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Cytotoxic triterpene glycosides from the roots of Sanguisorba officinalis

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Abstract

Phytochemical investigation of the ethanol extract of the roots of Sanguisorba officinalis resulted in the isolation of three new triterpene glycosides, 3β-[(α-L-arabinopyranosyl)oxy]-19α,23-dihydroxyolean-12-en-28-oic acid 28-[6-O-acetyl-β-D-glucopyranosyl] ester (1), 2α,3β,19α,23-tetrahydroxyurs-12-en-28-oic acid 28-[6-O-acetyl-β-D-glucopyranosyl] ester (2), and 3β-[(α-L-arabinopyranosyl)oxy]-19α-hydroxyurs-12,20(30)-dien-28-oic acid 28-[6-O-acetyl-β-D-glucopyranosyl] ester (3). All the triterpene glycosides exhibited the significant cytotoxic potential with low IC50 values (IC50 < 5.0 μM) against six tumor cell lines (MCF-7, HeLa, HepG2, SGC-7901, NCI-H460, and BGC-823).

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Acknowledgments

The above research was made possible by the grant from the Scientific Planning Project of the Applied Basic Research of Yunnan Province (S2012FZ0005) and the Developing Key Subject of Ecology of Qujing Normal University.

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Authors and Affiliations

  1. College of Biological Resources and Environment Science, Qujing Normal University, Sanjiang Avenue, Unicorn District, Qujing, 655011, Yunnan, China

    Jiang Hu, Xia Mao, Yongmao Zhao & Xiaodong Shi

  2. Department of Pharmacy, 455 Hospital of People’s Liberation Army, Shanghai, 200052, China

    Yan Song

  3. College of Physics and Electronic Engineering, Qujing Normal University, Qujing, 655011, China

    Hui Li

  4. Institute of Microbiology, Qujing Medical College, Qujing, 655000, Yunnan, China

    Benshou Yang

Authors
  1. Jiang Hu
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  2. Yan Song
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  3. Hui Li
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  4. Benshou Yang
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  5. Xia Mao
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  6. Yongmao Zhao
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  7. Xiaodong Shi
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Corresponding author

Correspondence to Jiang Hu.

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Jiang Hu and Yan Song have contributed equally to this work.

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Hu, J., Song, Y., Li, H. et al. Cytotoxic triterpene glycosides from the roots of Sanguisorba officinalis . Arch. Pharm. Res. 38, 984–990 (2015). https://doi.org/10.1007/s12272-014-0477-3

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  • DOI: https://doi.org/10.1007/s12272-014-0477-3

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