–14.
Mohanty S, Di Biase L, Mohanty P, Trivedi C, Santangeli P, Bai R, et al. Effect of periprocedural amiodarone on procedure outcome in patients with longstanding persistent atrial fibrillation undergoing extended pulmonary vein antrum isolation: results from a randomized study (SPECULATE). Heart Rhythm. 2015;12:477–83.
Efremidis M, Bazoukis G, Vlachos K, Prappa E, Megarisiotou A, Dragasis S, et al. Safety of catheter ablation of atrial fibrillation without pre- or periprocedural imaging for the detection of left atrial thrombus in the era of uninterrupted anticoagulation. J Arrhythm. 2021;37:28–32.
Diab M, Wazni OM, Saliba WI, Tarakji KG, Ballout JA, Hutt E, et al. Ablation of atrial fibrillation without left atrial appendage imaging in patients treated with direct oral anticoagulants. Circ Arrhythm Electrophysiol. 2020;13: e008301.
Puwanant S, Varr BC, Shrestha K, Hussain SK, Tang WH, Gabriel RS, et al. Role of the CHADS2 score in the evaluation of thromboembolic risk in patients with atrial fibrillation undergoing transesophageal echocardiography before pulmonary vein isolation. J Am Coll Cardiol. 2009;54:2032–9.
Manning WJ, Weintraub RM, Waksmonski CA, Haering JM, Rooney PS, Maslow AD, et al. Accuracy of transesophageal echocardiography for identifying left atrial thrombi. A prospective, intraoperative study. Ann Intern Med. 1995;123:817–22.
Hahn RT, Abraham T, Adams MS, Bruce CJ, Glas KE, Lang RM, et al. Guidelines for performing a comprehensive transesophageal echocardiographic examination: recommendations from the American Society of Echocardiography and the Society of Cardiovascular Anesthesiologists. J Am Soc Echocardiogr. 2013;26:921–64.
Daniel WG, Erbel R, Kasper W, Visser CA, Engberding R, Sutherland GR, et al. Safety of transesophageal echocardiography. A multicenter survey of 10,419 examinations. Circulation. 1991;83:817–21.
Davenport MS, Perazella MA, Yee J, Dillman JR, Fine D, McDonald RJ, et al. Use of intravenous iodinated contrast media in patients with kidney disease: consensus statements from the American College of Radiology and the National Kidney Foundation. Kidney Med. 2020;2:85–93.
Stocker TJ, Deseive S, Leipsic J, Hadamitzky M, Chen MY, Rubinshtein R, et al. Reduction in radiation exposure in cardiovascular computed tomography imaging: results from the PROspective multicenter registry on radiaTion dose Estimates of cardiac CT angIOgraphy iN daily practice in 2017 (PROTECTION VI). Eur Heart J. 2018;39:3715–23.
Kitkungvan D, Nabi F, Ghosn MG, Dave AS, Quinones M, Zoghbi WA, et al. Detection of LA and LAA thrombus by CMR in patients referred for pulmonary vein isolation. JACC Cardiovasc Imaging. 2016;9:809–18.
Rathi VK, Reddy ST, Anreddy S, Belden W, Yamrozik JA, Williams RB, et al. Contrast-enhanced CMR is equally effective as TEE in the evaluation of left atrial appendage thrombus in patients with atrial fibrillation undergoing pulmonary vein isolation procedure. Heart Rhythm. 2013;10:1021–7.
Ohyama H, Hosomi N, Takahashi T, Mizushige K, Osaka K, Kohno M, et al. Comparison of magnetic resonance imaging and transesophageal echocardiography in detection of thrombus in the left atrial appendage. Stroke. 2003;34:2436–9.
Brooks AG, Wilson L, Chia NH, Lau DH, Alasady M, Leong DP, et al. Accuracy and clinical outcomes of CT image integration with Carto-Sound compared to electro-anatomical mapping for atrial fibrillation ablation: a randomized controlled study. Int J Cardiol. 2013;168:2774–82.
Di Biase L, Zou F, Lin AN, Grupposo V, Marazzato J, Tarantino N, et al. Feasibility of three-dimensional artificial intelligence algorithm integration with intracardiac echocardiography for left atrial imaging during atrial fibrillation catheter ablation. Europace. 2023;25:euad211.
Vicera JJB, Lin YJ, Lee PT, Chang SL, Lo LW, Hu YF, et al. Identification of critical isthmus using coherent mapping in patients with scar-related atrial tachycardia. J Cardiovasc Electrophysiol. 2020;31:1436–7.
Deno DC, Bhaskaran A, Morgan DJ, Goksu F, Batman K, Olson GK, et al. High-resolution, live, directional mapping. Heart Rhythm. 2020;17:1621–8.
Unland R, Bergau L, El Hamriti M, Guckel D, Piran M, Fink T, et al. Find me if you can: first clinical experience using the novel CARTOFINDER algorithm in a routine workflow for atrial fibrillation ablation. J Clin Med. 2021;10:2979.
Honarbakhsh S, Schilling RJ, Dhillon G, Ullah W, Keating E, Providencia R, et al. A novel mapping system for panoramic mapping of the left atrium: application to detect and characterize localized sources maintaining atrial fibrillation. JACC Clin Electrophysiol. 2018;4:124–34.
Chang TY, Lin CY, Lin YJ, Wu CI, Chang SL, Lo LW, et al. Long-term outcome of patients with long-standing persistent atrial fibrillation undergoing ablation guided by a novel high-density panoramic mapping system: a propensity score matching study. Heart Rhythm. 2022;O2(3):269–78.
Sporton SC, Earley MJ, Nathan AW, Schilling RJ. Electroanatomic versus fluoroscopic mapping for catheter ablation procedures: a prospective randomized study. J Cardiovasc Electrophysiol. 2004;15:310–5.
Estner HL, Deisenhofer I, Luik A, Ndrepepa G, von Bary C, Zrenner B, et al. Electrical isolation of pulmonary veins in patients with atrial fibrillation: reduction of fluoroscopy exposure and procedure duration by the use of a non-fluoroscopic navigation system (NavX). Europace. 2006;8:583–7.
Scaglione M, Biasco L, Caponi D, Anselmino M, Negro A, Di Donna P, et al. Visualization of multiple catheters with electroanatomical mapping reduces X-ray exposure during atrial fibrillation ablation. Europace. 2011;13:955–62.
Martinek M, Nesser HJ, Aichinger J, Boehm G, Purerfellner H. Impact of integration of multislice computed tomography imaging into three-dimensional electroanatomic mapping on clinical outcomes, safety, and efficacy using radiofrequency ablation for atrial fibrillation. Pacing Clin Electrophysiol. 2007;30:1215–23.
Caponi D, Corleto A, Scaglione M, Blandino A, Biasco L, Cristoforetti Y, et al. Ablation of atrial fibrillation: does the addition of three-dimensional magnetic resonance imaging of the left atrium to electroanatomic mapping improve the clinical outcome?: a randomized comparison of Carto-Merge vs. Carto-XP three-dimensional mapping ablation in patients with paroxysmal and persistent atrial fibrillation. Europace. 2010;12:1098–104.
Bertaglia E, Bella PD, Tondo C, Proclemer A, Bottoni N, De Ponti R, et al. Image integration increases efficacy of paroxysmal atrial fibrillation catheter ablation: results from the CartoMerge Italian Registry. Europace. 2009;11:1004–10.
Della Bella P, Fassini G, Cireddu M, Riva S, Carbucicchio C, Giraldi F, et al. Image integration-guided catheter ablation of atrial fibrillation: a prospective randomized study. J Cardiovasc Electrophysiol. 2009;20:258–65.
Kistler PM, Rajappan K, Harris S, Earley MJ, Richmond L, Sporton SC, et al. The impact of image integration on catheter ablation of atrial fibrillation using electroanatomic mapping: a prospective randomized study. Eur Heart J. 2008;29:3029–36.
Duytschaever M, Vijgen J, De Potter T, Scherr D, Van Herendael H, Knecht S, et al. Standardized pulmonary vein isolation workflow to enclose veins with contiguous lesions: the multicentre VISTAX trial. Europace. 2020;22:1645–52.
Duytschaever M, De Pooter J, Demolder A, El Haddad M, Phlips T, Strisciuglio T, et al. Long-term impact of catheter ablation on arrhythmia burden in low-risk patients with paroxysmal atrial fibrillation: the CLOSE to CURE study. Heart Rhythm. 2020;17:535–43.
De Pooter J, Strisciuglio T, El Haddad M, Wolf M, Phlips T, Vandekerckhove Y, et al. Pulmonary vein reconnection no longer occurs in the majority of patients after a single pulmonary vein isolation procedure. JACC Clin Electrophysiol. 2019;5:295–305.
Hussein A, Das M, Riva S, Morgan M, Ronayne C, Sahni A, et al. Use of ablation index-guided ablation results in high rates of durable pulmonary vein isolation and freedom from arrhythmia in persistent atrial fibrillation patients: the PRAISE study results. Circ Arrhythm Electrophysiol. 2018;11: e006576.
Taghji P, El Haddad M, Phlips T, Wolf M, Knecht S, Vandekerckhove Y, et al. Evaluation of a strategy aiming to enclose the pulmonary veins with contiguous and optimized radiofrequency lesions in paroxysmal atrial fibrillation: a pilot study. JACC Clin Electrophysiol. 2018;4:99–108.
Phlips T, Taghji P, El Haddad M, Wolf M, Knecht S, Vandekerckhove Y, et al. Improving procedural and one-year outcome after contact force-guided pulmonary vein isolation: the role of interlesion distance, ablation index, and contact force variability in the ‘CLOSE’-protocol. Europace. 2018;20:f419-27.
Grace A, Willems S, Meyer C, Verma A, Heck P, Zhu M, et al. High-resolution noncontact charge-density mapping of endocardial activation. JCI Insight. 2019;4: e126422.
Willems S, Verma A, Betts TR, Murray S, Neuzil P, Ince H, et al. Targeting nonpulmonary vein sources in persistent atrial fibrillation identified by noncontact charge density mapping: UNCOVER AF trial. Circ Arrhythm Electrophysiol. 2019;12: e007233.
Shi R, Parikh P, Chen Z, Angel N, Norman M, Hussain W, et al. Validation of dipole density mapping during atrial fibrillation and sinus rhythm in human left atrium. JACC Clin Electrophysiol. 2020;6:171–81.
Haines DE, Kong MH, Ruppersberg P, Haeusser P, Avitall B, Szili Torok T, et al. Electrographic flow mapping for atrial fibrillation: theoretical basis and preliminary observations. J Interv Card Electrophysiol. 2022;66:1015–28.
Reddy VY, Neuzil P, Langbein A, Petru J, Funasako M, Dinshaw L, et al. AB-453070-2 FLOW-AF: a randomized controlled trial of electrographic flow-guided ablation in redo patients with non-paroxysmal atrial fibrillation. Heart Rhythm. 2023;20:S1-2.
Nademanee K, Schwab MC, Kosar EM, Karwecki M, Moran MD, Visessook N, et al. Clinical outcomes of catheter substrate ablation for high-risk patients with atrial fibrillation. J Am Coll Cardiol. 2008;51:843–9.
Verma A, Jiang CY, Betts TR, Chen J, Deisenhofer I, Mantovan R, et al. Approaches to catheter ablation for persistent atrial fibrillation. N Engl J Med. 2015;372:1812–22.
Seitz J, Bars C, Theodore G, Beurtheret S, Lellouche N, Bremondy M, et al. AF ablation guided by spatiotemporal electrogram dispersion without pulmonary vein isolation: a wholly patient-tailored approach. J Am Coll Cardiol. 2017;69:303–21.
Lin R, Zeng C, Xu K, Wu S, Qin M, Liu X. Dispersion-guided ablation in conjunction with circumferential pulmonary vein isolation is superior to stepwise ablation approach for persistent atrial fibrillation. Int J Cardiol. 2019;278:97–103.
Jadidi AS, Lehrmann H, Keyl C, Sorrel J, Markstein V, Minners J, et al. Ablation of persistent atrial fibrillation targeting low-voltage areas with selective activation characteristics. Circ Arrhythm Electrophysiol. 2016;9: e002962.
Seitz J, Durdez TM, Albenque JP, Pisapia A, Gitenay E, Durand C, et al. Artificial intelligence software standardizes electrogram-based ablation outcome for persistent atrial fibrillation. J Cardiovasc Electrophysiol. 2022;33:2250–60.
Narayan SM, Krummen DE, Shivkumar K, Clopton P, Rappel WJ, Miller JM. Treatment of atrial fibrillation by the ablation of localized sources: CONFIRM (conventional ablation for atrial fibrillation with or without focal impulse and rotor modulation) trial. J Am Coll Cardiol. 2012;60:628–36.
Gray RA, Jalife J, Panfilov AV, Baxter WT, Cabo C, Davidenko JM, et al. Mechanisms of cardiac fibrillation. Science. 1995;270:1222–3; author reply 1224–5.
Salinet J, Molero R, Schlindwein FS, Karel J, Rodrigo M, Rojo-Alvarez JL, et al. Electrocardiographic imaging for atrial fibrillation: a perspective from computer models and animal experiments to clinical value. Front Physiol. 2021;12: 653013.
Ramanathan C, Ghanem RN, Jia P, Ryu K, Rudy Y. Noninvasive electrocardiographic imaging for cardiac electrophysiology and arrhythmia. Nat Med. 2004;10:422–8.
Molero R, González-Ascaso A, Climent AM, Guillem MS. Robustness of imageless electrocardiographic imaging against uncertainty in atrial morphology and location. J Electrocardiol. 2023;77:58–61.
Cuculich PS, Wang Y, Lindsay BD, Faddis MN, Schuessler RB, Damiano RJ Jr, et al. Noninvasive characterization of epicardial activation in humans with diverse atrial fibrillation patterns. Circulation. 2010;122:1364–72.
Haissaguerre M, Hocini M, Denis A, Shah AJ, Komatsu Y, Yamashita S, et al. Driver domains in persistent atrial fibrillation. Circulation. 2014;130:530–8.
Lim HS, Hocini M, Dubois R, Denis A, Derval N, Zellerhoff S, et al. Complexity and distribution of drivers in relation to duration of persistent atrial fibrillation. J Am Coll Cardiol. 2017;69:1257–69.
Knecht S, Sohal M, Deisenhofer I, Albenque JP, Arentz T, Neumann T, et al. Multicentre evaluation of non-invasive biatrial mapping for persistent atrial fibrillation ablation: the AFACART study. Europace. 2017;19:1302–9.
Honarbakhsh S, Dhillon G, Abbass H, Waddingham PH, Dennis A, Ahluwalia N, et al. Noninvasive electrocardiographic imaging-guided targeting of drivers of persistent atrial fibrillation: the TARGET-AF1 trial. Heart Rhythm. 2022;19:875–84.
Gao X, Lam AG, Bilchick KC, Darby A, Mehta N, Mason PK, et al. The use of non-invasive mapping in persistent AF to predict acute procedural outcome. J Electrocardiol. 2019;57S:S21-6.
Rodrigo M, Climent AM, Hernandez-Romero I, Liberos A, Baykaner T, Rogers AJ, et al. Noninvasive assessment of complexity of atrial fibrillation: correlation with contact mapping and impact of ablation. Circ Arrhythm Electrophysiol. 2020;13: e007700.
Badger TJ, Adjei-Poku YA, Marrouche NF. MRI in cardiac electrophysiology: the emerging role of delayed-enhancement MRI in atrial fibrillation ablation. Future Cardiol. 2009;5:63–70.
Bisbal F, Calvo M, Trucco E, Arbelo E, Berruezo A, Mont L. Left atrial tachycardia after atrial fibrillation ablation: can magnetic resonance imaging assist the ablation? Can J Cardiol. 2015;31(104):e1-3.
Reddy VY, Shah D, Kautzner J, Schmidt B, Saoudi N, Herrera C, et al. The relationship between contact force and clinical outcome during radiofrequency catheter ablation of atrial fibrillation in the TOCCATA study. Heart Rhythm. 2012;9:1789–95.
Neuzil P, Reddy VY, Kautzner J, Petru J, Wichterle D, Shah D, et al. Electrical reconnection after pulmonary vein isolation is contingent on contact force during initial treatment: results from the EFFICAS I study. Circ Arrhythm Electrophysiol. 2013;6:327–33.
Kautzner J, Neuzil P, Lambert H, Peichl P, Petru J, Cihak R, et al. EFFICAS II: optimization of catheter contact force improves outcome of pulmonary vein isolation for paroxysmal atrial fibrillation. Europace. 2015;17:1229–35.
Andrade JG, Monir G, Pollak SJ, Khairy P, Dubuc M, Roy D, et al. Pulmonary vein isolation using “contact force” ablation: the effect on dormant conduction and long-term freedom from recurrent atrial fibrillation—a prospective study. Heart Rhythm. 2014;11:1919–24.
Squara F, Latcu DG, Massaad Y, Mahjoub M, Bun SS, Saoudi N. Contact force and force-time integral in atrial radiofrequency ablation predict transmurality of lesions. Europace. 2014;16:660–7.
Whitaker J, Fish J, Harrison J, Chubb H, Williams SE, Fastl T, et al. Lesion index-guided ablation facilitates continuous, transmural, and durable lesions in a porcine recovery model. Circ Arrhythm Electrophysiol. 2018;11: e005892.
Das M, Loveday JJ, Wynn GJ, Gomes S, Saeed Y, Bonnett LJ, et al. Ablation index, a novel marker of ablation lesion quality: prediction of pulmonary vein reconnection at repeat electrophysiology study and regional differences in target values. Europace. 2017;19:775–83.
Bourier F, Duchateau J, Vlachos K, Lam A, Martin CA, Takigawa M, et al. High-power short-duration versus standard radiofrequency ablation: insights on lesion metrics. J Cardiovasc Electrophysiol. 2018;29:1570–5.
Borne RT, Sauer WH, Zipse MM, Zheng L, Tzou W, Nguyen DT. Longer duration versus increasing power during radiofrequency ablation yields different ablation lesion characteristics. JACC Clin Electrophysiol. 2018;4:902–8.
Kyriakopoulou M, Wielandts JY, Strisciuglio T, El Haddad M, Pooter J, Almorad A, et al. Evaluation of higher power delivery during RF pulmonary vein isolation using optimized and contiguous lesions. J Cardiovasc Electrophysiol. 2020;31:1091–8.
Berte B, Hilfiker G, Russi I, Moccetti F, Cuculi F, Toggweiler S, et al. Pulmonary vein isolation using a higher power shorter duration CLOSE protocol with a surround flow ablation catheter. J Cardiovasc Electrophysiol. 2019;30:2199–204.
Chen S, Schmidt B, Bordignon S, Urbanek L, Tohoku S, Bologna F, et al. Ablation index-guided 50 W ablation for pulmonary vein isolation in patients with atrial fibrillation: procedural data, lesion analysis, and initial results from the FAFA AI high power study. J Cardiovasc Electrophysiol. 2019;30:2724–31.
Winkle RA, Mohanty S, Patrawala RA, Mead RH, Kong MH, Engel G, et al. Low complication rates using high power (45–50 W) for short duration for atrial fibrillation ablations. Heart Rhythm. 2019;16:165–9.
Winkle RA, Moskovitz R, Hardwin Mead R, Engel G, Kong MH, Fleming W, et al. Atrial fibrillation ablation using very short duration 50 W ablations and contact force sensing catheters. J Interv Card Electrophysiol. 2018;52:1–8.
Wielandts JY, Kyriakopoulou M, Almorad A, Hilfiker G, Strisciuglio T, Phlips T, et al. Prospective randomized evaluation of high power during CLOSE-guided pulmonary vein isolation: the POWER-AF study. Circ Arrhythm Electrophysiol. 2021;14: e009112.
Lee AC, Voskoboinik A, Cheung CC, Yogi S, Tseng ZH, Moss JD, et al. A randomized trial of high vs standard power radiofrequency ablation for pulmonary vein isolation: SHORT-AF. JACC Clin Electrophysiol. 2023;9:1038–47.
Kottmaier M, Popa M, Bourier F, Reents T, Cifuentes J, Semmler V, et al. Safety and outcome of very high-power short-duration ablation using 70 W for pulmonary vein isolation in patients with paroxysmal atrial fibrillation. Europace. 2020;22:388–93.
Castrejón-Castrejón S, Martínez Cossiani M, Jáuregui-Abularach M, Basterra Sola N, Ibáñez Criado JL, Osca Asensi J, et al. POWER FAST III trial investigators. Multicenter prospective comparison of conventional and high-power short duration radiofrequency application for pulmonary vein isolation: the high-power shortduration radiofrequency application for faster and safer pulmonary vein ablation (POWER FAST III) trial. J Interv Card Electrophysiol. 2023;66:1889–99.
Leung LWM, Akhtar Z, Sheppard MN, Louis-Auguste J, Hayat J, Gallagher MM. Preventing esophageal complications from atrial fibrillation ablation: a review. Heart Rhythm. 2021;O2(2):651–64.
Kautzner J, Albenque JP, Natale A, Maddox W, Cuoco F, Neuzil P, et al. A novel temperature-controlled radiofrequency catheter ablation system used to treat patients with paroxysmal atrial fibrillation. JACC Clin Electrophysiol. 2021;7:352–63.
Almorad A, Wielandts JY, El Haddad M, Knecht S, Tavernier R, Kobza R, et al. Performance and safety of temperature- and flow-controlled radiofrequency ablation in ablation index-guided pulmonary vein isolation. JACC Clin Electrophysiol. 2021;7:408–9.
Bortone A, Albenque JP, Ramirez FD, Haïssaguerre M, Combes S, Constantin M, et al. 90 vs 50-watt radiofrequency applications for pulmonary vein isolation: experimental and clinical findings. Circ Arrhythm Electrophysiol. 2022;15: e010663.
Leshem E, Zilberman I, Tschabrunn CM, Barkagan M, Contreras-Valdes FM, Govari A, et al. High-power and short-duration ablation for pulmonary vein isolation: biophysical characterization. JACC Clin Electrophysiol. 2018;4:467–79.
Takigawa M, Kitamura T, Martin CA, Fuimaono K, Datta K, Joshi H, et al. Temperature- and flow-controlled ablation/very-high-power short-duration ablation vs conventional power-controlled ablation: comparison of focal and linear lesion characteristics. Heart Rhythm. 2021;18:553–61.
Nakagawa H, Ikeda A, Sharma T, Govari A, Ashton J, Maffre J, et al. Comparison of in vivo tissue temperature profile and lesion geometry for radiofrequency ablation with high power-short duration and moderate power-moderate duration: effects of thermal latency and contact force on lesion formation. Circ Arrhythm Electrophysiol. 2021;14: e009899.
Reddy VY, Grimaldi M, De Potter T, Vijgen JM, Bulava A, Duytschaever MF, et al. Pulmonary vein isolation with very high power, short duration, temperature-controlled lesions: the QDOT-FAST trial. JACC Clin Electrophysiol. 2019;5:778–86.
Halbfass P, Wielandts JY, Knecht S, Le Polain de Waroux JB, Tavernier R, De Wilde V, et al. Safety of very high-power short-duration radiofrequency ablation for pulmonary vein isolation: a two-centre report with emphasis on silent oesophageal injury. Europace. 2022;24:400–5.
Richard Tilz R, Sano M, Vogler J, Fink T, Saraei R, Sciacca V, et al. Very high-power short-duration temperature-controlled ablation versus conventional power-controlled ablation for pulmonary vein isolation: the fast and furious – AF study. Int J Cardiol Heart Vasc. 2021;35: 100847.
O’Neill L, El Haddad M, Berte B, Kobza R, Hilfiker G, Scherr D, et al. Very high-power ablation for contiguous pulmonary vein isolation: results from the randomized POWER PLUS trial. JACC Clin Electrophysiol. 2022;9:511–22.
Reddy VY, Schilling R, Grimaldi M, Horton R, Natale A, Riva S, et al. Pulmonary vein isolation with a novel multielectrode radiofrequency balloon catheter that allows directionally tailored energy delivery: short-term outcomes from a multicenter first-in-human study (RADIANCE). Circ Arrhythm Electrophysiol. 2019;12: e007541.
Dhillon GS, Honarbakhsh S, Di Monaco A, Coling AE, Lenka K, Pizzamiglio F, et al. Use of a multielectrode radiofrequency balloon catheter to achieve pulmonary vein isolation in patients with paroxysmal atrial fibrillation: 12-month outcomes of the RADIANCE study. J Cardiovasc Electrophysiol. 2020;31:1259–69.
Almorad A, Del Monte A, Della Rocca DG, Pannone L, Ramak R, Overeinder I, et al. Outcomes of pulmonary vein isolation with radiofrequency balloon vs. cryoballoon ablation: a multi-centric study. Europace. 2023;25:euad252.
Schilling R, Dhillon GS, Tondo C, Riva S, Grimaldi M, Quadrini F, et al. Safety, effectiveness, and quality of life following pulmonary vein isolation with a multielectrode radiofrequency balloon catheter in paroxysmal atrial fibrillation: 1-year outcomes from SHINE. Europace. 2021;23:851–60.
Del Monte A, Almorad A, Pannone L, Della Rocca DG, Bisignani A, Monaco C, et al. Pulmonary vein isolation with the radiofrequency balloon catheter: a single centre prospective study. Europace. 2023;25:896–904.
Reddy VY, Anter E, Rackauskas G, Peichl P, Koruth JS, Petru J, et al. Lattice-tip focal ablation catheter that toggles between radiofrequency and pulsed field energy to treat atrial fibrillation: a first-in-human trial. Circ Arrhythm Electrophysiol. 2020;13: e008718.
Reddy VY, Peichl P, Anter E, Rackauskas G, Petru J, Funasako M, et al. A focal ablation catheter toggling between radiofrequency and pulsed field energy to treat atrial fibrillation. JACC Clin Electrophysiol. 2023;9:1786–801.
Dubuc M, Khairy P, Rodriguez-Santiago A, Talajic M, Tardif JC, Thibault B, et al. Catheter cryoablation of the atrioventricular node in patients with atrial fibrillation: a novel technology for ablation of cardiac arrhythmias. J Cardiovasc Electrophysiol. 2001;12:439–44.
Andrade JG, Champagne J, Dubuc M, Deyell MW, Verma A, Macle L, et al. Cryoballoon or radiofrequency ablation for atrial fibrillation assessed by continuous monitoring: a randomized clinical trial. Circulation. 2019;140:1779–88.
Furnkranz A, Chun KR, Nuyens D, Metzner A, Koster I, Schmidt B, et al. Characterization of conduction recovery after pulmonary vein isolation using the “single big cryoballoon” technique. Heart Rhythm. 2010;7:184–90.
Martin CA, Tilz RRR, Anic A, Defaye P, Luik A, de Asmundis C, et al. Acute procedural efficacy and safety of a novel cryoballoon for the treatment of paroxysmal atrial fibrillation: results from the POLAR ICE study. J Cardiovasc Electrophysiol. 2023;34:833–40.
Tilz RR, Meyer-Saraei R, Eitel C, Fink T, Sciacca V, Lopez LD, et al. Novel cryoballoon ablation system for single shot pulmonary vein isolation- the prospective ICE-AGE-X study. Circ J. 2021;85:1296–304.
Assaf A, Bhagwandien R, Szili-Torok T, Yap SC. Comparison of procedural efficacy, balloon nadir temperature, and incidence of phrenic nerve palsy between two cryoballoon technologies for pulmonary vein isolation: a systematic review and metaanalysis. J Cardiovasc Electrophysiol. 2021;32:2424–31.
Reichlin T, Kaueffer T, Knecht S, Madaffari A, Badertscher P, Maurhofer J, et al. Comparison of the PolarX and the Arctic Front cryoballoon for pulmonary vein isolation in patients with paroxysmal atrial fibrillation (COMPARE CRYO). Presented at ESC Congress 2023, Late Breaking Sciences in Atrial Fibrillation Session 2023.
Kuck KH, Furnkranz A, Chun KR, Metzner A, Ouyang F, Schluter M, et al. Cryoballoon or radiofrequency ablation for symptomatic paroxysmal atrial fibrillation: reintervention, rehospitalization, and quality-of-life outcomes in the FIRE AND ICE trial. Eur Heart J. 2016;37:2858–65.
Bredikis A, Wilber DJ. Cryoablation of Cardiac Arrhythmias. 1st ed. Philadelphia, PA: Elsevier/Saunders; 2011.
De Potter T, Klaver M, Babkin A, Iliodromitis K, Hocini M, Cox J, et al. Ultra-low temperature cryoablation for atrial fibrillation: primary outcomes for efficacy and safety: the cryocure-2 study. JACC Clin Electrophysiol. 2022;8:1034–9.
Verma A, Asivatham SJ, Deneke T, Castellvi Q, Neal RE 2nd. Primer on pulsed electrical field ablation: understanding the benefits and limitations. Circ Arrhythm Electrophysiol. 2021;14: e010086.
Ruzgys P, Novickij V, Novickij J, Satkauskas S. Influence of the electrode material on ROS generation and electroporation efficiency in low and high frequency nanosecond pulse range. Bioelectrochemistry. 2019;127:87–93.
Rubinsky L, Guenther E, Mikus P, Stehling M, Rubinsky B. Electrolytic effects during tissue ablation by electroporation. Technol Cancer Res Treat. 2016;15:NP95-103.
Xie F, Varghese F, Pakhomov AG, Semenov I, Xiao S, Philpott J, et al. Ablation of myocardial tissue with nanosecond pulsed electric fields. PLoS One. 2015;10: e0144833.
Maor E, Ivorra A, Leor J, Rubinsky B. The effect of irreversible electroporation on blood vessels. Technol Cancer Res Treat. 2007;6:307–12.
Scheinman MM, Morady F, Hess DS, Gonzalez R. Catheter-induced ablation of the atrioventricular junction to control refractory supraventricular arrhythmias. JAMA. 1982;248:851–5.
van den Bos W, Scheffer HJ, Vogel JA, Wagstaff PG, de Bruin DM, de Jong MC, et al. Thermal energy during irreversible electroporation and the influence of different ablation parameters. J Vasc Interv Radiol. 2016;27:433–43.
Stewart MT, Haines DE, Miklavcic D, Kos B, Kirchhof N, Barka N, et al. Safety and chronic lesion characterization of pulsed field ablation in a porcine model. J Cardiovasc Electrophysiol. 2021;32:958–69.
Meckes D, Emami M, Fong I, Lau DH, Sanders P. Pulsed-field ablation: computational modeling of electric fields for lesion depth analysis. Heart Rhythm. 2022;O2(3):433–40.
Verma A, Howard BT, Tzou WT, Mattison LM, Kos B, Miklavcic D, et al. Effects of tissue proximity on cardiac lesion formation using pulsed field ablation. Heart Rhythm. 2022;19:S228.
Reddy VY, Neuzil P, Koruth JS, Petru J, Funosako M, Cochet H, et al. Pulsed field ablation for pulmonary vein isolation in atrial fibrillation. J Am Coll Cardiol. 2019;74:315–26.
Verma A, Boersma L, Haines DE, Natale A, Marchlinski FE, Sanders P, et al. First-in-human experience and acute procedural outcomes using a novel pulsed field ablation system: the PULSED AF pilot trial. Circ Arrhythm Electrophysiol. 2022;15: e010168.
Ekanem E, Reddy VY, Schmidt B, Reichlin T, Neven K, Metzner A, et al. Multinational survey on the methods, efficacy, and safety on the post-approval clinical use of pulsed field ablation (MANIFEST-PF). Europace. 2022;24:1256–66.
Schmidt B, Bordignon S, Neven K, Reichlin T, Blaauw Y, Hansen J, et al. EUropean real-world outcomes with pulsed field ablatiOn in patients with symptomatic atRIAl fibrillation: lessons from the multi-centre EU-PORIA registry. Europace. 2023;25:euad185.
Maor E, Ivorra A, Rubinsky B. Non thermal irreversible electroporation: novel technology for vascular smooth muscle cells ablation. PLoS One. 2009;4: e4757.
Li W, Fan Q, Ji Z, Qiu X, Li Z. The effects of irreversible electroporation (IRE) on nerves. PLoS One. 2011;6: e18831.
Koruth JS, Kuroki K, Kawamura I, Brose R, Viswanathan R, Buck ED, et al. Pulsed field ablation versus radiofrequency ablation: esophageal injury in a novel porcine model. Circ Arrhythm Electrophysiol. 2020;13: e008303.
Stewart MT, Haines DE, Verma A, Kirchhof N, Barka N, Grassl E, et al. Intracardiac pulsed field ablation: proof of feasibility in a chronic porcine model. Heart Rhythm. 2019;16:754–64.
Howard B, Haines DE, Verma A, Kirchhof N, Barka N, Onal B, et al. Characterization of phrenic nerve response to pulsed field ablation. Circ Arrhythm Electrophysiol. 2022;15: e010127.
Howard B, Haines DE, Verma A, Packer D, Kirchhof N, Barka N, et al. Reduction in pulmonary vein stenosis and collateral damage with pulsed field ablation compared with radiofrequency ablation in a canine model. Circ Arrhythm Electrophysiol. 2020;13: e008337.
Reddy VY, Dukkipati SR, Neuzil P, Anic A, Petru J, Funasako M, et al. Pulsed field ablation of paroxysmal atrial fibrillation: 1-year outcomes of IMPULSE, PEFCAT, and PEFCAT II. JACC Clin Electrophysiol. 2021;7:614–27.
Chung EM, Banahan C, Patel N, Janus J, Marshall D, Horsfield MA, et al. Size distribution of air bubbles entering the brain during cardiac surgery. PLoS One. 2015;10: e0122166.
Reinsch N, Füting A, Höwel D, Bell J, Lin Y, Neven K. Cerebral safety after pulsed field ablation for paroxysmal atrial fibrillation. Heart Rhythm. 2022;19:1813–8.
Loh P, van Es R, Groen MHA, Neven K, Kassenberg W, Wittkampf FHM, et al. Pulmonary vein isolation with single pulse irreversible electroporation: a first in human study in 10 patients with atrial fibrillation. Circ Arrhythm Electrophysiol. 2020;13: e008192.
Gunawardene Melanie A, Schaeffer Benjamin N, Jularic M, Eickholt C, Maurer T, Akbulak Ruken Ö, et al. Coronary spasm during pulsed field ablation of the mitral isthmus line. JACC Clin Electrophysiol. 2021;7:1618–20.
Reddy VY, Petru J, Funasako M, Kopriva K, Hala P, Chovanec M, et al. Coronary arterial spasm during pulsed field ablation to treat atrial fibrillation. Circulation. 2022;146:1808–19.
Reddy VY, Anic A, Koruth J, Petru J, Funasako M, Minami K, et al. Pulsed field ablation in patients with persistent atrial fibrillation. J Am Coll Cardiol. 2020;76:1068–80.
Anić A, Phlips T, Brešković T, Koopman P, Girouard S, Mediratta V, et al. Pulsed field ablation using focal contact force-sensing catheters for treatment of atrial fibrillation: acute and 90-day invasive remapping results. Europace. 2023;25:euad147.
Turagam MK, Neuzil P, Schmidt B, Reichlin T, Neven K, Metzner A, et al. Safety and effectiveness of pulsed field ablation to treat atrial fibrillation: one-year outcomes from the MANIFEST-PF registry. Circulation. 2023;148:35–46.
Verma A, Haines DE, Boersma LV, Sood N, Natale A, Marchlinski FE, et al. Pulsed field ablation for the treatment of atrial fibrillation: PULSED AF pivotal trial. Circulation. 2023;147:1422–32.
Duytschaever M, De Potter T, Grimaldi M, Anic A, Vijgen J, Neuzil P, et al. Paroxysmal atrial fibrillation ablation using a novel variable-loop biphasic pulsed field ablation catheter integrated with a 3-dimensional mapping system: 1-year outcomes of the multicenter inspIRE study. Circ Arrhythm Electrophysiol. 2023;16: e011780.
Reddy VY, Gerstenfeld EP, Natale A, Whang W, Cuoco FA, Patel C, et al. Pulsed field or conventional thermal ablation for paroxysmal atrial fibrillation. N Engl J Med. 2023;389:1660–71.
Rovaris G, Ciconte G, Schiavone M, Mitacchione G, Gasperetti A, Piazzi E, et al. Second-generation laser balloon ablation for the treatment of atrial fibrillation assessed by continuous rhythm monitoring: the LIGHT-AF study. Europace. 2021;23:1380–90.
Schmidt B, Neuzil P, Luik A, Osca Asensi J, Schrickel JW, Deneke T, et al. Laser balloon or wide-area circumferential irrigated radiofrequency ablation for persistent atrial fibrillation: a multicenter prospective randomized study. Circ Arrhythm Electrophysiol. 2017;10: e005767.
Chun JKR, Bordignon S, Last J, Mayer L, Tohoku S, Zanchi S, et al. Cryoballoon versus laserballoon: insights from the first prospective randomized balloon trial in catheter ablation of atrial fibrillation. Circ Arrhythm Electrophysiol. 2021;14: e009294.
Ye W, Chen Q, Fan G, Zhou X, Wang X, Mao W, et al. Efficacy and safety of visually guided laser balloon versus cryoballoon ablation for paroxysmal atrial fibrillation: a systematic review and metaanalysis. Front Cardiovasc Med. 2023;10:1229223.
Schiavone M, Gasperetti A, Montemerlo E, Pozzi M, Sabato F, Piazzi E, et al. Long-term comparisons of atrial fibrillation ablation outcomes with a cryoballoon or laser-balloon: a propensity-matched analysis based on continuous rhythm monitoring. Hellenic J Cardiol. 2022;65:1–7.
Proietti R, Pecoraro V, Di Biase L, Natale A, Santangeli P, Viecca M, et al. Remote magnetic with open-irrigated catheter vs. manual navigation for ablation of atrial fibrillation: a systematic review and metaanalysis. Europace. 2013;15:1241–8.
Jia K, Jin Q, Liu A, Wu L. Remote magnetic navigation versus manual control navigation for atrial fibrillation ablation: a systematic review and metaanalysis. J Electrocardiol. 2019;55:78–86.
Li X, Bao Y, Jia K, Zhang N, Lin C, Wei Y, et al. Comparison of the mid-term outcomes of robotic magnetic navigation-guided radiofrequency ablation versus cryoballoon ablation for persistent atrial fibrillation. J Cardiovasc Dev Dis. 2022;9:88.
Verma A, Feld GK, Cox JL, Dewland TA, Babkin A, De Potter T, et al. Combined pulsed field ablation with ultra-low temperature cryoablation: a preclinical experience. J Cardiovasc Electrophysiol. 2022;34:2124–33.
Hilbert S, Sommer P, Gutberlet M, Gaspar T, Foldyna B, Piorkowski C, et al. Real-time magnetic resonance-guided ablation of typical right atrial flutter using a combination of active catheter tracking and passive catheter visualization in man: initial results from a consecutive patient series. Europace. 2016;18:572–7.
Lehmann HI, Graeff C, Simoniello P, Constantinescu A, Takami M, Lugenbiel P, et al. Feasibility study on cardiac arrhythmia ablation using high-energy heavy ion beams. Sci Rep. 2016;6:38895.
Ströker E, de Asmundis C, Kupics K, Takarada K, Mugnai G, De Cocker J, et al. Value of ultrasound for access guidance and detection of subclinical vascular complications in the setting of atrial fibrillation cryoballoon ablation. Europace. 2019;21:434–9.
Wynn GJ, Haq I, Hung J, Bonnett LJ, Lewis G, Webber M, et al. Improving safety in catheter ablation for atrial fibrillation: a prospective study of the use of ultrasound to guide vascular access. J Cardiovasc Electrophysiol. 2014;25:680–5.
Yamagata K, Wichterle D, Roubicek T, Jarkovsky P, Sato Y, Kogure T, et al. Ultrasound-guided versus conventional femoral venipuncture for catheter ablation of atrial fibrillation: a multicentre randomized efficacy and safety trial (ULTRA-FAST trial). Europace. 2018;20:1107–14.
Sharma PS, Padala SK, Gunda S, Koneru JN, Ellenbogen KA. Vascular complications during catheter ablation of cardiac arrhythmias: a comparison between vascular ultrasound guided access and conventional vascular access. J Cardiovasc Electrophysiol. 2016;27:1160–6.
Pellegrino PL, Di Monaco A, Santoro F, Grimaldi M, D’Arienzo G, Casavecchia G, et al. Near zero vascular complications using echo-guided puncture during catheter ablation of arrhythmias: a retrospective study and literature review. J Arrhythm. 2022;38:395–9.
Sobolev M, Shiloh AL, Di Biase L, Slovut DP. Ultrasound-guided cannulation of the femoral vein in electrophysiological procedures: a systematic review and metaanalysis. Europace. 2017;19:850–5.
Wang TKM, Wang MTM, Martin A. Metaanalysis of ultrasound-guided vs conventional vascular access for cardiac electrophysiology procedures. J Arrhythm. 2019;35:858–62.
Verma A, Debruyne P, Nardi S, Deneke T, DeGreef Y, Spitzer S, et al. Evaluation and reduction of asymptomatic cerebral embolism in ablation of atrial fibrillation, but high prevalence of chronic silent infarction: results of the evaluation of reduction of asymptomatic cerebral embolism trial. Circ Arrhythm Electrophysiol. 2013;6:835–42.
Yu Y, Wang X, Li X, Zhou X, Liao S, Yang W, et al. Higher incidence of asymptomatic cerebral emboli after atrial fibrillation ablation found with high-resolution diffusion-weighted magnetic resonance imaging. Circ Arrhythm Electrophysiol. 2020;13: e007548.
Briceno DF, Villablanca PA, Lupercio F, Kargoli F, Jagannath A, Londono A, et al. Clinical impact of heparin kinetics during catheter ablation of atrial fibrillation: metaanalysis and meta-regression. J Cardiovasc Electrophysiol. 2016;27:683–93.
Maleki K, Mohammadi R, Hart D, Cotiga D, Farhat N, Steinberg JS. Intracardiac ultrasound detection of thrombus on transseptal sheath: incidence, treatment, and prevention. J Cardiovasc Electrophysiol. 2005;16:561–5.
Ren JF, Marchlinski FE, Callans DJ, Gerstenfeld EP, Dixit S, Lin D, et al. Increased intensity of anticoagulation may reduce risk of thrombus during atrial fibrillation ablation procedures in patients with spontaneous echo contrast. J Cardiovasc Electrophysiol. 2005;16:474–7.
Bruce CJ, Friedman PA, Narayan O, Munger TM, Hammill SC, Packer DL, et al. Early heparinization decreases the incidence of left atrial thrombi detected by intracardiac echocardiography during radiofrequency ablation for atrial fibrillation. J Interv Card Electrophysiol. 2008;22:211–9.
Asbach S, Biermann J, Bode C, Faber TS. Early heparin administration reduces risk for left atrial thrombus formation during atrial fibrillation ablation procedures. Cardiol Res Pract. 2011;2011: 615087.
Di Biase L, Gaita F, Toso E, Santangeli P, Mohanty P, Rutledge N, et al. Does periprocedural anticoagulation management of atrial fibrillation affect the prevalence of silent thromboembolic lesion detected by diffusion cerebral magnetic resonance imaging in patients undergoing radiofrequency atrial fibrillation ablation with open irrigated catheters? Results from a prospective multicenter study. Heart Rhythm. 2014;11:791–8.
Meininghaus DG, Blembel K, Waniek C, Kruells-Muench J, Ernst H, Kleemann T, et al. Temperature monitoring and temperature-driven irrigated radiofrequency energy titration do not prevent thermally induced esophageal lesions in pulmonary vein isolation: a randomized study controlled by esophagoscopy before and after catheter ablation. Heart Rhythm. 2021;18:926–34.
Schoene K, Arya A, Grashoff F, Knopp H, Weber A, Lerche M, et al. Oesophageal probe evaluation in radiofrequency ablation of atrial fibrillation (OPERA): results from a prospective randomized trial. Europace. 2020;22:1487–94.
Deneke T, Nentwich K, Berkovitz A, Sonne K, Ene E, Pavlov B, et al. High-resolution infrared thermal imaging of the esophagus during atrial fibrillation ablation as a predictor of endoscopically detected thermal lesions. Circ Arrhythm Electrophysiol. 2018;11: e006681.
Ayoub T, El Hajjar AH, Singh Sidhu GD, Bhatnagar A, Zhang Y, Mekhael M, et al. Esophageal temperature during atrial fibrillation ablation poorly predicts esophageal injury: an observational study. Heart Rhythm. 2021;O2(2):570–7.
Ha FJ, Han HC, Sanders P, Teh AW, O’Donnell D, Farouque O, et al. Prevalence and prevention of oesophageal injury during atrial fibrillation ablation: a systematic review and metaanalysis. Europace. 2019;21:80–90.
Chen S, Schmidt B, Seeger A, Bordignon S, Tohoku S, Willems F, et al. Catheter ablation of atrial fibrillation using ablation index-guided high power (50 W) for pulmonary vein isolation with or without esophageal temperature probe (the AI-HP ESO II). Heart Rhythm. 2020;17:1833–40.
Garcia R, Waldmann V, Vanduynhoven P, Nesti M, Jansen de Oliveira Figueiredo M, Narayanan K, et al. Worldwide sedation strategies for atrial fibrillation ablation: current status and evolution over the last decade. Europace. 2021;23:2039–45.
Dada RS, Hayanga JWA, Woods K, Schwartzman D, Thibault D, Ellison M, et al. Anesthetic choice for atrial fibrillation ablation: a national anesthesia clinical outcomes registry analysis. J Cardiothorac Vasc Anesth. 2021;35:2600–6.
Di Biase L, Conti S, Mohanty P, Bai R, Sanchez J, Walton D, et al. General anesthesia reduces the prevalence of pulmonary vein reconnection during repeat ablation when compared with conscious sedation: results from a randomized study. Heart Rhythm. 2011;8:368–72.
Chikata A, Kato T, Yaegashi T, Sakagami S, Kato C, Saeki T, et al. General anesthesia improves contact force and reduces gap formation in pulmonary vein isolation: a comparison with conscious sedation. Heart Vessels. 2017;32:997–1005.
Martin CA, Curtain JP, Gajendragadkar PR, Begley DA, Fynn SP, Grace AA, et al. Improved outcome and cost effectiveness in ablation of persistent atrial fibrillation under general anaesthetic. Europace. 2018;20:935–42.
Pang N, Gao J, Zhang N, Zhang B, Wang R. Comparison of the different anesthesia strategies for atrial fibrillation catheter ablation: a systematic review and metaanalysis. Cardiol Res Pract. 2022;2022:1124372.
Weinmann K, Heudorfer R, Lenz A, Aktolga D, Rattka M, Bothner C, et al. Safety of conscious sedation in electroanatomical mapping procedures and cryoballoon pulmonary vein isolation. Heart Vessels. 2021;36:561–7.
Wasserlauf J, Knight BP, Li Z, Andrei AC, Arora R, Chicos AB, et al. Moderate sedation reduces lab time compared to general anesthesia during cryoballoon ablation for AF without compromising safety or long-term efficacy. Pacing Clin Electrophysiol. 2016;39:1359–65.
Tohoku S, Schmidt B, Bordignon S, Chen S, Bologna F, Chun JK. Initial clinical experience of pulmonary vein isolation using the ultra-low temperature cryoablation catheter for patients with atrial fibrillation. J Cardiovasc Electrophysiol. 2022;33:1371–9.
Schmidt B, Bordignon S, Tohoku S, Chen S, Bologna F, Urbanek L, et al. 5S study: safe and simple single shot pulmonary vein isolation with pulsed field ablation using sedation. Circ Arrhythm Electrophysiol. 2022;15: e010817.
Iacopino S, Colella J, Dini D, Mantovani L, Sorrenti PF, Malacrida M, et al. Sedation strategies for pulsed-field ablation of atrial fibrillation: focus on deep sedation with intravenous ketamine in spontaneous respiration. Europace. 2023;25:euad230.
Grimaldi M, Quadrini F, Caporusso N, Troisi F, Vitulano N, Delmonte V, et al. Deep sedation protocol during atrial fibrillation ablation using a novel variable-loop biphasic pulsed field ablation catheter. Europace. 2023;25:euad222.
Kumar S, Morton JB, Halloran K, Spence SJ, Lee G, Wong MC, et al. Effect of respiration on catheter-tissue contact force during ablation of atrial arrhythmias. Heart Rhythm. 2012;9:1041-7.e1.
Sivasambu B, Hakim JB, Barodka V, Chrispin J, Berger RD, Ashikaga H, et al. Initiation of a high-frequency jet ventilation strategy for catheter ablation for atrial fibrillation: safety and outcomes data. JACC Clin Electrophysiol. 2018;4:1519–25.
Aizer A, Qiu JK, Cheng AV, Wu PB, Barbhaiya CR, Jankelson L, et al. Rapid pacing and high-frequency jet ventilation additively improve catheter stability during atrial fibrillation ablation. J Cardiovasc Electrophysiol. 2020;31:1678–86.
Fernandez-Bustamante A, Ibañez V, Alfaro JJ, de Miguel E, Germán MJ, Mayo A, et al. High-frequency jet ventilation in interventional bronchoscopy: factors with predictive value on high-frequency jet ventilation complications. J Clin Anesth. 2006;18:349–56.
Babapoor-Farrokhran S, Alzubi J, Port Z, Khraisha O, Mainigi SK. Utility of high-frequency jet ventilation in atrial fibrillation ablation. J Innov Card Rhythm Manag. 2021;12:4590–3.
Osorio J, Varley A, Kreidieh O, Godfrey B, Schrappe G, Rajendra A, et al. High-frequency, low-tidal-volume mechanical ventilation safely improves catheter stability and procedural efficiency during radiofrequency ablation of atrial fibrillation. Circ Arrhythm Electrophysiol. 2022;15: e010722.
Gabriels J, Donnelly J, Khan M, Anca D, Beldner S, Willner J, et al. High-frequency, low tidal volume ventilation to improve catheter stability during atrial fibrillation ablation. JACC Clin Electrophysiol. 2019;5:1224–6.
Kadado AJ, Gobeil K, Fakhoury F, Pervaiz A, Chalhoub F. Very low tidal volume, high-frequency ventilation in atrial fibrillation ablation: a systematic review. J Interv Card Electrophysiol. 2022;64:539–43.
Osorio J, Zei PC, Díaz JC, Varley AL, Morales GX, Silverstein JR, et al. High-frequency low-tidal-volume ventilation improves long-term outcomes in atrial fibrillation ablation: a multicenter prospective study. JACC Clin Electrophysiol. 2023;9:1543–54.
Hoyt H, Bhonsale A, Chilukuri K, Alhumaid F, Needleman M, Edwards D, et al. Complications arising from catheter ablation of atrial fibrillation: temporal trends and predictors. Heart Rhythm. 2011;8:1869–74.
Deshmukh A, Patel NJ, Pant S, Shah N, Chothani A, Mehta K, et al. In-hospital complications associated with catheter ablation of atrial fibrillation in the United States between 2000 and 2010: analysis of 93 801 procedures. Circulation. 2013;128:2104–12.
Iqbal AM, Li KY, Aznaurov SG, Lugo RM, Venkataraman R, Gautam S. Catheter ablation for atrial fibrillation can be safely performed without invasive hemodynamic monitoring: a multi-center study. J Interv Card Electrophysiol. 2022;64:743–9.
Deneke T, Shin DI, Balta O, Bünz K, Fassbender F, Mügge A, et al. Postablation asymptomatic cerebral lesions: long-term follow-up using magnetic resonance imaging. Heart Rhythm. 2011;8:1705–11.
Maleki K, Mohammadi R, Hart D, Cotiga D, Farhat N, Steinberg JS. Intracardiac ultrasound detection of thrombus on transseptal sheath: incidence, treatment, and prevention. J Cardiovasc Electrophysiol. 2005;16:561–5.
Zhang RF, Ma CM, Wang N, Yang MH, Li WW, Yin XM, et al. Appropriate intraprocedural initial heparin dosing in patients undergoing catheter ablation for atrial fibrillation receiving uninterrupted non-vitamin-K antagonist oral anticoagulant treatment. BMC Cardiovasc Disord. 2021;21:214.
Benali K, Verain J, Hammache N, Guenancia C, Hooks D, Magnin-Poull I, et al. Running after activated clotting time values in patients receiving direct oral anticoagulants: a potentially dangerous race. Results from a prospective study in atrial fibrillation catheter ablation procedures. J Clin Med. 2021;10:4240.
Hohnloser SH, Camm AJ, Cappato R, Diener HC, Heidbuchel H, Mont L, et al. Periprocedural anticoagulation in the uninterrupted edoxaban vs. vitamin K antagonists for ablation of atrial fibrillation (ELIMINATE-AF) trial. Europace. 2021;23:65–72.
Calkins H, Willems S, Verma A, Schilling R, Hohnloser SH, Okumura K, et al. Heparin dosing in uninterrupted anticoagulation with dabigatran vs. warfarin in atrial fibrillation ablation: RE-CIRCUIT study. Europace. 2019;21:879–85.
Payne JE, Koerber SM, Bickel T, Ghadban R, Flaker G, Gautam S. Higher initial weight-based heparin dosing is required with direct oral anticoagulants during catheter ablation for atrial fibrillation. J Interv Card Electrophysiol. 2020;58:185–91.
Martin AC, Kyheng M, Foissaud V, Duhamel A, Marijon E, Susen S, et al. Activated clotting time monitoring during atrial fibrillation catheter ablation: does the anticoagulant matter? J Clin Med. 2020;9:350.
Songqun H, Chunling W, Zhifu G, Xinmiao H, Jiang C. Effects of rivaroxaban on activated clotting time in catheter ablation for atrial fibrillation in Chinese patients. J Interv Card Electrophysiol. 2020;59:509–16.
Safani M, Tobias S, Shandling AH, Redmond K, Lee MY. Comprehensive intraprocedural unfractionated heparin protocol during catheter ablation of atrial fibrillation in the presence of direct oral anticoagulants and wide spectrum of body mass index. J Cardiovasc Pharmacol Ther. 2021;26:349–58.
Ghannam M, Chugh A, Dillon P, Alyesh D, Kossidas K, Sharma S, et al. Protamine to expedite vascular hemostasis after catheter ablation of atrial fibrillation: a randomized controlled trial. Heart Rhythm. 2018;15:1642–7.
Pollack CV Jr, Reilly PA, van Ryn J, Eikelboom JW, Glund S, Bernstein RA, et al. Idarucizumab for dabigatran reversal. N Engl J Med. 2015;373:511–20.
Siegal DM, Curnutte JT, Connolly SJ, Lu G, Conley PB, Wiens BL, et al. Andexanet alfa for the reversal of factor Xa inhibitor activity. N Engl J Med. 2015;373:2413–24.
Steffel J, Collins R, Antz M, Cornu P, Desteghe L, Haeusler KG, et al. 2021 European heart rhythm association practical guide on the use of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation. Europace. 2021;23:1612–76.
Hsu JC, Badhwar N, Gerstenfeld EP, Lee RJ, Mandyam MC, Dewland TA, et al. Randomized trial of conventional transseptal needle versus radiofrequency energy needle puncture for left atrial access (the TRAVERSE-LA study). J Am Heart Assoc. 2013;2: e000428.
Andrade JG, Macle L, Bennett MT, Hawkins NM, Essebag V, Champagne J, et al. Randomized trial of conventional versus radiofrequency needle transseptal puncture for cryoballoon ablation: the CRYO-LATS trial. J Interv Card Electrophysiol. 2022;65:481–9.
Tokuda M, Yamashita S, Matsuo S, Kato M, Sato H, Oseto H, et al. Radiofrequency needle for transseptal puncture is associated with lower incidence of thromboembolism during catheter ablation of atrial fibrillation: propensity score-matched analysis. Heart Vessels. 2018;33:1238–44.
Chow AWC, Cobb V, Sepahpour A, McCready JW. Transseptal puncture performed with the new needle-free ‘SafeSept’ guidewire: a multicentre experience. J Interv Card Electrophysiol. 2020;59:29–34.
Maclean E, Mahtani K, Roelas M, Vyas R, Butcher C, Ahluwalia N, et al. Transseptal puncture for left atrial ablation: risk factors for cardiac tamponade and a proposed causative classification system. J Cardiovasc Electrophysiol. 2022;33:1747–55.
Stauber A, Kornej J, Sepehri Shamloo A, Dinov B, Bacevicius J, Dagres N, et al. Impact of single versus double transseptal puncture on outcome and complications in pulmonary vein isolation procedures. Cardiol J. 2021;28:671–7.
Deyell MW, Wen G, Laksman Z, Bennett MT, Chakrabarti S, Yeung-Lai-Wah JA, et al. The impact of steerable sheaths on unblinded contact force during catheter ablation for atrial fibrillation. J Interv Card Electrophysiol. 2020;57:417–24.
Piorkowski C, Eitel C, Rolf S, Bode K, Sommer P, Gaspar T, et al. Steerable versus nonsteerable sheath technology in atrial fibrillation ablation: a prospective, randomized study. Circ Arrhythm Electrophysiol. 2011;4:157–65.
Janosi K, Debreceni D, Janosa B, Bocz B, Simor T, Kupo P. Visualizable vs. standard, non-visualizable steerable sheath for pulmonary vein isolation procedures: randomized, single-centre trial. Front Cardiovasc Med. 2022;9:1033755.
Rajendra A, Hunter TD, Morales GX, Zei P, Boo LM, Varley A, et al. Steerable sheath visualizable under 3D electroanatomical mapping facilitates paroxysmal atrial fibrillation ablation with minimal fluoroscopy. J Interv Card Electrophysiol. 2023;66:381–8.
Fitzpatrick N, Mittal A, Galvin J, Jauvert G, Keaney J, Keelan E, et al. The impact of steerable sheath visualization during catheter ablation for atrial fibrillation. Europace. 2023.
Khalaph M, Sommer P, Lucas P, Guckel D, Fink T, Sciacca V, et al. First clinical experience using a visualized sheath for atrial fibrillation ablation. Pacing Clin Electrophysiol. 2022;45:922–9.
Goya M, Frame D, Gache L, Ichishima Y, Tayar DO, Goldstein L, et al. The use of intracardiac echocardiography catheters in endocardial ablation of cardiac arrhythmia: metaanalysis of efficiency, effectiveness, and safety outcomes. J Cardiovasc Electrophysiol. 2020;31:664–73.
Xu J, Gao Y, Liu C, Wang Y. Radiofrequency ablation for treatment of atrial fibrillation with the use of intracardiac echocardiography versus without intracardiac echocardiography: a metaanalysis of observational and randomized studies. J Cardiovasc Electrophysiol. 2022;33:897–907.
Pimentel RC, Rahai N, Maccioni S, Khanna R. Differences in outcomes among patients with atrial fibrillation undergoing catheter ablation with versus without intracardiac echocardiography. J Cardiovasc Electrophysiol. 2022;33:2015–47.
La Greca C, Cirasa A, Di Modica D, Sorgato A, Simoncelli U, Pecora D. Advantages of the integration of ICE and 3D electroanatomical mapping and ultrasound-guided femoral venipuncture in catheter ablation of atrial fibrillation. J Interv Card Electrophysiol. 2021;61:559–66.
Isath A, Padmanabhan D, Haider SW, Siroky G, Perimbeti S, Correa A, et al. Does the use of intracardiac echocardiography during atrial fibrillation catheter ablation improve outcomes and cost? A nationwide 14-year analysis from 2001 to 2014. J Interv Card Electrophysiol. 2021;61:461–8.
Deshpande S, Sawatari H, Ahmed R, Nair RG, Khan H, Khanji MY, et al. Impact of intracardiac echocardiography on readmission morbidity and mortality following atrial fibrillation ablation. J Cardiovasc Electrophysiol. 2022;33:2496–503.
Ren JF, Chen S, Callans DJ, Jiang C, Marchlinski FE. Role of intracardiac echocardiography for catheter ablation of atrial fibrillation: reduction of complications and mortality. J Am Coll Cardiol. 2020;75:1244–5.
Catanzariti D, Maines M, Angheben C, Centonze M, Cemin C, Vergara G. Usefulness of contrast intracardiac echocardiography in performing pulmonary vein balloon occlusion during cryo-ablation for atrial fibrillation. Indian Pacing Electrophysiol J. 2012;12:237–49.
Makino Y, Mizutani Y, Yamashita D, Yonekawa J, Satake A, Kurobe M, et al. Cryoballoon ablation for atrial fibrillation without the use of a contrast medium: a combination of the intracardiac echocardiography and pressure wave monitoring guided approach. Heart Vessels. 2022;37:765–74.
Suzuki A, Fujiwara R, Asada H, Iwasa K, Miyata T, Song WH, et al. Peri-balloon leak flow velocity assessed by intracardiac echography predicts pulmonary vein electrical gap-intracardiac echography-guided contrast-free cryoballoon ablation. Circ J. 2022;86:256–65.
Kanda T, Masuda M, Kurata N, Asai M, Iida O, Okamoto S, et al. A saline contrast-enhanced echocardiography-guided approach to cryoballoon ablation. Pacing Clin Electrophysiol. 2020;43:664–70.
Motoike Y, Harada M, Ito T, Nomura Y, Nishimura A, Koshikawa M, et al. Wall thickness-based adjustment of ablation index improves efficacy of pulmonary vein isolation in atrial fibrillation: real-time assessment by intracardiac echocardiography. J Cardiovasc Electrophysiol. 2021;32:1620–30.
Chen J, Einstein AJ, Fazel R, Krumholz HM, Wang Y, Ross JS, et al. Cumulative exposure to ionizing radiation from diagnostic and therapeutic cardiac imaging procedures: a population-based analysis. J Am Coll Cardiol. 2010;56:702–11.
Lickfett L, Mahesh M, Vasamreddy C, Bradley D, Jayam V, Eldadah Z, et al. Radiation exposure during catheter ablation of atrial fibrillation. Circulation. 2004;110:3003–10.
Ector J, Dragusin O, Adriaenssens B, Huybrechts W, Willems R, Ector H, et al. Obesity is a major determinant of radiation dose in patients undergoing pulmonary vein isolation for atrial fibrillation. J Am Coll Cardiol. 2007;50:234–42.
Voskoboinik A, Kalman ES, Savicky Y, Sparks PB, Morton JB, Lee G, et al. Reduction in radiation dose for atrial fibrillation ablation over time: a 12-year single-center experience of 2344 patients. Heart Rhythm. 2017;14:810–6.
Lee G, Hunter RJ, Lovell MJ, Finlay M, Ullah W, Baker V, et al. Use of a contact force-sensing ablation catheter with advanced catheter location significantly reduces fluoroscopy time and radiation dose in catheter ablation of atrial fibrillation. Europace. 2016;18:211–8.
Walters TE, Kistler PM, Morton JB, Sparks PB, Halloran K, Kalman JM. Impact of collimation on radiation exposure during interventional electrophysiology. Europace. 2012;14:1670–3.
Schneider R, Lauschke J, Schneider C, Tischer T, Glass A, Bänsch D. Reduction of radiation exposure during ablation of atrial fibrillation. Herz. 2015;40:883–91.
Heidbuchel H, Wittkampf FH, Vano E, Ernst S, Schilling R, Picano E, et al. Practical ways to reduce radiation dose for patients and staff during device implantations and electrophysiological procedures. Europace. 2014;16:946–64.
Sommer P, Sciacca V, Anselmino M, Tilz R, Bourier F, Lehrmann H, et al. Practical guidance to reduce radiation exposure in electrophysiology applying ultra low-dose protocols: a European heart rhythm association review. Europace. 2023;25:euad191.
Zei PC, Quadros KK, Clopton P, Thosani A, Ferguson J, Brodt C, et al. Safety and efficacy of minimal- versus zero-fluoroscopy radiofrequency catheter ablation for atrial fibrillation: a multicenter, prospective study. J Innov Card Rhythm Manag. 2020;11:4281–91.
Tahin T, Riba A, Nemeth B, Arvai F, Lupkovics G, Szeplaki G, et al. Implementation of a zero fluoroscopic workflow using a simplified intracardiac echocardiography guided method for catheter ablation of atrial fibrillation, including repeat procedures. BMC Cardiovasc Disord. 2021;21:407.
Lyan E, Tsyganov A, Abdrahmanov A, Morozov A, Bakytzhanuly A, Tursunbekov A, et al. Nonfluoroscopic catheter ablation of paroxysmal atrial fibrillation. Pacing Clin Electrophysiol. 2018;41:611–9.
Falasconi G, Penela D, Soto-Iglesias D, Jauregui B, Chauca A, Antonio RS, et al. A standardized stepwise zero-fluoroscopy approach with transesophageal echocardiography guidance for atrial fibrillation ablation. J Interv Card Electrophysiol. 2022;64:629–39.
Bulava A, Hanis J, Eisenberger M. Catheter ablation of atrial fibrillation using zero-fluoroscopy technique: a randomized trial. Pacing Clin Electrophysiol. 2015;38:797–806.
Lurie A, Amit G, Divakaramenon S, Acosta JG, Healey JS, Wong JA. Outcomes and safety of fluoroless catheter ablation for atrial fibrillation. CJC Open. 2021;3:303–10.
Sommer P, Bertagnolli L, Kircher S, Arya A, Bollmann A, Richter S, et al. Safety profile of near-zero fluoroscopy atrial fibrillation ablation with non-fluoroscopic catheter visualization: experience from 1000 consecutive procedures. Europace. 2018;20:1952–8.
Enriquez A, Velasco A, Diaz JC, Sadek M, Osorio J, Zei P, et al. Fluoroless catheter ablation of atrial fibrillation: a step-by-step workflow. J Interv Card Electrophysiol. 2023;66:1291–301.
Ahn J, Shin DG, Han S-J, Lim HE. Safety and efficacy of intracardiac echocardiography–guided zero-fluoroscopic cryoballoon ablation for atrial fibrillation: a prospective randomized controlled trial. Europace. 2023;25:euad086.
Alyesh D, Venkataraman G, Stucky A, Joyner J, Choe W, Sundaram S. Acute safety and efficacy of fluoroless cryoballoon ablation for atrial fibrillation. J Innov Card Rhythm Manag. 2021;12:4413–20.
Halbfass P, Pavlov B, Müller P, Nentwich K, Sonne K, Barth S, et al. Progression from esophageal thermal asymptomatic lesion to perforation complicating atrial fibrillation ablation: a single-center registry. Circ Arrhythm Electrophysiol. 2017;10: e005233.
Ripley KL, Gage AA, Olsen DB, Van Vleet JF, Lau CP, Tse HF. Time course of esophageal lesions after catheter ablation with cryothermal and radiofrequency ablation: implication for atrio-esophageal fistula formation after catheter ablation for atrial fibrillation. J Cardiovasc Electrophysiol. 2007;18:642–6.
Tschabrunn CM, Silverstein J, Berzin T, Ellis E, Buxton AE, Josephson ME, et al. Comparison between single- and multisensor oesophageal temperature probes during atrial fibrillation ablation: thermodynamic characteristics. Europace. 2015;17:891–7.
Turagam MK, Miller S, Sharma SP, Prakash P, Gopinathannair R, Lakkireddy P, et al. Differences in transient thermal response of commercial esophageal temperature probes: insights from an experimental study. JACC Clin Electrophysiol. 2019;5:1280–8.
Barbhaiya CR, Kogan EV, Jankelson L, Knotts RJ, Spinelli M, Bernstein S, et al. Esophageal temperature dynamics during high-power short-duration posterior wall ablation. Heart Rhythm. 2020;17:721–7.
Bhardwaj R, Naniwadekar A, Whang W, Mittnacht AJ, Palaniswamy C, Koruth JS, et al. Esophageal deviation during atrial fibrillation ablation: clinical experience with a dedicated esophageal balloon retractor. JACC Clin Electrophysiol. 2018;4:1020–30.
Hamed M, Elseidy SA, Abdelazeem M, Morcos R, Abdallah A, Sammour Y, et al. Role of oesophageal cooling in the prevention of oesophageal injury in atrial fibrillation catheter ablation: a systematic review and metaanalysis of randomized controlled trials. Europace. 2023;25:euad080.
Leung LWM, Bajpai A, Zuberi Z, Li A, Norman M, Kaba RA, et al. Randomized comparison of oesophageal protection with a temperature control device: results of the IMPACT study. Europace. 2021;23:205–15.
Joseph C, Nazari J, Zagrodzky J, Brumback B, Sherman J, Zagrodzky W, et al. Improved 1-year outcomes after active cooling during left atrial radiofrequency ablation. J Interv Card Electrophysiol. 2023;66:1621–9.
Sanchez J, Woods C, Zagrodzky J, Nazari J, Singleton MJ, Schricker A, et al. Atrioesophageal fistula rates before and after adoption of active esophageal cooling during atrial fibrillation ablation. JACC Clin Electrophysiol. 2023;9:2558–70.
Teres C, Soto-Iglesias D, Penela D, Falasconi G, Viveros D, Meca-Santamaria J, et al. Relationship between the posterior atrial wall and the esophagus: esophageal position and temperature measurement during atrial fibrillation ablation (AWESOME-AF). A randomized controlled trial. J Interv Card Electrophysiol. 2022;65:651–61.
Zhang X, Kuang X, Gao X, Xiang H, Wei F, Liu T, et al. RESCUE-AF in patients undergoing atrial fibrillation ablation: the RESCUE-AF trial. Circ Arrhythm Electrophysiol. 2019;12: e007044.
Reddy VY, Dukkipati SR, Neuzil P, Natale A, Albenque J-P, Kautzner J, et al. Randomized, controlled trial of the safety and effectiveness of a contact force-sensing irrigated catheter for ablation of paroxysmal atrial fibrillation: results of the TactiCath contact force ablation catheter study for atrial fibrillation (TOCCASTAR) study. Circulation. 2015;132:907–15.
Arentz T, Jander N, von Rosenthal J, Blum T, Fürmaier R, Görnandt L, et al. Incidence of pulmonary vein stenosis 2 years after radiofrequency catheter ablation of refractory atrial fibrillation. Eur Heart J. 2003;24:963–9.
Mochizuki A, Nagahara D, Kamiyama N, Fujito T, Miura T. Revaluation of the significance of demonstrable exit block after radiofrequency pulmonary vein isolation. Circ Rep. 2020;2:218–25.
Duytschaever M, De Meyer G, Acena M, El-Haddad M, De Greef Y, Van Heuverswyn F, et al. Lessons from dissociated pulmonary vein potentials: entry block implies exit block. Europace. 2013;15:805–12.
Chen S, Meng W, Sheng He D, Chen G, Zhang F, Yan Y, et al. Blocking the pulmonary vein to left atrium conduction in addition to the entrance block enhances clinical efficacy in atrial fibrillation ablation. Pacing Clin Electrophysiol. 2012;35:524–31.
Wang X-h, Liu X, Sun Y-m, Gu J-n, Shi H-f, Zhou L, et al. Early identification and treatment of PV re-connections: role of observation time and impact on clinical results of atrial fibrillation ablation. Europace. 2007;9:481–6.
Jiang CY, Jiang RH, Matsuo S, Liu Q, Fan YQ, Zhang ZW, et al. Early detection of pulmonary vein reconnection after isolation in patients with paroxysmal atrial fibrillation: a comparison of ATP-induction and reassessment at 30 minutes postisolation. J Cardiovasc Electrophysiol. 2009;20:1382–7.
Cheema A, Dong J, Dalal D, Marine JE, Henrikson CA, Spragg D, et al. Incidence and time course of early recovery of pulmonary vein conduction after catheter ablation of atrial fibrillation. J Cardiovasc Electrophysiol. 2007;18:387–91.
Brunelli M, Raffa S, Große A, Hanazawa K, Sammut M, Roos M, et al. Residual conduction after pulmonary vein isolation with a circular multielectrode radiofrequency ablation catheter: the role of adenosine and orciprenalin during a prolonged observation time. Int J Cardiol. 2013;168:4122–31.
Efremidis M, Letsas K, Giannopoulos G, Lioni L, Vlachos K, Asvestas D, et al. Early pulmonary vein reconnection as a predictor of left atrial ablation outcomes for paroxysmal atrial fibrillation. Europace. 2015;17:741–6.
Andrade JG, Deyell MW, Nattel S, Khairy P, Dubuc M, Champagne J, et al. Prevalence and clinical impact of spontaneous and adenosine-induced pulmonary vein reconduction in the contact-force vs. cryoballoon atrial fibrillation ablation (CIRCA-DOSE) study. Heart Rhythm. 2020;17:897–904.
Jiang R, Chen M, Yang B, Liu Q, Zhang Z, Zhang F, et al. Intraprocedural endpoints to predict durable pulmonary vein isolation: a randomized trial of four postablation techniques. Europace. 2020;22:567–75.
Sousa PA, Barra S, Adão L, Primo J, Khoueiry Z, Puga L, et al. Assessment of the need of a waiting period after pulmonary vein isolation with the ablation index software. J Cardiovasc Electrophysiol. 2022;33:1725–33.
Miller MA, d’Avila A, Dukkipati SR, Koruth JS, Viles-Gonzalez J, Napolitano C, et al. Acute electrical isolation is a necessary but insufficient endpoint for achieving durable PV isolation: the importance of closing the visual gap. Europace. 2012;14:653–60.
Macle L, Khairy P, Weerasooriya R, Novak P, Verma A, Willems S, et al. Adenosine-guided pulmonary vein isolation for the treatment of paroxysmal atrial fibrillation: an international, multicentre, randomised superiority trial. Lancet. 2015;386:672–9.
Kapa S, Killu A, Deshmukh A, Mulpuru SK, Asirvatham SJ. Dose-dependent pulmonary vein reconnection in response to adenosine: relevance of atrioventricular block during infusion. J Interv Card Electrophysiol. 2016;47:117–23.
Teunissen C, Clappers N, Kassenberg W, Hassink RJ, van der Heijden JF, Loh P. Time matters: adenosine testing immediately after pulmonary vein isolation does not substitute a waiting period. Europace. 2017;19:1140–5.
McLellan AJA, Kumar S, Smith C, Ling LH, Prabhu S, Kalman JM, et al. The role of adenosine challenge in catheter ablation for atrial fibrillation: a systematic review and metaanalysis. Int J Cardiol. 2017;236:253–61.
Kobori A, Shizuta S, Inoue K, Kaitani K, Morimoto T, Nakazawa Y, et al. Adenosine triphosphate-guided pulmonary vein isolation for atrial fibrillation: the unmasking dormant electrical reconduction by adenosine triphosphate (UNDER-ATP) trial. Eur Heart J. 2015;36:3276–87.
Zeng LJ, Shi L, Tian Y, Wang YJ, Yin XD, Liu XQ, et al. Pace capture and adenosine triphosphate provocation are complementary rather than mutually exclusive methods to ensure durable pulmonary vein isolation. J Cardiovasc Electrophysiol. 2019;30:815–23.
Moser J, Sultan A, Luker J, Servatius H, Salzbrunn T, Altenburg M, et al. 5-Year outcome of pulmonary vein isolation by loss of pace capture on the ablation line versus electrical circumferential pulmonary vein isolation. JACC Clin Electrophysiol. 2017;3:1262–71.
Masuda M, Fujita M, Iida O, Okamoto S, Ishihara T, Nanto K, et al. Pace-capture-guided ablation after contact-force-guided pulmonary vein isolation: results of the randomized controlled DRAGON trial. Europace. 2018;20:1451–8.
Steven D, Sultan A, Reddy V, Luker J, Altenburg M, Hoffmann B, et al. Benefit of pulmonary vein isolation guided by loss of pace capture on the ablation line: results from a prospective 2-center randomized trial. J Am Coll Cardiol. 2013;62:44–50.
Sawhney N, Anousheh R, Chen W, Feld GK. Circumferential pulmonary vein ablation with additional linear ablation results in an increased incidence of left atrial flutter compared with segmental pulmonary vein isolation as an initial approach to ablation of paroxysmal atrial fibrillation. Circ Arrhythm Electrophysiol. 2010;3:243–8.
Ouyang F, Ernst S, Vogtmann T, Goya M, Volkmer M, Schaumann A, et al. Characterization of reentrant circuits in left atrial macroreentrant tachycardia: critical isthmus block can prevent atrial tachycardia recurrence. Circulation. 2002;105:1934–42.
Mujović N, Marinković M, Marković N, Stanković G, Lip GYH, Blomstrom-Lundqvist C, et al. Persistency of left atrial linear lesions after radiofrequency catheter ablation for atrial fibrillation: data from an invasive follow-up electrophysiology study. J Cardiovasc Electrophysiol. 2017;28:1403–14.
Sanchez-Somonte P, Jiang CY, Betts TR, Chen J, Mantovan R, Macle L, et al. Completeness of linear or fractionated electrogram ablation in addition to pulmonary vein isolation on ablation outcome: a substudy of the STAR AF II trial. Circ Arrhythm Electrophysiol. 2021;14: e010146.
Chae S, Oral H, Good E, Dey S, Wimmer A, Crawford T, et al. Atrial tachycardia after circumferential pulmonary vein ablation of atrial fibrillation: mechanistic insights, results of catheter ablation, and risk factors for recurrence. J Am Coll Cardiol. 2007;50:1781–7.
Tzeis S, Luik A, Jilek C, Schmitt C, Estner HL, Wu J, et al. The modified anterior line: an alternative linear lesion in perimitral flutter. J Cardiovasc Electrophysiol. 2010;21:665–70.
Pappone C, Manguso F, Vicedomini G, Gugliotta F, Santinelli O, Ferro A, et al. Prevention of iatrogenic atrial tachycardia after ablation of atrial fibrillation: a prospective randomized study comparing circumferential pulmonary vein ablation with a modified approach. Circulation. 2004;110:3036–42.
Takagi T, Derval N, Duchateau J, Chauvel R, Tixier R, Marchand H, et al. Gaps after linear ablation of persistent atrial fibrillation (Marshall-PLAN): clinical implication. Heart Rhythm. 2023;20:14–21.
Di Biase L, Burkhardt JD, Mohanty P, Sanchez J, Mohanty S, Horton R, et al. Left atrial appendage: an underrecognized trigger site of atrial fibrillation. Circulation. 2010;122:109–18.
Ikenouchi T, Nitta J, Inaba O, Kono T, Murata K, Takamiya T, et al. Effect of isolation feasibility of non-pulmonary vein foci on efficacy of ablation for atrial fibrillation: comparison of the isolation and focal ablation methods. J Interv Card Electrophysiol. 2022;65:441–51.
Della Rocca DG, Di Biase L, Mohanty S, Trivedi C, Gianni C, Romero J, et al. Targeting non-pulmonary vein triggers in persistent atrial fibrillation: results from a prospective, multicentre, observational registry. Europace. 2021;23:1939–49.
Takamiya T, Nitta J, Inaba O, Sato A, Ikenouchi T, Murata K, et al. One-year outcomes after pulmonary vein isolation plus posterior wall isolation and additional non-pulmonary vein trigger ablation for persistent atrial fibrillation with or without contact force sensing: a propensity score-matched comparison. J Interv Card Electrophysiol. 2020;59:585–93.
Zhao Y, Di Biase L, Trivedi C, Mohanty S, Bai R, Mohanty P, et al. Importance of non-pulmonary vein triggers ablation to achieve long-term freedom from paroxysmal atrial fibrillation in patients with low ejection fraction. Heart Rhythm. 2016;13:141–9.
Nakashima T, Pambrun T, Vlachos K, Goujeau C, André C, Krisai P, et al. Impact of vein of Marshall ethanol infusion on mitral isthmus block: efficacy and durability. Circ Arrhythm Electrophysiol. 2020;13: e008884.
Valderrábano M, Liu X, Sasaridis C, Sidhu J, Little S, Khoury DS. Ethanol infusion in the vein of Marshall: adjunctive effects during ablation of atrial fibrillation. Heart Rhythm. 2009;6:1552–8.
Gillis K, O’Neill L, Wielandts JY, Hilfiker G, Almorad A, Lycke M, et al. Vein of Marshall ethanol infusion as first step for mitral isthmus linear ablation. JACC Clin Electrophysiol. 2022;8:367–76.
Yang G, Zheng L, Jiang C, Fan J, Liu X, Zhan X, et al. Circumferential pulmonary vein isolation plus low-voltage area modification in persistent atrial fibrillation: the STABLE-SR-II trial. JACC Clin Electrophysiol. 2022;8:882–91.
Huo Y, Gaspar T, Schönbauer R, Wójcik M, Fiedler L, Roithinger Franz X, et al. Low-voltage myocardium-guided ablation trial of persistent atrial fibrillation. NEJM Evidence. 2022;1:EVIDoa2200141.
Kottkamp H, Berg J, Bender R, Rieger A, Schreiber D. Box isolation of fibrotic areas (BIFA): a patient-tailored substrate modification approach for ablation of atrial fibrillation. J Cardiovasc Electrophysiol. 2016;27:22–30.
Valderrábano M, Peterson LE, Swarup V, Schurmann PA, Makkar A, Doshi RN, et al. Effect of catheter ablation with vein of Marshall ethanol infusion vs catheter ablation alone on persistent atrial fibrillation: the VENUS randomized clinical trial. JAMA. 2020;324:1620–8.
Huang L, Gao M, Lai Y, Guo Q, Li S, Li C, et al. The adjunctive effect for left pulmonary vein isolation of vein of Marshall ethanol infusion in persistent atrial fibrillation. Europace. 2023;25:441–9.
Nakashima T, Pambrun T, Vlachos K, Goujeau C, André C, Krisai P, et al. Strategy for repeat procedures in patients with persistent atrial fibrillation: systematic linear ablation with adjunctive ethanol infusion into the vein of Marshall versus electrophysiology-guided ablation. J Cardiovasc Electrophysiol. 2022;33:1116–24.
Lador A, Peterson LE, Swarup V, Schurmann PA, Makkar A, Doshi RN, et al. Determinants of outcome impact of vein of Marshall ethanol infusion when added to catheter ablation of persistent atrial fibrillation: a secondary analysis of the VENUS randomized clinical trial. Heart Rhythm. 2021;18:1045–54.
Derval N, Duchateau J, Denis A, Ramirez FD, Mahida S, André C, et al. Marshall bundle elimination, pulmonary vein isolation, and line completion for ANATOmical ablation of persistent atrial fibrillation (Marshall-PLAN): prospective, single-center study. Heart Rhythm. 2021;18:529–37.
Dixit S, Marchlinski FE, Lin D, Callans DJ, Bala R, Riley MP, et al. Randomized ablation strategies for the treatment of persistent atrial fibrillation: RASTA study. Circ Arrhythm Electrophysiol. 2012;5:287–94.
Bai R, Di Biase L, Mohanty P, Trivedi C, Dello Russo A, Themistoclakis S, et al. Proven isolation of the pulmonary vein antrum with or without left atrial posterior wall isolation in patients with persistent atrial fibrillation. Heart Rhythm. 2016;13:132–40.
Lee JM, Shim J, Park J, Yu HT, Kim TH, Park JK, et al. The electrical isolation of the left atrial posterior wall in catheter ablation of persistent atrial fibrillation. JACC Clin Electrophysiol. 2019;5:1253–61.
Kistler PM, Chieng D, Sugumar H, Ling LH, Segan L, Azzopardi S, et al. Effect of catheter ablation using pulmonary vein isolation with vs without posterior left atrial wall isolation on atrial arrhythmia recurrence in patients with persistent atrial fibrillation: the CAPLA randomized clinical trial. JAMA. 2023;329:127–35.
Jiang X, Liao J, Ling Z, Meyer C, Sommer P, Futyma P, et al. Adjunctive left atrial posterior wall isolation in treating atrial fibrillation: insight from a large secondary analysis. JACC Clin Electrophysiol. 2022;8:605–18.
Sirico G, Sirico D, Montisci A, Cerrato E, Morosato M, Panigada S, et al. Contact-Force guided posterior wall isolation as an adjunctive ablation strategy for persistent atrial fibrillation. J Atr Fibrillation. 2021;14:20200475.
Tokioka S, Fukamizu S, Kimura T, Takahashi M, Kitamura T, Hojo R. The effect of posterior wall isolation for persistent atrial fibrillation on recurrent arrhythmia. J Cardiovasc Electrophysiol. 2021;32:597–604.
Pothineni NVK, Lin A, Frankel DS, Supple GE, Garcia FC, Lin D, et al. Impact of left atrial posterior wall isolation on arrhythmia outcomes in patients with atrial fibrillation undergoing repeat ablation. Heart Rhythm. 2021;O2(2):489–97.
Salih M, Darrat Y, Ibrahim AM, Al-Akchar M, Bhattarai M, Koester C, et al. Clinical outcomes of adjunctive posterior wall isolation in persistent atrial fibrillation: a metaanalysis. J Cardiovasc Electrophysiol. 2020;31:1394–402.
Sutter JS, Lokhnygina Y, Daubert JP, Bahnson T, Jackson K, Koontz JI, et al. Safety and efficacy outcomes of left atrial posterior wall isolation compared to pulmonary vein isolation and pulmonary vein isolation with linear ablation for the treatment of persistent atrial fibrillation. Am Heart J. 2020;220:89–96.
Yamaji H, Higashiya S, Murakami T, Hina K, Kawamura H, Murakami M, et al. Efficacy of an adjunctive electrophysiological test-guided left atrial posterior wall isolation in persistent atrial fibrillation without a left atrial low-voltage area. Circ Arrhythm Electrophysiol. 2020;13: e008191.
McLellan AJA, Prabhu S, Voskoboinik A, Wong MCG, Walters TE, Pathik B, et al. Isolation of the posterior left atrium for patients with persistent atrial fibrillation: routine adenosine challenge for dormant posterior left atrial conduction improves long-term outcome. Europace. 2017;19:1958–66.
Kim JS, Shin SY, Na JO, Choi CU, Kim SH, Kim JW, et al. Does isolation of the left atrial posterior wall improve clinical outcomes after radiofrequency catheter ablation for persistent atrial fibrillation?: a prospective randomized clinical trial. Int J Cardiol. 2015;181:277–83.
Bisbal F, Benito E, Teis A, Alarcón F, Sarrias A, Caixal G, et al. Magnetic resonance imaging-guided fibrosis ablation for the treatment of atrial fibrillation: the ALICIA trial. Circ Arrhythm Electrophysiol. 2020;13: e008707.
Marrouche NF, Wazni O, McGann C, Greene T, Dean JM, Dagher L, et al. Effect of MRI-guided fibrosis ablation vs conventional catheter ablation on atrial arrhythmia recurrence in patients with persistent atrial fibrillation: the DECAAF II randomized clinical trial. JAMA. 2022;327:2296–305.
Ip JE, Markowitz SM, Cheung JW, Liu CF, Thomas G, Lessner SJ, et al. Method for differentiating left superior pulmonary vein exit conduction from pseudo-exit conduction. Pacing Clin Electrophysiol. 2013;36:299–308.
Vijayaraman P, Dandamudi G, Naperkowski A, Oren J, Storm R, Ellenbogen KA. Assessment of exit block following pulmonary vein isolation: far-field capture masquerading as entrance without exit block. Heart Rhythm. 2012;9:1653–9.
Squara F, Liuba I, Chik W, Santangeli P, Zado ES, Callans DJ, et al. Loss of local capture of the pulmonary vein myocardium after antral isolation: prevalence and clinical significance. J Cardiovasc Electrophysiol. 2015;26:242–50.
Gerstenfeld EP, Dixit S, Callans D, Rho R, Rajawat Y, Zado E, et al. Utility of exit block for identifying electrical isolation of the pulmonary veins. J Cardiovasc Electrophysiol. 2002;13:971–9.
Tada H, Oral H, Wasmer K, Greenstein R, Pelosi F, Knight BP, et al. Pulmonary vein isolation: comparison of bipolar and unipolar electrograms at successful and unsuccessful ostial ablation sites. J Cardiovasc Electrophysiol. 2002;13:13–9.
Tada H, Oral H, Knight BP, Ozaydin M, Chugh A, Scharf C, et al. Randomized comparison of bipolar versus unipolar plus bipolar recordings during segmental ostial ablation of pulmonary veins. J Cardiovasc Electrophysiol. 2002;13:851–6.
Michowitz Y, Buch E, Bourke T, Tung R, Bradfield J, Mathuria N, et al. Unipolar and bipolar electrogram characteristics predict exit block during pulmonary vein antral isolation. Pacing Clin Electrophysiol. 2012;35:1294–301.
Bortone A, Appetiti A, Bouzeman A, Maupas E, Ciobotaru V, Boulenc JM, et al. Unipolar signal modification as a guide for lesion creation during radiofrequency application in the left atrium: prospective study in humans in the setting of paroxysmal atrial fibrillation catheter ablation. Circ Arrhythm Electrophysiol. 2013;6:1095–102.
Bortone A, Brault-Noble G, Appetiti A, Marijon E. Elimination of the negative component of the unipolar atrial electrogram as an in vivo marker of transmural lesion creation: acute study in canines. Circ Arrhythm Electrophysiol. 2015;8:905–11.
Bortone A, Lagrange P, Cauchemez B, Durand C, Dieuzaide P, Prévot S, et al. Elimination of the negative component of the unipolar electrogram as a local procedural endpoint during paroxysmal atrial fibrillation catheter ablation using contact-force sensing: the UNIFORCE study. J Interv Card Electrophysiol. 2017;49:299–306.
Ejima K, Kato K, Okada A, Wakisaka O, Kimura R, Ishizawa M, et al. Comparison between contact force monitoring and unipolar signal modification as a guide for catheter ablation of atrial fibrillation: prospective multi-center randomized study. Circ Arrhythm Electrophysiol. 2019;12: e007311.
Fu G, He B, Wang B, Feng M, Du X, Liu J, et al. Unipolar electrogram-guided versus lesion size index-guided catheter ablation in patients with paroxysmal atrial fibrillation. J Cardiovasc Dev Dis. 2022;9:229.
Coeman M, Haddad ME, Wol M, Choudhury R, Vandekerckhove Y, Choudhury R, et al. ‘CLOSE’-guided pulmonary vein isolation and changes in local bipolar and unipolar atrial electrograms: observations from the EP lab. J Atr Fibrillation. 2018;10:1794.
Tomlinson DR, Myles M, Stevens KN, Streeter AJ. Transmural unipolar electrogram change occurs within 7 s at the left atrial posterior wall during pulmonary vein isolation. Pacing Clin Electrophysiol. 2019;42:922–9.
Zheng X, Walcott GP, Hall JA, Rollins DL, Smith WM, Kay GN, et al. Electrode impedance: an indicator of electrode-tissue contact and lesion dimensions during linear ablation. J Interv Card Electrophysiol. 2000;4:645–54.
Chinitz JS, Kapur S, Barbhaiya C, Kumar S, John R, Epstein LM, et al. Sites with small impedance decrease during catheter ablation for atrial fibrillation are associated with recovery of pulmonary vein conduction. J Cardiovasc Electrophysiol. 2016;27:1390–8.
Reichlin T, Knecht S, Lane C, Kuhne M, Nof E, Chopra N, et al. Initial impedance decrease as an indicator of good catheter contact: insights from radiofrequency ablation with force sensing catheters. Heart Rhythm. 2014;11:194–201.
Wakili R, Clauss S, Schmidt V, Ulbrich M, Hahnefeld A, Schüssler F, et al. Impact of real-time contact force and impedance measurement in pulmonary vein isolation procedures for treatment of atrial fibrillation. Clin Res Cardiol. 2014;103:97–106.
Park HS, Kim IC, Cho YK, Yoon HJ, Kim H, Nam CW, et al. Comparison of the efficacy between impedance-guided and contact force-guided atrial fibrillation ablation using an automated annotation system. J Arrhythm. 2018;34:239–46.
Knecht S, Reichlin T, Pavlovic N, Schaer B, Osswald S, Sticherling C, et al. Contact force and impedance decrease during ablation depends on catheter location and orientation: insights from pulmonary vein isolation using a contact force-sensing catheter. J Interv Card Electrophysiol. 2015;43:297–306.
Yasumoto K, Egami Y, Kawanami S, Sugae H, Ukita K, Kawamura A, et al. The correlation between local impedance drop and catheter contact in clinical pulmonary vein isolation use. Pacing Clin Electrophysiol. 2022;45:984–92.
Segreti L, De Simone A, Schillaci V, Bongiorni MG, Pelargonio G, Pandozi C, et al. A novel local impedance algorithm to guide effective pulmonary vein isolation in atrial fibrillation patients: preliminary experience across different ablation sites from the CHARISMA pilot study. J Cardiovasc Electrophysiol. 2020;31:2319–27.
Hashimoto K, Tsuzuki I, Seki Y, Ibe S, Yamashita T, Miyama H, et al. Change in the local impedance and electrograms recorded by a micro-electrode tip catheter during initial atrial fibrillation ablation. Journal of Arrhythmia. 2021;37:566–73.
Solimene F, Giannotti Santoro M, De Simone A, Malacrida M, Stabile G, Pandozi C, et al. Pulmonary vein isolation in atrial fibrillation patients guided by a novel local impedance algorithm: 1-year outcome from the CHARISMA study. J Cardiovasc Electrophysiol. 2021;32:1540–8.
Yokoyama K, Nakagawa H, Shah DC, Lambert H, Leo G, Aeby N, et al. Novel contact force sensor incorporated in irrigated radiofrequency ablation catheter predicts lesion size and incidence of steam pop and thrombus. Circ Arrhythm Electrophysiol. 2008;1:354–62.
Kumar S, Morton JB, Lee J, Halloran K, Spence SJ, Gorelik A, et al. Prospective characterization of catheter-tissue contact force at different anatomic sites during antral pulmonary vein isolation. Circ Arrhythm Electrophysiol. 2012;5:1124–9.
Reddy VY, Shah D, Kautzner J, Schmidt B, Saoudi N, Herrera C, et al. The relationship between contact force and clinical outcome during radiofrequency catheter ablation of atrial fibrillation in the TOCCATA study. Heart Rhythm. 2012;9:1789–95.
Neuzil P, Reddy VY, Kautzner J, Petru J, Wichterle D, Shah D, et al. Electrical reconnection after pulmonary vein isolation is contingent on contact force during initial treatment: results from the EFFICAS I study. Circ Arrhythm Electrophysiol. 2013;6:327–33.
Kautzner J, Neuzil P, Lambert H, Peichl P, Petru J, Cihak R, et al. EFFICAS II: optimization of catheter contact force improves outcome of pulmonary vein isolation for paroxysmal atrial fibrillation. Europace. 2015;17:1229–35.
Shah DC, Lambert H, Nakagawa H, Langenkamp A, Aeby N, Leo G. Area under the real-time contact force curve (force-time integral) predicts radiofrequency lesion size in an in vitro contractile model. J Cardiovasc Electrophysiol. 2010;21:1038–43.
Kuck K-H, Reddy VY, Schmidt B, Natale A, Neuzil P, Saoudi N, et al. A novel radiofrequency ablation catheter using contact force sensing: Toccata study. Heart Rhythm. 2012;9:18–23.
Kumar S, Morton JB, Halloran K, Spence SJ, Lee G, Wong MCG, et al. Effect of respiration on catheter-tissue contact force during ablation of atrial arrhythmias. Heart Rhythm. 2012;9:1041-47.e1.
El Haddad E, Taghji P, Phlips T, Wolf M, Demolder A, Choudhury R, et al. Determinants of acute and late pulmonary vein reconnection in contact force-guided pulmonary vein isolation: identifying the weakest link in the ablation chain. Circ Arrhythm Electrophysiol. 2017;10: e004867.
Nakagawa H, Ikeda A, Govari A, Papaioannou T, Constantine G, Bar-Tal M, et al. Abstract 12104: prospective study using a new formula incorporating contact force, radiofrequency power and application time (force-power-time index) for quantifying lesion formation to guide long continuous atrial lesions in the beating canine heart. Circulation. 2013;128:A12104–A12104.
Ullah W, Hunter RJ, Finlay MC, McLean A, Dhinoja MB, Sporton S, et al. Ablation index and surround flow catheter irrigation: impedance-based appraisal in clinical ablation. JACC Clin Electrophysiol. 2017;3:1080–8.
Teres C, Soto-Iglesias D, Penela D, Jáuregui B, Ordoñez A, Chauca A, et al. Personalized paroxysmal atrial fibrillation ablation by tailoring ablation index to the left atrial wall thickness: the ‘ablate by-LAW’ single-centre study-a pilot study. Europace. 2022;24:390–9.
Kyriakopoulou M, Strisciuglio T, El Haddad M, De Pooter J, Almorad A, Van Beeumen K, et al. Evaluation of a simple technique aiming at optimizing point-by-point isolation of the left pulmonary veins: a randomized study. Europace. 2019;21:1185–92.
Berte B, Hilfiker G, Moccetti F, Schefer T, Weberndörfer V, Cuculi F, et al. Pulmonary vein isolation using ablation index vs. CLOSE protocol with a surround flow ablation catheter. Europace. 2020;22:84–9.
Hoffmann P, Diaz Ramirez I, Baldenhofer G, Stangl K, Mont L, Althoff TF. Randomized study defining the optimum target interlesion distance in ablation index-guided atrial fibrillation ablation. Europace. 2020;22:1480–6.
Kobayashi S, Fukaya H, Oikawa J, Saito D, Sato T, Matsuura G, et al. Optimal interlesion distance in ablation index-guided pulmonary vein isolation for atrial fibrillation. J Interv Card Electrophysiol. 2021;62:123–31.
Francke A, Taha NS, Scharfe F, Schoen S, Wunderlich C, Christoph M. Procedural efficacy and safety of standardized, ablation index guided fixed 50 W high-power short-duration pulmonary vein isolation and substrate modification using the CLOSE protocol. J Cardiovasc Electrophysiol. 2021;32:2408–17.
Francke A, Scharfe F, Schoen S, Wunderlich C, Christoph M. Reconnection patterns after CLOSE-guided 50 W high-power-short-duration circumferential pulmonary vein isolation and substrate modification-PV reconnection might no longer be an issue. J Cardiovasc Electrophysiol. 2022;33:1136–45.
Chen S, Schmidt B, Bordignon S, Tohoku S, Urban VC, Schulte-Hahn B, et al. Catheter ablation of atrial fibrillation using ablation index-guided high-power technique: Frankfurt AI high-power 15-month follow-up. J Cardiovasc Electrophysiol. 2021;32:616–24.
Jiang C-Y, Jiang R-H, Matsuo S, Liu Q, Fan Y-Q, Zhang Z-W, et al. Early detection of pulmonary vein reconnection after isolation in patients with paroxysmal atrial fibrillation: a comparison of ATP-induction and reassessment at 30 minutes postisolation. J Cardiovasc Electrophysiol. 2009;20:1382–7.
Cheema A, Dong J, Dalal D, Marine JE, Henrikson CA, Spragg D, et al. Incidence and time course of early recovery of pulmonary vein conduction after catheter ablation of atrial fibrillation. J Cardiovasc Electrophysiol. 2007;18:387–91.
Brunelli M, Raffa S, Große A, Hanazawa K, Sammut M, Roos M, et al. Residual conduction after pulmonary vein isolation with a circular multielectrode radiofrequency ablation catheter: the role of adenosine and orciprenalin during a prolonged observation time. Int J Cardiol. 2013;168:4122–31.
Dallaglio PD, Betts TR, Ginks M, Bashir Y, Anguera I, Rajappan K. The role of adenosine in pulmonary vein isolation: a critical review. Cardiol Res Pract. 2016;2016:8632509.
le Polain de Waroux J-B, Weerasooriya R, Anvardeen K, Barbraud C, Marchandise S, De Meester C, et al. Low contact force and force-time integral predict early recovery and dormant conduction revealed by adenosine after pulmonary vein isolation. Europace. 2015;17:877–83.
Datino T, Macle L, Qi XY, Maguy A, Comtois P, Chartier D, et al. Mechanisms by which adenosine restores conduction in dormant canine pulmonary veins. Circulation. 2010;121:963–72.
Tokuda M, Matsuo S, Isogai R, Uno G, Tokutake K, Yokoyama K, et al. Adenosine testing during cryoballoon ablation and radiofrequency ablation of atrial fibrillation: a propensity score-matched analysis. Heart Rhythm. 2016;13:2128–34.
Ghanbari H, Jani R, Hussain-Amin A, Al-Assad W, Huether E, Ansari S, et al. Role of adenosine after antral pulmonary vein isolation of paroxysmal atrial fibrillation: a randomized controlled trial. Heart Rhythm. 2016;13:407–15.
Prabhu S, Mackin V, McLellan AJ, Phan T, McGlade D, Ling LH, et al. Determining the optimal dose of adenosine for unmasking dormant pulmonary vein conduction following atrial fibrillation ablation: electrophysiological and hemodynamic assessment. DORMANT-AF study J Cardiovasc Electrophysiol. 2017;28:13–22.
Osorio J, Hunter TD, Rajendra A, Zei P, Silverstein J, Morales G. Predictors of clinical success after paroxysmal atrial fibrillation catheter ablation. J Cardiovasc Electrophysiol. 2021;32:1814–21.
Ninomiya Y, Inoue K, Tanaka N, Okada M, Tanaka K, Onishi T, et al. Absence of first-pass isolation is associated with poor pulmonary vein isolation durability and atrial fibrillation ablation outcomes. J Arrhythm. 2021;37:1468–76.
Barbhaiya CR, Aizer A, Knotts R, Bernstein S, Park D, Holmes D, et al. Simultaneous pace-ablate during CARTO-guided pulmonary vein isolation with a contact-force sensing radiofrequency ablation catheter. J Interv Card Electrophysiol. 2019;54:119–24.
Kogawa R, Okumura Y, Watanabe I, Sonoda K, Sasaki N, Takahashi K, et al. Difference between dormant conduction sites revealed by adenosine triphosphate provocation and unipolar pace-capture sites along the ablation line after pulmonary vein isolation. Int Heart J. 2016;57:25–9.
Okumura Y, Watanabe I, Nagashima K, Sonoda K, Mano H, Sasaki N, et al. The effects of standard electrical PV isolation vs. “pace and ablate” on ATP-provoked PV reconnections. J Interv Card Electrophysiol. 2014;40:39–45.
Kumar S, Kalman JM, Sutherland F, Spence SJ, Finch S, Sparks PB. Atrial fibrillation inducibility in the absence of structural heart disease or clinical atrial fibrillation: critical dependence on induction protocol, inducibility definition, and number of inductions. Circ Arrhythm Electrophysiol. 2012;5:531–6.
Darma A, Daneschnejad SS, Gaspar T, Huo Y, Wetzel U, Dagres N, et al. Role of inducibility and its dynamic change in the outcome of catheter ablation of atrial fibrillation: a single center prospective study. J Cardiovasc Electrophysiol. 2020;31:705–11.
Santangeli P, Zado ES, Garcia FC, Riley MP, Lin D, Frankel DS, et al. Lack of prognostic value of atrial arrhythmia inducibility and change in inducibility status after catheter ablation of atrial fibrillation. Heart Rhythm. 2018;15:660–5.
Leong-Sit P, Robinson M, Zado ES, Callans DJ, Garcia F, Lin D, et al. Inducibility of atrial fibrillation and flutter following pulmonary vein ablation. J Cardiovasc Electrophysiol. 2013;24:617–23.
Millenaar D, Becker N, Pavlicek V, Wintrich J, Böhm M, Mahfoud F, et al. Inducibility of atrial fibrillation after catheter ablation predicts recurrences of atrial fibrillation: a metaanalysis. Pacing Clin Electrophysiol. 2021;44:667–76.
Neumann T, Vogt J, Schumacher B, Dorszewski A, Kuniss M, Neuser H, et al. Circumferential pulmonary vein isolation with the cryoballoon technique results from a prospective 3-center study. J Am Coll Cardiol. 2008;52:273–8.
Alyesh D, Frederick J, Choe W, Sundaram S. Step by step: how to perform a fluoroless cryoballoon ablation for atrial fibrillation. J Cardiovasc Electrophysiol. 2022;33:2351–5.
Siklódy CH, Minners J, Allgeier M, Allgeier HJ, Jander N, Keyl C, et al. Pressure-guided cryoballoon isolation of the pulmonary veins for the treatment of paroxysmal atrial fibrillation. J Cardiovasc Electrophysiol. 2010;21:120–5.
Rottner L, Sinning C, Reissmann B, Schleberger R, Dinshaw L, Münkler P, et al. Wide-band dielectric imaging and the novel cryoballoon-occlusion tool to guide cryoballoon-based pulmonary vein isolation. Circ Arrhythm Electrophysiol. 2020;13: e008507.
Takami M, Lehmann HI, Misiri J, Parker KD, Sarmiento RI, Johnson SB, et al. Impact of freezing time and balloon size on the thermodynamics and isolation efficacy during pulmonary vein isolation using the second generation cryoballoon. Circ Arrhythm Electrophysiol. 2015;8:836–45.
Andrade JG, Dubuc M, Guerra PG, Landry E, Coulombe N, Leduc H, et al. Pulmonary vein isolation using a second-generation cryoballoon catheter: a randomized comparison of ablation duration and method of deflation. J Cardiovasc Electrophysiol. 2013;24:692–8.
Cheung CC, Deyell MW, Macle L, Verma A, Champagne J, Leong-Sit P, et al. Repeat atrial fibrillation ablation procedures in the CIRCA-DOSE study. Circ Arrhythm Electrophysiol. 2020;13: e008480.
Chun KR, Stich M, Fürnkranz A, Bordignon S, Perrotta L, Dugo D, et al. Individualized cryoballoon energy pulmonary vein isolation guided by real-time pulmonary vein recordings, the randomized ICE-T trial. Heart Rhythm. 2017;14:495–500.
Wissner E, Heeger CH, Grahn H, Reissmann B, Wohlmuth P, Lemes C, et al. One-year clinical success of a ‘no-bonus’ freeze protocol using the second-generation 28 mm cryoballoon for pulmonary vein isolation. Europace. 2015;17:1236–40.
Farkowski MM, Karlinski M, Barra S, Providencia R, Golicki D, Pytkowski M, et al. Effectiveness and safety of a single freeze strategy of cryoballoon ablation of atrial fibrillation: an EHRA systematic review and metaanalysis. Europace. 2022;24:58–69.
Bordignon S, Chen S, Bologna F, Thohoku S, Urbanek L, Willems F, et al. Optimizing cryoballoon pulmonary vein isolation: lessons from >1000 procedures- the Frankfurt approach. Europace. 2021;23:868–77.
Chen S, Schmidt B, Bordignon S, Perrotta L, Bologna F, Chun KRJ. Impact of cryoballoon freeze duration on long-term durability of pulmonary vein isolation: ICE re-map study. JACC Clin Electrophysiol. 2019;5:551–9.
Heeger CH, Popescu SS, Saraei R, Kirstein B, Hatahet S, Samara O, et al. Individualized or fixed approach to pulmonary vein isolation utilizing the fourth-generation cryoballoon in patients with paroxysmal atrial fibrillation: the randomized INDI-FREEZE trial. Europace. 2022;24:921–7.
Ferrero-de-Loma-Osorio Á, García-Fernández A, Castillo-Castillo J, Izquierdo-de-Francisco M, Ibáñez-Críado A, Moreno-Arribas J, et al. Time-to-effect-based dosing strategy for cryoballoon ablation in patients with paroxysmal atrial fibrillation: results of the plusONE multicenter randomized controlled noninferiority trial. Circ Arrhythm Electrophysiol. 2017;10: e005318.
Ciconte G, Mugnai G, Sieira J, Velagić V, Saitoh Y, Irfan G, et al. On the quest for the best freeze: predictors of late pulmonary vein reconnections after second-generation cryoballoon ablation. Circ Arrhythm Electrophysiol. 2015;8:1359–65.
Aryana A, Mugnai G, Singh SM, Pujara DK, de Asmundis C, Singh SK, et al. Procedural and biophysical indicators of durable pulmonary vein isolation during cryoballoon ablation of atrial fibrillation. Heart Rhythm. 2016;13:424–32.
Ghosh J, Martin A, Keech AC, Chan KH, Gomes S, Singarayar S, et al. Balloon warming time is the strongest predictor of late pulmonary vein electrical reconnection following cryoballoon ablation for atrial fibrillation. Heart Rhythm. 2013;10:1311–7.
Bose A, Chevli PA, Berberian G, Januszkiewicz J, Ahmad G, Hashmath Z, et al. Presence of a left common pulmonary vein and pulmonary vein anatomical characteristics as predictors of outcome following cryoballoon ablation for paroxysmal atrial fibrillation. J Interv Card Electrophysiol. 2021;62:409–17.
Coutiño HE, Ströker E, Takarada K, Mugnai G, Abugattas JP, Sieira J, et al. Radiofrequency versus cryoballoon ablation for atrial fibrillation in the setting of left common pulmonary veins. Pacing Clin Electrophysiol. 2019;42:1456–62.
Yamaguchi M, Miyazaki S, Kajiyama T, Hada M, Nakamura H, Hachiya H, et al. Pulmonary vein isolation in patients with a left common pulmonary vein: comparison between second-generation cryoballoon and radiofrequency ablation. J Cardiol. 2019;73:292–8.
Shigeta T, Okishige K, Yamauchi Y, Aoyagi H, Nakamura T, Yamashita M, et al. Clinical assessment of cryoballoon ablation in cases with atrial fibrillation and a left common pulmonary vein. J Cardiovasc Electrophysiol. 2017;28:1021–7.
Asvestas D, Sousonis V, Kotsovolis G, Karanikas S, Xintarakou A, Sakadakis E, et al. Cavotricuspid isthmus ablation guided by force-time integral – a randomized study. Clin Cardiol. 2022;45:503–8.
Sakama S, Yagishita A, Sakai T, Morise M, Ayabe K, Amino M, et al. Ablation index-guided cavotricuspid isthmus ablation with contiguous lesions using fluoroscopy integrated 3D mapping in atrial flutter. J Interv Card Electrophysiol. 2022;64:217–22.
Sasaki T, Nakamura K, Inoue M, Minami K, Miki Y, Goto K, et al. Optimal local impedance drops for an effective radiofrequency ablation during cavo-tricuspid isthmus ablation. J Arrhythm. 2020;36:905–11.
Sau A, Kapadia S, Al-Aidarous S, Howard J, Sohaib A, Sikkel MB, et al. Temporal trends and lesion sets for persistent atrial fibrillation ablation: a metaanalysis with trial sequential analysis and meta-regression. Circ Arrhythm Electrophysiol. 2023;16: e011861.
Clarnette JA, Brooks AG, Mahajan R, Elliott AD, Twomey DJ, Pathak RK, et al. Outcomes of persistent and long-standing persistent atrial fibrillation ablation: a systematic review and metaanalysis. Europace. 2018;20:f366-76.
Bergonti M, Spera FR, Ferrero TG, Nsahlai M, Bonomi A, Boris W, et al. Anterior mitral line in patients with persistent atrial fibrillation and anterior scar: a multicenter matched comparison-The MiLine study. Heart Rhythm. 2023;20:658–65.
Nademanee K, McKenzie J, Kosar E, Schwab M, Sunsaneewitayakul B, Vasavakul T, et al. A new approach for catheter ablation of atrial fibrillation: mapping of the electrophysiologic substrate. J Am Coll Cardiol. 2004;43:2044–53.
Lau DH, Maesen B, Zeemering S, Verheule S, Crijns HJ, Schotten U. Stability of complex fractionated atrial electrograms: a systematic review. J Cardiovasc Electrophysiol. 2012;23:980–7.
Vogler J, Willems S, Sultan A, Schreiber D, Lüker J, Servatius H, et al. Pulmonary vein isolation versus defragmentation: the CHASE-AF clinical trial. J Am Coll Cardiol. 2015;66:2743–52.
Providência R, Lambiase PD, Srinivasan N, Ganesh Babu G, Bronis K, Ahsan S, et al. Is there still a role for complex fractionated atrial electrogram ablation in addition to pulmonary vein isolation in patients with paroxysmal and persistent atrial fibrillation? Metaanalysis of 1415 patients. Circ Arrhythm Electrophysiol. 2015;8:1017–29.
O’Neill MD, Wright M, Knecht S, Jaïs P, Hocini M, Takahashi Y, et al. Long-term follow-up of persistent atrial fibrillation ablation using termination as a procedural endpoint. Eur Heart J. 2009;30:1105–12.
Schreiber D, Rostock T, Fröhlich M, Sultan A, Servatius H, Hoffmann BA, et al. Five-year follow-up after catheter ablation of persistent atrial fibrillation using the stepwise approach and prognostic factors for success. Circ Arrhythm Electrophysiol. 2015;8:308–17.
Suenari K, Chen YC, Kao YH, Cheng CC, Lin YK, Chen YJ, et al. Discrepant electrophysiological characteristics and calcium homeostasis of left atrial anterior and posterior myocytes. Basic Res Cardiol. 2011;106:65–74.
Markides V, Schilling RJ, Ho SY, Chow AW, Davies DW, Peters NS. Characterization of left atrial activation in the intact human heart. Circulation. 2003;107:733–9.
Pauza DH, Skripka V, Pauziene N. Morphology of the intrinsic cardiac nervous system in the dog: a whole-mount study employing histochemical staining with acetylcholinesterase. Cells Tissues Organs. 2002;172:297–320.
Thiyagarajah A, Mahajan R, Iwai S, Griffin A, Mishima RS, Linz D, et al. Single ring isolation with inferior line sparing for atrial fibrillation: a proof-of-concept study. Circ Arrhythm Electrophysiol. 2021;14: e009552.
Thomas SP, Lim TW, McCall R, Seow SC, Ross DL. Electrical isolation of the posterior left atrial wall and pulmonary veins for atrial fibrillation: feasibility of and rationale for a single-ring approach. Heart Rhythm. 2007;4:722–30.
Bisignani A, Pannone L, Miraglia V, Sieira J, Iacopino S, Bala G, et al. Feasibility and safety of left atrial posterior wall isolation with a new Cryoballoon technology in patients with persistent atrial fibrillation. Pacing Clin Electrophysiol. 2022;45:605–11.
Aryana A, Baker JH, Espinosa Ginic MA, Pujara DK, Bowers MR, O’Neill PG, et al. Posterior wall isolation using the cryoballoon in conjunction with pulmonary vein ablation is superior to pulmonary vein isolation alone in patients with persistent atrial fibrillation: a multicenter experience. Heart Rhythm. 2018;15:1121–9.
Aryana A, Allen SL, Pujara DK, Bowers MR, O’Neill PG, Yamauchi Y, et al. Concomitant pulmonary vein and posterior wall isolation using cryoballoon with adjunct radiofrequency in persistent atrial fibrillation. JACC Clin Electrophysiol. 2021;7:187–96.
Ahn J, Shin DG, Han SJ, Lim HE. Does isolation of the left atrial posterior wall using cryoballoon ablation improve clinical outcomes in patients with persistent atrial fibrillation? A prospective randomized controlled trial Europace. 2022;24:1093–101.
Gunawardene MA, Frommeyer G, Ellermann C, Jularic M, Leitz P, Hartmann J, et al. Left atrial posterior wall isolation with pulsed field ablation in persistent atrial fibrillation. J Clin Med. 2023;12:6304.
Sohns C, Fink T, Braun M, Sciacca V, Piran M, Khalaph M, et al. Lesion formation following pulsed field ablation for pulmonary vein and posterior wall isolation. Pacing Clin Electrophysiol. 2023;46:714–6.
Yu HT, Shim J, Park J, Kim IS, Kim TH, Uhm JS, et al. Pulmonary vein isolation alone versus additional linear ablation in patients with persistent atrial fibrillation converted to paroxysmal type with antiarrhythmic drug therapy: a multicenter, prospective, randomized study. Circ Arrhythm Electrophysiol. 2017;10: e004915.
Wong K, Schricker AA, Nerlekar R, Feng Z, Sudat S, Cook K, et al. The posterior wall isolation for persistent atrial fibrillation high-power short duration (PEF-HOT) trial. JACC Clin Electrophysiol. 2023;9:2166–8.
Jankelson L, Garber L, Shulman E, Cohen RB, Peterson C, Wadhwani L, et al. Outcomes of posterior wall isolation with pulmonary vein isolation for paroxysmal atrial fibrillation. J Cardiovasc Electrophysiol. 2022;33:209–17.
Sugumar H, Thomas SP, Prabhu S, Voskoboinik A, Kistler PM. How to perform posterior wall isolation in catheter ablation for atrial fibrillation. J Cardiovasc Electrophysiol. 2018;29:345–52.
Tran VN, Kusa S, Smietana J, Tsai WC, Bhasin K, Teh A, et al. The relationship between oesophageal heating during left atrial posterior wall ablation and the durability of pulmonary vein isolation. Europace. 2017;19:1664–9.
Markman TM, Hyman MC, Kumareswaran R, Arkles JS, Santangeli P, Schaller RD, et al. Durability of posterior wall isolation after catheter ablation among patients with recurrent atrial fibrillation. Heart Rhythm. 2020;17:1740–4.
Kumar P, Bamimore AM, Schwartz JD, Chung EH, Gehi AK, Kiser AC, et al. Challenges and outcomes of posterior wall isolation for ablation of atrial fibrillation. J Am Heart Assoc. 2016;5: e003885.
Segan L, Chieng D, Prabhu S, Hunt A, Watts T, Klys B, et al. Posterior wall isolation improves outcomes for persistent AF with rapid posterior wall activity: a CAPLA substudy. Clin Electrophysiol. 2023;9:2536–46.
Al-Kaisey AM, Parameswaran R, Kalman JM. Atrial fibrillation structural substrates: aetiology, identification and implications. Arrhythm Electrophysiol Rev. 2020;9:113–20.
Prabhu S, Voskoboinik A, McLellan AJA, Peck KY, Pathik B, Nalliah CJ, et al. Biatrial electrical and structural atrial changes in heart failure: electroanatomic mapping in persistent atrial fibrillation in humans. JACC Clin Electrophysiol. 2018;4:87–96.
Kistler PM, Sanders P, Fynn SP, Stevenson IH, Spence SJ, Vohra JK, et al. Electrophysiologic and electroanatomic changes in the human atrium associated with age. J Am Coll Cardiol. 2004;44:109–16.
Mahajan R, Lau DH, Brooks AG, Shipp NJ, Wood JPM, Manavis J, et al. Atrial fibrillation and obesity: reverse remodeling of atrial substrate with weight reduction. JACC Clin Electrophysiol. 2021;7:630–41.
Voskoboinik A, Kalman JM, De Silva A, Nicholls T, Costello B, Nanayakkara S, et al. Alcohol abstinence in drinkers with atrial fibrillation. N Engl J Med. 2020;382:20–8.
Trivedi SJ, Claessen G, Stefani L, Flannery MD, Brown P, Janssens K, et al. Differing mechanisms of atrial fibrillation in athletes and non-athletes: alterations in atrial structure and function. Eur Heart J Cardiovasc Imaging. 2020;21:1374–83.
Kottkamp H, Bender R, Berg J. Catheter ablation of atrial fibrillation: how to modify the substrate? J Am Coll Cardiol. 2015;65:196–206.
Rolf S, Kircher S, Arya A, Eitel C, Sommer P, Richter S, et al. Tailored atrial substrate modification based on low-voltage areas in catheter ablation of atrial fibrillation. Circ Arrhythm Electrophysiol. 2014;7:825–33.
Cutler MJ, Johnson J, Abozguia K, Rowan S, Lewis W, Costantini O, et al. Impact of voltage mapping to guide whether to perform ablation of the posterior wall in patients with persistent atrial fibrillation. J Cardiovasc Electrophysiol. 2016;27:13–21.
Yang G, Yang B, Wei Y, Zhang F, Ju W, Chen H, et al. Catheter ablation of nonparoxysmal atrial fibrillation using electrophysiologically guided substrate modification during sinus rhythm after pulmonary vein isolation. Circ Arrhythm Electrophysiol. 2016;9: e003382.
Masuda M, Asai M, Iida O, Okamoto S, Ishihara T, Nanto K, et al. Additional low-voltage-area ablation in patients with paroxysmal atrial fibrillation: results of the randomized controlled VOLCANO trial. J Am Heart Assoc. 2020;9: e015927.
Chen H, Li C, Han B, Xiao F, Yi F, Wei Y, et al. Circumferential pulmonary vein isolation with vs without additional low-voltage-area ablation in older patients with paroxysmal atrial fibrillation: a randomized clinical trial. JAMA Cardiol. 2023;8:765–72.
Wong GR, Nalliah CJ, Lee G, Voskoboinik A, Prabhu S, Parameswaran R, et al. Dynamic atrial substrate during high-density mapping of paroxysmal and persistent AF: implications for substrate ablation. JACC Clin Electrophysiol. 2019;5:1265–77.
Kapa S, Desjardins B, Callans DJ, Marchlinski FE, Dixit S. Contact electroanatomic mapping derived voltage criteria for characterizing left atrial scar in patients undergoing ablation for atrial fibrillation. J Cardiovasc Electrophysiol. 2014;25:1044–52.
Takahashi Y, Yamaguchi T, Otsubo T, Nakashima K, Shinzato K, Osako R, et al. Histological validation of atrial structural remodelling in patients with atrial fibrillation. Eur Heart J. 2023;44:3339–53.
Vlachos K, Derval N, Pambrun T, Duchateau J, Martin CA, Bazoukis G, et al. Ligament of Marshall ablation for persistent atrial fibrillation. Pacing Clin Electrophysiol. 2021;44:782–91.
Kamakura T, Derval N, Duchateau J, Denis A, Nakashima T, Takagi T, et al. Vein of Marshall ethanol infusion: feasibility, pitfalls, and complications in over 700 patients. Circ Arrhythm Electrophysiol. 2021;14: e010001.
Gianni C, Mohanty S, Trivedi C, Di Biase L, Natale A. Novel concepts and approaches in ablation of atrial fibrillation: the role of non-pulmonary vein triggers. Europace. 2018;20:1566–76.
Mohanty S, Trivedi C, Horton P, Della Rocca DG, Gianni C, MacDonald B, et al. Natural history of arrhythmia after successful isolation of pulmonary veins, left atrial posterior wall, and superior vena cava in patients with paroxysmal atrial fibrillation: a multi-center experience. J Am Heart Assoc. 2021;10: e020563.
Sørensen SK, Johannessen A, Worck R, Hansen ML, Hansen J. Radiofrequency versus cryoballoon catheter ablation for paroxysmal atrial fibrillation: durability of pulmonary vein isolation and effect on atrial fibrillation burden: the RACE-AF randomized controlled trial. Circ Arrhythm Electrophysiol. 2021;14: e009573.
Della Rocca DG, Tarantino N, Trivedi C, Mohanty S, Anannab A, Salwan AS, et al. Non-pulmonary vein triggers in nonparoxysmal atrial fibrillation: implications of pathophysiology for catheter ablation. J Cardiovasc Electrophysiol. 2020;31:2154–67.
Hsu LF, Jaïs P, Keane D, Wharton JM, Deisenhofer I, Hocini M, et al. Atrial fibrillation originating from persistent left superior vena cava. Circulation. 2004;109:828–32.
Di Biase L, Burkhardt JD, Mohanty P, Mohanty S, Sanchez JE, Trivedi C, et al. Left atrial appendage isolation in patients with longstanding persistent AF undergoing catheter ablation: BELIEF trial. J Am Coll Cardiol. 2016;68:1929–40.
Romero J, Di Biase L, Mohanty S, Trivedi C, Patel K, Parides M, et al. Long-term outcomes of left atrial appendage electrical isolation in patients with nonparoxysmal atrial fibrillation: a propensity score-matched analysis. Circ Arrhythm Electrophysiol. 2020;13: e008390.
Romero J, Gabr M, Patel K, Briceno D, Diaz JC, Alviz I, et al. Efficacy and safety of left atrial appendage electrical isolation during catheter ablation of atrial fibrillation: an updated metaanalysis. Europace. 2021;23:226–37.
Friedman DJ, Black-Maier EW, Barnett AS, Pokorney SD, Al-Khatib SM, Jackson KP, et al. Left atrial appendage electrical isolation for treatment of recurrent atrial fibrillation: a metaanalysis. JACC Clin Electrophysiol. 2018;4:112–20.
Bavry A. Outcomes of adjunctive left atrial appendage ligation utilizing the LARIAT compared to pulmonary vein antral isolation alone - aMAZE. Presented by Dr. David J. Wilber at the american heart association virtual annual scientific sessions (AHA 2021), 2021.
Fink T, Vogler J, Heeger CH, Sano M, Sciacca V, Reissmann B, et al. Impact of left atrial appendage closure on LAA thrombus formation and thromboembolism after LAA isolation. JACC Clin Electrophysiol. 2020;6:1687–97.
Rillig A, Tilz RR, Lin T, Fink T, Heeger CH, Arya A, et al. Unexpectedly high incidence of stroke and left atrial appendage thrombus formation after electrical isolation of the left atrial appendage for the treatment of atrial tachyarrhythmias. Circ Arrhythm Electrophysiol. 2016;9: e003461.
Kim YG, Shim J, Oh SK, Lee KN, Choi JI, Kim YH. Electrical isolation of the left atrial appendage increases the risk of ischemic stroke and transient ischemic attack regardless of postisolation flow velocity. Heart Rhythm. 2018;15:1746–53.
Zender N, Weise FK, Bordignon S, Herrmann E, Konstantinou A, Bologna F, et al. Thromboembolism after electrical isolation of the left atrial appendage: a new indication for interventional closure? Europace. 2019;21:1502–8.
Dixit S, Lin D, Frankel DS, Marchlinski FE. Catheter ablation for persistent atrial fibrillation: antral pulmonary vein isolation and elimination of nonpulmonary vein triggers are sufficient. Circ Arrhythm Electrophysiol. 2012;5:1216–23; discussion 1223.
Inoue K, Kurotobi T, Kimura R, Toyoshima Y, Itoh N, Masuda M, et al. Trigger-based mechanism of the persistence of atrial fibrillation and its impact on the efficacy of catheter ablation. Circ Arrhythm Electrophysiol. 2012;5:295–301.
Santangeli P, Di Biase L, Mohanty P, Burkhardt JD, Horton R, Bai R, et al. Catheter ablation of atrial fibrillation in octogenarians: safety and outcomes. J Cardiovasc Electrophysiol. 2012;23:687–93.
Choi EK, Shen MJ, Han S, Kim D, Hwang S, Sayfo S, et al. Intrinsic cardiac nerve activity and paroxysmal atrial tachyarrhythmia in ambulatory dogs. Circulation. 2010;121:2615–23.
Nakagawa H, Scherlag BJ, Patterson E, Ikeda A, Lockwood D, Jackman WM. Pathophysiologic basis of autonomic ganglionated plexus ablation in patients with atrial fibrillation. Heart Rhythm. 2009;6:S26-34.
Pauza DH, Skripka V, Pauziene N, Stropus R. Morphology, distribution, and variability of the epicardiac neural ganglionated subplexuses in the human heart. Anat Rec. 2000;259:353–82.
Patterson E, Lazzara R, Szabo B, Liu H, Tang D, Li YH, et al. Sodium-calcium exchange initiated by the Ca2+ transient: an arrhythmia trigger within pulmonary veins. J Am Coll Cardiol. 2006;47:1196–206.
Lemola K, Chartier D, Yeh YH, Dubuc M, Cartier R, Armour A, et al. Pulmonary vein region ablation in experimental vagal atrial fibrillation: role of pulmonary veins versus autonomic ganglia. Circulation. 2008;117:470–7.
Nishida K, Maguy A, Sakabe M, Comtois P, Inoue H, Nattel S. The role of pulmonary veins vs. autonomic ganglia in different experimental substrates of canine atrial fibrillation. Cardiovasc Res. 2011;89:825–33.
Nishida K, Datino T, Macle L, Nattel S. Atrial fibrillation ablation: translating basic mechanistic insights to the patient. J Am Coll Cardiol. 2014;64:823–31.
Stavrakis S, Nakagawa H, Po SS, Scherlag BJ, Lazzara R, Jackman WM. The role of the autonomic ganglia in atrial fibrillation. JACC Clin Electrophysiol. 2015;1:1–13.
Katritsis DG, Pokushalov E, Romanov A, Giazitzoglou E, Siontis GC, Po SS, et al. Autonomic denervation added to pulmonary vein isolation for paroxysmal atrial fibrillation: a randomized clinical trial. J Am Coll Cardiol. 2013;62:2318–25.
Pokushalov E, Romanov A, Katritsis DG, Artyomenko S, Shirokova N, Karaskov A, et al. Ganglionated plexus ablation vs linear ablation in patients undergoing pulmonary vein isolation for persistent/long-standing persistent atrial fibrillation: a randomized comparison. Heart Rhythm. 2013;10:1280–6.
Driessen AHG, Berger WR, Krul SPJ, van den Berg NWE, Neefs J, Piersma FR, et al. Ganglion plexus ablation in advanced atrial fibrillation: the AFACT study. J Am Coll Cardiol. 2016;68:1155–65.
Connolly SJ, Ezekowitz MD, Yusuf S, Eikelboom J, Oldgren J, Parekh A, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med. 2009;361:1139–51.
Patel MR, Mahaffey KW, Garg J, Pan G, Singer DE, Hacke W, et al. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med. 2011;365:883–91.
Granger CB, Alexander JH, McMurray JJ, Lopes RD, Hylek EM, Hanna M, et al. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2011;365:981–92.
Giugliano RP, Ruff CT, Braunwald E, Murphy SA, Wiviott SD, Halperin JL, et al. Edoxaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2013;369:2093–104.
Ruff CT, Giugliano RP, Braunwald E, Hoffman EB, Deenadayalu N, Ezekowitz MD, et al. Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a metaanalysis of randomised trials. Lancet. 2014;383:955–62.
Kaitani K, Inoue K, Kobori A, Nakazawa Y, Ozawa T, Kurotobi T, et al. Efficacy of antiarrhythmic drugs short-term use after catheter ablation for atrial fibrillation (EAST-AF) trial. Eur Heart J. 2016;37:610–8.
Darkner S, Chen X, Hansen J, Pehrson S, Johannessen A, Nielsen JB, et al. Recurrence of arrhythmia following short-term oral amiodarone after catheter ablation for atrial fibrillation: a double-blind, randomized, placebo-controlled study (AMIO-CAT trial). Eur Heart J. 2014;35:3356–64.
Hayashi M, Miyauchi Y, Iwasaki YK, Yodogawa K, Tsuboi I, Uetake S, et al. Three-month lower-dose flecainide after catheter ablation of atrial fibrillation. Europace. 2014;16:1160–7.
Roux JF, Zado E, Callans DJ, Garcia F, Lin D, Marchlinski FE, et al. Antiarrhythmics after ablation of atrial fibrillation (5A study). Circulation. 2009;120:1036–40.
Leong-Sit P, Roux JF, Zado E, Callans DJ, Garcia F, Lin D, et al. Antiarrhythmics after ablation of atrial fibrillation (5A Study): six-month follow-up study. Circ Arrhythm Electrophysiol. 2011;4:11–4.
Gu J, Liu X, Tan H, Zhou L, Gu J, Jiang W, et al. Extensive antiarrhythmic drugs after catheter ablation of persistent atrial fibrillation. Acta Cardiol. 2012;67:407–14.
Chen W, Liu H, Ling Z, Xu Y, Fan J, Du H, et al. Efficacy of short-term antiarrhythmic drugs use after catheter ablation of atrial fibrillation-a systematic review with metaanalyses and trial sequential analyses of randomized controlled trials. PLoS One. 2016;11: e0156121.
Goldenberg GR, Burd D, Lodzinski P, Stabile G, Udell JA, Newman D, et al. Antiarrhythmic therapy as an adjuvant to promote post pulmonary vein isolation success—a metaanalysis. J Interv Card Electrophysiol. 2016;47:171–6.
Deyell MW, Leather RA, Macle L, Forman J, Khairy P, Zhang R, et al. Efficacy and safety of same-day discharge for atrial fibrillation ablation. JACC Clin Electrophysiol. 2020;6:609–19.
Creta A, Ventrella N, Providência R, Earley MJ, Sporton S, Dhillon G, et al. Same-day discharge following catheter ablation of atrial fibrillation: a safe and cost-effective approach. J Cardiovasc Electrophysiol. 2020;31:3097–103.
Kowalski M, Parikh V, Salcido JR, Chalfoun N, Albano A, O’Neill PG, et al. Same-day discharge after cryoballoon ablation of atrial fibrillation: a multicenter experience. J Cardiovasc Electrophysiol. 2021;32:183–90.
Tang PT, Davies M, Bashir Y, Betts TR, Pedersen M, Rajappan K, et al. Efficacy and safety of same-day discharge after atrial fibrillation ablation compared with postprocedural overnight stay: a systematic review and metaanalysis. Europace. 2022;24:1569–84.
Jafry AH, Akhtar KH, Khan JA, Clifton S, Reese J, Sami KN, et al. Safety and feasibility of same-day discharge for catheter ablation of atrial fibrillation: a systematic review and metaanalysis. J Interv Card Electrophysiol. 2022;65:803–11.
Sangrigoli R, Harding J, Venkataraman G, Tomaiko-Clark E, Bai R, Su W. Randomized prospective evaluation of same-day discharge after cryoballoon ablation of atrial fibrillation: results of the EASY PVI study. J Interv Card Electrophysiol. 2023;66:1601–7.
Deyell MW, Hoskin K, Forman J, Laksman ZW, Hawkins NM, Bennett MT, et al. Same-day discharge for atrial fibrillation ablation: outcomes and impact of ablation modality. Europace. 2023;25:400–7.
Rajendra A, Osorio J, Diaz JC, Hoyos C, Rivera E, Matos CD, et al. Performance of the REAL-AF same-day discharge protocol in patients undergoing catheter ablation of atrial fibrillation. JACC Clin Electrophysiol. 2023;9:1515–26.
Jimenez-Candil J, Hernandez Hernandez J, Cruz Galban A, Blanco F, Moriñigo JL, Sanchez García M, et al. Clinical and economic outcomes of a systematic same-day discharge programme after pulmonary vein isolation: comparison between cryoballoon vs radiofrequency ablation. Europace. 2023;25:euad265.
Zellerhoff S, Lenze F, Eckardt L. Prophylactic proton pump inhibition after atrial fibrillation ablation: is there any evidence? Europace. 2011;13:1219–21.
Yokoyama K, Nakagawa H, Seres KA, Jung E, Merino J, Zou Y, et al. Canine model of esophageal injury and atrial-esophageal fistula after applications of forward-firing high-intensity focused ultrasound and side-firing unfocused ultrasound in the left atrium and inside the pulmonary vein. Circ Arrhythm Electrophysiol. 2009;2:41–9.
Cordes F, Ellermann C, Dechering DG, Frommeyer G, Kochhäuser S, Lange PS, et al. Preprocedural proton pump inhibition is associated with fewer peri-oesophageal lesions after cryoballoon pulmonary vein isolation. Sci Rep. 2021;11:4728.
Rolantova L, Bulava A, Eisenberger M, Chloubova I, Tothova V, Hanis J. Nurse-performed venous sheath removal in patients undergoing radiofrequency catheter ablation for atrial fibrillation: a randomised study. Eur J Cardiovasc Nurs. 2019;18:332–9.
Kewcharoen J, Shah K, Bhardwaj R, Contractor T, Turagam MK, Mandapati R, et al. Periprocedural outcomes of protamine administration after catheter ablation of atrial fibrillation. Rev Cardiovasc Med. 2022;23:34.
Chilukuri K, Henrikson CA, Dalal D, Scherr D, MacPherson EC, Cheng A, et al. Incidence and outcomes of protamine reactions in patients undergoing catheter ablation of atrial fibrillation. J Interv Card Electrophysiol. 2009;25:175–81.
Traullé S, Kubala M, Doucy A, Quenum S, Hermida JS. Feasibility and safety of temporary subcutaneous venous figure-of-eight suture to achieve haemostasis after ablation of atrial fibrillation. Europace. 2016;18:815–9.
Kumar V, Wish M, Venkataraman G, Bliden K, Jindal M, Strickberger A. A randomized comparison of manual pressure versus figure-of-eight suture for hemostasis after cryoballoon ablation for atrial fibrillation. J Cardiovasc Electrophysiol. 2019;30:2806–10.
Aytemir K, Canpolat U, Yorgun H, Evranos B, Kaya EB, Şahiner ML, et al. Usefulness of ‘figure-of-eight’ suture to achieve haemostasis after removal of 15-French calibre femoral venous sheath in patients undergoing cryoablation. Europace. 2016;18:1545–50.
Natale A, Mohanty S, Liu PY, Mittal S, Al-Ahmad A, De Lurgio David B, et al. Venous vascular closure system versus manual compression following multiple access electrophysiology procedures. JACC Clin Electrophysiol. 2020;6:111–24.
Calkins H, Hindricks G, Cappato R, Kim YH, Saad EB, Aguinaga L, et al. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation. Europace. 2018;20:e1-160.
Verma A, Champagne J, Sapp J, Essebag V, Novak P, Skanes A, et al. Discerning the incidence of symptomatic and asymptomatic episodes of atrial fibrillation before and after catheter ablation (DISCERN AF): a prospective, multicenter study. JAMA Intern Med. 2013;173:149–56.
Bunch TJ, May HT, Bair TL, Weiss JP, Crandall BG, Osborn JS, et al. Atrial fibrillation ablation patients have long-term stroke rates similar to patients without atrial fibrillation regardless of CHADS2 score. Heart Rhythm. 2013;10:1272–7.
Friberg L, Tabrizi F, Englund A. Catheter ablation for atrial fibrillation is associated with lower incidence of stroke and death: data from Swedish health registries. Eur Heart J. 2016;37:2478–87.
Packer DL, Mark DB, Robb RA, Monahan KH, Bahnson TD, Poole JE, et al. Effect of catheter ablation vs antiarrhythmic drug therapy on mortality, stroke, bleeding, and cardiac arrest among patients with atrial fibrillation: the CABANA randomized clinical trial. JAMA. 2019;321:1261–74.
Daoud EG, Glotzer TV, Wyse DG, Ezekowitz MD, Hilker C, Koehler J, et al. Temporal relationship of atrial tachyarrhythmias, cerebrovascular events, and systemic emboli based on stored device data: a subgroup analysis of TRENDS. Heart Rhythm. 2011;8:1416–23.
Brambatti M, Connolly SJ, Gold MR, Morillo CA, Capucci A, Muto C, et al. Temporal relationship between subclinical atrial fibrillation and embolic events. Circulation. 2014;129:2094–9.
Camen S, Ojeda FM, Niiranen T, Gianfagna F, Vishram-Nielsen JK, Costanzo S, et al. Temporal relations between atrial fibrillation and ischaemic stroke and their prognostic impact on mortality. Europace. 2020;22:522–9.
Romero J, Cerrud-Rodriguez RC, Diaz JC, Rodriguez D, Arshad S, Alviz I, et al. Oral anticoagulation after catheter ablation of atrial fibrillation and the associated risk of thromboembolic events and intracranial hemorrhage: a systematic review and metaanalysis. J Cardiovasc Electrophysiol. 2019;30:1250–7.
Proietti R, AlTurki A, Di Biase L, China P, Forleo G, Corrado A, et al. Anticoagulation after catheter ablation of atrial fibrillation: an unnecessary evil? A systematic review and metaanalysis. J Cardiovasc Electrophysiol. 2019;30:468–78.
Liang JJ, Elafros MA, Mullen MT, Muser D, Hayashi T, Enriquez A, et al. Anticoagulation use and clinical outcomes after catheter ablation in patients with persistent and longstanding persistent atrial fibrillation. J Cardiovasc Electrophysiol. 2018;29:823–32.
Verma A, Ha ACT, Kirchhof P, Hindricks G, Healey JS, Hill MD, et al. The optimal anti-coagulation for enhanced-risk patients post-catheter ablation for atrial fibrillation (OCEAN) trial. Am Heart J. 2018;197:124–32.
Healey JS, Connolly SJ, Gold MR, Israel CW, Van Gelder IC, Capucci A, et al. Subclinical atrial fibrillation and the risk of stroke. N Engl J Med. 2012;366:120–9.
Glotzer TV, Daoud EG, Wyse DG, Singer DE, Ezekowitz MD, Hilker C, et al. The relationship between daily atrial tachyarrhythmia burden from implantable device diagnostics and stroke risk: the TRENDS study. Circ Arrhythm Electrophysiol. 2009;2:474–80.
Martin DT, Bersohn MM, Waldo AL, Wathen MS, Choucair WK, Lip GY, et al. Randomized trial of atrial arrhythmia monitoring to guide anticoagulation in patients with implanted defibrillator and cardiac resynchronization devices. Eur Heart J. 2015;36:1660–8.
Waks JW, Passman RS, Matos J, Reynolds M, Thosani A, Mela T, et al. Intermittent anticoagulation guided by continuous atrial fibrillation burden monitoring using dual-chamber pacemakers and implantable cardioverter-defibrillators: results from the tailored anticoagulation for non-continuous atrial fibrillation (TACTIC-AF) pilot study. Heart Rhythm. 2018;15:1601–7.
Passman R, Leong-Sit P, Andrei AC, Huskin A, Tomson TT, Bernstein R, et al. Targeted anticoagulation for atrial fibrillation guided by continuous rhythm assessment with an insertable cardiac monitor: the rhythm evaluation for anticoagulation with continuous monitoring (REACT.COM) pilot study. J Cardiovasc Electrophysiol. 2016;27:264–70.
Barbhaiya CR, Kumar S, John RM, Tedrow UB, Koplan BA, Epstein LM, et al. Global survey of esophageal and gastric injury in atrial fibrillation ablation: incidence, time to presentation, and outcomes. J Am Coll Cardiol. 2015;65:1377–8.
Piccini JP, Braegelmann KM, Simma S, Koneru JN, Ellenbogen KA. Risk of atrioesophageal fistula with cryoballoon ablation of atrial fibrillation. Heart Rhythm. 2020;O2(1):173–9.
Tilz RR, Schmidt V, Pürerfellner H, Maury P, Chun KJ, Martinek M, et al. A worldwide survey on incidence, management and prognosis of oesophageal fistula formation following atrial fibrillation catheter ablation: the POTTER-AF study. Eur Heart J. 2023;44:2458–69.
Barbhaiya Chirag R, Kumar S, Guo Y, Zhong J, John Roy M, Tedrow Usha B, et al. Global survey of esophageal injury in atrial fibrillation ablation. JACC Clin Electrophysiol. 2016;2:143–50.
Gandjbakhch E, Mandel F, Dagher Y, Hidden-Lucet F, Rollin A, Maury P. Incidence, epidemiology, diagnosis and prognosis of atriooesophageal fistula following percutaneous catheter ablation: a French nationwide survey. Europace. 2021;23:557–64.
Della Rocca DG, Magnocavallo M, Natale VN, Gianni C, Mohanty S, Trivedi C, et al. Clinical presentation, diagnosis, and treatment of atrioesophageal fistula resulting from atrial fibrillation ablation. J Cardiovasc Electrophysiol. 2021;32:2441–50.
Dagres N, Kottkamp H, Piorkowski C, Doll N, Mohr F, Horlitz M, et al. Rapid detection and successful treatment of esophageal perforation after radiofrequency ablation of atrial fibrillation: lessons from five cases. J Cardiovasc Electrophysiol. 2006;17:1213–5.
Dagres N, Hindricks G, Kottkamp H, Sommer P, Gaspar T, Bode K, et al. Complications of atrial fibrillation ablation in a high-volume center in 1,000 procedures: still cause for concern? J Cardiovasc Electrophysiol. 2009;20:1014–9.
Arbelo E, Brugada J, Blomström-Lundqvist C, Laroche C, Kautzner J, Pokushalov E, et al. Contemporary management of patients undergoing atrial fibrillation ablation: in-hospital and 1-year follow-up findings from the ESC-EHRA atrial fibrillation ablation long-term registry. Eur Heart J. 2017;38:1303–16.
Markar SR, Koehler R, Low DE, Ross A. Novel multimodality endoscopic closure of postoperative esophageal fistula. Int J Surg Case Rep. 2012;3:577–9.
Kapur S, Barbhaiya C, Deneke T, Michaud GF. Esophageal injury and atrioesophageal fistula caused by ablation for atrial fibrillation. Circulation. 2017;136:1247–55.
Ugata Y, Michihata N, Matsui H, Fushimi K, Yasunaga H. Impact of proton pump inhibitors on mortality and severe esophageal injury after catheter ablation for atrial fibrillation: a nationwide retrospective study using propensity score matching. Heart Vessels. 2021;36:1730–8.
Deftereos S, Giannopoulos G, Kossyvakis C, Efremidis M, Panagopoulou V, Kaoukis A, et al. Colchicine for prevention of early atrial fibrillation recurrence after pulmonary vein isolation: a randomized controlled study. J Am Coll Cardiol. 2012;60:1790–6.
Deftereos S, Giannopoulos G, Efremidis M, Kossyvakis C, Katsivas A, Panagopoulou V, et al. Colchicine for prevention of atrial fibrillation recurrence after pulmonary vein isolation: mid-term efficacy and effect on quality of life. Heart Rhythm. 2014;11:620–8.
Koyama T, Tada H, Sekiguchi Y, Arimoto T, Yamasaki H, Kuroki K, et al. Prevention of atrial fibrillation recurrence with corticosteroids after radiofrequency catheter ablation: a randomized controlled trial. J Am Coll Cardiol. 2010;56:1463–72.
Kim YR, Nam GB, Han S, Kim SH, Kim KH, Lee S, et al. Effect of short-term steroid therapy on early recurrence during the blanking period after catheter ablation of atrial fibrillation. Circ Arrhythm Electrophysiol. 2015;8:1366–72.
Iskandar S, Reddy M, Afzal MR, Rajasingh J, Atoui M, Lavu M, et al. Use of oral steroid and its effects on atrial fibrillation recurrence and inflammatory cytokines post ablation – the steroid AF study. J Atr Fibrillation. 2017;9:1604.
Kim DR, Won H, Uhm JS, Kim JY, Sung JH, Pak HN, et al. Comparison of two different doses of single bolus steroid injection to prevent atrial fibrillation recurrence after radiofrequency catheter ablation. Yonsei Med J. 2015;56:324–31.
Won H, Kim JY, Shim J, Uhm JS, Pak HN, Lee MH, et al. Effect of a single bolus injection of low-dose hydrocortisone for prevention of atrial fibrillation recurrence after radiofrequency catheter ablation. Circ J. 2013;77:53–9.
Vasamreddy CR, Dalal D, Dong J, Cheng A, Spragg D, Lamiy SZ, et al. Symptomatic and asymptomatic atrial fibrillation in patients undergoing radiofrequency catheter ablation. J Cardiovasc Electrophysiol. 2006;17:134–9.
Janse PA, van Belle YL, Theuns DA, Rivero-Ayerza M, Scholten MF, Jordaens LJ. Symptoms versus objective rhythm monitoring in patients with paroxysmal atrial fibrillation undergoing pulmonary vein isolation. Eur J Cardiovasc Nurs. 2008;7:147–51.
Piorkowski C, Kottkamp H, Tanner H, Kobza R, Nielsen JC, Arya A, et al. Value of different follow-up strategies to assess the efficacy of circumferential pulmonary vein ablation for the curative treatment of atrial fibrillation. J Cardiovasc Electrophysiol. 2005;16:1286–92.
Klemm HU, Ventura R, Rostock T, Brandstrup B, Risius T, Meinertz T, et al. Correlation of symptoms to ECG diagnosis following atrial fibrillation ablation. J Cardiovasc Electrophysiol. 2006;17:146–50.
Kaufman ES, Israel CW, Nair GM, Armaganijan L, Divakaramenon S, Mairesse GH, et al. Positive predictive value of device-detected atrial high-rate episodes at different rates and durations: an analysis from ASSERT. Heart Rhythm. 2012;9:1241–6.
Hindricks G, Pokushalov E, Urban L, Taborsky M, Kuck KH, Lebedev D, et al. Performance of a new leadless implantable cardiac monitor in detecting and quantifying atrial fibrillation: results of the XPECT trial. Circ Arrhythm Electrophysiol. 2010;3:141–7.
Xing LY, Diederichsen SZ, Højberg S, Krieger DW, Graff C, Olesen MS, et al. Electrocardiographic markers of subclinical atrial fibrillation detected by implantable loop recorder: insights from the LOOP Study. Europace. 2023;25:euad014.
Charitos EI, Ziegler PD, Stierle U, Graf B, Sievers HH, Hanke T. Long-term outcomes after surgical ablation for atrial fibrillation in patients with continuous heart rhythm monitoring devices. Interact Cardiovasc Thorac Surg. 2015;21:712–21.
Perez-Castellano N, Fernandez-Cavazos R, Moreno J, Canadas V, Conde A, Gonzalez-Ferrer JJ, et al. The COR trial: a randomized study with continuous rhythm monitoring to compare the efficacy of cryoenergy and radiofrequency for pulmonary vein isolation. Heart Rhythm. 2014;11:8–14.
Kapa S, Epstein AE, Callans DJ, Garcia FC, Lin D, Bala R, et al. Assessing arrhythmia burden after catheter ablation of atrial fibrillation using an implantable loop recorder: the ABACUS study. J Cardiovasc Electrophysiol. 2013;24:875–81.
Damiano RJ Jr, Lawrance CP, Saint LL, Henn MC, Sinn LA, Kruse J, et al. Detection of atrial fibrillation after surgical ablation: conventional versus continuous monitoring. Ann Thorac Surg. 2016;101:42–7; discussion 47–8.
Andrade JG, Wells GA, Deyell MW, Bennett M, Essebag V, Champagne J, et al. Cryoablation or drug therapy for initial treatment of atrial fibrillation. N Engl J Med. 2021;384:305–15.
Goldenthal IL, Sciacca RR, Riga T, Bakken S, Baumeister M, Biviano AB, et al. Recurrent atrial fibrillation/flutter detection after ablation or cardioversion using the AliveCor KardiaMobile device: iHEART results. J Cardiovasc Electrophysiol. 2019;30:2220–8.
Tarakji KG, Wazni OM, Callahan T, Kanj M, Hakim AH, Wolski K, et al. Using a novel wireless system for monitoring patients after the atrial fibrillation ablation procedure: the iTransmit study. Heart Rhythm. 2015;12:554–9.
Rizas KD, Freyer L, Sappler N, von Stülpnagel L, Spielbichler P, Krasniqi A, et al. Smartphone-based screening for atrial fibrillation: a pragmatic randomized clinical trial. Nat Med. 2022;28:1823–30.
Svennberg E, Tjong F, Goette A, Akoum N, Di Biase L, Bordachar P, et al. How to use digital devices to detect and manage arrhythmias: an EHRA practical guide. Europace. 2022;24:979–1005.
Lambert CT, Patel D, Bumgarner JM, Kanj M, Cantillon D, Saliba W, et al. Atrial fibrillation future clinic. Novel platform to integrate smart device electrocardiogram into clinical practice. Cardiovasc Digit Health J. 2021;2:92–100.
Hermans ANL, Gawalko M, Pluymaekers N, Dinh T, Weijs B, van Mourik MJW, et al. Long-term intermittent versus short continuous heart rhythm monitoring for the detection of atrial fibrillation recurrences after catheter ablation. Int J Cardiol. 2021;329:105–12.
Gawałko M, Duncker D, Manninger M, van der Velden RMJ, Hermans ANL, Verhaert DVM, et al. The European TeleCheck-AF project on remote app-based management of atrial fibrillation during the COVID-19 pandemic: centre and patient experiences. Europace. 2021;23:1003–15.
Unni RR, Prager RT, Odabashian R, Zhang JJ, Fat Hing NN, Nery PB, et al. Rhythm-monitoring strategy and arrhythmia recurrence in atrial fibrillation ablation trials: a systematic review. CJC Open. 2022;4:488–96.
Andrade JG, Khairy P, Verma A, Guerra PG, Dubuc M, Rivard L, et al. Early recurrence of atrial tachyarrhythmias following radiofrequency catheter ablation of atrial fibrillation. Pacing Clin Electrophysiol. 2012;35:106–16.
Calkins H, Hindricks G, Cappato R, Kim YH, Saad EB, Aguinaga L, et al. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: executive summary. Europace. 2018;20:157–208.
Gottlieb LA, Dekker LRC, Coronel R. The blinding period following ablation therapy for atrial fibrillation: proarrhythmic and antiarrhythmic pathophysiological mechanisms. JACC Clin Electrophysiol. 2021;7:416–30.
Opacic D, van Bragt KA, Nasrallah HM, Schotten U, Verheule S. Atrial metabolism and tissue perfusion as determinants of electrical and structural remodelling in atrial fibrillation. Cardiovasc Res. 2016;109:527–41.
Lim HS, Schultz C, Dang J, Alasady M, Lau DH, Brooks AG, et al. Time course of inflammation, myocardial injury, and prothrombotic response after radiofrequency catheter ablation for atrial fibrillation. Circ Arrhythm Electrophysiol. 2014;7:83–9.
Richter B, Gwechenberger M, Socas A, Zorn G, Albinni S, Marx M, et al. Markers of oxidative stress after ablation of atrial fibrillation are associated with inflammation, delivered radiofrequency energy and early recurrence of atrial fibrillation. Clin Res Cardiol. 2012;101:217–25.
Sepehri Shamloo A, Bollmann A, Dagres N, Hindricks G, Arya A. Natriuretic peptides: biomarkers for atrial fibrillation management. Clin Res Cardiol. 2020;109:957–66.
Liang JJ, Dixit S, Santangeli P. Mechanisms and clinical significance of early recurrences of atrial arrhythmias after catheter ablation for atrial fibrillation. World J Cardiol. 2016;8:638–46.
Grégoire JM, Gilon C, Carlier S, Bersini H. Role of the autonomic nervous system and premature atrial contractions in short-term paroxysmal atrial fibrillation forecasting: insights from machine learning models. Arch Cardiovasc Dis. 2022;115:377–87.
Scherschel K, Hedenus K, Jungen C, Lemoine MD, Rübsamen N, Veldkamp MW, et al. Cardiac glial cells release neurotrophic S100B upon catheter-based treatment of atrial fibrillation. Sci Transl Med. 2019;11:eaav7770.
Sasaki N, Okumura Y, Watanabe I, Nagashima K, Sonoda K, Kogawa R, et al. Transthoracic echocardiographic backscatter-based assessment of left atrial remodeling involving left atrial and ventricular fibrosis in patients with atrial fibrillation. Int J Cardiol. 2014;176:1064–6.
McGann C, Kholmovski E, Blauer J, Vijayakumar S, Haslam T, Cates J, et al. Dark regions of no-reflow on late gadolinium enhancement magnetic resonance imaging result in scar formation after atrial fibrillation ablation. J Am Coll Cardiol. 2011;58:177–85.
Peters DC, Wylie JV, Hauser TH, Nezafat R, Han Y, Woo JJ, et al. Recurrence of atrial fibrillation correlates with the extent of postprocedural late gadolinium enhancement: a pilot study. JACC Cardiovasc Imaging. 2009;2:308–16.
Steinberg C, Champagne J, Deyell MW, Dubuc M, Leong-Sit P, Calkins H, et al. Prevalence and outcome of early recurrence of atrial tachyarrhythmias in the cryoballoon vs irrigated radiofrequency catheter ablation (CIRCA-DOSE) study. Heart Rhythm. 2021;18:1463–70.
Charitakis E, Metelli S, Karlsson LO, Antoniadis AP, Rizas KD, Liuba I, et al. Comparing efficacy and safety in catheter ablation strategies for atrial fibrillation: a network metaanalysis. BMC Med. 2022;20:193.
Andrade JG, Khairy P, Verma A, Guerra PG, Dubuc M, Rivard L, et al. Early recurrence of atrial tachyarrhythmias following radiofrequency catheter ablation of atrial fibrillation. Pacing Clin Electrophysiol. 2012;35:106–16.
Baimbetov AK, Bizhanov KA, Jukenova AM, Aubakirova AT, Ualiyeva AY, Sagatov IY. Comparative effectiveness and safety of cryoablation versus radiofrequency ablation treatments for persistent atrial fibrillation. Am J Cardiol. 2022;184:22–30.
Choi J-H, Kwon H-J, Kim HR, Park S-J, Kim JS, On YK, et al. Electrocardiographic predictors of early recurrence of atrial fibrillation. Ann Noninvasive Electrocardiol. 2021;26: e12884.
Ribeiro Da Silva M, Santos Silva G, Ribeiro Queiros P, Teixeira R, Almeida J, Fonseca P, et al. Predictors of early and late recurrence of atrial fibrillation after catheter ablation: two sides of the same coin? Eur Heart J. 2021;42:ehab724.
Kim Yun G, Boo Ki Y, Choi J-I, Choi Yun Y, Choi Ha Y, Roh S-Y, et al. Early recurrence is reliable predictor of late recurrence after radiofrequency catheter ablation of atrial fibrillation. JACC Clin Electrophysiol. 2021;7:343–51.
Calkins H, Gache L, Frame D, Boo LM, Ghaly N, Schilling R, et al. Predictive value of atrial fibrillation during the postradiofrequency ablation blanking period. Heart Rhythm. 2021;18:366–73.
Filipovic K, Dittrich S, Scheurlen C, Arica Z, Erlhoefer S, Woermann J, et al. Validation of seven risk scores in a prospective and independent cohort: the challenge of predicting recurrence after atrial fibrillation ablation. Europace. 2022;24:euac053.191.
Dretzke J, Chuchu N, Agarwal R, Herd C, Chua W, Fabritz L, et al. Predicting recurrent atrial fibrillation after catheter ablation: a systematic review of prognostic models. Europace. 2020;22:748–60.
Winkle RA, Jarman JW, Mead RH, Engel G, Kong MH, Fleming W, et al. Predicting atrial fibrillation ablation outcome: the CAAP-AF score. Heart Rhythm. 2016;13:2119–25.
Kornej J, Hindricks G, Arya A, Sommer P, Husser D, Bollmann A. The APPLE score – a novel score for the prediction of rhythm outcomes after repeat catheter ablation of atrial fibrillation. PLOS ONE. 2017;12: e0169933.
Jud FN, Obeid S, Duru F, Haegeli LM. A novel score in the prediction of rhythm outcome after ablation of atrial fibrillation: the SUCCESS score. Anatol J Cardiol. 2019;21:142–9.
Mesquita J, Ferreira AM, Cavaco D, Moscoso Costa F, Carmo P, Marques H, et al. Development and validation of a risk score for predicting atrial fibrillation recurrence after a first catheter ablation procedure – ATLAS score. Europace. 2018;20:f428-35.
Nielsen JC, Lin Y-J, de Oliveira Figueiredo MJ, Sepehri Shamloo A, Alfie A, Boveda S, et al. European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) expert consensus on risk assessment in cardiac arrhythmias: use the right tool for the right outcome, in the right population. Europace. 2020;22:1147–8.
Lee S-H, Tai C-T, Hsieh M-H, Tsai C-F, Lin Y-K, Tsao H-M, et al. Predictors of early and late recurrence of atrial fibrillation after catheter ablation of paroxysmal atrial fibrillation. J Interv Card Electrophysiol. 2004;10:221–6.
Kuck K-H, Hoffmann BA, Ernst S, Wegscheider K, Treszl A, Metzner A, et al. Impact of complete versus incomplete circumferential lines around the pulmonary veins during catheter ablation of paroxysmal atrial fibrillation: results from the gap-atrial fibrillation–German atrial fibrillation competence network 1 trial. Circ Arrhythm Electrophysiol. 2016;9: e003337.
Liu H, Yuan P, Zhu X, Fu L, Hong K, Hu J. Is atrial fibrillation noninducibility by burst pacing after catheter ablation associated with reduced clinical recurrence? A systematic review and meta-analysis. J Am Heart Assoc. 2020;9: e015260.
Okada M, Inoue K, Tanaka N, Masuda M, Furukawa Y, Hirata A, et al. Reappraising the role of baseline plasma C-reactive protein levels on recurrence after catheter ablation of persistent atrial fibrillation: insight from EARNEST-PVI trial. Eur Heart J. 2021;42(ehab724):0507.
Charalampidis P, Teperikidis E, Boulmpou A, Papadopoulos CE, Potoupni V, Tsioni K, et al. Homocysteine as a predictor of paroxysmal atrial fibrillation-related events: a scoping review of the literature. Diagnostics. 2022;12:2192.
Liang JJ, Elafros MA, Chik WW, Santangeli P, Zado ES, Frankel DS, et al. Early recurrence of atrial arrhythmias following pulmonary vein antral isolation: timing and frequency of early recurrences predicts long-term ablation success. Heart Rhythm. 2015;12:2461–8.
Amankwah NA, Pothineni NVK, Guandalini G, Santangeli P, Schaller R, Supple GE, et al. Impact of atrial fibrillation recurrences during the blanking period following catheter ablation on long-term arrhythmia-free survival: a prospective study with continuous monitoring. J Interv Card Electrophysiol. 2022;65:519–25.
Mugnai G, de Asmundis C, Hünük B, Ströker E, Velagic V, Moran D, et al. Second-generation cryoballoon ablation for paroxysmal atrial fibrillation: predictive role of atrial arrhythmias occurring in the blanking period on the incidence of late recurrences. Heart Rhythm. 2016;13:845–51.
Stabile G, Iacopino S, Verlato R, Arena G, Pieragnoli P, Molon G, et al. Predictive role of early recurrence of atrial fibrillation after cryoballoon ablation. Europace. 2020;22:1798–804.
Willems S, Khairy P, Andrade JG, Hoffmann BA, Levesque S, Verma A, et al. Redefining the blanking period after catheter ablation for paroxysmal atrial fibrillation: insights from the ADVICE (adenosine following pulmonary vein isolation to target dormant conduction elimination) trial. Circ Arrhythm Electrophysiol. 2016;9: e003909.
Alipour P, Azizi Z, Pirbaglou M, Ritvo P, Pantano A, Verma A, et al. Defining blanking period post-pulmonary vein antrum isolation. JACC Clin Electrophysiol. 2017;3:568–76.
Themistoclakis S, Schweikert RA, Saliba WI, Bonso A, Rossillo A, Bader G, et al. Clinical predictors and relationship between early and late atrial tachyarrhythmias after pulmonary vein antrum isolation. Heart Rhythm. 2008;5:679–85.
Noujaim C, Lim C, Mekhael M, Feng H, Chouman N, Younes H, et al. Identifying the prognostic significance of early arrhythmia recurrence during the blanking period and the optimal blanking period duration: insights from the DECAAF II study. Europace. 2023;25:euad173.
Cosio FG, Aliot E, Botto GL, Heidbüchel H, Geller CJ, Kirchhof P, et al. Delayed rhythm control of atrial fibrillation may be a cause of failure to prevent recurrences: reasons for change to active antiarrhythmic treatment at the time of the first detected episode. Europace. 2007;10:21–7.
Chilukuri K, Dukes J, Dalal D, Marine JE, Henrikson CA, Scherr D, et al. Outcomes in patients requiring cardioversion following catheter ablation of atrial fibrillation. J Cardiovasc Electrophysiol. 2010;21:27–32.
Ebert M, Stegmann C, Kosiuk J, Dinov B, Richter S, Arya A, et al. Predictors, management, and outcome of cardioversion failure early after atrial fibrillation ablation. Europace. 2018;20:1428–34.
Dong Z, Du X, Hou XX, He L, Dong JZ, Ma CS. Effect of electrical cardioversion on 1-year outcomes in patients with early recurrence after catheter ablation for atrial fibrillation. Clin Cardiol. 2021;44:1128–38.
Malasana G, Day JD, Weiss JP, Crandall BG, Bair TL, May HT, et al. A strategy of rapid cardioversion minimizes the significance of early recurrent atrial tachyarrhythmias after ablation for atrial fibrillation. J Cardiovasc Electrophysiol. 2011;22:761–6.
Sponga S, Leoni L, Buja G, Nalli C, Voisine P, Gerosa G. Role of an aggressive rhythm control strategy on sinus rhythm maintenance following intraoperative radiofrequency ablation of atrial fibrillation in patients undergoing surgical correction of valvular disease. J Cardiol. 2012;60:316–20.
Baman TS, Gupta SK, Billakanty SR, Ilg KJ, Good E, Crawford T, et al. Time to cardioversion of recurrent atrial arrhythmias after catheter ablation of atrial fibrillation and long-term clinical outcome. J Cardiovasc Electrophysiol. 2009;20:1321–5.
Lellouche N, Jaïs P, Nault I, Wright M, Bevilacqua M, Knecht S, et al. Early recurrences after atrial fibrillation ablation: prognostic value and effect of early reablation. J Cardiovasc Electrophysiol. 2008;19:599–605.
Andrade JG, Khairy P, Macle L, Packer DL, Lehmann JW, Holcomb RG, et al. Incidence and significance of early recurrences of atrial fibrillation after cryoballoon ablation: insights from the multicenter sustained treatment of paroxysmal atrial fibrillation (STOP AF) Trial. Circ Arrhythm Electrophysiol. 2014;7:69–75.
Proietti M, Romiti GF, Olshansky B, Lane DA, Lip GYH. Improved outcomes by integrated care of anticoagulated patients with atrial fibrillation using the simple ABC (atrial fibrillation better care) pathway. Am J Med. 2018;131:1359-66.e6.
Rivera-Caravaca JM, Roldán V, Martínez-Montesinos L, Vicente V, Lip GYH, Marín F. The atrial fibrillation better care (ABC) pathway and clinical outcomes in patients with atrial fibrillation: the prospective murcia AF project phase II cohort. J Gen Intern Med. 2023;38:315–23.
Kotalczyk A, Guo Y, Stefil M, Wang Y, Lip GYH. Effects of the atrial fibrillation better care pathway on outcomes among clinically complex Chinese patients with atrial fibrillation with multimorbidity and polypharmacy: a report from the ChiOTEAF registry. J Am Heart Assoc. 2022;11: e024319.
Patel SM, Palazzolo MG, Murphy SA, Antman EM, Braunwald E, Lanz HJ, et al. Evaluation of the atrial fibrillation better care pathway in the ENGAGE AF-TIMI 48 trial. Europace. 2022;24:1730–8.
Stevens D, Harrison SL, Kolamunnage-Dona R, Lip GYH, Lane DA. The atrial fibrillation better care pathway for managing atrial fibrillation: a review. Europace. 2021;23:1511–27.
Proietti M, Lip GYH, Laroche C, Fauchier L, Marin F, Nabauer M, et al. Relation of outcomes to ABC (atrial fibrillation better care) pathway adherent care in European patients with atrial fibrillation: an analysis from the ESC-EHRA EORP Atrial Fibrillation General Long-Term (AFGen LT) registry. Europace. 2021;23:174–83.
Gerstenfeld EP, Callans DJ, Dixit S, Russo AM, Nayak H, Lin D, et al. Mechanisms of organized left atrial tachycardias occurring after pulmonary vein isolation. Circulation. 2004;110:1351–7.
Chugh A, Oral H, Good E, Han J, Tamirisa K, Lemola K, et al. Catheter ablation of atypical atrial flutter and atrial tachycardia within the coronary sinus after left atrial ablation for atrial fibrillation. J Am Coll Cardiol. 2005;46:83–91.
Deisenhofer I, Estner H, Zrenner B, Schreieck J, Weyerbrock S, Hessling G, et al. Left atrial tachycardia after circumferential pulmonary vein ablation for atrial fibrillation: incidence, electrophysiological characteristics, and results of radiofrequency ablation. Europace. 2006;8:573–82.
Gerstenfeld EP, Callans DJ, Sauer W, Jacobson J, Marchlinski FE. Reentrant and nonreentrant focal left atrial tachycardias occur after pulmonary vein isolation. Heart Rhythm. 2005;2:1195–202.
Gerstenfeld EP, Marchlinski FE. Mapping and ablation of left atrial tachycardias occurring after atrial fibrillation ablation. Heart Rhythm. 2007;4:S65-72.
Lim TW, Koay CH, McCall R, See VA, Ross DL, Thomas SP. Atrial arrhythmias after single-ring isolation of the posterior left atrium and pulmonary veins for atrial fibrillation: mechanisms and management. Circ Arrhythm Electrophysiol. 2008;1:120–6.
Anousheh R, Sawhney NS, Panutich M, Tate C, Chen WC, Feld GK. Effect of mitral isthmus block on development of atrial tachycardia following ablation for atrial fibrillation. Pacing Clin Electrophysiol. 2010;33:460–8.
Wasmer K, Monnig G, Bittner A, Dechering D, Zellerhoff S, Milberg P, et al. Incidence, characteristics, and outcome of left atrial tachycardias after circumferential antral ablation of atrial fibrillation. Heart Rhythm. 2012;9:1660–6.
Karch MR, Zrenner B, Deisenhofer I, Schreieck J, Ndrepepa G, Dong J, et al. Freedom from atrial tachyarrhythmias after catheter ablation of atrial fibrillation: a randomized comparison between 2 current ablation strategies. Circulation. 2005;111:2875–80.
Ouyang F, Antz M, Ernst S, Hachiya H, Mavrakis H, Deger FT, et al. Recovered pulmonary vein conduction as a dominant factor for recurrent atrial tachyarrhythmias after complete circular isolation of the pulmonary veins: lessons from double Lasso technique. Circulation. 2005;111:127–35.
Yamashita S, Takigawa M, Denis A, Derval N, Sakamoto Y, Masuda M, et al. Pulmonary vein-gap reentrant atrial tachycardia following atrial fibrillation ablation: an electrophysiological insight with high-resolution mapping. Europace. 2019;21:1039–47.
Wojcik M, Berkowitsch A, Zaltsberg S, Hamm CW, Pitschner HF, Kuniss M, et al. Predictors of early and late left atrial tachycardia and left atrial flutter after catheter ablation of atrial fibrillation: long-term follow-up. Cardiol J. 2015;22:557–66.
Mesas CE, Pappone C, Lang CC, Gugliotta F, Tomita T, Vicedomini G, et al. Left atrial tachycardia after circumferential pulmonary vein ablation for atrial fibrillation: electroanatomic characterization and treatment. J Am Coll Cardiol. 2004;44:1071–9.
Oral H, Chugh A, Good E, Wimmer A, Dey S, Gadeela N, et al. Radiofrequency catheter ablation of chronic atrial fibrillation guided by complex electrograms. Circulation. 2007;115:2606–12.
Mikhaylov EN, Bhagwandien R, Janse PA, Theuns DA, Szili-Torok T. Regular atrial tachycardias developing after cryoballoon pulmonary vein isolation: incidence, characteristics, and predictors. Europace. 2013;15:1710–7.
Hermida A, Kubala M, Traulle S, Buiciuc O, Quenum S, Hermida JS. Prevalence and predictive factors of left atrial tachycardia occurring after second-generation cryoballoon ablation of atrial fibrillation. J Cardiovasc Electrophysiol. 2018;29:46–54.
Guhl EN, Siddoway D, Adelstein E, Voigt A, Saba S, Jain SK. Efficacy of cryoballoon pulmonary vein isolation in patients with persistent atrial fibrillation. J Cardiovasc Electrophysiol. 2016;27:423–7.
Lyan E, Yalin K, Abdin A, Sawan N, Liosis S, Lange SA, et al. Mechanism, underlying substrate and predictors of atrial tachycardia following atrial fibrillation ablation using the second-generation cryoballoon. J Cardiol. 2019;73:497–506.
Julia J, Chierchia GB, de Asmundis C, Mugnai G, Sieira J, Ciconte G, et al. Regular atrial tachycardias following pulmonary vein isolation for paroxysmal atrial fibrillation: a retrospective comparison between the cryoballoon and conventional focal tip radiofrequency techniques. J Interv Card Electrophysiol. 2015;42:161–9.
Akerstrom F, Bastani H, Insulander P, Schwieler J, Arias MA, Jensen-Urstad M. Comparison of regular atrial tachycardia incidence after circumferential radiofrequency versus cryoballoon pulmonary vein isolation in real-life practice. J Cardiovasc Electrophysiol. 2014;25:948–52.
Van Belle Y, Knops P, Janse P, Rivero-Ayerza M, Jessurun E, Szili-Torok T, et al. Electro-anatomical mapping of the left atrium before and after cryothermal balloon isolation of the pulmonary veins. J Interv Card Electrophysiol. 2009;25:59–65.
Kenigsberg DN, Martin N, Lim HW, Kowalski M, Ellenbogen KA. Quantification of the cryoablation zone demarcated by pre- and postprocedural electroanatomic mapping in patients with atrial fibrillation using the 28-mm second-generation cryoballoon. Heart Rhythm. 2015;12:283–90.
Gopinathannair R, Mar PL, Afzal MR, Di Biase L, Tu Y, Lakkireddy T, et al. Atrial tachycardias after surgical atrial fibrillation ablation: clinical characteristics, electrophysiological mechanisms, and ablation outcomes from a large, multicenter study. JACC Clin Electrophysiol. 2017;3:865–74.
Huo Y, Schoenbauer R, Richter S, Rolf S, Sommer P, Arya A, et al. Atrial arrhythmias following surgical AF ablation: electrophysiological findings, ablation strategies, and clinical outcome. J Cardiovasc Electrophysiol. 2014;25:725–38.
Takigawa M, Derval N, Frontera A, Martin R, Yamashita S, Cheniti G, et al. Revisiting anatomic macroreentrant tachycardia after atrial fibrillation ablation using ultrahigh-resolution mapping: implications for ablation. Heart Rhythm. 2018;15:326–33.
Pascale P, Shah AJ, Roten L, Scherr D, Komatsu Y, Jadidi AS, et al. Pattern and timing of the coronary sinus activation to guide rapid diagnosis of atrial tachycardia after atrial fibrillation ablation. Circ Arrhythm Electrophysiol. 2013;6:481–90.
Arroyo RC, Latcu DG, Maeda S, Kubala M, Santangeli P, Garcia FC, et al. Coronary sinus activation and ECG characteristics of roof-dependent left atrial flutter after pulmonary vein isolation. Circ Arrhythm Electrophysiol. 2018;11: e005948.
Vlachos K, Efremidis M, Derval N, Martin CA, Takigawa M, Bazoukis G, et al. Use of high-density activation and voltage mapping in combination with entrainment to delineate gap-related atrial tachycardias post atrial fibrillation ablation. Europace. 2021;23:1052–62.
Sundaram S, Choe W, Ryan Jordan J, Mullins N, Boorman C, Kessler EJ, et al. Catheter ablation of atypical atrial flutter: a novel 3D anatomic mapping approach to quickly localize and terminate atypical atrial flutter. J Interv Card Electrophysiol. 2017;49:307–18.
Luik A, Schmidt K, Haas A, Unger L, Tzamalis P, Brüggenjürgen B. Ablation of left atrial tachycardia following catheter ablation of atrial fibrillation: 12-month success rates. J Clin Med. 2022;11:1047.
Lupercio F, Lin AY, Aldaas OM, Romero J, Briceno D, Hoffmayer KS, et al. Role of adjunctive posterior wall isolation in patients undergoing atrial fibrillation ablation: a systematic review and metaanalysis. J Interv Card Electrophysiol. 2020;58:77–86.
Kim MY, Coyle C, Tomlinson DR, Sikkel MB, Sohaib A, Luther V, et al. Ectopy-triggering ganglionated plexuses ablation to prevent atrial fibrillation: GANGLIA-AF study. Heart Rhythm. 2022;19:516–24.
Gianni C, Mohanty S, Di Biase L, Metz T, Trivedi C, Gokoglan Y, et al. Acute and early outcomes of focal impulse and rotor modulation (FIRM)-guided rotors-only ablation in patients with nonparoxysmal atrial fibrillation. Heart Rhythm. 2016;13:830–5.
Perera KS, Sharma M, Connolly SJ, Wang J, Gold MR, Hohnloser SH, et al. Stroke type and severity in patients with subclinical atrial fibrillation: an analysis from the asymptomatic atrial fibrillation and stroke evaluation in pacemaker patients and the atrial fibrillation reduction atrial pacing trial (ASSERT). Am Heart J. 2018;201:160–3.
Andrade JG, Deyell MW, Macle L, Steinberg JS, Glotzer TV, Hawkins NM, et al. Healthcare utilization and quality of life for atrial fibrillation burden: the CIRCA-DOSE study. Eur Heart J. 2023;44:765–76.
Blomstrom-Lundqvist C, Gizurarson S, Schwieler J, Jensen SM, Bergfeldt L, Kenneback G, et al. Effect of catheter ablation vs antiarrhythmic medication on quality of life in patients with atrial fibrillation: the CAPTAF randomized clinical trial. JAMA. 2019;321:1059–68.
Brachmann J, Sohns C, Andresen D, Siebels J, Sehner S, Boersma L, et al. Atrial fibrillation burden and clinical outcomes in heart failure: the CASTLE-AF trial. JACC Clin Electrophysiol. 2021;7:594–603.
Kuck KH, Lebedev DS, Mikhaylov EN, Romanov A, Geller L, Kalejs O, et al. Catheter ablation or medical therapy to delay progression of atrial fibrillation: the randomized controlled atrial fibrillation progression trial (ATTEST). Europace. 2021;23:362–9.
Packer D, Monahan K, Piccini J, Al-Khalidi H, Silverstein A, Poole J, et al. Impact of treatment strategies for AF on the progression and regression of AF type in the CABANA trial. Eur Heart J. 2020;41:ehaa946.0680.
Gupta D, Vijgen J, Potter T, Scherr D, Van Herendael H, Knecht S, et al. Quality of life and healthcare utilisation improvements after atrial fibrillation ablation. Heart. 2021;107:1296–302.
Mark DB, Anstrom KJ, Sheng S, Piccini JP, Baloch KN, Monahan KH, et al. Effect of catheter ablation vs medical therapy on quality of life among patients with atrial fibrillation: the CABANA randomized clinical trial. JAMA. 2019;321:1275–85.
Samuel M, Khairy P, Champagne J, Deyell MW, Macle L, Leong-Sit P, et al. Association of atrial fibrillation burden with health-related quality of life after atrial fibrillation ablation: substudy of the cryoballoon vs contact-force atrial fibrillation ablation (CIRCA-DOSE) randomized clinical trial. JAMA Cardiol. 2021;6:1324–8.
Wazni O, Dandamudi G, Sood N, Hoyt R, Tyler J, Durrani S, et al. Quality of life after the initial treatment of atrial fibrillation with cryoablation versus drug therapy. Heart Rhythm. 2022;19:197–205.
Wu L, Narasimhan B, Ho KS, Zheng Y, Shah AN, Kantharia BK. Safety and complications of catheter ablation for atrial fibrillation: predictors of complications from an updated analysis the national inpatient database. J Cardiovasc Electrophysiol. 2021;32:1024–34.
Ngo L, Ali A, Ganesan A, Woodman R, Adams R, Ranasinghe I. Ten-year trends in mortality and complications following catheter ablation of atrial fibrillation. Eur Heart J Qual Care Clin Outcomes. 2022;8:398–408.
Benali K, Khairy P, Hammache N, Petzl A, Da Costa A, Verma A, et al. Procedure-related complications of catheter ablation for atrial fibrillation. J Am Coll Cardiol. 2023;81:2089–99.
Hsu JC, Darden D, Du C, Marine JE, Nichols S, Marcus GM, et al. Initial findings from the national cardiovascular data registry of atrial fibrillation ablation procedures. J Am Coll Cardiol. 2023;81:867–78.
König S, Ueberham L, Schuler E, Wiedemann M, Reithmann C, Seyfarth M, et al. In-hospital mortality of patients with atrial arrhythmias: insights from the German-wide Helios hospital network of 161 502 patients and 34 025 arrhythmia-related procedures. Eur Heart J. 2018;39:3947–57.
Mszar R, Friedman DJ, Ong E, Du C, Wang Y, Zeitler EP, et al. Sex-based differences in atrial fibrillation ablation adverse events. Heart. 2023;109:595–605.
Forleo GB, Tondo C, De Luca L, Dello Russo A, Casella M, De Sanctis V, et al. Gender-related differences in catheter ablation of atrial fibrillation. Europace. 2007;9:613–20.
Ngo L, Ali A, Ganesan A, Woodman R, Adams R, Ranasinghe I. Gender differences in complications following catheter ablation of atrial fibrillation. Eur Heart J Qual Care Clin Outcomes. 2021;7:458–67.
Tonchev IR, Nam MCY, Gorelik A, Kumar S, Haqqani H, Sanders P, et al. Relationship between procedural volume and complication rates for catheter ablation of atrial fibrillation: a systematic review and metaanalysis. Europace. 2021;23:1024–32.
Cheung JW, Yeo I, Cheng EP, Ip JE, Thomas G, Liu CF, et al. Inpatient hospital procedural volume and outcomes following catheter ablation of atrial fibrillation. J Cardiovasc Electrophysiol. 2020;31:1908–19.
Mörtsell D, Arbelo E, Dagres N, Brugada J, Laroche C, Trines SA, et al. Cryoballoon vs. radiofrequency ablation for atrial fibrillation: a study of outcome and safety based on the ESC-EHRA atrial fibrillation ablation long-term registry and the Swedish catheter ablation registry. Europace. 2019;21:581–9.
Buiatti A, von Olshausen G, Barthel P, Schneider S, Luik A, Kaess B, et al. Cryoballoon vs. radiofrequency ablation for paroxysmal atrial fibrillation: an updated metaanalysis of randomized and observational studies. Europace. 2017;19:378–84.
Ravi V, Poudyal A, Abid QU, Larsen T, Krishnan K, Sharma PS, et al. High-power short duration vs. conventional radiofrequency ablation of atrial fibrillation: a systematic review and metaanalysis. Europace. 2021;23:710–21.
Hansom SP, Alqarawi W, Birnie DH, Golian M, Nery PB, Redpath CJ, et al. High-power, short-duration atrial fibrillation ablation compared with a conventional approach: outcomes and reconnection patterns. J Cardiovasc Electrophysiol. 2021;32:1219–28.
Mueller J, Halbfass P, Sonne K, Nentwich K, Ene E, Berkovitz A, et al. Safety aspects of very high power very short duration atrial fibrillation ablation using a modified radiofrequency RF-generator: single-center experience. J Cardiovasc Electrophysiol. 2022;33:920–7.
Chieng D, Segan L, Sugumar H, Al-Kaisey A, Hawson J, Moore BM, et al. Higher power short duration vs. lower power longer duration posterior wall ablation for atrial fibrillation and oesophageal injury outcomes: a prospective multi-centre randomized controlled study (Hi-Lo HEAT trial). Europace. 2023;25:417–24.
Lee AC, Voskoboinik A, Cheung CC, Yogi S, Tseng ZH, Moss JD, et al. A randomized trial of high vs standard power radiofrequency ablation for pulmonary vein isolation. JACC Clin Electrophysiol. 2023;9:1038–47.
Paul Nordin A, Drca N, Insulander P, Bastani H, Bourke T, Braunschweig F, et al. Low incidence of major complications after the first six hours post atrial fibrillation ablation: is same-day discharge safe and feasible in most patients? J Cardiovasc Electrophysiol. 2021;32:2953–60.
Opel A, Mansell J, Butler A, Schwartz R, Fannon M, Finlay M, et al. Comparison of a high throughput day case atrial fibrillation ablation service in a local hospital with standard regional tertiary cardiac centre care. Europace. 2019;21:440–4.
Dagres N, Anastasiou-Nana M. Prevention of atrial-esophageal fistula after catheter ablation of atrial fibrillation. Curr Opin Cardiol. 2011;26:1–5.
Cochet H, Nakatani Y, Sridi-Cheniti S, Cheniti G, Ramirez FD, Nakashima T, et al. Pulsed field ablation selectively spares the oesophagus during pulmonary vein isolation for atrial fibrillation. Europace. 2021;23:1391–9.
Marashly Q, Gopinath C, Baher A, Acharya M, Kheirkhahan M, Hardisty B, et al. Late gadolinium enhancement magnetic resonance imaging evaluation of post-atrial fibrillation ablation esophageal thermal injury across the spectrum of severity. J Am Heart Assoc. 2021;10: e018924.
Di Biase L, Saenz LC, Burkhardt DJ, Vacca M, Elayi CS, Barrett CD, et al. Esophageal capsule endoscopy after radiofrequency catheter ablation for atrial fibrillation: documented higher risk of luminal esophageal damage with general anesthesia as compared with conscious sedation. Circ Arrhythm Electrophysiol. 2009;2:108–12.
Martinek M, Meyer C, Hassanein S, Aichinger J, Bencsik G, Schoefl R, et al. Identification of a high-risk population for esophageal injury during radiofrequency catheter ablation of atrial fibrillation: procedural and anatomical considerations. Heart Rhythm. 2010;7:1224–30.
Singh SM, d’Avila A, Singh SK, Stelzer P, Saad EB, Skanes A, et al. Clinical outcomes after repair of left atrial esophageal fistulas occurring after atrial fibrillation ablation procedures. Heart Rhythm. 2013;10:1591–7.
Mohanty S, Santangeli P, Mohanty P, Di Biase L, Trivedi C, Bai R, et al. Outcomes of atrioesophageal fistula following catheter ablation of atrial fibrillation treated with surgical repair versus esophageal stenting. J Cardiovasc Electrophysiol. 2014;25:579–84.
Mohanty S, Santangeli P, Mohanty P, Di Biase L, Holcomb S, Trivedi C, et al. Catheter ablation of asymptomatic longstanding persistent atrial fibrillation: impact on quality of life, exercise performance, arrhythmia perception, and arrhythmia-free survival. J Cardiovasc Electrophysiol. 2014;25:1057–64.
Eitel C, Rolf S, Zachäus M, John S, Sommer P, Bollmann A, et al. Successful nonsurgical treatment of esophagopericardial fistulas after atrial fibrillation catheter ablation: a case series. Circ Arrhythm Electrophysiol. 2013;6:675–81.
Bunch TJ, Nelson J, Foley T, Allison S, Crandall BG, Osborn JS, et al. Temporary esophageal stenting allows healing of esophageal perforations following atrial fibrillation ablation procedures. J Cardiovasc Electrophysiol. 2006;17:435–9.
Liu Y, Zhan X, Xue Y, Deng H, Fang X, Liao H, et al. Incidence and outcomes of cerebrovascular events complicating catheter ablation for atrial fibrillation. Europace. 2016;18:1357–65.
Kosiuk J, Kornej J, Bollmann A, Piorkowski C, Myrda K, Arya A, et al. Early cerebral thromboembolic complications after radiofrequency catheter ablation of atrial fibrillation: incidence, characteristics, and risk factors. Heart Rhythm. 2014;11:1934–40.
Deneke T, Jais P, Scaglione M, Schmitt RLDIB, Christopoulos G, Schade A, et al. Silent cerebral events/lesions related to atrial fibrillation ablation: a clinical review. J Cardiovasc Electrophysiol. 2015;26:455–63.
Kimura T, Kashimura S, Nishiyama T, Katsumata Y, Inagawa K, Ikegami Y, et al. Asymptomatic cerebral infarction during catheter ablation for atrial fibrillation: comparing uninterrupted rivaroxaban and warfarin (ASCERTAIN). JACC Clin Electrophysiol. 2018;4:1598–609.
Medi C, Evered L, Silbert B, Teh A, Halloran K, Morton J, et al. Subtle postprocedural cognitive dysfunction after atrial fibrillation ablation. J Am Coll Cardiol. 2013;62:531–9.
Al-Kaisey AM, Parameswaran R, Bryant C, Anderson RD, Hawson J, Chieng D, et al. Impact of catheter ablation on cognitive function in atrial fibrillation: a randomized control trial. JACC Clin Electrophysiol. 2023;9:1024–34.
Kato N, Muraga K, Hirata Y, Shindo A, Matsuura K, Ii Y, et al. Brain magnetic resonance imaging and cognitive alterations after ablation in patients with atrial fibrillation. Sci Rep. 2021;11:18995.
Haeusler KG, Eichner FA, Heuschmann PU, Fiebach JB, Engelhorn T, Blank B, et al. MRI-detected brain lesions and cognitive function in patients with atrial fibrillation undergoing left atrial catheter ablation in the randomized AXAFA-AFNET 5 trial. Circulation. 2022;145:906–15.
Grecu M, Blomström-Lundqvist C, Kautzner J, Laroche C, Van Gelder IC, Jordaens L, et al. In-hospital and 12-month follow-up outcome from the ESC-EORP EHRA atrial fibrillation ablation long-term registry: sex differences. Europace. 2020;22:66–73.
Santangeli P, Di Biase L, Al-Ahmad A, Horton R, Burkhardt JD, Sanchez JE, et al. Ablation for atrial fibrillation: termination of atrial fibrillation is not the end point. Card Electrophysiol Clin. 2012;4:343–52.
Nairooz R, Sardar P, Payne J, Aronow WS, Paydak H. Metaanalysis of major bleeding with uninterrupted warfarin compared to interrupted warfarin and heparin bridging in ablation of atrial fibrillation. Int J Cardiol. 2015;187:426–9.
Ezekowitz MD, Pollack CV Jr, Halperin JL, England RD, VanPelt Nguyen S, Spahr J, et al. Apixaban compared to heparin/vitamin K antagonist in patients with atrial fibrillation scheduled for cardioversion: the EMANATE trial. Eur Heart J. 2018;39:2959–71.
Lin H, Chen YH, Hou JW, Lu ZY, Xiang Y, Li YG. Role of contact force-guided radiofrequency catheter ablation for treatment of atrial fibrillation: a systematic review and metaanalysis. J Cardiovasc Electrophysiol. 2017;28:994–1005.
Friedman DJ, Pokorney SD, Ghanem A, Marcello S, Kalsekar I, Yadalam S, et al. Predictors of cardiac perforation with catheter ablation of atrial fibrillation. JACC Clin Electrophysiol. 2020;6:636–45.
Cappato R, Calkins H, Chen SA, Davies W, Iesaka Y, Kalman J, et al. Delayed cardiac tamponade after radiofrequency catheter ablation of atrial fibrillation: a worldwide report. J Am Coll Cardiol. 2011;58:2696–7.
Cappato R, Calkins H, Chen SA, Davies W, Iesaka Y, Kalman J, et al. Prevalence and causes of fatal outcome in catheter ablation of atrial fibrillation. J Am Coll Cardiol. 2009;53:1798–803.
Tsang TS, Enriquez-Sarano M, Freeman WK, Barnes ME, Sinak LJ, Gersh BJ, et al. Consecutive 1127 therapeutic echocardiographically guided pericardiocenteses: clinical profile, practice patterns, and outcomes spanning 21 years. Mayo Clin Proc. 2002;77:429–36.
Bunch TJ, Asirvatham SJ, Friedman PA, Monahan KH, Munger TM, Rea RF, et al. Outcomes after cardiac perforation during radiofrequency ablation of the atrium. J Cardiovasc Electrophysiol. 2005;16:1172–9.
Michowitz Y, Rahkovich M, Oral H, Zado ES, Tilz R, John S, et al. Effects of sex on the incidence of cardiac tamponade after catheter ablation of atrial fibrillation: results from a worldwide survey in 34 943 atrial fibrillation ablation procedures. Circ Arrhythm Electrophysiol. 2014;7:274–80.
Zhao Q, Li L, Liu N, Zhang M, Wu K, Ruan Y, et al. Early versus delayed removal of the pericardial drain in patients with cardiac tamponade complicating radiofrequency ablation of atrial fibrillation. J Cardiovasc Electrophysiol. 2020;31:597–603.
Zhao X, Liu JF, Su X, Long DY, Sang CH, Tang RB, et al. Direct autotransfusion in the management of acute pericardial tamponade during catheter ablation for atrial fibrillation: an imperfect but practical method. Front Cardiovasc Med. 2022;9: 984251.
Pedersen MEF, Leo M, Kalla M, Malhotra A, Stone M, Wong K, et al. Management of tamponade complicating catheter ablation for atrial fibrillation: early removal of pericardial drains is safe and effective and reduces analgesic requirements and hospital stay compared to conventional delayed removal. JACC Clin Electrophysiol. 2017;3:367–73.
Raeisi-Giglou P, Wazni OM, Saliba WI, Barakat A, Tarakji KG, Rickard J, et al. Outcomes and management of patients with severe pulmonary vein stenosis from prior atrial fibrillation ablation. Circ Arrhythm Electrophysiol. 2018;11: e006001.
Andrade JG, Khairy P, Guerra PG, Deyell MW, Rivard L, Macle L, et al. Efficacy and safety of cryoballoon ablation for atrial fibrillation: a systematic review of published studies. Heart Rhythm. 2011;8:1444–51.
Fender EA, Packer DL, Holmes DR Jr. Pulmonary vein stenosis after atrial fibrillation ablation. EuroIntervention. 2016;12:X31-4.
Saad EB, Marrouche NF, Saad CP, Ha E, Bash D, White RD, et al. Pulmonary vein stenosis after catheter ablation of atrial fibrillation: emergence of a new clinical syndrome. Ann Intern Med. 2003;138:634–8.
Tokutake K, Tokuda M, Yamashita S, Sato H, Ikewaki H, Okajima E, et al. Anatomical and procedural factors of severe pulmonary vein stenosis after cryoballoon pulmonary vein ablation. JACC Clin Electrophysiol. 2019;5:1303–15.
Kim J, Kim D, Yu HT, Kim TH, Joung B, Lee MH, et al. Revisiting symptomatic pulmonary vein stenosis after high-power short-duration radiofrequency ablation in patients with atrial fibrillation. Europace. 2023;25:euad296.
Katz ES, Tsiamtsiouris T, Applebaum RM, Schwartzbard A, Tunick PA, Kronzon I. Surgical left atrial appendage ligation is frequently incomplete: a transesophageal echocardiograhic study. J Am Coll Cardiol. 2000;36:468–71.
Fender EA, Widmer RJ, Hodge DO, Cooper GM, Monahan KH, Peterson LA, et al. Severe pulmonary vein stenosis resulting from ablation for atrial fibrillation: presentation, management, and clinical outcomes. Circulation. 2016;134:1812–21.
Fender EA, Widmer RJ, Hodge DO, Packer DL, Holmes DR Jr. Assessment and management of pulmonary vein occlusion after atrial fibrillation ablation. JACC Cardiovasc Interv. 2018;11:1633–9.
Hilbert S, Paetsch I, Bollmann A, Jahnke C. Pulmonary vein collateral formation as a long-term result of post-interventional pulmonary vein stenosis. Eur Heart J. 2016;37:2474.
Hilbert S, Sommer P, Bollmann A. Pulmonary vein dilatation in a case of total pulmonary vein occlusion: contemporary approach using a combination of 3D-mapping system and image integration. Catheter Cardiovasc Interv. 2016;88:E227-32.
Holmes DR Jr, Monahan KH, Packer D. Pulmonary vein stenosis complicating ablation for atrial fibrillation: clinical spectrum and interventional considerations. JACC Cardiovasc Interv. 2009;2:267–76.
Fender EA, Widmer RJ, Mahowald MK, Hodge DO, Packer DL, Holmes DR Jr. Recurrent pulmonary vein stenosis after successful intervention: prognosis and management of restenosis. Catheter Cardiovasc Interv. 2020;95:954–8.
Mol D, Renskers L, Balt JC, Bhagwandien RE, Blaauw Y, van Driel V, et al. Persistent phrenic nerve palsy after atrial fibrillation ablation: follow-up data from The Netherlands Heart Registration. J Cardiovasc Electrophysiol. 2022;33:559–64.
Heeger CH, Sohns C, Pott A, Metzner A, Inaba O, Straube F, et al. Phrenic nerve injury during cryoballoon-based pulmonary vein isolation: results of the worldwide YETI registry. Circ Arrhythm Electrophysiol. 2022;15: e010516.
Sacher F, Monahan KH, Thomas SP, Davidson N, Adragao P, Sanders P, et al. Phrenic nerve injury after atrial fibrillation catheter ablation: characterization and outcome in a multicenter study. J Am Coll Cardiol. 2006;47:2498–503.
Yong Ji S, Dewire J, Barcelon B, Philips B, Catanzaro J, Nazarian S, et al. Phrenic nerve injury: an underrecognized and potentially preventable complication of pulmonary vein isolation using a wide-area circumferential ablation approach. J Cardiovasc Electrophysiol. 2013;24:1086–91.
Franceschi F, Dubuc M, Guerra PG, Khairy P. Phrenic nerve monitoring with diaphragmatic electromyography during cryoballoon ablation for atrial fibrillation: the first human application. Heart Rhythm. 2011;8:1068–71.
Miyazaki S, Hachiya H, Taniguchi H, Nakamura H, Ichihara N, Usui E, et al. Prospective evaluation of bilateral diaphragmatic electromyograms during cryoballoon ablation of atrial fibrillation. J Cardiovasc Electrophysiol. 2015;26:622–8.
Mondésert B, Andrade JG, Khairy P, Guerra PG, Dyrda K, Macle L, et al. Clinical experience with a novel electromyographic approach to preventing phrenic nerve injury during cryoballoon ablation in atrial fibrillation. Circ Arrhythm Electrophysiol. 2014;7:605–11.
Palaniswamy C, Kolte D, Harikrishnan P, Khera S, Aronow WS, Mujib M, et al. Catheter ablation of postinfarction ventricular tachycardia: ten-year trends in utilization, in-hospital complications, and in-hospital mortality in the United States. Heart Rhythm. 2014;11:2056–63.
Peichl P, Wichterle D, Pavlu L, Cihak R, Aldhoon B, Kautzner J. Complications of catheter ablation of ventricular tachycardia: a single-center experience. Circ Arrhythm Electrophysiol. 2014;7:684–90.
Waigand J, Uhlich F, Gross CM, Thalhammer C, Dietz R. Percutaneous treatment of pseudoaneurysms and arteriovenous fistulas after invasive vascular procedures. Catheter Cardiovasc Interv. 1999;47:157–64.
Kuwahara T, Takahashi A, Takahashi Y, Kobori A, Miyazaki S, Takei A, et al. Clinical characteristics of massive air embolism complicating left atrial ablation of atrial fibrillation: lessons from five cases. Europace. 2012;14:204–8.
Krivonyak GS, Warren SG. Cerebral arterial air embolism treated by a vertical head-down maneuver. Catheter Cardiovasc Interv. 2000;49:185–7.
Franzen OW, Klemm H, Hamann F, Koschyk D, von Kodolitsch Y, Weil J, et al. Mechanisms underlying air aspiration in patients undergoing left atrial catheterization. Catheter Cardiovasc Interv. 2008;71:553–8.
Chugh A, Makkar A, Yen Ho S, Yokokawa M, Sundaram B, Pelosi F, et al. Manifestations of coronary arterial injury during catheter ablation of atrial fibrillation and related arrhythmias. Heart Rhythm. 2013;10:1638–45.
Takahashi Y, Jaïs P, Hocini M, Sanders P, Rotter M, Rostock T, et al. Acute occlusion of the left circumflex coronary artery during mitral isthmus linear ablation. J Cardiovasc Electrophysiol. 2005;16:1104–7.
Kitamura T, Fukamizu S, Arai K, Hojo R, Aoyama Y, Komiyama K, et al. Transient sinus node dysfunction following sinus node artery occlusion due to radiofrequency catheter ablation of the septal superior vena cava-right atrium junction. J Electrocardiol. 2016;49:18–22.
Higuchi S, Im SI, Stillson C, Buck ED, Jerrell S, Schneider CW, et al. Effect of epicardial pulsed field ablation directly on coronary arteries. JACC Clin Electrophysiol. 2022;8:1486–96.
Kesek M, Englund A, Jensen SM, Jensen-Urstad M. Entrapment of circular mapping catheter in the mitral valve. Heart Rhythm. 2007;4:17–9.
Grove R, Kranig W, Coppoolse R, Lüdorff G, Wolff E, Warnecke H, et al. Demand for open heart surgery due to entrapment of a circular mapping catheter in the mitral valve in a patient undergoing atrial fibrillation ablation. Clin Res Cardiol. 2008;97:628–9.
Lakkireddy D, Nagarajan D, Di Biase L, Vanga SR, Mahapatra S, Jared Bunch T, et al. Radiofrequency ablation of atrial fibrillation in patients with mitral or aortic mechanical prosthetic valves: a feasibility, safety, and efficacy study. Heart Rhythm. 2011;8:975–80.
Zeljko HM, Mont L, Sitges M, Tolosana JM, Nadal M, Castella M, et al. Entrapment of the circular mapping catheter in the mitral valve in two patients undergoing atrial fibrillation ablation. Europace. 2011;13:132–3.
Wu RC, Brinker JA, Yuh DD, Berger RD, Calkins HG. Circular mapping catheter entrapment in the mitral valve apparatus: a previously unrecognized complication of focal atrial fibrillation ablation. J Cardiovasc Electrophysiol. 2002;13:819–21.
Kim EJ, Gerstenfeld EP, Pellegrini CN. Use of adenosine to release an entrapped catheter during ablation of premature ventricular complexes. JACC Case Rep. 2021;3:610–3.
Tavernier R, Duytschaever M, Taeymans Y. Fracture of a circular mapping catheter after entrapment in the mitral valve apparatus during segmental pulmonary vein isolation. Pacing Clin Electrophysiol. 2003;26:1774–5.
Gurbuz O, Ercan A, Ozkan H, Kumtepe G, Karal IH, Ener S. Case report: paravalvular leak as a complication of percutaneous catheter ablation for atrial fibrillation. J Cardiothorac Surg. 2014;9:187.
Kawaji T, Kato M, Yokomatsu T. How to release PentaRay catheter entrapped in the hinge point of mechanical mitral valve? Europace. 2020;22:204.
Yagishita A, Ayabe K, Sakama S, Morise M, Amino M, Ikari Y, et al. A novel technique to release a PentaRay entrapped in a mechanical mitral valve using an ablation catheter. JACC Clin Electrophysiol. 2020;6:1597–8.
Lopes J, Sousa PA, Elvas L, Gonçalves L. Successful retrieval of a broken PentaRay catheter spine in a patient with mechanic mitral valve prosthesis. J Interv Card Electrophysiol. 2021;61:625–6.
Cochet H, Scherr D, Zellerhoff S, Sacher F, Derval N, Denis A, et al. Atrial structure and function 5 years after successful ablation for persistent atrial fibrillation: an MRI study. J Cardiovasc Electrophysiol. 2014;25:671–9.
Gibson DN, Di Biase L, Mohanty P, Patel JD, Bai R, Sanchez J, et al. Stiff left atrial syndrome after catheter ablation for atrial fibrillation: clinical characterization, prevalence, and predictors. Heart Rhythm. 2011;8:1364–71.
Shoemaker MB, Hemnes AR, Robbins IM, Langberg JJ, Ellis CR, Aznaurov SG, et al. Left atrial hypertension after repeated catheter ablations for atrial fibrillation. J Am Coll Cardiol. 2011;57:1918–9.
Welch TD, Coylewright M, Powell BD, Asirvatham SJ, Gersh BJ, Dearani JA, et al. Symptomatic pulmonary hypertension with giant left atrial v waves after surgical maze procedures: evaluation by comprehensive hemodynamic catheterization. Heart Rhythm. 2013;10:1839–42.
Moon I, Lee SY, Lee E, Lee SR, Cha MJ, Choi EK, et al. Extensive left atrial ablation was associated with exacerbation of left atrial stiffness and dyspnea. J Cardiovasc Electrophysiol. 2019;30:2782–9.
Witt C, Powell B, Holmes D, Alli O. Recurrent dyspnea following multiple ablations for atrial fibrillation explained by the “stiff left atrial syndrome”. Catheter Cardiovasc Interv. 2013;82:E747-9.
Wong GR, Lau DH, Baillie TJ, Middeldorp ME, Steele PM, Sanders P. Novel use of sildenafil in the management of pulmonary hypertension due to post-catheter ablation ‘stiff left atrial syndrome’. Int J Cardiol. 2015;181:55–6.
Lakkireddy D, Reddy YM, Atkins D, Rajasingh J, Kanmanthareddy A, Olyaee M, et al. Effect of atrial fibrillation ablation on gastric motility: the atrial fibrillation gut study. Circ Arrhythm Electrophysiol. 2015;8:531–6.
Kuwahara T, Takahashi A, Takahashi Y, Kobori A, Miyazaki S, Takei A, et al. Clinical characteristics and management of periesophageal vagal nerve injury complicating left atrial ablation of atrial fibrillation: lessons from eleven cases. J Cardiovasc Electrophysiol. 2013;24:847–51.
Knopp H, Halm U, Lamberts R, Knigge I, Zachäus M, Sommer P, et al. Incidental and ablation-induced findings during upper gastrointestinal endoscopy in patients after ablation of atrial fibrillation: a retrospective study of 425 patients. Heart Rhythm. 2014;11:574–8.
Miyazaki S, Nakamura H, Taniguchi H, Hachiya H, Takagi T, Igarashi M, et al. Gastric hypomotility after second-generation cryoballoon ablation-unrecognized silent nerve injury after cryoballoon ablation. Heart Rhythm. 2017;14:670–7.
Aksu T, Golcuk S, Guler TE, Yalin K, Erden I. Gastroparesis as a complication of atrial fibrillation ablation. Am J Cardiol. 2015;116:92–7.
Shigeta T, Okishige K, Aoyagi H, Nishimura T, Nakamura RA, Ito N, et al. Clinical investigation of esophageal injury from cryoballoon ablation of persistent atrial fibrillation. Pacing Clin Electrophysiol. 2019;42:230–7.
Bunch TJ, Ellenbogen KA, Packer DL, Asirvatham SJ. Vagus nerve injury after posterior atrial radiofrequency ablation. Heart Rhythm. 2008;5:1327–30.
Miyazaki S, Taniguchi H, Kusa S, Komatsu Y, Ichihara N, Takagi T, et al. Factors associated with periesophageal vagal nerve injury after pulmonary vein antrum isolation. J Am Heart Assoc. 2014;3: e001209.
Pisani CF, Hachul D, Sosa E, Scanavacca M. Gastric hypomotility following epicardial vagal denervation ablation to treat atrial fibrillation. J Cardiovasc Electrophysiol. 2008;19:211–3.
Schwartz TW, Rehfeld JF, Stadil F, Larson LI, Chance RE, Moon N. Pancreatic-polypeptide response to food in duodenal-ulcer patients before and after vagotomy. Lancet. 1976;307:1102–5.
Janssens J, Peeters TL, Vantrappen G, Tack J, Urbain JL, De Roo M, et al. Improvement of gastric emptying in diabetic gastroparesis by erythromycin. Preliminary studies N Engl J Med. 1990;322:1028–31.
Camilleri M, Atieh J. New developments in prokinetic therapy for gastric motility disorders. Front Pharmacol. 2021;12: 711500.
Zheng T, Camilleri M. Management of gastroparesis. Gastroenterol Hepatol (N Y). 2021;17:515–25.
Badhwar V, Rankin JS, Ad N, Grau-Sepulveda M, Damiano RJ, Gillinov AM, et al. Surgical ablation of atrial fibrillation in the United States: trends and propensity matched outcomes. Ann Thorac Surg. 2017;104:493–500.
Budera P, Straka Z, Osmančík P, Vaněk T, Jelínek Š, Hlavička J, et al. Comparison of cardiac surgery with left atrial surgical ablation vs. cardiac surgery without atrial ablation in patients with coronary and/or valvular heart disease plus atrial fibrillation: final results of the PRAGUE-12 randomized multicentre study. Eur Heart J. 2012;33:2644–52.
Nashef SAM, Fynn S, Abu-Omar Y, Spyt TJ, Mills C, Everett CC, et al. Amaze: a randomized controlled trial of adjunct surgery for atrial fibrillation. Eur J Cardiothorac Surg. 2018;54:729–37.
Osmancik P, Budera P, Talavera D, Hlavicka J, Herman D, Holy J, et al. Five-year outcomes in cardiac surgery patients with atrial fibrillation undergoing concomitant surgical ablation versus no ablation. The long-term follow-up of the PRAGUE-12 study. Heart Rhythm. 2019;16:1334–40.
Wong JW, Mak KH. Impact of maze and concomitant mitral valve surgery on clinical outcomes. Ann Thorac Surg. 2006;82:1938–47.
Lee R, McCarthy PM, Wang EC, Vaduganathan M, Kruse J, Malaisrie SC Jr, et al. Midterm survival in patients treated for atrial fibrillation: a propensity-matched comparison to patients without a history of atrial fibrillation. J Thorac Cardiovasc Surg. 2012;143:1341–51; discussion 1350–1.
Musharbash FN, Schill MR, Sinn LA, Schuessler RB, Maniar HS, Moon MR, et al. Performance of the Cox-maze IV procedure is associated with improved long-term survival in patients with atrial fibrillation undergoing cardiac surgery. J Thorac Cardiovasc Surg. 2018;155:159–70.
Iribarne A, DiScipio AW, McCullough JN, Quinn R, Leavitt BJ, Westbrook BM, et al. Surgical atrial fibrillation ablation improves long-term survival: a multicenter analysis. Ann Thorac Surg. 2019;107:135–42.
Kowalewski M, Pasierski M, Kołodziejczak M, Litwinowicz R, Kowalówka A, Wańha W, et al. Atrial fibrillation ablation improves late survival after concomitant cardiac surgery. J Thorac Cardiovasc Surg. 2023;166:1656-68.e8.
Kim HJ, Kim YJ, Kim M, Yoo JS, Kim DH, Park DW, et al. Surgical ablation for atrial fibrillation during aortic and mitral valve surgery: a nationwide population-based cohort study. J Thorac Cardiovasc Surg. 2022.
Suwalski P, Kowalewski M, Jasiński M, Staromłyński J, Zembala M, Widenka K, et al. Survival after surgical ablation for atrial fibrillation in mitral valve surgery: analysis from the polish national registry of cardiac surgery procedures (KROK). J Thorac Cardiovasc Surg. 2019;157:1007-18.e4.
Gemelli M, Gallo M, Addonizio M, Van den Eynde J, Pradegan N, Danesi TH, et al. Surgical ablation for atrial fibrillation during mitral valve surgery: a systematic review and metaanalysis of randomized controlled trials. Am J Cardiol. 2023;209:104–13.
Reston JT, Shuhaiber JH. Metaanalysis of clinical outcomes of maze-related surgical procedures for medically refractory atrial fibrillation. Eur J Cardiothorac Surg. 2005;28:724–30.
Rankin JS, Lerner DJ, Braid-Forbes MJ, McCrea MM, Badhwar V. Surgical ablation of atrial fibrillation concomitant to coronary-artery bypass grafting provides cost-effective mortality reduction. J Thorac Cardiovasc Surg. 2020;160:675-86.e13.
Suwalski P, Kowalewski M, Jasiński M, Staromłyński J, Zembala M, Widenka K, et al. Surgical ablation for atrial fibrillation during isolated coronary artery bypass surgery. Eur J Cardiothorac Surg. 2020;57:691–700.
MacGregor RM, Bakir NH, Pedamallu H, Sinn LA, Maniar HS, Melby SJ, et al. Late results after stand-alone surgical ablation for atrial fibrillation. J Thorac Cardiovasc Surg. 2022;164:1515-28.e8.
Lapenna E, De Bonis M, Giambuzzi I, Del Forno B, Ruggeri S, Cireddu M, et al. Long-term outcomes of stand-alone maze IV for persistent or long-standing persistent atrial fibrillation. Ann Thorac Surg. 2020;109:124–31.
Ad N, Holmes SD, Friehling T. Minimally invasive stand-alone cox maze procedure for persistent and long-standing persistent atrial fibrillation: perioperative safety and 5-year outcomes. Circ Arrhythm Electrophysiol. 2017;10: e005352.
Henn MC, Lancaster TS, Miller JR, Sinn LA, Schuessler RB, Moon MR, et al. Late outcomes after the Cox maze IV procedure for atrial fibrillation. J Thorac Cardiovasc Surg. 2015;150(1168–76):1178.e1-2.
Gammie JS, Haddad M, Milford-Beland S, Welke KF, Ferguson TB Jr, O’Brien SM, et al. Atrial fibrillation correction surgery: lessons from the Society of Thoracic Surgeons National Cardiac Database. Ann Thorac Surg. 2008;85:909–14.
Gillinov AM, Gelijns AC, Parides MK, DeRose JJ Jr, Moskowitz AJ, Voisine P, et al. Surgical ablation of atrial fibrillation during mitral-valve surgery. N Engl J Med. 2015;372:1399–409.
Mokracek A, Kurfirst V, Bulava A, Hanis J, Tesarik R, Pesl L. Thoracoscopic occlusion of the left atrial appendage. Innovations. 2015;10:179–82.
Wang J-L, Zhou K, Qin Z, Cheng W-J, Zhang L-Z, Zhou Y-J. Minimally invasive thoracoscopic left atrial appendage occlusion compared with transcatheter left atrial appendage closure for stroke prevention in recurrent nonvalvular atrial fibrillation patients after radiofrequency ablation: a prospective cohort study. J Geriatr Cardiol. 2021;18:877–85.
Fu M, Qin Z, Zheng S, Li Y, Yang S, Zhao Y, et al. Thoracoscopic left atrial appendage occlusion for stroke prevention compared with long-term warfarin therapy in patients with nonvalvular atrial fibrillation. Am J Cardiol. 2019;123:50–6.
Kim JY, Jeong DS, Park S-J, Park K-M, Kim JS, On YK. Long-term efficacy and anticoagulation strategy of left atrial appendage occlusion during total thoracoscopic ablation of atrial fibrillation to prevent ischemic stroke. Front Cardiovasc Med. 2022;9: 853299.
Branzoli S, Marini M, Guarracini F, Pederzolli C, Pomarolli C, D’Onghia G, et al. Epicardial standalone left atrial appendage clipping for prevention of ischemic stroke in patients with atrial fibrillation contraindicated for oral anticaogulation. J Cardiovasc Electrophysiol. 2020;31:2187–91.
Cartledge R, Suwalski G, Witkowska A, Gottlieb G, Cioci A, Chidiac G, et al. Standalone epicardial left atrial appendage exclusion for thromboembolism prevention in atrial fibrillation. Interact Cardiovasc Thorac Surg. 2022;34:548–55.
Whitlock RP, Belley-Cote EP, Paparella D, Healey JS, Brady K, Sharma M, et al. Left atrial appendage occlusion during cardiac surgery to prevent stroke. N Engl J Med. 2021;384:2081–91.
Quader MA, McCarthy PM, Gillinov AM, Alster JM, Cosgrove DM 3rd, Lytle BW, et al. Does preoperative atrial fibrillation reduce survival after coronary artery bypass grafting? Ann Thorac Surg. 2004;77:1514–22; discussion 1522–4.
Ad N, Damiano RJ Jr, Badhwar V, Calkins H, La Meir M, Nitta T, et al. Expert consensus guidelines: examining surgical ablation for atrial fibrillation. J Thorac Cardiovasc Surg. 2017;153:1330-54.e1.
Cox JL, Ad N, Palazzo T. Impact of the maze procedure on the stroke rate in patients with atrial fibrillation. J Thorac Cardiovasc Surg. 1999;118:833–40.
Boersma LV, Castella M, van Boven W, Berruezo A, Yilmaz A, Nadal M, et al. Atrial fibrillation catheter ablation versus surgical ablation treatment (FAST): a 2-center randomized clinical trial. Circulation. 2012;125:23–30.
Castellá M, Kotecha D, van Laar C, Wintgens L, Castillo Y, Kelder J, et al. Thoracoscopic vs. catheter ablation for atrial fibrillation: long-term follow-up of the FAST randomized trial. Europace. 2019;21:746–53.
Pokushalov E, Romanov A, Elesin D, Bogachev-Prokophiev A, Losik D, Bairamova S, et al. Catheter versus surgical ablation of atrial fibrillation after a failed initial pulmonary vein isolation procedure: a randomized controlled trial. J Cardiovasc Electrophysiol. 2013;24:1338–43.
Adiyaman A, Buist TJ, Beukema RJ, Smit JJJ, Delnoy P, Hemels MEW, et al. Randomized controlled trial of surgical versus catheter ablation for paroxysmal and early persistent atrial fibrillation. Circ Arrhythm Electrophysiol. 2018;11: e006182.
Philpott JM, Zemlin CW, Cox JL, Stirling M, Mack M, Hooker RL, et al. The ABLATE trial: safety and efficacy of Cox maze-IV using a bipolar radiofrequency ablation system. Ann Thorac Surg. 2015;100:1541–6; discussion 1547–8.
McGilvray MMO, Barron L, Yates TE, Zemlin CW, Damiano RJ Jr. The Cox-maze procedure: what lesions and why. JTCVS Tech. 2023;17:84–93.
Gillinov AM, Gelijns AC, Parides MK, DeRose JJ Jr, Moskowitz AJ, Voisine P, et al. Surgical ablation of atrial fibrillation during mitral-valve surgery. N Engl J Med. 2015;372:1399–409.
Hamner CE, Potter DD Jr, Cho KR, Lutterman A, Francischelli D, Sundt TM 3rd, et al. Irrigated radiofrequency ablation with transmurality feedback reliably produces Cox maze lesions in vivo. Ann Thorac Surg. 2005;80:2263–70.
Schuessler RB, Lee AM, Melby SJ, Voeller RK, Gaynor SL, Sakamoto S-I, et al. Animal studies of epicardial atrial ablation. Heart Rhythm. 2009;6:S41-5.
Saint LL, Lawrance CP, Okada S, Kazui T, Robertson JO, Schuessler RB, et al. Performance of a novel bipolar/monopolar radiofrequency ablation device on the beating heart in an acute porcine model. Innovations. 2013;8:276–83.
Bugge E, Nicholson IA, Thomas SP. Comparison of bipolar and unipolar radiofrequency ablation in an in vivo experimental model. Eur J Cardiothorac Surg. 2005;28:76–80; discussion 80–2.
Thomas SP, Guy DJR, Boyd AC, Eipper VE, Ross DL, Chard RB. Comparison of epicardial and endocardial linear ablation using handheld probes. Ann Thorac Surg. 2003;75:543–8.
La Meir M. Surgical options for treatment of atrial fibrillation. Ann Cardiothorac Surg. 2014;3:30–7.
Khiabani AJ, MacGregor RM, Manghelli JL, Ruaengsri C, Carter DI, Melby SJ, et al. Bipolar radiofrequency ablation on explanted human hearts: how to ensure transmural lesions. Ann Thorac Surg. 2020;110:1933–9.
Jaïs P, Haïssaguerre M, Shah DC, Takahashi A, Hocini M, Lavergne T, et al. Successful irrigated-tip catheter ablation of atrial flutter resistant to conventional radiofrequency ablation. Circulation. 1998;98:835–8.
Haines DE. The biophysics and pathophysiology of lesion formation during radiofrequency catheter ablation. In Zipes DP, Jalife J, Stevenson WG (eds.), Cardiac Electrophysiology: From Cell to Bedside. 4th ed. Philadelphia: WB Saunders Co; 2005;1018–27.
Melby SJ, Zierer A, Voeller RK, Lall SC, Bailey MS, Moon MR, et al. Wide variations in energy delivery using an impedance-controlled algorithm in bipolar radiofrequency ablation: evidence against fixed time ablation. Innovations. 2007;2:67–72.
Dewhirst MW, Viglianti BL, Lora-Michiels M, Hanson M, Hoopes PJ. Basic principles of thermal dosimetry and thermal thresholds for tissue damage from hyperthermia. Int J Hyperthermia. 2003;19:267–94.
Varzaly JA, Chapman D, Lau DH, Edwards S, Louise J, Edwards J, et al. Contact force and ablation assessment of surgical bipolar radiofrequency clamps in the treatment of atrial fibrillation. Interact Cardiovasc Thorac Surg. 2019;28:85–93.
Schill MR, Melby SJ, Speltz M, Breitbach M, Schuessler RB, Damiano RJ. Evaluation of a novel cryoprobe for atrial ablation in a chronic ovine model. Ann Thorac Surg. 2017;104:1069–73.
Weimar T, Lee AM, Ray S, Schuessler RB, Damiano RJ. Evaluation of a novel cryoablation system: in vivo testing in a chronic porcine model. Innovations (Phila). 2012;7:410–6.
Cox JL, Malaisrie SC, Churyla A, Mehta C, Kruse J, Kislitsina ON, et al. Cryosurgery for atrial fibrillation: physiologic basis for creating optimal cryolesions. Ann Thorac Surg. 2021;112:354–62.
Masroor S, Jahnke M-E, Carlisle A, Cartier C, LaLonde J-P, MacNeil T, et al. Endocardial hypothermia and pulmonary vein isolation with epicardial cryoablation in a porcine beating-heart model. J Thorac Cardiovasc Surg. 2008;135:1327-33.e5.
Aupperle H, Doll N, Walther T, Ullmann C, Schoon HA, Wilhelm Mohr F. Histological findings induced by different energy sources in experimental atrial ablation in sheep. Interact Cardiovasc Thorac Surg. 2005;4:450–5.
Schuessler RB, Lee AM, Melby SJ, Voeller RK, Gaynor SL, Sakamoto S, et al. Animal studies of epicardial atrial ablation. Heart Rhythm. 2009;6:S41-5.
MacGregor RM, Melby SJ, Schuessler RB, Damiano RJ. Energy sources for the surgical treatment of atrial fibrillation. Innovations (Phila). 2019;14:503–8.
Yates TA, McGilvray M, Schill MR, Barron L, Razo N, Roberts HG Jr, et al. Performance of an irrigated bipolar radiofrequency ablation clamp on explanted human hearts. Ann Thorac Surg. 2023;116:307–13.
Yates T-A, McGilvray M, Razo N, McElligott S, Melby SJ, Zemlin C, et al. Efficacy of a novel bipolar radiofrequency clamp: an acute porcine model. Innovations (Phila). 2022;17:409–15.
Watanabe Y, Weimar T, Kazui T, Lee U, Schuessler RB, Damiano RJ Jr. Epicardial ablation performance of a novel radiofrequency device on the beating heart in pigs. Ann Thorac Surg. 2014;97:673–8.
Lee AM, Aziz A, Clark KL, Schuessler RB, Damiano RJ Jr. Chronic performance of a novel radiofrequency ablation device on the beating heart: limitations of conduction delay to assess transmurality. J Thorac Cardiovasc Surg. 2012;144:859–65.
Bringmans T, Verrijcken A, La Meir M, Rega F. Atrioesophageal fistula after epicardial ablation for atrial fibrillation. J Thorac Cardiovasc Surg. 2018;155:e19-21.
Kiser AC, Nifong LW, Raman J, Kasirajan V, Campbell N, Chitwood WR Jr. Evaluation of a novel epicardial atrial fibrillation treatment system. Ann Thorac Surg. 2008;85:300–3.
Weimar T, Lee AM, Ray S, Schuessler RB, Damiano RJ Jr. Evaluation of a novel cryoablation system: in vivo testing in a chronic porcine model. Innovations (Phila). 2012;7:410–6.
El Arid J-M, Sénage T, Toquet C, Al Habash O, Mugniot A, Baron O, et al. Human comparative experimental study of surgical treatment of atrial fibrillation by epicardial techniques. J Cardiothorac Surg. 2013;8:140.
Schill MR, Melby SJ, Speltz M, Breitbach M, Schuessler RB, Damiano RJ Jr. Evaluation of a novel cryoprobe for atrial ablation in a chronic ovine model. Ann Thorac Surg. 2017;104:1069–73.
Milla F, Skubas N, Briggs WM, Girardi LN, Lee LY, Ko W, et al. Epicardial beating heart cryoablation using a novel argon-based cryoclamp and linear probe. J Thorac Cardiovasc Surg. 2006;131:403–11.
Nitta T, Ishii Y, Miyagi Y, Ohmori H, Sakamoto S-I, Tanaka S. Concurrent multiple left atrial focal activations with fibrillatory conduction and right atrial focal or reentrant activation as the mechanism in atrial fibrillation. J Thorac Cardiovasc Surg. 2004;127:770–8.
Saini A, Hu YL, Kasirajan V, Han FT, Khan MZ, Wolfe L, et al. Long-term outcomes of minimally invasive surgical ablation for atrial fibrillation: a single-center experience. Heart Rhythm. 2017;14:1281–8.
Gillinov AM, Bhavani S, Blackstone EH, Rajeswaran J, Svensson LG, Navia JL, et al. Surgery for permanent atrial fibrillation: impact of patient factors and lesion set. Ann Thorac Surg. 2006;82:502–13; discussion 513–4.
Saint LL, Bailey MS, Prasad S, Guthrie TJ, Bell J, Moon MR, et al. Cox-maze IV results for patients with lone atrial fibrillation versus concomitant mitral disease. Ann Thorac Surg. 2012;93:789–94; discussion 794–5.
Enriquez A, Santangeli P, Zado ES, Liang J, Castro S, Garcia FC, et al. Postoperative atrial tachycardias after mitral valve surgery: mechanisms and outcomes of catheter ablation. Heart Rhythm. 2017;14:520–6.
Gwag HB, Jeong DS, Hwang JK, Park S-J, Park K-M, Kim JS, et al. Additional cavotricuspid isthmus ablation may reduce recurrent atrial tachyarrhythmia after total thoracoscopic ablation for persistent atrial fibrillation. Interact Cardiovasc Thorac Surg. 2019;28:177–82.
Ngaage DL, Schaff HV, Mullany CJ, Sundt TM 3rd, Dearani JA, Barnes S, et al. Does preoperative atrial fibrillation influence early and late outcomes of coronary artery bypass grafting? J Thorac Cardiovasc Surg. 2007;133:182–9.
McClure GR, Belley-Cote EP, Jaffer IH, Dvirnik N, An KR, Fortin G, et al. Surgical ablation of atrial fibrillation: a systematic review and metaanalysis of randomized controlled trials. Europace. 2018;20:1442–50.
Johansson B, Houltz B, Berglin E, Brandrup-Wognsen G, Karlsson T, Edvardsson N. Short-term sinus rhythm predicts long-term sinus rhythm and clinical improvement after intraoperative ablation of atrial fibrillation. Europace. 2008;10:610–7.
Grubitzsch H, Dushe S, Beholz S, Dohmen PM, Konertz W. Surgical ablation of atrial fibrillation in patients with congestive heart failure. J Card Fail. 2007;13:509–16.
Saint LL, Damiano RJ Jr, Cuculich PS, Guthrie TJ, Moon MR, Munfakh NA, et al. Incremental risk of the Cox-maze IV procedure for patients with atrial fibrillation undergoing mitral valve surgery. J Thorac Cardiovasc Surg. 2013;146:1072–7.
Bakir NH, Khiabani AJ, MacGregor RM, Kelly MO, Sinn LA, Schuessler RB, et al. Concomitant surgical ablation for atrial fibrillation is associated with increased risk of acute kidney injury but improved late survival. J Thorac Cardiovasc Surg. 2022;164:1847-57.e3.
Takahashi K, Miyauchi Y, Hayashi M, Iwasaki YK, Yodogawa K, Tsuboi I, et al. Mechanisms of postoperative atrial tachycardia following biatrial surgical ablation of atrial fibrillation in relation to the surgical lesion sets. Heart Rhythm. 2016;13:1059–65.
Ishii Y, Nitta T, Kambe M, Kurita J, Ochi M, Miyauchi Y, et al. Intraoperative verification of conduction block in atrial fibrillation surgery. J Thorac Cardiovasc Surg. 2008;136:998–1004.
Phan K, Xie A, Tsai YC, Kumar N, La Meir M, Yan TD. Biatrial ablation vs. left atrial concomitant surgical ablation for treatment of atrial fibrillation: a metaanalysis. Europace. 2015;17:38–47.
Bogachev-Prokophiev AV, Afanasyev AV, Pivkin AN, Ovcharov MA, Zheleznev SI, Sharifulin RM, et al. A left atrial versus a biatrial lesion set for persistent atrial fibrillation ablation during open heart surgery. Eur J Cardiothorac Surg. 2018;54:738–44.
Kowalewski M, Pasierski M, Finke J, Kołodziejczak M, Staromłyński J, Litwinowicz R, et al. Permanent pacemaker implantation after valve and arrhythmia surgery in patients with preoperative atrial fibrillation. Heart Rhythm. 2022;19:1442–9.
Cox JL, Ad N, Churyla A, Malaisrie SC, Pham DT, Kruse J, et al. The maze procedure and postoperative pacemakers. Ann Thorac Surg. 2018;106:1561–9.
Badhwar V, Rankin JS, Damiano RJ Jr, Gillinov AM, Bakaeen FG, Edgerton JR, et al. The Society of Thoracic Surgeons 2017 clinical practice guidelines for the surgical treatment of atrial fibrillation. Ann Thorac Surg. 2017;103:329–41.
Raanani E, Albage A, David TE, Yau TM, Armstrong S. The efficacy of the Cox/maze procedure combined with mitral valve surgery: a matched control study. Eur J Cardiothorac Surg. 2001;19:438–42.
Li H, Lin X, Ma X, Tao J, Zou R, Yang S, Liu H, Hua P. Biatrial versus isolated left atrial ablation in atrial fibrillation: a systematic review and metaanalysis. Biomed Res Int. 2018;2018:3651212.
Kainuma S, Mitsuno M, Toda K, Funatsu T, Nakamura T, Miyagawa S, et al. Dilated left atrium as a predictor of late outcome after pulmonary vein isolation concomitant with aortic valve replacement and/or coronary artery bypass grafting†. Eur J Cardiothorac Surg. 2015;48:765–77; discussion 777.
Barnett SD, Ad N. Surgical ablation as treatment for the elimination of atrial fibrillation: a metaanalysis. J Thorac Cardiovasc Surg. 2006;131:1029–35.
Kim HJ, Kim JB, Kim SO, Cho MS, Kim JK, Kim WK, et al. Long-term outcomes of surgical ablation for atrial fibrillation: impact of ablation lesion sets. JACC Asia. 2021;1:203–14.
Kainuma S, Mitsuno M, Toda K, Miyagawa S, Yoshikawa Y, Hata H, et al. Surgical ablation concomitant with nonmitral valve surgery for persistent atrial fibrillation. Ann Thorac Surg. 2021;112:1909–20.
La Meir M, Gelsomino S, Nonneman B. The problem with concomitant atrial fibrillation in non-mitral valve surgery. Ann Cardiothorac Surg. 2014;3:124–9.
Civello K, Smith C, Boedefeld W. Combined endocardial and epicardial ablation for symptomatic atrial fibrillation: single center experience in 100+ consecutive patients. J Innov Card Rhythm Manag. 2013;4:1–7.
Gehi AK, Mounsey JP, Pursell I, Landers M, Boyce K, Chung EH, et al. Hybrid epicardial-endocardial ablation using a pericardioscopic technique for the treatment of atrial fibrillation. Heart Rhythm. 2013;10:22–8.
Gersak B, Jan M. Long-term success for the convergent atrial fibrillation procedure: 4-year outcomes. Ann Thorac Surg. 2016;102:1550–7.
Gersak B, Zembala MO, Muller D, Folliguet T, Jan M, Kowalski O, et al. European experience of the convergent atrial fibrillation procedure: multicenter outcomes in consecutive patients. J Thorac Cardiovasc Surg. 2014;147:1411–6.
Gilligan D, Joyner C, Bundy G. Multidisciplinary collaboration for the treatment of atrial fibrillation: convergent procedure outcomes from a single center. J Innov Card Rhythm Manag. 2013;4:1396–403.
Tonks R, Lantz G, Mahlow J, Hirsh J, Lee LS. Short and intermediate term outcomes of the convergent procedure: initial experience in a tertiary referral center. Ann Thorac Cardiovasc Surg. 2020;26:13–21.
Toplisek J, Pernat A, Ruzic N, Robic B, Sinkovec M, Cvijic M, et al. Improvement of atrial and ventricular remodeling with low atrial fibrillation burden after hybrid ablation of persistent atrial fibrillation. Pacing Clin Electrophysiol. 2016;39:216–24.
Zembala M, Filipiak K, Kowalski O, Buchta P, Niklewski T, Nadziakiewicz P, et al. Staged hybrid ablation for persistent and longstanding persistent atrial fibrillation effectively restores sinus rhythm in long-term observation. Arch Med Sci. 2017;13:109–17.
Kiser AC, Landers M, Horton R, Hume A, Natale A, Gersak B. The convergent procedure: a multidisciplinary atrial fibrillation treatment. Heart Surg Forum. 2010;13:E317-21.
Edgerton Z, Perini AP, Horton R, Trivedi C, Santangeli P, Bai R, et al. Hybrid procedure (endo/epicardial) versus standard manual ablation in patients undergoing ablation of longstanding persistent atrial fibrillation: results from a single center. J Cardiovasc Electrophysiol. 2016;27:524–30.
Jan M, Zizek D, Gersak ZM, Gersak B. Comparison of treatment outcomes between convergent procedure and catheter ablation for paroxysmal atrial fibrillation evaluated with implantable loop recorder monitoring. J Cardiovasc Electrophysiol. 2018;29:1073–80.
Gersak B, Pernat A, Robic B, Sinkovec M. Low rate of atrial fibrillation recurrence verified by implantable loop recorder monitoring following a convergent epicardial and endocardial ablation of atrial fibrillation. J Cardiovasc Electrophysiol. 2012;23:1059–66.
Zannis K, Alam W, Sebag FA, Folliguet T, Bars C, Fahed M, et al. The convergent procedure: a hybrid approach for long lasting persistent atrial fibrillation ablation, the French experience. J Cardiovasc Surg (Torino). 2020;61:369–75.
Maclean E, Yap J, Saberwal B, Kolvekar S, Lim W, Wijesuriya N, et al. The convergent procedure versus catheter ablation alone in longstanding persistent atrial fibrillation: a single centre, propensity-matched cohort study. Int J Cardiol. 2020;303:49–53.
Kiser AC, Landers MD, Boyce K, Sinkovec M, Pernat A, Gersak B. Simultaneous catheter and epicardial ablations enable a comprehensive atrial fibrillation procedure. Innovations (Phila). 2011;6:243–7.
Lee LS. Subxiphoid minimally invasive epicardial ablation (convergent procedure) with left thoracoscopic closure of the left atrial appendage. Oper Tech Thorac Cardiovasc Surg. 2019;23:152–65.
Thosani AJ, Gerczuk P, Liu E, Belden W, Moraca R. Closed chest convergent epicardial-endocardial ablation of non-paroxysmal atrial fibrillation – a case series and literature review. Arrhythm Electrophysiol Rev. 2013;2:65–8.
Makati K, Davoudi R, Giedrimas A, Irwin J, Sherman A, Gerogiannis I, et al. Safety and efficacy of a convergent hybrid procedure using cryo as endocardial energy source for the treatment of persistent and longstanding persistent atrial fibrillation. J Am Coll Cardiol. 2020;75:424.
Starck CT, Steffel J, Emmert MY, Plass A, Mahapatra S, Falk V, et al. Epicardial left atrial appendage clip occlusion also provides the electrical isolation of the left atrial appendage. Interact Cardiovasc Thorac Surg. 2012;15:416–8.
Lee LS. Subxiphoid minimally invasive epicardial ablation (convergent procedure) with left thoracoscopic closure of the left atrial appendage. Oper Tech Thorac Cardiovasc Surg. 2018;23:152–65.
Gegochkori N, Yang F, Miller A, Kulbak G, Jacobwitz I, Greenberg Y. Comparison of hybrid ablation for persistent atrial fibrillation with and without left atrial appendage closure: report of 1 year follow up. Presented at Venice Arrhythmias, Venice, Italy, 2019. J Interv Card Electrophysiol. 2020;57:164.
Haldar S, Khan HR, Boyalla V, Kralj-Hans I, Jones S, Lord J, et al. Catheter ablation vs. thoracoscopic surgical ablation in long-standing persistent atrial fibrillation: CASA-AF randomized controlled trial. Eur Heart J. 2020;41:4471–80.
van der Heijden CAJ, Weberndörfer V, Vroomen M, Luermans JG, Chaldoupi S-M, Bidar E, et al. Hybrid ablation versus repeated catheter ablation in persistent atrial fibrillation. JACC Clin Electrophysiol. 2023;9:1013–23.
Doll N, Weimar T, Kosior DA, Bulava A, Mokracek A, Mönnig G, et al. Efficacy and safety of hybrid epicardial and endocardial ablation versus endocardial ablation in patients with persistent and longstanding persistent atrial fibrillation: a randomised, controlled trial. EClinicalMedicine. 2023;61: 102052.
Pearman CM, Poon SS, Bonnett LJ, Haldar S, Wong T, Mediratta N, et al. Minimally invasive epicardial surgical ablation alone versus hybrid ablation for atrial fibrillation: a systematic review and metaanalysis. Arrhythm Electrophysiol Rev. 2017;6:202–9.
Bhatia NK, Shah RL, Deb B, Pong T, Kapoor R, Rogers AJ, et al. Mapping atrial fibrillation after surgical therapy to guide endocardial ablation. Circ Arrhythm Electrophysiol. 2022;15: e010502.
de Asmundis C, Chierchia GB, Mugnai G, Van Loo I, Nijs J, Czapla J, et al. Midterm clinical outcomes of concomitant thoracoscopic epicardial and transcatheter endocardial ablation for persistent and long-standing persistent atrial fibrillation: a single-centre experience. Europace. 2017;19:58–65.
Blackshear JL, Odell JA. Appendage obliteration to reduce stroke in cardiac surgical patients with atrial fibrillation. Ann Thorac Surg. 1996;61:755–9.
Osmancik P, Herman D, Neuzil P, Hala P, Taborsky M, Kala P, et al. Left atrial appendage closure versus direct oral anticoagulants in high-risk patients with atrial fibrillation. J Am Coll Cardiol. 2020;75:3122–35.
Brouwer TF, Whang W, Kuroki K, Halperin JL, Reddy VY. Net clinical benefit of left atrial appendage closure versus warfarin in patients with atrial fibrillation: a pooled analysis of the randomized PROTECT-AF and PREVAIL studies. J Am Heart Assoc. 2019;8: e013525.
Albåge A, Sartipy U, Kennebäck G, Johansson B, Scherstén H, Jidéus L, Swedish Arrhythmia Surgery Group. Long-term risk of ischemic stroke after the Cox-maze III procedure for atrial fibrillation. Ann Thorac Surg. 2017;104:523–9.
Wang H, Han J, Wang Z, Yin Z, Liu Z, Jin Y, et al. A prospective randomized trial of the cut-and-sew maze procedure in patients undergoing surgery for rheumatic mitral valve disease. J Thorac Cardiovasc Surg. 2018;155:608–17.
Ad N, Holmes SD, Massimiano PS, Rongione AJ, Fornaresio LM. Long-term outcome following concomitant mitral valve surgery and Cox maze procedure for atrial fibrillation. J Thorac Cardiovasc Surg. 2018;155:983–94.
Pet M, Robertson JO, Bailey M, Guthrie TJ, Moon MR, Lawton JS, et al. The impact of CHADS2 score on late stroke after the Cox maze procedure. J Thorac Cardiovasc Surg. 2013;146:85–9.
Alqaqa A, Martin S, Hamdan A, Shamoon F, Asgarian KT. Concomitant left atrial appendage clipping during minimally invasive mitral valve surgery: technically feasible and safe. J Atr Fibrillation. 2016;9:1407.
Suwalski P, Witkowska A, Drobiński D, Rozbicka J, Sypuła S, Liszka I, et al. Stand-alone totally thoracoscopic left atrial appendage exclusion using a novel clipping system in patients with high risk of stroke – initial experience and literature review. Kardiochir Torakochirurgia Pol. 2015;12:298–303.
Osmancik P, Budera P, Zdarska J, Herman D, Petr R, Fojt R, et al. Residual echocardiographic and computed tomography findings after thoracoscopic occlusion of the left atrial appendage using the AtriClip PRO device. Interact Cardiovasc Thorac Surg. 2018;26:919–25.
Bedeir K, Warriner S, Kofsky E, Gullett C, Ramlawi B. Left atrial appendage epicardial clip (AtriClip): essentials and post-procedure management. J Atr Fibrillation. 2019;11:2087.
Lee R, Vassallo P, Kruse J, Malaisrie SC, Rigolin V, Andrei A-C, et al. A randomized, prospective pilot comparison of 3 atrial appendage elimination techniques: internal ligation, stapled excision, and surgical excision. J Thorac Cardiovasc Surg. 2016;152:1075–80.
Kanderian AS, Gillinov AM, Pettersson GB, Blackstone E, Klein AL. Success of surgical left atrial appendage closure: assessment by transesophageal echocardiography. J Am Coll Cardiol. 2008;52:924–9.
Vainrib AF, Harb SC, Jaber W, Benenstein RJ, Aizer A, Chinitz LA, et al. Left atrial appendage occlusion/exclusion: procedural image guidance with transesophageal echocardiography. J Am Soc Echocardiogr. 2018;31:454–74.
van Laar C, Verberkmoes NJ, van Es HW, Lewalter T, Dunnington G, Stark S, et al. Thoracoscopic left atrial appendage clipping: a multicenter cohort analysis. JACC Clin Electrophysiol. 2018;4:893–901.
Smith NE, Joseph J, Morgan J, Masroor S. Initial experience with minimally invasive surgical exclusion of the left atrial appendage with an epicardial clip. Innovations. 2017;12:28–32.
Ad N, Massimiano PS, Shuman DJ, Pritchard G, Holmes SD. New approach to exclude the left atrial appendage during minimally invasive cryothermic surgical ablation. Innovations. 2015;10:323–7.
Starck CT, Steffel J, Emmert MY, Plass A, Mahapatra S, Falk V, et al. Epicardial left atrial appendage clip occlusion also provides the electrical isolation of the left atrial appendage. Interact Cardiovasc Thorac Surg. 2012;15:416–8.
Toale C, Fitzmaurice GJ, Eaton D, Lyne J, Redmond KC. Outcomes of left atrial appendage occlusion using the AtriClip device: a systematic review. Interact Cardiovasc Thorac Surg. 2019;29:655–62.
Ailawadi G, Gerdisch MW, Harvey RL, Hooker RL, Damiano RJ Jr, Salamon T, et al. Exclusion of the left atrial appendage with a novel device: early results of a multicenter trial. J Thorac Cardiovasc Surg. 2011;142(1002–9):1009.e1.
Emmert MY, Puippe G, Baumüller S, Alkadhi H, Landmesser U, Plass A, et al. Safe, effective and durable epicardial left atrial appendage clip occlusion in patients with atrial fibrillation undergoing cardiac surgery: first long-term results from a prospective device trial. Eur J Cardiothorac Surg. 2014;45:126–31.
Caliskan E, Sahin A, Yilmaz M, Seifert B, Hinzpeter R, Alkadhi H, et al. Epicardial left atrial appendage AtriClip occlusion reduces the incidence of stroke in patients with atrial fibrillation undergoing cardiac surgery. Europace. 2018;20:e105-14.
Zhang S, Cui Y, Li J, Tian H, Yun Y, Zhou X, et al. Concomitant transcatheter occlusion versus thoracoscopic surgical clipping for left atrial appendage in patients undergoing ablation for atrial fibrillation: a metaanalysis. Front Cardiovasc Med. 2022;9: 970847.
Branzoli S, Guarracini F, Marini M, D’Onghia G, Catanzariti D, Merola E, et al. Heart team for left appendage occlusion without the use of antithrombotic therapy: the epicardial perspective. J Clin Med. 2022;11:6492.
Zipes DP, Calkins H, Daubert JP, Ellenbogen KA, Field ME, Fisher JD, et al. 2015 ACC/AHA/HRS advanced training statement on clinical cardiac electrophysiology (a revision of the ACC/AHA 2006 update of the clinical competence statement on invasive electrophysiology studies, catheter ablation, and cardioversion). Circ Arrhythm Electrophysiol. 2015;8:1522–51.
Hoffmann R, Parade U, Bauerle H, Winter KD, Rauschenbach U, Mischke K, et al. Safety and acute efficacy of cryoballoon ablation for atrial fibrillation at community hospitals. Europace. 2021;23:1744–50.
Vassilikos VP, Pagourelias ED, Laroche C, Blomström-Lundqvist C, Kautzner J, Maggioni AP, et al. Impact of centre volume on atrial fibrillation ablation outcomes in Europe: a report from the ESC EHRA EORP Atrial Fibrillation Ablation Long-Term (AFA LT) registry. Europace. 2021;23:49–58.
Steinemann S, Berg B, Skinner A, DiTulio A, Anzelon K, Terada K, et al. In situ, multidisciplinary, simulation-based teamwork training improves early trauma care. J Surg Educ. 2011;68:472–7.
Miller D, Crandall C, Washington C 3rd, McLaughlin S. Improving teamwork and communication in trauma care through in situ simulations. Acad Emerg Med. 2012;19:608–12.
Friedman DJ, Pokorney SD, Khanna R, Goldstein L, Atwater BD, Bahnson TD, et al. Catheter ablation of atrial fibrillation with and without on-site cardiothoracic surgery. J Am Coll Cardiol. 2019;73:2487–9.
Pope MTB, Kuklik P, Briosa EGA, Leo M, Mahmoudi M, Paisey J, et al. Impact of adenosine on wavefront propagation in persistent atrial fibrillation: insights from global noncontact charge density mapping of the left atrium. J Am Heart Assoc. 2022;11: e021166.
Tang S, Razeghi O, Kapoor R, Alhusseini MI, Fazal M, Rogers AJ, et al. Machine learning-enabled multimodal fusion of intra-atrial and body surface signals in prediction of atrial fibrillation ablation outcomes. Circ Arrhythm Electrophysiol. 2022;15: e010850.
Saglietto A, Gaita F, Blomstrom-Lundqvist C, Arbelo E, Dagres N, Brugada J, et al. AFA-Recur: an ESC EORP AFA-LT registry machine-learning web calculator predicting atrial fibrillation recurrence after ablation. Europace. 2023;25:92–100.
Stojadinovic P, Wichterle D, Peichl P, Nakagawa H, Cihak R, Haskova J, et al. Autonomic changes are more durable after radiofrequency than pulsed electric field pulmonary vein ablation. JACC Clin Electrophysiol. 2022;8:895–904.
Boyle PM, Zghaib T, Zahid S, Ali RL, Deng D, Franceschi WH, et al. Computationally guided personalized targeted ablation of persistent atrial fibrillation. Nat Biomed Eng. 2019;3:870–9.
Cuculich PS, Schill MR, Kashani R, Mutic S, Lang A, Cooper D, et al. Noninvasive cardiac radiation for ablation of ventricular tachycardia. N Engl J Med. 2017;377:2325–36.
Qian PC, Azpiri JR, Assad J, Gonzales Aceves EN, Cardona Ibarra CE, de la Pena C, et al. Noninvasive stereotactic radioablation for the treatment of atrial fibrillation: first-in-man experience. J Arrhythm. 2020;36:67–74.
Hohmann S, Deisher AJ, Konishi H, Rettmann ME, Suzuki A, Merrell KW, et al. Catheter-free ablation of infarct scar through proton beam therapy: tissue effects in a porcine model. Heart Rhythm. 2020;17:2190–9.
Avram R, Ramsis M, Cristal AD, Nathan V, Zhu L, Kim J, et al. Validation of an algorithm for continuous monitoring of atrial fibrillation using a consumer smartwatch. Heart Rhythm. 2021;18:1482–90.
Zhu L, Nathan V, Kuang J, Kim J, Avram R, Olgin J, et al. Atrial fibrillation detection and atrial fibrillation burden estimation via wearables. IEEE J Biomed Health Inform. 2022;26:2063–74.
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Tzeis Stylianos, 2021, Direct personal payment from healthcare industry: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Abbott: Speaker fees, advisory board fees, honoraria. Bayer: Speaker fees, advisory board fees, honoraria. Pfizer: Speaker fees, advisory board fees, honoraria. Biosense Webster: Speaker fees, advisory board fees, honoraria.
Zeppenfeld Katja, 2021, Research funding from healthcare industry under your direct/personal responsibility (to department or institution). Biosense Webster: Research electrophysiology.
Andrade Jason, 2021, Direct personal payment from healthcare industry: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Biosense Webster: Ablation. Medtronic: Ablation, CIED. Servier: SPAF. Bayer Healthcare: SPAF. Bristol Myers Squibb-Pfizer Alliance: SPAF. Employment in healthcare industry (including part time) during the year for which you are declaring. Chair Cardiovascular Disease Network for the provincial government (British Columbia, Canada) - reimbursement <10 k€/year.
Barbhaiya Chirag, 2021, Direct personal payment from healthcare industry: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Abbott: Catheter Ablation. Biosense Webster: Catheter Ablation. Zoll Medical: Sudden Cardiac Death.
Baykaner Tina, 2021, Direct personal payment from healthcare industry: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Medtronic: Advisory board.
Boveda Serge, 2021, Direct personal payment from healthcare industry: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Medtronic: Arrhythmias (cryoablation). Microport: Arrhythmias (ICD). Boston Scientific: Arrhythmias (S-ICD). Pfizer: OAD. Bristol Myers Squibb: OAD. Zoll Medical: WCD.
Calkins Hugh, 2021, Direct personal payment from healthcare industry: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Boehringer-Ingelheim: catheter ablation. Boston Scientific: catheter ablation. Medtronic: catheter ablation. Sanofi Aventis: catheter ablation. Atricure: catheter ablation. Abbott Medical: catheter ablation. Johnson and Johnson: catheter ablation. Research funding from healthcare industry under your direct/personal responsibility (to department or institution). Boston Scientific: ventricular tachycardia. Membership or affiliation in political, advocacy or patients organisations working in the field of cardiology. I am a member of the ACC and AHA.
Chan Ngai-Yin, 2021, Nothing to be declared.
Chen Shih-Ann, 2021, Direct personal payment from healthcare industry: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Abbott: Cardiac arrhythmias.
Chen Minglong, 2021, Direct personal payment from healthcare industry: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Bayer: Lecture fee. Medtronic: Lecture fee. Biosense Webster: Lecture fee. St. Jude Medical: Lecture fee. Boehringer Ingelheim: Lecture fee. Research funding from healthcare industry under your direct/personal responsibility (to department or institution). Biosense Webster: Research funding.
Dagres Nikolaos, 2021, Nothing to be declared.
Damiano Ralph, 2021, Direct personal payment from healthcare industry: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Medtronic: Atrial fibrillation ablation. Atricure: Atrial Fibrillation ablation. Edwards Lifesciences: Valve Disease. Research funding from healthcare industry under your direct/personal responsibility (to department or institution). Atricure: AF Ablation. Medtronic: Testing ablation device.
De Potter Tom, 2021, Nothing to be declared.
Deisenhofer Isabel, 2021, Direct personal payment from healthcare industry: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Abbott: Catheter ablation. Boston Scientific: Catheter ablation. Bristol Myers Squibb: Catheter ablation. Biosense Webster: Catheter ablation. Volta: catheter ablation, PI in multicenter study. Payment from healthcare industry to your department or institution or any other body for your personal services: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Daiichi Sankyo: Link between AF ablation success and genetic predisposition (multicenter study). Abbott: multipoint high resolution mapping of persistent AF. Abbott: Real world registry of MD. Biosense Webster: Real world registry of MD. Travel and meeting support from healthcare industry, independent of the above activities. Abbott: Travel to the German Arrhythmia fall meeting and to HRS (Boston). Membership or affiliation in political, advocacy or patients organisations working in the field of cardiology. Fellow of Heart Rhythm Society (HRS), member of the German Society of Cardiology (DGK), member of American Heart Association (AHA), member of American College of Cardiology (ACC).
Derval Nicolas, 2021, Direct personal payment from healthcare industry: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Biosense Webster: atrial fibrillation. Travel and meeting support from healthcare industry, independent of the above activities. Abbott: arrhythmia. Research funding from healthcare industry under your direct/personal responsibility (to department or institution). Biosense Webster: atrial fibrillation ablation.
Di Biase Luigi, 2021, Direct personal payment from healthcare industry: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Abbott: Consultant. Boston Scientific: Consultant. Medtronic: Consultant. Stereotaxis: Consultant. Atricure: Consultant. Baylis: Consultant. Biosense Webster: Consultant for Ablation. Rhythm Management Group: Consultant Remote Medicine. Biotronik: Consultant/Teacher. Zoll Medical: Teaching.
Duytschaever Mattias, 2021, Payment from healthcare industry to your department or institution or any other body for your personal services: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Boston Scientific: atrial fibrillation-speaker. Medtronic: atrial fibrillation-speaker. Biotronik: atrial fibrillation-speaker. Biosense Webster: atrial fibrillation-speaker.
Dyrda Katia, 2021, Direct personal payment from healthcare industry: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. thermedical: Catheter ablation. Johnson & Johnson: Ventricular Tachycardia.
Gerstenfeld Edward, 2021, Direct personal payment from healthcare industry: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Biosense Webster: Advisory Board. Abbott: Lecture Honoraria. Boston Scientific: Lecture honoraria. Medtronic: Lecture honoraria. Lecture Honoraria: Lecture honoraria. Research funding (personal) from healthcare industry. Abbott: Research grant. Adagio Medical: Research grant.
Hindricks Gerhard, 2021, Nothing to be declared.
Hocini Meleze, 2021, Nothing to be declared.
Kalman Jonathan, 2021, Payment from healthcare industry to your department or institution or any other body for your personal services: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Abbott, Medtronic, Biosense Webster: Speaker fees and Honoraria paid to institutional fund. Travel and meeting support from healthcare industry, independent of the above activities. Biosense Webster: Travel support to attend a meeting at which I was delivering the keynote address, February 2019. Research funding from healthcare industry under your direct/personal responsibility (to department or institution). Abbott, Medtronic, Biosense Webster: Fellowship and research support administered via institutional fund. Membership or affiliation in political, advocacy or patients organisations working in the field of cardiology. Board Member, Hearts for Hearts patient advocacy organisation. Unpaid.
Kim Young-Hoon, 2021, Nothing to be declared.
Michaud Gregory F, 2021, Direct personal payment from healthcare industry: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. GE Healthcare: Consulting. Abbott: Honoraria/ Consulting. Boston Scientific: Honoraria/ Consulting. Medtronic: Honoraria/ Consulting. Biosense Webster: Honoraria/ Consulting.
Natale Andrea, 2021, Direct personal payment from healthcare industry: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Boston Scientific: catheter ablation. Medtronic: catheter ablation. Biotronik: catheter ablation. Abbott Laboratories: catheter ablation. Biosense Webster: catheter ablation. Baylis: catheter ablation.
Nault Isabelle, 2021, Direct personal payment from healthcare industry: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Bayer: anticoagulation and atrial fibrillation. Pfizer: anticoagulation and atrial fibrillation. Servier: anticoagulation and atrial fibrillation. Biosense Webster: atrial fibrillation. Membership or affiliation in political, advocacy or patients organisations working in the field of cardiology. Member of the climate changes committee of the Canadian Cardiology Society.
Nava Townsend Santiago, 2021, Direct personal payment from healthcare industry: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Johnson & Johnson: Cardiac ablation. Medtronic: Cardiac Pacing an Defibrillators. Abbott: Cardiac Pacing and Defibrillators. Cook Medical: Lead Extraction.
Nitta Takashi, 2021, Nothing to be declared.
O’Neill Mark, 2021, Direct personal payment from healthcare industry: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Medtronic: Cardiac Electrophysiology. Biosense Webster: Cardiac Electrophysiology, Research funding from healthcare industry under your direct/personal responsibility (to department or institution). Abbott: Cardiac Electrophysiology. Biosense Webster: Cardiac Electrophysiology.
Pak Hui-Nam, 2021, Nothing to be declared.
Piccini Jonathan, 2021, Direct personal payment from healthcare industry: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Boston Scientific: Arrhythmia. Philips: Arrhythmia. Biotronik: Arrhythmia. Element Science: Arrhythmia. Itamar: Arrhythmia. Milestone: Arrhythmia. Altathera: Arrhythmia. Abbott: Atrial fibrillation. Sanofi Aventis: Atrial fibrillation. Bayer Healthcare: Atrial fibrillation. Myocardial/BMS: Atrial fibrillation. Electrophysiology Frontiers: Atrial fibrillation. Medtronic: Atrial fibrillation & Pacing. LIvanova: Event Adjudication. Research funding from healthcare industry under your direct/personal responsibility (to department or institution). iRhythm: Arrhythmia. Bayer: Atrial fibrillation. Advancement of Medical Instrumentation: CIED lead safety. Boston Scientific: Core Lab Adjudication. American Heart Association: CV disease. Abbott: Electroanatomic mapping. Philips: Lead management.
Puererfellner Helmut, 2021, Direct personal payment from healthcare industry: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Abbott: Arrhythmology. Bayer: Arrhythmology. Boehringer-Ingelheim: Arrhythmology. Boston Scientific: Arrhythmology. Daiichi Sankyo: Arrhythmology. Medtronic: Arrhythmology. Pfizer: Arrhythmology. Bristol Myers Squibb: Arrhythmology. Biosense Webster: Arrhythmology.
Reichlin Tobias, 2021, Payment from healthcare industry to your department or institution or any other body for your personal services: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Medtronic: Leadless Pacemaker, Diabetes, Ablation catheters. Biosense Webster: Mapping & Ablation System. Boston Scientific: Mapping System, Ablation Catheters. Biotronik: Mapping System, Ablation Catheters, Pacemaker. Bayer: NOAC. Research funding from healthcare industry under your direct/personal responsibility (to department or institution). Biosense Webster: Mapping & Ablation. Medtronic: PM & ICD, Ablation. Boston Scientific: PM & ICD, Mapping & Ablation. Biotronik: PM, ICD & ICM.
Saad Eduardo, 2021, Direct personal payment from healthcare industry: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Abbott: Speaker Fees. Biotronik: Speaker Fees. Biosense Webster: Speaker Fees.
Saenz Morales Luis Carlos, 2021, Direct personal payment from healthcare industry: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Biosense Webster: ABLATION. Payment from healthcare industry to your department or institution or any other body for your personal services: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Biosense Webster: PRECEPTOR.
Sanders Prashanthan, 2021, Payment from healthcare industry to your department or institution or any other body for your personal services: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Boston Scientific: Advisory Board. Medtronic: Advisory Board. CathRx: Advisory Board. Abbott Medical: Advisory Board. Pacemate: Advisory Board. Research funding from healthcare industry under your direct/personal responsibility (to department or institution). Boston Scientific: CAAN AF. Medtronic: Multiple studies. Microport: Multiple studies. Abbott Medical: Multiple studies. Becton Dickenson: POWDER-CIED. Membership or affiliation in political, advocacy or patients organisations working in the field of cardiology. Medical Advisory Committee for Hearts4Heart a patient advocacy organization in Australia.
Schilling Richard, 2021, Direct personal payment from healthcare industry: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Abbott: rhythm management. Boston Scientific: rhythm management. Medtronic: rhythm management. Biosense Webster: rhythm management. Direct ownership of shares or direct financial interest in healthcare, media, education companies or in companies related to (suppliers), or in competition with the ESC and its mission: to reduce the burden of cardiovascular disease. Healthcare - ARRHYTHMIAS - Shareholder and chair Rhythm AI limited. Employment in healthcare industry (including part time) during the year for which you are declaring. Consultant to Welbeck Health partners.
Schmidt Boris, 2021, Research funding from healthcare industry under your direct/personal responsibility (to department or institution). Medtronic: AF ablation. Biosense Webster: AF ablation. Abbott: LAA occlusion. Membership or affiliation in political, advocacy or patients organisations working in the field of cardiology. German Cardiac Society - Member of the Working Group for Arrhythmias Member and Fellow of HRS Member of EHRA Member of ALKK - Leading Cardiologists in Germany.
Supple Gregory, 2021, Direct personal payment from healthcare industry: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Biotronik: VT ablation. Membership or affiliation in political, advocacy or patients organisations working in the field of cardiology. Heart Rhythm Society.
Thomas Kevin, 2021, Direct personal payment from healthcare industry: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Biosense Webster: Racial equity. Membership or affiliation in political, advocacy or patients organisations working in the field of cardiology. American Heart Association American College of Cardiology Heart Rhythm Society Association of Black Cardiologists.
Tondo Claudio, 2021, Direct personal payment from healthcare industry: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Boston Scientific: Ablation/LAA. Payment from healthcare industry to your department or institution or any other body for your personal services: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Medtronic: Pacing/Ablation. Travel and meeting support from healthcare industry, independent of the above activities. Boston Scientific: Ablation/LAA.
Verma Atul, 2021, Direct personal payment from healthcare industry: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Medtronic: Consultancy, Investigator. Biosense Webster: Consultancy, Investigator. Adagio Medical: Consultancy, Investigator. Galaxy Medical: Consultancy, Investigator. Medlumics: Consultancy, Investigator. Research funding from healthcare industry under your direct/personal responsibility (to department or institution). Biosense Webster: Investigator-initiated randomized trial.
Wan Elaine, 2021, Research funding (personal) from healthcare industry. National Institute for Health Research: Ion channel research.
Zoghbi William, 2021, Nothing to be declared.
Sepehri Shamloo Alireza, 2022, Nothing to be declared.
Steven Daniel, 2022, Direct personal payment from healthcare industry: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Abbott: Atrial Fibrillation (AF). Boston Scientific: Atrial Fibrillation (AF). Johnson & Johnson: Atrial Fibrillation (AF). Travel and meeting support from healthcare industry, independent of the above activities. Abbott: Atrial Fibrillation (AF). Johnson & Johnson: Atrial Fibrillation (AF). Research funding (personal) from healthcare industry. Abbott: Device Registry, PI.
Agbayani Michael Joseph, 2022, Direct personal payment from healthcare industry: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Bayer: Atrial Fibrillation (AF). Menarini: Atrial Fibrillation (AF). Astra Zeneca: Chronic Heart Failure. Travel and meeting support from healthcare industry, independent of the above activities. Medtronic: Arrhythmias, General.
Bunch T Jared, 2022, Research funding from healthcare industry under your direct/personal responsibility (to department or institution). Abbott Medical: AVEIR DR study, AVEIR DR i2i study, Steering committee, Site PI. Boehringer-Ingelheim: Cognitive Atrial Fibrillation study - randomized trial of dabigatran vs warfarin with assessment of cognition, Principle investigator. Altathera: Sotalol economics analysis for IV versus oral administration, Principle Investigator. Membership or affiliation in political or advocacy groups working in the field of cardiology. Heart Rhythm Society (member), American College of Cardiology (member).
Chugh Aman, 2022, Nothing to be declared.
Diaz Juan, 2022, Direct personal payment from healthcare industry: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Astra Zeneca: Chronic Heart Failure. Medtronic: Device Therapy, Chronic Heart Failure. Boston Scientific: Other. Travel and meeting support from healthcare industry, independent of the above activities. Boston Scientific: Other.
Freeman James, 2022, Direct personal payment from healthcare industry: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. American College of Cardiology: Atrial Fibrillation (AF), Stroke. Biosense Webster: Atrial Fibrillation (AF), Ventricular Arrhythmias and Sudden Cardiac Death (SCD). Boston Scientific: Device Therapy. Medtronic: Device Therapy. Research funding (personal) from healthcare industry. NIH: R01 grant, PI.
Hardy Carina Abigail, 2022, Direct personal payment from healthcare industry: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Biosense Webster: Interventional Cardiology.
Heidbuchel Hein, 2022, Payment from healthcare industry to your department or institution or any other body for your personal services: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Daiichi Sankyo: Arrhythmias, General, Atrial Fibrillation (AF). Pfizer: Arrhythmias, General, Atrial Fibrillation (AF). Biotronik: Arrhythmias, General, Atrial Fibrillation (AF). Medscape: Arrhythmias, General, Atrial Fibrillation (AF). European Society of Cardiology: Arrhythmias, General, Atrial Fibrillation (AF). BMS: Arrhythmias, General, Atrial Fibrillation (AF). Milestone Pharmaceuticals: Arrhythmias, General, Atrial Fibrillation (AF). Springer Healthcare Ltd.: Arrhythmias, General, Atrial Fibrillation (AF). Centrix India: Arrhythmias, General, Atrial Fibrillation (AF). CTI Germany: Arrhythmias, General, Atrial Fibrillation (AF). Research funding from healthcare industry under your direct/personal responsibility (to department or institution). Fibricheck-Qompium: site investigator, site investigator. Abbott: Whole portfolio of investigator-initiated studies of the Antwerp University Cardiology Research Fund , site investigator. Bayer: Whole portfolio of investigator-initiated studies of the Antwerp University Cardiology Research Fund , site investigator. Boston Scientific: Whole portfolio of investigator-initiated studies of the Antwerp University Cardiology Research Fund , site investigator. Daiichi Sankyo: Whole portfolio of investigator-initiated studies of the Antwerp University Cardiology Research Fund , site investigator. Medtronic: Whole portfolio of investigator-initiated studies of the Antwerp University Cardiology Research Fund , site investigator. Pfizer/BMS: Whole portfolio of investigator-initiated studies of the Antwerp University Cardiology Research Fund , site investigator. Biosense-Webster: Whole portfolio of investigator-initiated studies of the Antwerp University Cardiology Research Fund , site investigator. Fibricheck/Qompium: Whole portfolio of investigator-initiated studies of the Antwerp University Cardiology Research Fund , site investigator. Any other interest (financial or otherwise) that should be declared in view of holding an ESC position. Shareholder and executive officer of my VAT-compliant speaker company Jorestha Solutions BV, as required by Belgian law, including official reporting of payments to Jorestha Solutions bv according to the Belgian Sunshine Act, for all lectures and advisory committee work reported under 2.A above.
Johar Sofian, 2022, Direct personal payment from healthcare industry: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Biosense Webster: Atrial Fibrillation (AF).
Linz Dominik, 2022, Nothing to be declared.
Llorente Jose, 2022, Nothing to be declared.
Maesen Bart, 2022, Payment from healthcare industry to your department or institution or any other body for your personal services: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Medtronic: Atrial Fibrillation (AF). Atricure: Atrial Fibrillation (AF). Research funding from healthcare industry under your direct/personal responsibility (to department or institution). Medtronic: research grant 1 95.000 EUR over 2 years, research grant 2 240.000 EUR over 4 years , PI.
Nair Devi, 2022, Research funding from healthcare industry under your direct/personal responsibility (to department or institution). Medtronic: IDE Trial, Principal Investigator. Abbott: IDE Trials, Principal Investigator. Boston Scientific: IDE Trials, Principal Investigator. Biosense Webster: IDE Trials, Principal Investigator.
Noseworthy Peter, 2022, Receipt of royalties for intellectual property. Anumana: Risk Factors and Prevention.
Oh Seil, 2022, Membership or affiliation in political or advocacy groups working in the field of cardiology. Fellow of the Heart RHythm Society (FHRS).
Porta-Sanchez Andreu, 2022, Direct personal payment from healthcare industry: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Boston Scientific: Arrhythmias, General. Biosense Webster: Atrial Fibrillation (AF). Abbott Laboratories: Ventricular Arrhythmias and Sudden Cardiac Death (SCD). Travel and meeting support from healthcare industry, independent of the above activities. Biosense Webster: Ventricular Arrhythmias and Sudden Cardiac Death (SCD).
Potpara Tatjana, 2022, Nothing to be declared.
Rodriguez-Diez Gerardo, 2022, Direct personal payment from healthcare industry: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Medtronic: Atrial Fibrillation (AF).
Sacher Frederic, 2022, Direct personal payment from healthcare industry: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Inheart medical: 5 items checked. Boston Scientific: Arrhythmias, General. Biosense Webster: Arrhythmias, General. Abbott: Ventricular Arrhythmias and Sudden Cardiac Death (SCD).
Sepehri Shamloo Alireza, 2022, Nothing to be declared.
Steven Daniel, 2022, Direct personal payment from healthcare industry: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Abbott: Atrial Fibrillation (AF). Boston Scientific: Atrial Fibrillation (AF). Johnson & Johnson: Atrial Fibrillation (AF). Travel and meeting support from healthcare industry, independent of the above activities. Abbott: Atrial Fibrillation (AF). Johnson & Johnson: Atrial Fibrillation (AF). Research funding (personal) from healthcare industry. Abbott: Device Registry, PI.
Suwalski Piotr, 2022, Direct personal payment from healthcare industry: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Medtronic: 4 items checked. Atricure: Atrial Fibrillation (AF).
Trines Serge Alexander, 2022, Payment from healthcare industry to your department or institution or any other body for your personal services: speaker fees, honoraria, consultancy, advisory board fees, investigator, committee member, etc. Biosense Webster: Atrial Fibrillation (AF), Ventricular Arrhythmias and Sudden Cardiac Death (SCD), Training and Education. Any other interest (financial or otherwise) that should be declared in view of holding an ESC position. Member of the Supervisory Board, Netherlands Society for Cardiology.
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Document Reviewers: Daniel Steven (Reviewer Coordinator), Michael-Joseph Agbayani, T. Jared Bunch, Aman Chugh, Juan Carlos Díaz, James V. Freeman, Carina Abigail Hardy, Hein Heidbuchel, Sofian Johar, Dominik Linz, Bart Maesen, Peter A. Noseworthy, Seil Oh, Andreu Porta-Sanchez, Tatjana Potpara, Gerardo Rodríguez Diez, Frederic Sacher, Piotr Suwalski, and Serge Alexander Trines.
Developed in partnership with and endorsed by the European Heart Rhythm Association (EHRA), a branch of the European Society of Cardiology (ESC), the Heart Rhythm Society (HRS), the Asia Pacific Heart Rhythm Society (APHRS), and the Latin American Heart Rhythm Society (LAHRS). The document was peer-reviewed (anonymous review) by official external reviewers representing EHRA, HRS, APHRS, and LAHRS. This article has been co-published with permission in Europace, Heart Rhythm, Journal of Arrhythmia and Journal of Interventional Cardiac Electrophysiology. © Heart Rhythm Society, the European Society of Cardiology, the Asia Pacific Heart Rhythm Society, and the Latin American Heart Rhythm Society 2024. The articles are identical except for minor stylistic and spelling differences in keeping with each journal’s style. Any citation can be used when citing this article.
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Tzeis, S., Gerstenfeld, E.P., Kalman, J. et al. 2024 European Heart Rhythm Association/Heart Rhythm Society/Asia Pacific Heart Rhythm Society/Latin American Heart Rhythm Society expert consensus statement on catheter and surgical ablation of atrial fibrillation. J Interv Card Electrophysiol (2024). https://doi.org/10.1007/s10840-024-01771-5
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DOI: https://doi.org/10.1007/s10840-024-01771-5