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Heart Failure Reviews

, Volume 22, Issue 6, pp 665–683 | Cite as

Angiogenic growth factors in myocardial infarction: a critical appraisal

  • Hemalatha Thiagarajan
  • UmaMaheswari Thiyagamoorthy
  • Iswariya Shanmugham
  • Gunadharini Dharmalingam Nandagopal
  • Anbukkarasi Kaliyaperumal
Article

Abstract

In the recent past, substantial advances have been made in the treatment of myocardial infarction (MI). Despite the impact of these positive developments, MI remains to be a leading cause of morbidity as well as mortality. An interesting hypothesis is that the development of new blood vessels (angiogenesis) or the remodeling of preexisting collaterals may form natural bypasses that could compensate for the occlusion of an epicardial coronary artery. A number of angiogenic factors are proven to be elicited during MI. Exogenous supplementation of these growth factors either in the form of recombinant protein or gene would enhance the collateral vessel formation and thereby improve the outcome after MI. The aim of this review is to describe the nature and potentials of different angiogenic factors, their expression, their efficacy in animal studies, and clinical trials pertaining to MI.

Keywords

Angiogenesis Myocardial infarction Angiogenic growth factors Therapeutic angiogenesis Clinical trials 

Notes

Acknowledgements

The award of DST-Women scientist fellowship to T. Hemalatha, S. Iswariya, and D.N. Gunadharini is gratefully acknowledged.

Compliance with ethical standards

Conflict of interest

The authors T. Hemalatha, T. UmaMaheswari, S. Iswariya, D.N. Gunadharini, and K. Anbukkarasi declare that there are no conflicts of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Hemalatha Thiagarajan
    • 1
  • UmaMaheswari Thiyagamoorthy
    • 2
  • Iswariya Shanmugham
    • 1
  • Gunadharini Dharmalingam Nandagopal
    • 1
  • Anbukkarasi Kaliyaperumal
    • 3
  1. 1.Department of Biological MaterialsCSIR - Central Leather Research InstituteChennaiIndia
  2. 2.Department of Food Science and Nutrition, Home Science College and Research InstituteTamil Nadu Agricultural UniversityMaduraiIndia
  3. 3.Department of Agricultural MicrobiologyRVS Agriculture CollegeThanjavurIndia

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