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Chemical Constituents from Acanthopanax senticosus and Their Cytotoxic Activities

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Chemistry of Natural Compounds Aims and scope

A new lignan, named 1,6-bis-(3-methoxy-4-hydroxyphenyl)hexane-1,6-dione (1), together with seven known compounds (2–8) were isolated from the EtOAc-soluble extract of Acanthopanax senticosus. Their structures were elucidated based on extensive spectroscopic analyses. All isolates were evaluated for in vitro cytotoxic activity against human cancer cells of HepG2, A549, HeLa, and MCF-7. Among them, compound 8 showed significant cytotoxic activity on HepG2 and MCF-7 cells with IC50 values of 10.9 ± 1.7 and 9.2 ± 1.5 μM, respectively.

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Acknowledgment

This work was financially supported by the General Project of Zhejiang Provincial Education Department (Grant No. Y201840285).

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Authors and Affiliations

  1. Department of Pharmacy, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science & Technology, 430030, Wuhan, P. R. China

    Ying-Ying Wei

  2. Department of Thoracic Surgery, Tongji Hospital affiliated to Tongji Medical College, Huazhong University of Science & Technology, 430030, Wuhan, P. R. China

    Peng Han, Jia-Qi Yue & Fan Li

Authors
  1. Ying-Ying Wei
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  2. Peng Han
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  3. Jia-Qi Yue
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  4. Fan Li
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Corresponding author

Correspondence to Fan Li.

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Published in Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2022, pp. 521–523.

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Wei, YY., Han, P., Yue, JQ. et al. Chemical Constituents from Acanthopanax senticosus and Their Cytotoxic Activities. Chem Nat Compd 58, 610–613 (2022). https://doi.org/10.1007/s10600-022-03753-3

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  • DOI: https://doi.org/10.1007/s10600-022-03753-3

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