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Ethylenediaminetetraacetic acid intercalated MgAl-layered double-hydroxides nanocomposite as an efficient platform in the development of electrochemical sensor for the detection of iron (II)

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Abstract

The significance of iron in maintaining physiological homeostasis in the human body is well recognized. However, the presence of unbound iron, specifically the non-transferrin bound iron (NTBI), can potentially induce tissue damage in crucial organs, such as the heart, kidney, and liver. Consequently, there arises a critical need to establish a sensing platform with the capability of detecting exceedingly low concentrations of iron (II). To address this imperative, a layered double-hydroxide (LDH) structure comprising Mg2+ and Al3+ with ethylenediaminetetraacetic acid (EDTA) intercalated between the layers has been successfully synthesized. The proposed methodology involves the utilization of a differential pulse voltammetric detection approach to identify Fe2+ on an EDTA-MgAl LDHs composite-modified glassy carbon electrode. Scanning Electron Microscopy (SEM) analysis of the EDTA-MgAl LDHs revealed the stratified structure of sheets with thicknesses ranging from 95 to 160 nm. Voltammetry studies further demonstrated the effective Fe2+ capturing ability of EDTA and confirmed the existence of multi-layered MgAl LDHs, which contribute to the electrocatalytic oxidation of Fe2+ to Fe3+. The developed sensor exhibited an elevated sensitivity (0.061 µA µM−1) towards Fe2+ and a wide linear detection ranges from 0.1 to 102.1 µM, with an exceptionally low detection limit of 50 nM. Furthermore, the applicability of a two-segmented piecewise linear function to estimate the breakpoint Fe2+ concentration, above and below which the sensor's response behaviour changes, was assessed for the direct determination of Fe2+ in a 0.1 M KCl solution. In conclusion, the developed sensor possesses several advantageous attributes, including a rapid response time, effective Fe2+ capturing ability, electrocatalytic capability, wide linearity, and resistance to interference from other metal ions. These characteristics collectively render it a highly promising and efficient sensing platform for diverse Fe2+ detection applications.

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Acknowledgements

The research was supported by Professor T. R. Rajagopalan research fund, SASTRA Deemed University. The authors are grateful to Department of Science and Technology, New Delhi (SR/FST/ET-I/2018/221(c)) for the financial support. We acknowledge SASTRA Deemed to be University, Thanjavur for extending infrastructure support to carry out the study.

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Authors and Affiliations

  1. School of Chemical & Biotechnology (SCBT), SASTRA Deemed University, Thanjavur, Tamil Nadu, 613 401, India

    Shruthee Sankarlinkam & Noel Nesakumar

  2. School of Electrical & Electronics Engineering (SEEE), SASTRA Deemed University, Thanjavur, Tamil Nadu, 613 401, India

    Indhu Suresh, Arockia Jayalatha Kulandaisamy & John Bosco Balaguru Rayappan

  3. School of Humanities & Sciences, SASTRA Deemed University, Thanjavur, Tamil Nadu, 613 401, India

    G. Hariharan

  4. Centre for Nanotechnology & Advanced Biomaterials (CeNTAB), SASTRA Deemed University, Thanjavur, Tamil Nadu, 613 401, India

    Indhu Suresh, Noel Nesakumar & John Bosco Balaguru Rayappan

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  1. Shruthee Sankarlinkam
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Contributions

Shruthee Sankarlinkam—investigation, methodology, conceptualization, data curation, writing original draft, Indhu Suresh—investigation, methodology, conceptualization, writing original draft, G. Hariharan—mathematical analysis, review and editing, Noel Nesakumar—formal analysis, data curation, writing review & editing, Arockia Jayalatha Kulandaisamy—formal analysis, data curation, original draft, John Bosco Balaguru Rayappan—formal analysis, project administration, funding acquisition, and writing review & editing. All authors participated in the discussion, contributing to the final manuscript.

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Correspondence to John Bosco Balaguru Rayappan.

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Sankarlinkam, S., Suresh, I., Hariharan, G. et al. Ethylenediaminetetraacetic acid intercalated MgAl-layered double-hydroxides nanocomposite as an efficient platform in the development of electrochemical sensor for the detection of iron (II). J Appl Electrochem 54, 309–321 (2024). https://doi.org/10.1007/s10800-023-01970-4

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