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Folipidine, a New Type Quinoline Alkaloid from Plants of the Haplophyllum Genus

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Abstract

The new quinoline alkaloid folipidine, the structure of which was established by chemical transformations and spectral data (UV, IR, mass, NMR) using APT, 2D 1H-1H COSY, NOESY, and 1H-13C HSQC, HMBC, was isolated from two plants of the Haplophyllum genus. Folipidine is the first representative of a new type of quinoline alkaloids that contain a heteroaromatic skeleton of [3,4-b] conjugated pyrrole and quinoline fragments. The total alkaloids of these plants exhibit antitumor activity. Folipidine does not possess such activity.

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Authors and Affiliations

  1. S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent, Uzbekistan

    V. I. Akhmedzhanova, Kh. A. Rasulova, I. A. Bessonova & N. D. Abdullaev

  2. N. D. Zelinskii Institute of Organic Chemistry, Russian Academy of Sciences, 117913, Moscow, B-334, Leninskii prospekt, 47, Russia

    A. S. Shashkov

  3. Liege University, Belgium, B-4000, Liege, CHU, B36

    L. Angenot

Authors
  1. V. I. Akhmedzhanova
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  2. Kh. A. Rasulova
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  3. I. A. Bessonova
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  4. A. S. Shashkov
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  5. N. D. Abdullaev
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  6. L. Angenot
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Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 49–52, January–February, 2005.

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Akhmedzhanova, V.I., Rasulova, K.A., Bessonova, I.A. et al. Folipidine, a New Type Quinoline Alkaloid from Plants of the Haplophyllum Genus. Chem Nat Compd 41, 60–64 (2005). https://doi.org/10.1007/s10600-005-0075-1

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  • DOI: https://doi.org/10.1007/s10600-005-0075-1

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