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Antifungal Cytosporone Derivatives from the Mangrove-Derived Fungus Dothiorella sp. ML002

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Chemistry of Natural Compounds Aims and scope

A new cytosporone derivative, dothiorelone P (1), and one known analog, dothiorelone E (2), were isolated from fermentation culture of the mangrove-derived fungus Dothiorella sp. ML002. Their structures were identified by comprehensive analyses of 1D and 2D NMR and HR-ESI-MS spectroscopic data. Compound 2 exhibited inhibitory activity against Candida albicans with the MIC value of 6.25 μg/mL.

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ACKNOWLEDGMENT

This work was supported by the Key Science and Technology Program of Hainan Province (No. ZDKJ202008), Hainan Provincial Natural Science Foundation of China (No. 220RC593), the National Natural Science Foundation of China (No. 31760093), the specific research fund of the Innovation Platform for Academicians of Hainan Province (No. YSPTZX202030), and the Academician Innovation Center of Hainan Province.

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Authors and Affiliations

  1. Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, 571158, Hainan, P. R. China

    Daniel Osei Dankyira, Bin Wang, Jin Cai, Wei-nv Zeng, Guo-Lei Huang & Cai-Juan Zheng

  2. Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, 571158, Hainan, P. R. China

    Daniel Osei Dankyira, Bin Wang, Jin Cai, Wei-nv Zeng, Guo-Lei Huang & Cai-Juan Zheng

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  1. Daniel Osei Dankyira
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  2. Bin Wang
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  3. Jin Cai
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  4. Wei-nv Zeng
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  5. Guo-Lei Huang
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  6. Cai-Juan Zheng
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Corresponding authors

Correspondence to Guo-Lei Huang or Cai-Juan Zheng.

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Published in Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2022, pp. 711–713.

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Dankyira, D.O., Wang, B., Cai, J. et al. Antifungal Cytosporone Derivatives from the Mangrove-Derived Fungus Dothiorella sp. ML002. Chem Nat Compd 58, 842–844 (2022). https://doi.org/10.1007/s10600-022-03812-9

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  • DOI: https://doi.org/10.1007/s10600-022-03812-9

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