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Anti-oxidant activities ofacanthopanax senticosus stems and their lignan components

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Abstract

The antioxidant activities ofAcanthopanax senticosus stems were evaluated in CCI4-intoxicated rats. Then-butanol fraction from the water extract of the stems, when pretreated orally at 200 mg/kg/day for 7 consecutive days in rats, was demonstrated to exhibit significant increases in antioxidant enzyme activities such as hepatic cytosolic superoxide dismutase, catalase and glutathione peroxidase by 30.31, 19.82 and 155%, respectively. Then-butanol fraction whereas showed a significant inhibition of serum GPT activity (65.79% inhibition) elevated with hepatic damage induced by CCI4-intoxication. Eleutheroside B, a lignan component, isolated from then-butanol fraction was found to cause a moderate free radical scavenging effect on DPPH, its scavenging potency as indicated in IC50 value, being 58.5 μM. These results suggested that the stems ofA. senticosus possess not only antioxidant but also hepatoprotective activities.

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Authors and Affiliations

  1. Natural Products Research Institute and College of Pharmacy, Seoul National University, 110-460, Seoul, Korea

    Sanghyun Lee & Sang Hoon Jung

  2. R & D Center for Functional Foods, Institute of Food and Culture, Pulmuone Co. Ltd., 120-600, Seoul, Korea

    Dongwook Son, Jiyoung Ryu, Jungil Kang, Sang Yun Lee & Hyun-Su Kim

  3. Seokwon Life Science Research Institute, World Sea Green Co. Ltd., 413-832, Paju, Korea

    Yeon Sil Lee & Kuk Hyun Shin

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  1. Sanghyun Lee
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  2. Dongwook Son
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  3. Jiyoung Ryu
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  4. Yeon Sil Lee
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  5. Sang Hoon Jung
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  7. Sang Yun Lee
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  9. Kuk Hyun Shin
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Correspondence to Kuk Hyun Shin.

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Lee, S., Son, D., Ryu, J. et al. Anti-oxidant activities ofacanthopanax senticosus stems and their lignan components. Arch Pharm Res 27, 106–110 (2004). https://doi.org/10.1007/BF02980055

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  • DOI: https://doi.org/10.1007/BF02980055

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