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Current status and future directions in pediatric ventricular assist device

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Abstract

A ventricular assist device (VAD) is a form of mechanical circulatory support that uses a mechanical pump to partially or fully take over the function of a failed heart. In recent decades, the VAD has become a crucial option in the treatment of end-stage heart failure in adult patients. However, due to the lack of suitable devices and more complicated patient profiles, this therapeutic approach is still not widely used for pediatric populations. This article reviews the clinically available devices, adverse events, and future directions of design and implementation in pediatric VADs.

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Funding

This work was supported by the National Natural Science Foundation of China (82000389), the project of Shanghai Municipal Science and Technology Commission (20MC1920400) and Innovative research team of high-level universities in Shanghai (2021).

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  1. Xu Huang and Yi Shen contributed equally to this work.

Authors and Affiliations

  1. Heart Center and Shanghai Institute of Pediatric Congenital Heart Disease, Shanghai Children’s Medical Center, National Children’s Medical Center, Shanghai Jiaotong University School of Medicine, No. 1678, Dongfang Rd, Pudong District, Shanghai, 200127, China

    Xu Huang, Yi Shen, Yiwei Liu & Hao Zhang

  2. Department of Cardiothoracic Surgery, Shanghai Children’s Medical Center, National Children’s Medical Center, Shanghai Jiaotong University School of Medicine, No. 1678, Dongfang Rd, Pudong District, Shanghai, 200127, China

    Xu Huang, Yi Shen, Yiwei Liu & Hao Zhang

  3. Shanghai Clinical Research Center for Rare Pediatric Diseases, Shanghai Children’s Medical Center, National Children’s Medical Center, Shanghai Jiaotong University School of Medicine, No. 1678, Dongfang Rd, Pudong District, Shanghai, 200127, China

    Xu Huang, Yi Shen, Yiwei Liu & Hao Zhang

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Hao Zhang contributed to the conceptualization of this work. Literature search and visualization were performed by Xu Huang. The original draft of the manuscript was written by Xu Huang, and Yi Shen and Yiwei Liu contributed to the review and editing of the manuscript. Funding acquisition was provided by Yiwei Liu and Hao Zhang. All authors read and approved the final manuscript.

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Huang, X., Shen, Y., Liu, Y. et al. Current status and future directions in pediatric ventricular assist device. Heart Fail Rev (2024). https://doi.org/10.1007/s10741-024-10396-9

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