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Inhibitory effect of hot-water extract of quince (Cydonia oblonga) on immunoglobulin E-dependent late-phase immune reactions of mast cells

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An Erratum to this article was published on 21 July 2011

An Erratum to this article was published on 21 July 2011

Abstract

We evaluated the effect of a crude hot-water extract (HW) of quince (Cydonia oblonga Miller) fruit on immunoglobulin E (IgE)-dependent late-phase immune reactions of mast cells using in vitro system. Mast cell-like RBL-2H3 cells were treated with quince HW and late-phase reaction was then induced by stimulation with IgE + Antigen. Quince HW reduced the elevation of interleukin-13 and tumor necrosis factor-α expression level. Furthermore, quince HW suppressed these cytokine expressions of mouse bone marrow-derived mast cells (BMMCs), a normal mast cell model. Leukotriene C4 and prostaglandin D2 production in BMMCs after 1 and 6 h of stimulation, respectively, were also reduced by treating the cells with quince HW. We found that the induction of intracellular cyclooxygenase (COX)-2 expression but not COX-1 expression in BMMCs was reduced by quince HW. These results suggest that quince HW has an inhibitory effect on broad range of the late-phase immune reactions of mast cells.

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Abbreviations

Ag:

Antigen

BMMC:

Bone marrow-derived mast cell

COX:

Cyclooxygenase

ELISA:

Enzyme-linked immunosorbent assay

FBS:

Fetal bovine serum

FcεRI:

High-affinity IgE receptor

FITC:

Fluorescein isothiocyanate

GAPDH:

Glyceraldehyde-3-phosphate dehydrogenase

HW:

Hot-water extract

IgE:

Immunoglobulin E

IL:

Interleukin

LT:

Leukotriene

NSAID:

Nonsteroidal anti-inflammatory drug

PBS:

Phosphate-buffered saline

PE:

Phycoerythrin

PG:

Prostaglandin

RT–PCR:

Reverse transcription-polymerase chain reaction

SD:

Standard deviation

TNF:

Tumor necrosis factor

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Acknowledgments

This research was partly supported by a grant from the Shinshu Foundation for Promotion of Agricultural and Forest Science. I would like to express my sincere gratitude to Professor Hajime Otani, Laboratory of Food Bioscience, Faculty of Agriculture, Shinshu University, for providing me the opportunity to study in his laboratory. This work was also technically supported by the Collaborated Research Center for Food Functions, Faculty of Agriculture, Shinshu University (CREFAS) and the Research Center for Human and Environmental Sciences Division of Instrumental Analysis, Shinshu University.

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Authors and Affiliations

  1. Laboratory of Food Bioscience, Faculty of Agriculture, Shinshu University, 8304, Minamiminowa, Kamiina, Nagano, 399-4598, Japan

    Takeshi Kawahara & Tatsuhiro Iizuka

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  1. Takeshi Kawahara
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  2. Tatsuhiro Iizuka
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Correspondence to Takeshi Kawahara.

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An erratum to this article can be found at http://dx.doi.org/10.1007/s10616-011-9370-9

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Kawahara, T., Iizuka, T. Inhibitory effect of hot-water extract of quince (Cydonia oblonga) on immunoglobulin E-dependent late-phase immune reactions of mast cells. Cytotechnology 63, 143–152 (2011). https://doi.org/10.1007/s10616-010-9323-8

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