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Therapeutic Effects of Ecabet Sodium, an Antiulcer Drug, on Dextran Sodium Sulfate–Induced Ulcerative Colitis in Rats

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Abstract

Ecabet, an antiulcer drug, is reported to be effective in patients with ulcerative colitis. We investigated the effect of ecabet enema on ulcerative colitis in rats and some mechanisms underlying this effect. In vivo ecabet enema showed a therapeutic effect in the rat ulcerative colitis model induced by dextran sodium sulfate in the drinking water. The amount of ecabet bound to damaged mucosa was higher than that bound to normal mucosa 30 min after intrarectal administration. In vitro ecabet accelerated the restitution of epithelial cells, which was not affected by a TGF-β antibody. Ecabet inhibited the leukotriene B4 production and 5-lipoxygenase activity in human neutrophils. In conclusion, ecabet enema showed a therapeutic effect in rats with ulcerative colitis. This effect may be attributable to the high binding affinity for damaged mucosa, the acceleration of restitution, and the inhibition of leukotriene B4 production.

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Authors and Affiliations

  1. Discovery & Pharmacology Research Laboratories, Toda, Saitama, Japan

    Tsunehisa Noto PhD, Hiroshi Yamada MSc, Takashi Inui DVM, Kayoko Okuyama PhD, Ayako Watanable MSc, Isami Kimura PhD & Masaaki Nagasaki PhD

  2. Discovery & Pharmacology Research Laboratories, Tanabe Seiyaku Co., Ltd., 2-2-50 Kawagishi, Toda, Saitama, 335-8505, Japan

    Tsunehisa Noto PhD

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  1. Tsunehisa Noto PhD
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  2. Hiroshi Yamada MSc
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  3. Takashi Inui DVM
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  4. Kayoko Okuyama PhD
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  5. Ayako Watanable MSc
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  6. Isami Kimura PhD
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  7. Masaaki Nagasaki PhD
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Correspondence to Tsunehisa Noto PhD.

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Noto, T., Yamada, H., Inui, T. et al. Therapeutic Effects of Ecabet Sodium, an Antiulcer Drug, on Dextran Sodium Sulfate–Induced Ulcerative Colitis in Rats. Dig Dis Sci 50, 922–927 (2005). https://doi.org/10.1007/s10620-005-2665-y

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  • DOI: https://doi.org/10.1007/s10620-005-2665-y

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