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Anti-Proliferative Naphthalene Glucoside from Aerial Part of Neanotis wightiana

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Chemistry of Natural Compounds Aims and scope

A new bioactive naphthalene glucoside, named neanoside C (1), was isolated from the aerial part of Neanotis wightiana. The structure of neanoside C (1) was elucidated as 1,4-dihydroxy-2-(6′-Omethylglucopyranosyloxymethyl)-naphthalene-3-vinyloxyglucopyranoside by interpretation of the spectroscopic data, including 2D NMR and chemical studies. Neanoside C (1) was further subjected to screening for anticancer potential using MTT based cytotoxicity assay, LDH leakage assay, and estimation of intracellular ROS production in two human breast cancer cell line. The compound exhibited promising anti-proliferative and cytotoxic effect against MCF-7 and MDA-MB-231 cell lines with an IC50 value of 22.77 nM and 35.71 nM, respectively. Neanoside C (1) also exhibited concentration-dependent intracellular LDH leakage and ROS production.

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Acknowledgment

The authors are thankful to Prof. B. K. Datta, Department of Botany, Tripura University, India for identification of the plant. The authors wish to thank Prof. B. Dinda (Retd.), Department of Chemistry, Tripura University, India for support, co-operation and encouragement during the work.

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Authors and Affiliations

  1. Department of Chemistry, Iswar Chandra Vidyasagar College, Belonia, Tripura, 799 155, India

    Niranjan Das

  2. Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, 835 215, India

    Prashanta Kumar Deb & Biswatrish Sarkar

  3. Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, 320 E Superior St, Chicago, IL, 60611, USA

    Eunus S. Ali

  4. Department of Medical Laboratory Technology, Women′s Polytechnic, Hapania, Agartala, Tripura, 799 130, India

    Manash C. Das

  5. Department of Life Sciences, Chhatrapati Shahu Ji Maharaj University, Kanpur, Uttar Pradesh, 208025, India

    Siddhartha Kumar Mishra

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  1. Niranjan Das
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  2. Prashanta Kumar Deb
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  3. Eunus S. Ali
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  4. Manash C. Das
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  5. Biswatrish Sarkar
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Correspondence to Niranjan Das.

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Published in Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2022, pp. 23–27.

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Das, N., Deb, P.K., Ali, E.S. et al. Anti-Proliferative Naphthalene Glucoside from Aerial Part of Neanotis wightiana. Chem Nat Compd 58, 21–26 (2022). https://doi.org/10.1007/s10600-022-03591-3

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  • DOI: https://doi.org/10.1007/s10600-022-03591-3

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