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Comparison of different sources of mesenchymal stem cells: focus on inflammatory bowel disease

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Abstract

Inflammatory bowel disease (IBD) poses a significant challenge in modern medicine, with conventional treatments limited by efficacy and associated side effects, necessitating innovative therapeutic approaches. Mesenchymal stem cells (MSC) have emerged as promising candidates for IBD treatment due to their immunomodulatory properties and regenerative potential. This thesis aims to explore and compare various sources of MSC and evaluate their efficacy in treating IBD. This study comprehensively analyses MSC derived from multiple sources, including bone marrow, adipose tissue, umbilical cord, and other potential reservoirs. Core elements of this investigation include assessing differences in cell acquisition, immunomodulatory effects, and differentiation capabilities among these MSC sources, as well as comparing their clinical trial outcomes in IBD patients to their therapeutic efficacy in animal models. Through meticulous evaluation and comparative analysis, this thesis aims to elucidate disparities in the efficacy of different MSC sources for IBD treatment, thereby identifying the most promising therapeutic applications. The findings of this study are intended to advance our understanding of MSC biology and offer valuable insights for selecting the most effective MSC sources for personalized IBD therapy. Ultimately, this research endeavor will optimise therapeutic strategies for managing inflammatory bowel disease through the utilization of MSC.

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Funding

This work was supported by grants from the Tai Shan Young Scholar Foundation of Shandong Province [tsqn202103190]; the National Natural Science Foundation of China [82270562, 82200591]; Shandong Provincial Traditional Chinese Medicine Science and Technology Program [M-2023173, Q-2022134].

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Authors and Affiliations

  1. Cheeloo College of Medicine, Shandong University, Jinan, 250012, China

    Lihao Shi, Leilei Chen & Guangxi Zhou

  2. Department of Gastroenterology, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, 272000, People’s Republic of China

    Fengqin Zhu & Guangxi Zhou

  3. Medical Research Center, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, People’s Republic of China

    Guiyuan Jin & Yonghong Yang

  4. Department of Burns and Plastic Surgery, Affiliated Hospital of Jining Medical University, Jining, China

    Yiming Shao

  5. Clinical Medical College of Jining Medical University, Jining Medical University, Jining, Shandong, 272000, People’s Republic of China

    Xizhuang Gao & Xufan Sun

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Lihao Shi wrote the manuscript and designed the figures. Leilei Chen, Xizhuang Gao, Xufan Sun, Guiyuan Jin, Yonghong Yang, Yiming Shao, and Fengqin Zhu revised the manuscript. Guangxi Zhou conceived the idea and designed the manuscript. All authors gave final approval for the submission. All authors agree to be accountable for all aspects of the work and all authors read and approved the final manuscript.

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Shi, L., Chen, L., Gao, X. et al. Comparison of different sources of mesenchymal stem cells: focus on inflammatory bowel disease. Inflammopharmacol (2024). https://doi.org/10.1007/s10787-024-01468-1

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