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Effects of Gastric Electrical Stimulation with Short Pulses and Long Pulses on Gastric Dysrhythmia and Signs Induced by Vasopressin in Dogs

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Abstract

Aims: This study was to investigate the effect of gastric electrical stimulation (GES) with short pulses, long pulses, short-pulse trains or long-pulse trains on gastric dysrhythmia and motion-sickness signs induced by vasopressin. Methods: Seven male beagle dogs implanted with four pairs of electrodes on gastric serosa were studied. The study was performed in six sessions in a randomized order. In session 1 or 2, either saline or vasopressin was infused without GES. In session 3, 4, 5 and 6, GES with short pulses, long pulses, trains of short pulses or trains of long pulses was performed before and during vasopressin infusion. Gastric slow waves and motion-sickness signs were recorded in each session. Results: (1) Vasopressin induced gastric dysrhythmia and motion sickness-like signs (ANOVA, P < 0.001). (2) GES with short pulses or trains of short pulses was capable of preventing vasopressin-induced emetic response (P < 0.001), but did not normalize gastric dysrhythmia. (3) GES with long pulses or trains of long pulses was able to normalize gastric dysrhythmia induced by vasopressin (P < 0.001), but showed no effects on vasopressin-induced motion-sickness signs. Conclusion: GES with short pulses or trains of short pulses prevents vasopressin-induced emetic response with no improvement in gastric dysrhythmia. GES with long pulses or trains of long pulses normalizes gastric dysrhythmia induced by vasopressin with no effects on signs.

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Acknowledgement

This study was partially supported by a research grant from National Institutes of Health (1R43DK066709–01).

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Authors and Affiliations

  1. Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Road, Wuhan, 430022, P.R. China

    Xiaohua Hou, Geng-Qing Song, Bin Yang, Yan Sun & Wei Qian

  2. Division of Gastroenterology, University of Texas Medical Branch, Galveston, TX, USA

    Jiande D. Z. Chen

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  1. Xiaohua Hou
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  2. Geng-Qing Song
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  3. Bin Yang
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  4. Yan Sun
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  5. Wei Qian
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  6. Jiande D. Z. Chen
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Correspondence to Xiaohua Hou.

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Xiaohua Hou and Geng-Qing Song contributed equally to this work.

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Hou, X., Song, GQ., Yang, B. et al. Effects of Gastric Electrical Stimulation with Short Pulses and Long Pulses on Gastric Dysrhythmia and Signs Induced by Vasopressin in Dogs. Dig Dis Sci 53, 630–635 (2008). https://doi.org/10.1007/s10620-007-9918-x

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  • DOI: https://doi.org/10.1007/s10620-007-9918-x

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