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Gastric Electrical Stimulation Optimized to Inhibit Gastric Motility Reduces Food Intake in Dogs

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Abstract

Aims

The aim of this study was to test the hypothesis that that a method of gastric electrical stimulation (GES) optimized to inhibit gastric motility was effective in reducing food intake in dogs.

Methods

Female dogs with a gastric cannula and gastric serosal electrodes were studied in three experiments: (1) to determine the best parameters and locations of GES in inhibiting gastric tone, slow waves, and contractions in dogs;( 2) to investigate the reproducibility of the inhibitory effects of GES; and (3) to study the effect of the GES method on food intake in dogs.

Results

(1) For GES to exert significant effects on gastric motility, a pulse width of ≥2 ms was required, and with other appropriate inhibitory parameters, GES was able to increase gastric volume by 190.4 %, reduce antral contractions by 39.7 %, and decrease the percentage of normal slow waves by 47.6 %. In addition, the inhibitory effect of GES was more potent with the stimulation electrodes placed along the lesser or greater curvature than placed in the middle, and more potent with the electrodes placed in the distal stomach than in the proximal stomach; (2) the inhibitory effects of GES on gastric motility were reproducible; (3) the GES method optimized to inhibit gastric motility produced a 20 % reduction in food intakes in non-obese dogs.

Conclusion

GES with appropriate parameters inhibits gastric motility, and the effects are reproducible. The GES method optimized to inhibit gastric motility reduces food intake in healthy dogs and may have a therapeutic potential for treating obesity.

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Acknowledgments

This study was supported by Medtronic and a research grant from the Oklahoma Center for the Advancement of Science and Technology (HR07-114).

Conflict of Interest

None of the authors (Geng-Qing Song, Hongbing Zhu, Yong Lei, Charlene Yuan, Warren Starkebaum, Jieyun Yin, or Jiande DZ Chen) had conflicts of interest.

Informed Consent Statement

Informed consent was obtained from all individual participants included in the study.

Statement of Human and Animal Rights

All applicable institutional and/or national guidelines for the care and use of animals were followed.

Author information

Author notes

  1. Geng-Qing Song

    Present address: Internal Medicine Department of Texas Tech University Health Sciences Center, Paul L. Foster School of Medicine, El Paso, TX, USA

Authors and Affiliations

  1. Veterans Research and Education Foundation, VA Medical Center, Oklahoma City, OK, USA

    Geng-Qing Song, Hongbing Zhu, Yong Lei, Jieyun Yin & Jiande D. Z. Chen

  2. Medtronic, Inc., Minneapolis, MN, USA

    Charlene Yuan & Warren Starkebaum

  3. Ningbo Pace Translational Medical Research Center, Beilun, Ningbo, China

    Jieyun Yin & Jiande D. Z. Chen

  4. Johns Hopkins Center for Neurogastroenterology, Baltimore, MD, USA

    Jiande D. Z. Chen

Authors
  1. Geng-Qing Song
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  2. Hongbing Zhu
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  3. Yong Lei
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  4. Charlene Yuan
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  5. Warren Starkebaum
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  6. Jieyun Yin
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  7. Jiande D. Z. Chen
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Corresponding author

Correspondence to Jiande D. Z. Chen.

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Song, GQ., Zhu, H., Lei, Y. et al. Gastric Electrical Stimulation Optimized to Inhibit Gastric Motility Reduces Food Intake in Dogs. OBES SURG 25, 1047–1055 (2015). https://doi.org/10.1007/s11695-014-1491-8

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  • DOI: https://doi.org/10.1007/s11695-014-1491-8

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